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Piezo机械敏感性离子通道在骨关节系统中的作用

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中国修复重建外科杂志 2024年第2期38卷 240-248页

作者：陈国辉李亚星张晖解慧琪四川大学华西医院骨科成都610041 四川大学华西医院骨科研究所成都610041 四川大学华西医院国家重点实验室干细胞与组织工程研究室成都610041

目的总结Piezo机械敏感性离子通道在骨关节系统中的作用,以期为后续研究提供参考。方法广泛查阅国内外相关文献,对Piezo离子通道的结构特点、门控机制、激活剂与阻滞剂及其在骨关节系统中的作用进行总结。结果骨关节系统是机体主要承重... 详细信息

目的总结Piezo机械敏感性离子通道在骨关节系统中的作用,以期为后续研究提供参考。方法广泛查阅国内外相关文献,对Piezo离子通道的结构特点、门控机制、激活剂与阻滞剂及其在骨关节系统中的作用进行总结。结果骨关节系统是机体主要承重和运动组织,其感知并响应机械刺激的能力是维持骨关节正常生理功能的保障之一,许多骨关节疾病的发生、发展与异常机械负荷有紧密关系。目前研究显示Piezo机械敏感性离子通道通过响应拉伸刺激、细胞Ca^(2+)内流信号调节向成骨方向分化;并影响成骨细胞的增殖与迁移,通过成骨细胞-破骨细胞之间细胞交流维持骨内稳态。同时,Piezo1蛋白可以通过其宿主细胞间接参与调控破骨细胞的形成及活性,进而调节骨重塑过程。而Piezo1离子通道在机械刺激时,通过调节Akt、Wnt1信号通路表达,维持骨内稳态;针对Piezo1、2离子通道对高应变机械信号的敏感性,介导的Ca^(2+)内流以及炎症信号使得软骨细胞中Piezo1离子通道机械转导敏感性增加的特性,有望成为靶向性防治骨关节炎的新切入点。但机械刺激如何调控骨关节生理/病理过程仍待阐明。结论Piezo机械敏感性离子通道赋予了骨关节系统感知并响应机械应力的重要能力,在其细胞命运转归、骨骼发育、骨与软骨稳态维持等方面扮演关键的机械传感作用。

关键词：骨关节系统 Piezo 机械敏感性离子通道机械转导

Modeling of U-shaped Ba0.5Sr0.5Co0.8Fe0.2O3-δhollow-fiber membrane for oxygen permeation

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Chinese Journal of Chemical Engineering 2017年第7期25卷 892-897页

作者： huiqi xie Yanying Wei Haihui Wang School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China

A mathematic model is developed for the perovskite-type mixed ionic-electronic conducting(MIEC) membrane,which makes it possible to simulate the process of oxygen separation in the U-shaped Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_3-δhollow-fiber membrane. The model correlates the oxygen permeation flux to the measurable variables. The trends of calculated results for purge operation coincide well with the experimental data, therefore the model is considerable for flux prediction under vacuum operation. Higher oxygen separation efficiency can be achieved with vacuum operation than purge operation. Parameter study with vacuum operation reveals that oxygen permeation flux increases with higher vacuum levels, and vacuum pressure of around 1.013 × 10~3 Pa is the ***, vacuum operation on the lumen side is much more efficient to achieve higher oxygen permeation flux compared with compression mode on the shell side.

关键词： Membranes Mathematical modeling Separation Oxygen permeation Perovskite

Development of Therapy for Duchenne Muscular Dystrophy

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中国修复重建外科杂志 2007年第2期21卷 194-203页

作者： ZHANG Suzhen xie huiqi ZHOU Guangqian YANG Zhiming Division of Stem Cell and Tissue Engineering State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu Sichuan 610041 P. R. China.

Objective To review and summarize the latest development of the therapy for the Duchenne muscular dystrophy （DMD）. Methods The recently-published articles related to the therapies for DMD were extensively reviewed and briefly summarized. Results The therapeutic approaches for DMD included the gene therapy, the cell therapy, and the pharmacological therapy. The gene therapy and the cell therapy were focused on the treatment for the cause of DMD by the delivery of the missing gene, the modification of the mutated gene, and the transfer of the normal cells including the stem cells, while the pharmacological therapy dealt with the downstream events caused by the dystrophin gene defect, slowed down the pathologic progress of DMD, and improved the DMD patient＇s life quality and life span, by medication and other factor treatments. Conclusion There is still no cure for DMD because of various difficulties in replacing or repairing the defected gene and of the multifaceted nature of the severe symptoms. Therefore, it is imperative for us to find out a more effective treatment that can solve these problems.

关键词： Dystrophin gene Muscular dystrophy Gene therapy Cell therapy Pharmacological therapy

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食管组织工程：研究、应用与展望

现代仪器与医疗 2024年第04期30卷 10-15页

作者：张冀野张玥琦解慧琪四川大学华西医院干细胞与组织工程研究中心

食管作为人体消化系统的重要组成部分，其损伤与疾病严重影响着患者的健康与生活质量。近年来，组织工程技术在食管修复和重建中取得显著进展。本文旨在探讨食管组织工程在食管损伤修复和重建中的应用研究，以应对传统食管替代术带来的... 详细信息

食管作为人体消化系统的重要组成部分，其损伤与疾病严重影响着患者的健康与生活质量。近年来，组织工程技术在食管修复和重建中取得显著进展。本文旨在探讨食管组织工程在食管损伤修复和重建中的应用研究，以应对传统食管替代术带来的高并发症风险。本文综述了支架材料、种子细胞、生长因子等关键要素在组织工程食管构建中的一些最新研究进展，并总结了组织工程技术在内镜黏膜下剥离术后食管修复中的应用情况。最后，本文讨论了食管组织工程面临的挑战与未来研究方向，以期为食管组织工程的发展及转化提供参考。

关键词：食管组织工程支架材料种子细胞生长因子内镜黏膜下剥离术

Intra-articular injection of stromal vascular fraction for knee degenerative joint disease:a concise review of preclinical and clinical evidence

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Science China(Life Sciences) 2022年第10期65卷 1959-1970页

作者： Yuan Liu Liping Huang Yi Zeng Mingyang Li huiqi xie Bin Shen Orthopedics Research Institute Department of OrthopedicsNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Autologous fat-derived stromal vascular fraction(SVF) is a mixed cell population that has been used for many years in regenerative plastic *** terms of animal and clinical research,this concise review was performed to evaluate the efficacy of SVF in knee degenerative joint disease(KDJD),which could cause pain,disability and severely affect patients’ *** studies retrieved and screened from the databases were included,including six animal studies and seven clinical *** metaanalysis of clinical research shows that intra-articular injection of SVF,in combination with adjuvant surgery,could alleviate pain and improve early functional recovery for patients with KDJD at Kellgren-Lawrence(KL) grades Ⅱ–Ⅲ.

关键词： stromal vascular fraction knee degenerative joint disease meta-analysis review

Urine-derived stem cells:applications in skin,bone and articular cartilage repair

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Burns & Trauma 2021年第1期9卷 95-108页

作者： Wenqian Zhang Jungen Hu Yizhou Huang Chenyu Wu huiqi xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

As an emerging type of adult stem cell featuring non-invasive acquisition,urine-derived stem cells(USCs)have shown great potential for applications in tissue engineering and regenerative *** a growing amount of research on the topic,the effectiveness of USCs in various disease models has been shown and the underlying mechanisms have also been explored,though many aspects still remain *** this review,we aim to provide an up-to-date overview of the biological characteristics of USCs and their applications in skin,bone and articular cartilage *** addition to the identification procedure of USCs,we also summarize current knowledge of the underlying repair mechanisms and application modes of *** concerns and perspectives have also been summarized.

关键词： Urine-derived stem cells Skin Bone Articular cartilage Tissue engineering Cell therapy

Mesenchymal stem cell-based therapy for burn wound healing

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Burns & Trauma 2021年第1期9卷 507-522页

作者： Mingyao Wang Xinxuan Xu Xiongxin Lei Jie Tan huiqi xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyKeyuan Road 4Gaopeng StreetChengduSichuan 610041China

Burns,with their high incidence and mortality rates,have a devastating effect on *** are still huge challenges in the management of *** stem cells(MSCs),which have multidirectional differentiation potential,have aroused interest in exploring the capacity for treating different intractable diseases due to their strong proliferation,tissue repair,immune tolerance and paracrine abilities,among other ***,several animal studies have shown that MSCs play various roles and have beneficial effects in promoting wound healing,inhibiting burn inflammation and preventing the formation of pathological scars during burn healing *** substances MSCs secrete can act on peripheral cells and promote burn *** to preclinical research,MSC-based treatments can effectively improve burn wound healing and reduce ***,due to the small number of patients and the lack of controls,treatment plans and evaluation criteria vary widely,thus limiting the value of these clinical ***,to better evaluate the safety and effectiveness of MSC-based burn treatments,standardization of the application scheme and evaluation criteria of MSC therapy in burn treatment is required in the *** addition,the combination of MSC pretreatment and dressing materials are also conducive to improving the therapeutic effect of MSCs on *** this article,we review current animal research and clinical trials based on the use of stem cell therapy for treating burns and discuss the main challenges and coping strategies facing future clinical applications.

关键词： Burn Wound healing Stem cell-based therapy Clinical trial Regenerative medicine Proliferation Tissue repair Inflammation

Al-Mg铝合金电子束焊接头组织及性能研究

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焊接技术 2024年第7期53卷 43-48页

作者：李亚哲赵健谢会起吕竹文石磊王雅仙中国兵器科学研究院宁波分院浙江宁波315103

采用电子束焊对3 mm厚的5A06铝合金进行了焊接,对焊接接头的焊缝形貌、显微组织和力学性能进行了测试分析。结果表明,电子束焊能量密度和焊接热输入对焊缝形貌、组织和性能产生重要影响;随着聚焦电流和焊接热输入增加,焊缝熔宽逐渐变大... 详细信息

采用电子束焊对3 mm厚的5A06铝合金进行了焊接,对焊接接头的焊缝形貌、显微组织和力学性能进行了测试分析。结果表明,电子束焊能量密度和焊接热输入对焊缝形貌、组织和性能产生重要影响;随着聚焦电流和焊接热输入增加,焊缝熔宽逐渐变大,热影响区逐渐变宽;电子束焊缝中心组织为均匀的细小等轴晶,没有明显的方向性,沿熔合线附近生成细等轴晶带;随着焊接热输入增加,焊缝中Mg元素含量减小,焊缝晶粒尺寸变大,导致焊接接头力学性能下降。

关键词：铝合金电子束焊热输入组织性能

Metal-phenolic networks modified polyurethane as periosteum for bone regeneration

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Chinese Chemical Letters 2022年第3期33卷 1623-1626页

作者： Qingyi Zhang Kai Huang Jie Tan Xiongxin Lei Liping Huang Yuting Song Qianjin Li Chenyu Zou huiqi xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Treatment of bone defects still poses a great challenge in orthopedic clinics, and the vital role of periosteum in such processes has attracted widespread attention. However, studies focusing on the oxidative stress micro-environment with an artificial periosteum at the site of defect have been scarce. The intrinsic anti-oxidative properties and therapeutic potential for bone defects of metal-phenolic networks(MPNs)have provided a potential solution to this. Herein, we have developed a protocatechualdehyde + zinc ion(PCA+Zn^(Ⅱ)) MPN coating on a thermoplastic polyurethane membrane with a one-pot method to fabricate a new-type of periosteum with meritorious biocompatibility and abilities of modulating oxidative stress condition and promoting osteogenesis and mineralization for better bone regeneration, which has shown to be a promising strategy for constructing artificial periosteum with various MPNs.

关键词： Metal-phenolic networks Surface modification Periosteum Oxidative stress Mineralization