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The RALF1-FERONIA complex interacts with and activates TOR signaling in response to low nutrients

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Molecular Plant 2022年第7期15卷 1120-1136页

作者： Limei Song Guoyun Xu Tingting Li huina Zhou Qinlu lin Jia Chen Long Wang Dousheng Wu Xiaoxu Li Lifeng Wang Sirui Zhu Feng Yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Biologyand Hunan Key Laboratory of Plant Functional Genomics and Developmental RegulationHunan UniversityChangsha 410082P.R.China Zhengzhou Tobacco Research Institute of CNTC Zhengzhou 450001P.R.China National Engineering Laboratory for Rice and By-product Deep Processing Central South University of Forestry and TechnologyChangsha 410004P.R.China Technology Center China Tobacco Hunan Industrial Co.Ltd.Changsha 410007P.R.China State Key Laboratory of Hybrid Rice Hunan Agricultural Biotechnology Research InstituteHunan Academy of Agricultural SciencesChangsha 410125P.R.China

Target of rapamycin(TOR)kinase is an evolutionarily conserved major regulator of nutrient metabolism and organismal growth in *** plants,nutrients are remobilized and reallocated between shoots and roots under low-nutrient conditions,and nitrogen and nitrogen-related nutrients(e.g.,amino acids)are key upstream signals leading to TOR activation in shoots under low-nutrient ***,how these forms of nitrogen can be sensed to activate TOR in plants is still poorly *** we report that the Arabidopsis receptor kinase FERON IA(FER)interacts with the TOR pathway to regulate nutrient(nitrogen and amino acid)signaling under low-nutrient conditions and exerts similar metabolic effects in response to nitrogen *** found that FER and its partner,RPM1-induced protein kinase(RIPK),interact with the TOR/RAPTOR complex to positively modulate TOR signaling *** this process,the receptor complex FER/RIPK phosphorylates the TOR complex component *** RALF1 peptide,a ligand of the FER/RIPK receptor complex,increases TOR activation in the young leaf by enhancing FER-TOR interactions,leading to promotion of true leaf growth in Arabidopsis under lownutrient ***,we showed that specific amino acids(e.g.,Gin,Asp,and Gly)promote true leaf growth under nitrogen-deficient conditions via the FER-TOR ***,our study reveals a mechanism by which the RALF1-FER pathway activates TOR in the plant adaptive response to low nutrients and suggests that plants prioritize nutritional stress response over RALF1-mediated inhibition of cell growth under low-nutrient conditions.

关键词： TOR FERON IA nitrogen response amino acid response energy metabolism

Research Progress on the Function of Melatonin and Its Receptor in Animal Reproduction

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Agricultural Biotechnology 2022年第1期11卷 67-72页

作者： Tian lin Hefeng ZHANG Xiaoliang PEI huina BO Tangshan Food and Drug Comprehensive Testing Center Tangshan 063000China

Melatonin has been a research hotspot in the field of medicine and life sciences for more than 60 years since it was *** order to accelerate the increase of economic animal productivity,a large number of studies also have focused on the regulation of melatonin and its receptors during animal reproduction in recent *** this paper,the relevant characteristics of melatonin and the latest research progress in animal reproduction were discussed,and the biological functions of melatonin were reviewed from the aspects of germ cells,reproductive endocrine and embryo development,laying a theoretical foundation for further exploring the regulation mechanism of melatonin on reproductive process.

关键词： Melatonin Germ cells Hormones Embryo development

Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations

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Protein & Cell 2018年第4期9卷 351-364页

作者： Zhanpinq Shi Yanan Geng Jiping Liu huina Zhang Liqiang Zhou Quan lin Juehua Yu Kunshan Zhang Jie Liu Xinpei Gao Chunxue Zhang Yinan Yao Chong Zhang Yi E. Sun Stem Cell Translational Research Center Tongji Hospital Tongji University School of Medicine Shanghai 200065 China Department of Psychiatry and Biobehavioral Sciences and Intellectual Development and Disabilities Research Center David Geffen School of Medicine University of California Los Angeles CA 90095 USA Collaborative Innovation Center for Brain Science Tongji University Shanghai 200092 China

Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells （NSC/NPCs） activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal molecular alterations of cells undergoing various biological processes, the search for molecular mechanisms underlying aging of NSC/NPCs has been confronted by the enormous heterogeneity in cellular compositions of the brain and the complex cellular microenvironment where NSC/NPCs reside. Moreover, brain NSClNPCs themselves are not a homogenous population, making it even more difficult to uncover NSC/NPC sub-type specific aging mechanisms. Here, using both population-based and single cell transcriptome analyses of young and aged mouse forebrain ependymal and subependymal regions and comprehensive ＂big-data＂ processing, we report that NSCINPCs reside in a rather inflammatory environment in aged brain, which likely contributes to the differentiation bias towards astrocytes versus neurons. Moreover, single cell transcriptome analyses revealed that different aged NSCINPC subpopulations, while all have reduced cell proliferation, use different gene transcription programs to regulate age-dependent decline in cell cycle. Inter- estingly, changes in cell proliferation capacity are not influenced by inflammatory cytokines, but likely result from cell intrinsic mechanisms. The ErkJMapk pathway appears to be critically involved in regulating age-dependent changes in the capacity for NSCINPCs to undergo clonal expansion. Together this study is the first example of using population and single cell based transcriptome analyses to unveil the molecular interplay between different NSCINPCs and their microenvironment in the context of the aging brain.

关键词： NSC/NPCs SEZ/SVZ single cell transcriptome aging cell cycle Erk1/2

培智学校低年段生活语文信息化课堂教学互动研究

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中国特殊教育 2023年第9期 28-36页

作者：朱涵林晨宫慧娜华东师范大学教育学部上海200062 武汉市第二聋哑学校武汉430070 华中师范大学教育学院武汉430079

随着特殊教育信息化成为强化特殊教育普惠发展的创新引擎,以信息技术驱动特殊教育学校课堂教学变革已是推进中国式特殊教育现代化的关键抓手。本研究以培智学校低年段生活语文信息化课堂为着眼点,借助改进型弗兰德斯互动分析系统、滞后... 详细信息

随着特殊教育信息化成为强化特殊教育普惠发展的创新引擎,以信息技术驱动特殊教育学校课堂教学变革已是推进中国式特殊教育现代化的关键抓手。本研究以培智学校低年段生活语文信息化课堂为着眼点,借助改进型弗兰德斯互动分析系统、滞后序列分析法和课堂观察法揭示其教学互动的特征。研究发现:技术应用整体朝向通用学习设计本土实施发展,师生数字能力发展鸿沟仍旧存在;教学互动体现信息技术与学科教学融合趋势,培智学校学生主体性学习机会有待丰富;受教学惯习和功能限制模式影响,技术催生多元互动结构的作用有待加强。基于研究结果,提出优化低年段生活语文信息化课堂教学互动的若干建议。

关键词：信息化课堂教学互动培智学校生活语文

用高光谱成像技术检测柑橘红蜘蛛为害叶片的色素含量

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农业工程学报 2014年第6期30卷 124-130页

作者：李震洪添胜倪慧娜李楠王建郑建宝林瀚南方农业机械与装备关键技术教育部重点实验室广州510642 华南农业大学工程学院广州510642 华南农业大学公共基础课实验教学中心广州510642

为解决传统理化法检测柑橘树叶片受红蜘蛛为害后色素含量变化时存在的工作量大、效率低等问题,该文研究应用高光谱成像技术检测柑橘红蜘蛛为害叶片色素含量的方法。研究中对比了正常叶片与受害叶片的原始光谱以及原始光谱一阶微分曲线... 详细信息

为解决传统理化法检测柑橘树叶片受红蜘蛛为害后色素含量变化时存在的工作量大、效率低等问题,该文研究应用高光谱成像技术检测柑橘红蜘蛛为害叶片色素含量的方法。研究中对比了正常叶片与受害叶片的原始光谱以及原始光谱一阶微分曲线的差异,寻找反映叶片色素含量变化的特征波段;分析了特征波段反射率比值与叶片色素间相关性;采用单变量线性回归法分析了常用植被指数预测叶片色素含量的效果;采用逐步回归分析法建立了叶片色素含量预测模型,并对模型预测效果进行了F检验。结果表明:常用植被指数预测叶片色素含量结果不理想;选取的667/522、667/647和522/647 nm等3个特征波段反射率比值与叶片3种色素含量间具有较高的相关性;用于建立叶片色素含量预测模型的最佳特征波段反射率比值为667/522和667/647 nm,所建立的模型可较好地预测健康及受害叶片的叶绿素a、叶绿素b和类胡萝卜素含量。

关键词：光谱检测预测模型叶绿素高光谱成像特征波段柑橘红蜘蛛

RNA Sequencing Analysis Reveals Transcriptomic Variations in Tobacco (Nicotiana tabacum) Leaves Affected by Climate,Soil,and Tillage Factors

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RNA Sequencing Analysis Reveals Transcriptomic Variations in...

FERONIA interacts with E3 ubiquitin ligase ATL6 to regulate carbon/nitrogen balance in Arabidopsis

中国烟草学会2015年年会

作者： Bo Lei Kun Lu Fuzhang Ding Kai Zhang Yi Chen huina Zhao lin Zhang Zhu Ren Cunmin Qu Wenjing Guo Jing Wang Wenjie Pan Key Laboratory of Molecular Genetics China National Tobacco CorporationGuizhou Academy of Tobacco Science Engineering Research Center of South Upland Agriculture College of Agronomy and BiotechnologySouthwest University

The growth and development of plants are sensitive to their surroundings. Although numerous studies have analyzed plant transcriptomic variation, few have quantified the effect of combinations of factors or identified factor-specific effects. In this study, we performed RNA sequencing(RNA-seq) analysis on tobacco leaves derived from 10 treatment combinations of three groups of ecological factors, i.e., climate factors(CFs), soil factors(SFs), and tillage factors(TFs). We detected 4980, 2916, and 1605 differentially expressed genes(DEGs) that were affected by CFs, SFs, and TFs, which included 2703, 768, and 507 specific and 703 common DEGs(simultaneously regulated by CFs, SFs, and TFs), respectively. GO and KEGG enrichment analyses showed that genes involved in abiotic stress responses and secondary metabolic pathways were overrepresented in the common and CF-specific DEGs. In addition, we noted enrichment in CF-specific DEGs related to the circadian rhythm, SF-specific DEGs involved in mineral nutrient absorption and transport, and SF- and TF-specific DEGs associated with photosynthesis. Based on these results, we propose a model that explains how plants adapt to various ecological factors at the transcriptomic level. Additionally, the identified DEGs lay the foundation for future investigations of stress resistance, circadian rhythm and photosynthesis in tobacco.

关键词： climate factors soil factors tillage factors tobacco leaves transcriptome RNA-seq

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FERONIA interacts with E3 ubiquitin ligase ATL6 to regulate ...

全国农业生物化学与分子生物学第十五届学术研讨会

作者： Guoyun Xu Changqing Du Hui Zhang Qiansi Chen Xia Chen Niu Zhai Pingping Liu Qingxia Zheng Xiaoye Shen Lifeng Jin Fucheng lin Feng Yu huina Zhou Zhengzhou Tobacco Research Institute of China National Tobacco Corporation Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan University State Key Laboratory for Rice Biology

The balance between carbon(C)and nitrogen(N)utilization must be precisely coordinated to optimize plant growth,development and *** numerous physiological and molecular studies have been conducted in C/N or ratio response,few genes have been identified to play critical roles in signaling of C/N balance.A yeast-two hybrid(Y2H)screening for potential FER

关键词： FER C/N balance 14-3-3 protein Arabidopsis

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智慧康复在自闭症儿童康复训练中的应用

现代特殊教育 2021年第10期 57-62页

作者：林晨宫慧娜华中师范大学教育学院武汉430079

依托于现代信息技术的智慧康复模式给自闭症儿童的康复训练带来了诸多益处。以语音输出设备、机器人技术、虚拟现实技术为代表的智慧康复模式不仅能促进自闭症儿童功能障碍的康复,还能推动自闭症的早期诊断,为家长和机构提供专业支持。... 详细信息

依托于现代信息技术的智慧康复模式给自闭症儿童的康复训练带来了诸多益处。以语音输出设备、机器人技术、虚拟现实技术为代表的智慧康复模式不仅能促进自闭症儿童功能障碍的康复,还能推动自闭症的早期诊断,为家长和机构提供专业支持。期望通过对智慧康复在自闭症儿童康复训练中的应用进行梳理总结,为后续智慧康复的应用研究和本土化发展提供参考。

关键词：智慧康复自闭症功能康复早期诊断专业支持

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自闭症人士沟通障碍研究热点可视化分析

中国特殊教育 2021年第5期 22-30页

作者：林晨宫慧娜邓柳雷江华华中师范大学教育学院武汉430079

为明确把握自闭症人士沟通障碍的国际研究热点和主题,探明该领域的研究前沿和发展趋势,本研究利用CiteSpace软件对2010—2020年Web of Science核心合集数据库的研究文献进行可视化分析。结果表明,自闭症人士沟通障碍的三大研究热点为自... 详细信息

为明确把握自闭症人士沟通障碍的国际研究热点和主题,探明该领域的研究前沿和发展趋势,本研究利用CiteSpace软件对2010—2020年Web of Science核心合集数据库的研究文献进行可视化分析。结果表明,自闭症人士沟通障碍的三大研究热点为自闭症沟通障碍的全程发展研究、自闭症核心障碍表现的交互作用研究、以共同注意为核心的干预策略研究等。研究发展趋势从关注自闭症儿童沟通障碍的评估与诊断,到聚焦自闭症儿童沟通障碍的认知神经机制,再到围绕视觉注意对自闭症儿童沟通障碍进行干预。通过解读可视化结果可以为我国后续深入开展自闭症人士沟通障碍领域研究与促进自闭症儿童沟通与交往提供启示。

关键词：自闭症人士沟通障碍研究热点可视化