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耐药菌的环境分布、传播及新型抗菌技术研究进展

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环境化学 2024年第1期43卷 1-13页

作者：欧阳富成曹慧明陈博磊李准洁李智梁勇南方医科大学第一临床医学院广州510515 持久性有毒污染物环境与健康危害湖北省重点实验室环境与健康学院江汉大学武汉430056 中部战区总医院骨科武汉430070

抗生素的广泛使用导致细菌耐药性增加、多重耐药菌菌群数量急剧增多,严重威胁着人类生命健康.环境中耐药菌(ARB)及耐药基因(ARGs)的存在给临床治疗耐药菌感染带来了巨大挑战.有关医院中常见耐药致病菌的研究已有很多,尚缺乏环境中耐药... 详细信息

抗生素的广泛使用导致细菌耐药性增加、多重耐药菌菌群数量急剧增多,严重威胁着人类生命健康.环境中耐药菌(ARB)及耐药基因(ARGs)的存在给临床治疗耐药菌感染带来了巨大挑战.有关医院中常见耐药致病菌的研究已有很多,尚缺乏环境中耐药菌的分布、传播及新型耐药菌抗菌技术等的相关研究.本文综述了耐药菌的环境分布特征及其传播机制,概述了新型抗菌技术及其应用,最后展望了有关环境耐药菌研究的未来发展方向.

关键词：耐药菌环境分布传播抗菌技术展望

A novel ceria hollow nanosphere catalyst for low temperature NOx storage

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Journal of Rare Earths 2022年第4期40卷 626-635,I0004页

作者： Wenxu Liu huiming cao Zhongpeng Wang Chenchen Cui Liangran Gan Wei Liu Liguo Wang School of Water Conservancy and Environment University of JinanJinan 250022China Shandong Provincial Eco-environment Monitoring Center Jinan 250101China

In this work,a highly active CeO_(2) catalyst with hollow nanosphere morphology for low temperature NO_(x) storage was prepared by a surfactant-assisted solvothermal *** physicochemical properties of ceria samples were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),N_(2) adsorption–desorption,H_(2)-temperature programmed reduction(H_(2)-TPR),X-ray photoelectron spectroscopy(XPS)and in situ diffused reflectance infrared Fourier transform spectroscopy(DRIFTS).The as-prepared CeO_(2) nanosphere possesses excellent NO oxidation capacity,smaller mesopores,better reducibility and more surface Ce^(3+)*** with CeO_(2) with nanorod and nanoparticle morphologies,CeO_(2) nanosphere shows better intrinsic low temperature NO_(x) trapping performance,with a wide operating temperature window(150–300℃),high NO_(x) adsorption capacity(NAC,640–745μmol/g)and high NO_(x) storage capacity(NSC,250–350μmol/g).Two reaction pathways are speculated for NO_(x) adsorption on CeO_(2) nanosphere,including“nitrate route”and“nitrite route”.The thermally unstable surface nitrites formed on the CeO_(2) nanosphere allow ceria to release more NO_(x) during the desorption *** present work provides a new ceria morphology for NO_(x) traps,which may become a potential excellent NO_(x) storage material.

关键词： Ceria Nanosphere NO_(x)storage Low temperature DRIFTS Rare earths

Development of a Completely New PFOS Alternative with Lower Surface Tension for Minimizing the Environmental Burden

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Chemical Research in Chinese Universities 2023年第3期39卷 408-414页

作者： ZHOU Zhen GUO Rui CHEN Bolei WANG Ling cao huiming WEI Cuiyun HU Ming ZHAN Yuhang LI Shutao WANG Yawei LIANG Yong Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances School of Environment and HealthJianghan UniversityWuhan430056P.R.China Hubei Hengxin Chemical Co. Ltd.Yingcheng432400P.R.China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085P.R.China

Improving the technical performance of related industrial products is an efficient strategy to reducing the application quantities and environmental burden for toxic chemicals.A novel polyfluoroalkyl surfactant potassium 1,1,2,2,3,3,4,4-octafluoro-4-(perfluorobutoxy)butane-1-sulfonate(F404)was synthesized by a commercializable *** had a surface tension(γ)of 18.2 mN/m at the critical micelle concentration(CMC,1.04 g/L),significantly lower than that of perfluorooctane sulfonate(PFOS,ca.33.0 mN/m,0.72 g/L),and exhibited remarkable suppression of chromium-fog at a dose half that of *** half maximal inhibitory concentration(IC_(50))values in HepG2 cells and the lethal concentration of 50%(LC_(50))in zebrafish embryos after 72 hpf indicated a lower toxicity for F404 in comparison to *** a UV/sulphite system,89.3%of F404 were decomposed after 3 h,representing a defluorination efficiency of 43%.The cleavage of the ether C—O bond during the decomposition would be expected to form a short chain·C_(4)F_(9) as the position of the ether C—O in the F404 fluorocarbon chains is C4—*** ether unit is introduced in the perfluoroalkyl chain to improve water solubility,biocompatibility and degradation,thereby minimizing the environmental burden.

关键词： Perfluorooctane sulfonate(PFOS) Surface tension Chromium-fog inhibitor Perfluoropolyether

From Environmental Toxicants to Antibacterial Agents:BPA Analogues Selectively Inhibit the Growth of Gram-Positive Bacteria by Disturbing Biosynthesis of the Cell Wall

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Environment & Health 2023年第4期1卷 291-299页

作者： huiming cao Zhunjie Li Bolei Chen Jing Wang Zhen Zhou Zhi Li Yun Qian Yong Liang Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances School of Environment and HealthJianghan UniversityWuhan 430056P.R.China Department of Orthopedics General Hospital of Central Theater Command of Chinese People’s Liberation ArmyWuhan 430070P.R.China Department of Biomedical Engineering Florida International UniversityMiamiFlorida 33174United States

Remarkable antibacterial activity of BPA analogues especially for tetrabromobi-sphenol A against Staphylococcus aureus 25923(Sa25923)and methicillin-resistant Staphylococcus aureus(MRSA)has been reported in our previous ***,the toxic effects of the compounds as environmental contaminants on the endocrine system limited their applications in the field of medicine and *** the abuse of antibiotics has led to the emergence of multiple super-resistant bacteria,we considered that structural modifications based on the BPA structure will be available for molecular designing of potential antimicrobial agents without drug *** this study,to further improve the antibacterial activity and reduce the biological toxicity,we performed the computational models to evaluate the binding affinities of BPA analogues to the potential target DltA protein in the biosynthesis of cell wall.A series of synthesized achiral analogues ofα,α,α′-tris(4-hydroxyphenyl)-1-ethyl-4-isopropylbenzene(α,α,α′-TEIB)exhibited low minimum inhibitory concentration against Sa25923 and MRSA(2 or 1μg mL−1).Especially,the analogue A4 did not induce the drug-resistant mutants for all tested Gram-positive bacterial strains and exhibited relatively lower cytotoxicity in HepG2 *** developed classification model based on the light gradient boosting algorithm showed the superior performances on the internal robustness and generalization ability for the ligand-based virtual screening of bisphenol and polyphenol antimicrobial ***,our findings suggest that the molecular structure ofα,α,α′-TEIB is promising as a scaffold,which is expected to achieve a breakthrough in the development of antibiotics which can prevent the invasion of MRSA and other super bacteria.

关键词： Environmental toxicants Antibacterial agents BPA analogues Lipoteichoic acid Virtual screening Machine learning

Reconfigurable paper-based metamaterial antenna: Structural transition from 2D to 3D

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Science China(Technological Sciences) 2024年第9期67卷 2811-2816页

作者： PANG YaChen GAO Song YAO huiming WANG LiWei cao JinQing ZHANG ZiDong XU JianChun GUO YunSheng BI Ke State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing 100876China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China School of Electronic Information Engineering Inner Mongolia UniversityHohhot 010021China

Paper-based electronics offer a simple and cost-effective means to fabricate reconfigurable devices. In response to the problem of fixed shape and single function of most antennas, which limits their applications, a reconfigurable paper-based metamaterial antenna with 2D and 3D forms is presented for tunable operating frequency. The proposed antenna consists of two square split resonant rings fed by a coplanar waveguide. The working frequency of the 2D antenna is adjusted by the length, width, and opening size of the internal open resonant ring. While the folding angle of the antenna turns from 0° to 90°, the operating frequency of the paper-based metamaterial antenna changes from 2.759 to 4.223 GHz. In terms of 3D form, an additional resonant peak is generated by bending the paper-based metamaterial antenna, thus further realizing dual-band antenna *** a simple process flow, a series of proposed antennas are fabricated and evaluated. The simulated and measured results both demonstrate that the proposed antenna has a good performance in turning the working band. The environment-friendly nature and pliability of paper, as well as simple fabrication procedures, make paper-based metamaterial promising candidates for future green electronics.

关键词： paper-based reconfigurable antennas metamaterial

Trends in Respiratory Infectious Pathogens in Children Under the Age of 14—Xiamen City,Fujian Province,China,2017-2023

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China CDC weekly 2024年第8期6卷 143-147页

作者： Jiali cao Jie Pan Xiaoqing Yang Jumei Liu Min Zhu Zeyu Zhao Ling Chen Tianmu Chen huiming Ye Department of Laboratory Medicine Fujian Key Clinical Specialty of Laboratory MedicineWomen and Children’s HospitalSchool of MedicineXiamen UniversityXiamen CityFujian ProvinceChina State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen CityFujian ProvinceChina Department of Pediatrics Women and Children's HospitalSchool of MedicineXiamen UniversityXiamen CityFujian ProvinceChina

Summary What is already known about this topic?Respiratory infections pose a significant burden on public *** recent outbreaks occurring in various locations,there is limited information available on the prevalence tr... 详细信息

关键词： Xiamen spite Fujian

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建设项目跟踪审计若干问题研究

审计研究 2009年第5期 45-50页

作者：曹慧明南京大学会计与财务研究院江苏省常州市审计局 210093

近年来,我国审计机关广泛开展建设项目跟踪审计,为提高财政资金使用效率、防止浪费和腐败作出了重要贡献。但目前我国的建设项目跟踪审计在跟踪审计的概念与内涵、审计角色定位、审计力量及专业结构、审计成果考核、聘请中介机构的付酬(... 详细信息

近年来,我国审计机关广泛开展建设项目跟踪审计,为提高财政资金使用效率、防止浪费和腐败作出了重要贡献。但目前我国的建设项目跟踪审计在跟踪审计的概念与内涵、审计角色定位、审计力量及专业结构、审计成果考核、聘请中介机构的付酬(费)办法、审计质量控制、审计项目控制与审计形式选择等方面尚存在许多问题,这些问题将会阻碍跟踪审计的进一步发展。因此,需要我们运用创新思维,结合我国建设项目审计的实际,研究、解决这些问题。

关键词：建设项目跟踪审计效益审计问题

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左氧氟沙星的临床应用及药物经济学研究进展

药学服务与研究 2011年第5期11卷 351-355页

作者：金昭曹惠明上海市长宁区同仁医院药剂科上海200050 上海交通大学医学院附属仁济医院药剂科上海200127

左氧氟沙星作为新一代的氟喹诺酮类药物,其抗菌谱较广,在临床广泛应用于消化系统、呼吸系统、泌尿系统以及眼、耳等器官感染性疾病的治疗。本文对左氧氟沙星的抗菌活性、耐药性、药动学特点、临床应用,以及相关的药物经济学研究进展进... 详细信息

左氧氟沙星作为新一代的氟喹诺酮类药物,其抗菌谱较广,在临床广泛应用于消化系统、呼吸系统、泌尿系统以及眼、耳等器官感染性疾病的治疗。本文对左氧氟沙星的抗菌活性、耐药性、药动学特点、临床应用,以及相关的药物经济学研究进展进行了综述。

关键词：左氧氟沙星临床应用药物经济学综述

基于膜雌激素受体(GPER)结合化合物能力的分类预测模型

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环境化学 2022年第2期41卷 417-428页

作者：王宇飞曹慧明梁勇持久性有毒污染物环境与健康危害湖北省重点实验室环境与健康研究院江汉大学武汉430056

近年来,计算毒理学的方法被广泛应用于潜在的环境内分泌干扰物(EDCs)的筛选.膜雌激素受体(GPER),作为一种可以快速响应内源性配体雌激素的关键靶蛋白,调控其介导的多项生理学功能.但是针对GPER的化合物毒性预测模型仍未见报道.因此,本... 详细信息

近年来,计算毒理学的方法被广泛应用于潜在的环境内分泌干扰物(EDCs)的筛选.膜雌激素受体(GPER),作为一种可以快速响应内源性配体雌激素的关键靶蛋白,调控其介导的多项生理学功能.但是针对GPER的化合物毒性预测模型仍未见报道.因此,本研究收集了130个化合物对GPER的结合活性数据,主要包括双酚类、多溴联苯类以及农药杀虫剂类环境污染物.利用随机森林(RF)、支持向量机(SVM)、人工神经网络(ANN)、K最近邻(KNN)、朴素贝叶斯(NB)以及逻辑回归(LG)等6种机器学习算法构建二分类模型.结果显示,所有被测试算法的测试集准确率均达到85%以上,其中SVM、RF、ANN、KNN等4种算法的训练集准确率高于93%,10折交叉验证准确率高于80%,说明得到的模型具有优秀的分类预测性能.因此,本研究基于机器学习算法构建的分类模型,可以用来快速、准确地预测环境污染物是否通过结合GPER产生内分泌干扰效应.为评估环境污染物的潜在健康风险提供了理论依据.

关键词：内分泌干扰物膜雌激素受体机器学习算法分类预测模型