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以全程健康教育为导向的护理模式在糖尿病患者中的临床应用

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中西医结合护理（中英文） 2024年第5期10卷 174-176页

作者：郭惠萍张瑜肖丽华中山市人民医院广东中山528400

目的探讨对糖尿病患者应用以全程健康教育为导向的护理模式对其血糖水平及健康知识掌握程度的影响。方法回顾性分析2020年2月至2023年2月中山市人民医院收治的112例糖尿病患者的资料,按照不同的护理方法分为2组。对照组56例患者用常规护... 详细信息

目的探讨对糖尿病患者应用以全程健康教育为导向的护理模式对其血糖水平及健康知识掌握程度的影响。方法回顾性分析2020年2月至2023年2月中山市人民医院收治的112例糖尿病患者的资料,按照不同的护理方法分为2组。对照组56例患者用常规护理,观察组56例患者用以全程健康教育为导向的护理模式。比较2组的血糖水平、健康知识掌握程度、胰岛素抵抗指数(HOMA-IR)、β细胞功能指数(HOMA-β)和胰岛素敏感指数(INS)。结果出院时、出院2个月后,2组的空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于入院时,且观察组均低于同期对照组;随访2个月后,观察组的健康知识掌握程度6项评分均高于对照组;干预1个月后,2组的HOMA-IR、HOMA-β、INS均优于干预前,且观察组均优于对照组,以上所有结果均有统计学差异(P均<0.05)。结论以全程健康教育为导向的护理模式可稳定糖尿病患者的血糖水平,促使其掌握健康知识,改善其HOMA-IR、HOMA-β、INS指标。

关键词：糖尿病全程健康教育血糖水平健康知识掌握程度

艾瑞昔布联合甲氨蝶呤对强直性脊柱炎患者血清VEGF、ESR、DKK-1及骨代谢的影响

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世界临床药物 2024年第4期45卷 403-407,423页

作者：蔡玉霞王玲郑悦玲郭会平山西省长治市人民医院风湿免疫科山西长治046000

目的探讨艾瑞昔布联合甲氨蝶呤(methotrexate,MTX)对强直性脊柱炎(ankylosing spondylitis,AS)患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、Dickkopf-1相关蛋白(recombinant Dickkopfrelated protein 1,DKK-1)及骨代谢的影响。方法选择2020年6月至2023年6月我院风湿免疫科就诊的AS患者113例,采用随机数表法分为试验组(艾瑞昔布+MTX,n=57)和对照组(MTX,n=56)。比较两组临床疗效、血清VEGF、ESR、DKK-1、骨代谢指标[骨钙素(bone gla protein,BGP)、骨碱性磷酸酶(bone alkaline phosphatase,BALP)]及Bath AS疾病活动性指数(Bathankylosing spondylitis disease activity index,BASDAI)评分、指地距及并发症发生情况。结果治疗后,试验组总有效率高于对照组(91.23%vs 76.79%,P0.05)。结论艾瑞昔布联合MTX在AS的治疗中效果较好,可提高骨代谢水平,值得临床推广与运用。

关键词：艾瑞昔布甲氨蝶呤强直性脊柱炎血管内皮生长因子红细胞沉降率 Dickkopf-1相关蛋白骨代谢

Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1258-1270页

作者： Ziwen Zheng guo Li Chong Cui Fang Wang Xiaohan Wang Zhijiao Xu huiping guo Yuxin Chen Honghai Tang Daqi Wang Mingqian Huang Zheng-Yi Chen Xingxu Huang Huawei Li Geng-Lin Li Xiaoxiang Hu Yilai Shu ENT Institute and Department of Otorhinolaryngology Eye&ENT HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200032China State Key Laboratory of Agrobiotechnology China Agricultural UniversityBeijing 100193China College of Biological Sciences China Agricultural UniversityBeijing 100193China School of Life Science and Technology Southeast UniversityNanjing 210096China Department of Otolaryngology-Head and Neck Surgery Graduate Program in Speech and Hearing Bioscience and Technology and Program in NeuroscienceHarvard Medical SchoolBostonMA 02115USA Eaton-Peabody Laboratory Massachusetts Eye and Ear InfirmaryBostonMA 02114USA School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200031China

CRISPR/RfxCas13d(CasRx)editing system can specifically and precisely cleave single-strand RNAs,which is a promising treatment for various disorders by downregulation of related gene ***,we tested this RNA-editing approach on Beethoven(Bth)mice,an animal model for human DFNA36 due to a point mutation in *** first screened 30 sgRNAs in cell cultures and found that CasRx with sgRNA3 reduced the Tmc1^(Bth)transcript by 90.8%,and the Tmc1 wild type transcript(Tmc1^(+))by 44.3%.We then injected a newly developed AAV vector(***)based CasRx into the inner ears of neonatal Bth mice,and we found that Tmc1^(Bth)was reduced by 70.2%in 2 weeks with few off-target effects in the whole ***,we found improved hair cell survival,rescued hair bundle degeneration,and reduced mechanoelectrical transduction ***,the hearing performance,measured in both ABR and DPOAE thresholds,was improved significantly in all ages over 8 ***,therefore,have validated the CRISPR/CasRx-based RNA editing strategy in treating autosomal-dominant hearing loss,paving way for its further application in many other hereditary diseases in hearing and beyond.

关键词： CRISPR/Cas editing hearing

Effects of substituting Ni with M (M=Cu, Al and Mn) on microstructures and electrochemical characteristics of La-Mg-Ni system (PuNi_3-type) electrode alloys

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Rare Metals 2006年第Z1期25卷 25-32页

作者： ZHANG Yanghuan ZHAO Dongliang DONG Xiaoping REN huiping guo Shihai WANG Xinlin Department of Functional Material Research Central Iron and Steel Research Institute Beijing 100081 China School of Material Inner Mongolia University of Science and Technology Baotou 014010 China Department of Functional Material Research Central Iron and Steel Research Institute Beijing 100081 China Department of Functional Material Research Central Iron and Steel Research Institute Beijing 100081 China School of Material University of Science and Technology Beijing Beijing 100083 China School of Material Inner Mongolia University of Science and Technology Baotou 014010 China Department of Functional Material Research Central Iron and Steel Research Institute Beijing 100081 China Department of Functional Material Research Central Iron and Steel Research Institute Beijing 100081 China

In order to improve the electrochemical cycle stability of La-Mg-Ni system (PuNi3-type) hydrogen storage alloy, Ni in the alloys was partially substituted by M (M=Cu, Al, Mn). A new La-Mg-Ni system electrode alloys La0.7Mg0.3Ni2.55-xCo0.45Mx (M=Cu, Al, Mn; x=0, 0.1) were prepared by casting and rapid quenching. The effects of element substitution and rapid quenching on the microstructures and electrochemical performances of the alloys were investigated. The results by XRD, SEM and TEM show that the alloys have a multiphase structure, including the (La, Mg)Ni3 phase, the LaNi5 phase and the LaNi2 phase. The rapid quenching and element substitution have an imperceptible influence on the phase compositions of the alloys, but both change the phase abundance of the alloys. The rapid quenching significantly improves the composition homogeneity of the alloys and markedly decreases the grain size of the alloys. The Cu substitution promotes the formation of an amorphous phase in the as-quenched alloy, and a reversal result by the Al substitution. The electrochemical measurement indicates that the element substitution decreases the discharge capacity of the alloys, whereas it obviously improves the cycle stability of the alloys. The positive influence of element substitution on the cycle life of the alloys is in sequence Al>Cu>Mn, and negative influence on the discharge capacity is in sequence Al>Mn>Cu. The rapid quenching significantly enhances the cycle stability of the alloys, but it leads to a different extent decrease of the discharge capacity of the alloys.

关键词： element substitution rapid quenching La-Mg-Ni system electrode alloy microstructures electrochemical performances

马云枝从“虚-瘀-毒”分期辨治帕金森病经验

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山东中医杂志 2024年第2期43卷 181-184页

作者：孟明贤沈晓明卢瑾周娇宁允帆郝诗楠郭惠平马云枝(指导) 河南中医药大学第一附属医院脑病二区河南郑州450099 河南中医药大学第一临床医学院河南郑州450046 不详

马云枝教授认为帕金森病的病因病机与虚、瘀、毒密切相关,肝肾虚损为发病之端,久虚致瘀为病情虚实互结之本,瘀久化毒乃疾病难解之根。临床可根据患者的不同表现,分期辨治。早期病在筋脉,以气虚少动为主,治疗应采用滋补肝肾、息风通络法... 详细信息

马云枝教授认为帕金森病的病因病机与虚、瘀、毒密切相关,肝肾虚损为发病之端,久虚致瘀为病情虚实互结之本,瘀久化毒乃疾病难解之根。临床可根据患者的不同表现,分期辨治。早期病在筋脉,以气虚少动为主,治疗应采用滋补肝肾、息风通络法,处方选六味地黄汤或知柏地黄汤加减。中期病在四肢,以肢体颤动多见,治疗应采用化瘀通络、活血止颤法,处方可选血府逐瘀汤。晚期病在五脏,以元气虚损为要,治疗应采用化瘀扶正、解毒除颤法,方选独活寄生汤合四君子汤加味。

关键词：帕金森病虚瘀毒补虚化瘀解毒分期论治

Mannanase improves the growth performance of broilers by alleviating inflammation of the intestinal epithelium and improving intestinal microbiota

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Animal Nutrition 2024年第1期16卷 376-394页

作者： Xiaodan Zhang huiping Xu Lu Gong Jiao Wang Jianyang Fu Zengpeng Lv Liangjuan Zhou Xuejun Li Qiong Liu Pingyu Xia Yuming guo State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and Technology China Agricultural University Beijing Strowin Biotechnology Co. Ltd.

This experiment aimed to discuss and reveal the effect and mechanism of mannanase on intestinal inflammation in broilers triggered by a soybean meal diet. In this experiment, 384 Arbor Acres broilers at1 d old were randomly divided into 3 treatment groups. The broilers were fed a corn-soybean meal basal diet, a low-energy diet(metabolizable energy reduced by 50 kcal/kg), and a low-energy diet supplemented with 100 mg/kg mannanase for 42 d. The low-energy diet increased feed conversion ratio from0 to 42 d, reduced ileal villus height and villus height-to-crypt depth ratio and upregulated the expression of nuclear factor kappa B(NF-κB) in the ileum(P < 0.05). It also reduced cecal short-chain fatty acids(SCFA), such as acetic acid(P < 0.05). Compared with low-energy diets, the addition of mannanase increased body weight at 42 d, promoted the digestibility of nutrients, and maintained the morphology and integrity of the intestinal epithelium of broilers(P < 0.05). In addition, mannanase upregulated the expression of claudin-1(CLDN1) and zonula occludens-1(ZO-1) in the jejunum at 21 d,downregulated the expression of ileal NF-κB, and increased the content of isobutyric acid in the cecum of broilers(P < 0.05). The results for the ileal microbiota showed that a low-energy diet led to a decrease in the relative abundance of Lactobacillus reuteri in the ileum of broilers. The addition of mannanase increased the relative abundance of Lactobacillus-KC45b and Lactobacillus johnsonii in broilers. Furthermore, a low-energy diet reduced the relative abundance of Butyricicoccus in the intestine of broilers and inhibited oxidative phosphorylation and phosphoinositol metabolism. Mannanase increased the relative abundance of Odoribacter, promoted energy metabolism and N-glycan biosynthesis, and increased the activities of GH3 and GH18. It is concluded that mannanase could improve the growth performance of broilers by reducing the expression of NF-κB in the ileum, increasing the produc

关键词： Broiler Low-energy diet Mannanase Intestinal inflammatory response Intestinal microbiota Metagenome

Size- and shape-controlled synthesis of monodisperse Co nanoparticles from cobalt acetate by thermal decomposition

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Rare Metals 2009年第3期28卷 241-244页

作者： LIN Tao SHAO huiping guo Zhimeng LUO Ji HAO Junjie School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Monodisperse cobalt nanoparticles with relatively high coercivities were synthesized by thermal decomposition of cobalt acetate for the application of ultra-high density magnetic recording media. Without using any reducing agent, Co nanoparticles of 13.9-21.3 nm in size were prepared using various protecting agents and a high boiling point solvent trioctylamine. The Co nanoparticles prepared with the mixture of oleic acid, oleylamine, and polyvinylpyrrolidone （PVP） showed clear crystalline structure of face centered cubic, and their coercivity was measured to be 27.2 kA/m. PVP was effective in controlling particle growth while hindering agglomeration between the particles. The as-prepared Co nanoparticles with a moderate coercivity can be applicable to patterned media.

关键词： cobalt nanoparticles high coercivity cobalt acetate thermal decomposition

Characterization of nanometer tungsten powders

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Rare Metals 2008年第2期27卷 197-200页

作者： LI Huiqian LIN Tao SHAO huiping WU Chengyi guo Zhimeng LUO Ji School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Three types of tungsten powders were prepared by hydrogen reduction of three precursor powders at low temperature, which were used as samples, and were then characterized by Brunauer-Emmer-Teller （BET） method, scanning electron microscopy （SEM）, transmission electronic microscopy （TEM）, small angle X-ray scattering （SAXS）, and field-emission scanning election microscopy （FESEM） respectively. The results showed that although BET and SEM could not characterize the particle size of nanometer powders, they were important means of assistance to exclude non-nanometer powders. TEM and FESEM could directly measure the particle size of nanometer powders, but this needs a lot of time, to count the average particle size and particle size distribution. SAXS could not describe the state of agglomeration. By the combination of FESEM and SAXS, the particle size, particle size distribution, and particle shape of nanometer powders could be precisely characterized.

关键词： nanometer tungsten powder particle size particle size distribution

Consolidation and properties of ultrafine binderless cemented carbide by spark plasma sintering

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Rare Metals 2008年第3期27卷 320-323页

作者： LIU Xiangqing LIN Tao Shao huiping guo Zhimeng LUO Ji HAO Junjie School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Owing to the absence of metal binder, binderless cemented carbides have higher wear, corrosion, and oxidation resistance. WC-0.3VC- 0.5Cr3C2 powders with an average particle size of 200 nm and a little amount of active element were consolidated by spark plasma sintering. The sintered microstructure revealed that the average WC grain size was 0.24μm, which was almost consistent with the initial free powder. The results of XRD showed that W2C phase was formed. Nearly complete densification of ultrafine binderless cemented carbide was achieved by sintering at 1400℃ for 120 s under 50 MPa. The resulting hardness and the fracture toughness were 28.18 GPa and 6.05 MPa·m1/2, respectively.

关键词： cemented carbide binderless carbide ultrafme mechanical properties spark plasma sintering