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Cr^(3+)/Y^(3+)co-doped persistent luminescence nanoparticles with biological window activation for in vivo repeatable imaging

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Journal of Rare Earths 2022年第9期40卷 1389-1398,I0002页

作者： huimin jiang Lin Liu Kexin Yu Xianggui Yin Shenghui Zheng Liang Song Junpeng Shi Yun Zhang College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021China Institute of Urban Environment Chinese Academy of SciencesXiamen 361021China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China

The near-infrared(NIR)persistent luminescence materials(PLMs)can remain long-lasting luminescence after removal of the excitation light,which permits bioimaging with high sensitivity owing to the absence of background fluorescence interference from in situ ***,the NIR PLMs have aroused intensive research interest in ***,the optimal excitation wavelength of current NIR PLMs is located in the ultraviolet region with shallow tissue penetration,making it difficult to activate effectively in vivo,and seriously hindering their further application in ***,we report a novel kind of Cr^(3+)ions and Y^(3+)ions co-doped NIR PLM,Zn_(1.3)Ga_(1.4)Sn_(0.3)O_(4):Cr^(3+),Y^(3+)(ZGSCY),which emits NIR persistent luminescence at 696 *** with Zn_(1.3)Ga_(1.4)Sn_(0.3)O_(4):Cr^(3+)(ZGSC)excited by the light with a wavelength in the biological window(>650 nm),after being co-doped with Y^(3+)ions,the NIR persistent luminescence performance of ZGSCY is significantly improved because of the increase of trap concentration in the *** addition,we synthesized ZGSCY nanoparticles(NPs)by the combustion method,which exhibit excellent optical properties after being excited by the light with a wavelength in the biological *** surface modification with PEG,the ZGSCY NPs present low ***,due to the co-doping of Y^(3+)ions,the signal-to-noise ratio(SNR)of ZGSCY NPs in vivo imaging is about 1.8 times higher than that of the ZGSC ***,the rechargeable in vivo imaging and passive tumor-targeted imaging are successfully achieved by activating with a lightemitting diode(LED,659 nm)after intravenous injection of ***,this kind of NIR PLM with high excitation efficiency performance in the biological window is expected to promote its biomedical application in deep tissues.

关键词： Near-infrared Persistent luminescence Co-doping Biological window In vivo imaging Rare earths

A multisite-binding fluorescent probe for simultaneous monitoring of mitochondrial homocysteine, cysteine and glutathione in live cells and zebrafish

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Chinese Chemical Letters 2022年第3期33卷 1609-1612页

作者： huimin jiang Guoxing Yin Yabing Gan Ting Yu Youyu Zhang Haitao Li Peng Yin Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China

Homocysteine(Hcy), cysteine(Cys) and glutathione(GSH) play crucial roles in redox homeostasis during mitochondria functions. Simultaneous differentiation and visualization of mitochondrial biothiols dynamics are significant for understanding cell metabolism and their related diseases. Herein, a multisitebinding fluorescent probe(MCP) was developed for simultaneous sensing of mitochondrial Cys, GSH and Hcy from three fluorescence channels for the first time. This novel probe exhibited rapid fluorescence turn-on, good water-solubility, high selectivity and large spectral separation for discriminating Cys, GSH and Hcy with 131-, 96-, 748-fold fluorescence increasement at 471, 520, 567 nm through different excitation wavelengths, respectively. Importantly, this probe was successfully applied to simultaneous monitoring of mitochondrial Cys, GSH, and Hcy in live cells and zebrafish from three fluorescence channels,promoting the understanding of the functions of Hcy, Cys and GSH.

关键词： Fluorescent probe Multiple sites Biothiols Mitochondrial-targeted Homocysteine Imaging

Electrochemical Surface Restructuring of Phosphorus-Doped Carbon@MoP Electrocatalysts for Hydrogen Evolution

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Nano-Micro Letters 2021年第12期13卷 484-498页

作者： huimin jiang Liting Yan Shuo Zhang Yanchao Zhao Xue Yang Yameng Wang Jianxing Shen Xuebo Zhao Lianzhou Wang School of Materials Science and Engineering Qilu University of Technology(Shandong Academy of Sciences)No.3501Daxue RoadChangqing DistrictJinan 250353People’s Republic of China Nanomaterials Centre School of Chemical Engineering and Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandSt LuciaQLD 4072Australia College of Chemical Engineering China University of Petroleum(East China)Huangdao DistrictNo.66West Changjiang RoadQingdao 266580People’s Republic of China

The hydrogen evolution reaction(HER) through electrocatalysis is promising for the production of clean hydrogen fuel. However,designing the structure of catalysts,controlling their electronic properties,and manipulating their catalytic sites are a significant challenge in this field. Here,we propose an electrochemical surface restructuring strategy to design synergistically interactive phosphorus-doped carbon@MoP electrocatalysts for the HER. A simple electrochemical cycling method is developed to tune the thickness of the carbon layers that cover on MoP core,which significantly influences HER performance. Experimental investigations and theoretical calculations indicate that the inactive surface carbon layers can be removed through electrochemical cycling,leading to a close bond between the MoP and a few layers of coated graphene. The electronsdonated by the MoP core enhance the adhesion and electronegativity of the carbon layers;the negatively charged carbon layers act as an active surface. The electrochemically induced optimization of the surface/interface electronic structures in the electrocatalysts significantly promotes the HER. Using this strategy endows the catalyst with excellent activity in terms of the HER in both acidic and alkaline environments(current density of 10 mA cm^(-2) at low overpotentials,of 68 mV in 0.5 M H_(2)SO_(4) and 67 mV in 1.0 M KOH).

关键词： Electrochemical surface restructuring Hydrogen evolution Molybdenum phosphide nanowires Phosphorus-doped carbon Synergistic interaction

Expression of sulfur uptake assimilation-related genes in response to cadmium,bensulfuron-methyl and their co-contamination in rice roots

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Journal of Environmental Sciences 2014年第3期26卷 650-661页

作者： Jian Zhou Zegang Wang Zhiwei Huang Chao Lu Zhuo Han Jianfeng Zhang huimin jiang Cailin Ge Juncheng Yang College of Bioscience and Biotechnology Yangzhou University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences

The responses of sulfur （S） uptake assimilation-related genes＇ expression in roots of two rice cultivars to cadmium （Cd）, bensulfuron-methyl （BSM） and their co-contamination （Cd＋BSM） were investigated by gene-chip microarray analysis and quantitative real-time PCR （QRT-PCR） technology. Treatments of Cd and Cd＋BSM induced expression of sulfate transporter and permease genes, and promoted sulfate uptake in rice roots. Cd＋BSM could alleviate Cd toxicity to cv. Fengmeizhan seedlings, probably due to Cd＋BSM promoting greater S absorption by seedlings. Cd and Cd＋BSM induced expression of sulfate assimilation-related genes, and thus activated the sulfur assimilation pathway. Cd and Cd＋BSM induced expression of phytochelatin synthase and metallothionein genes, and induced expression of glutathione S-transferases （GSTs）, glutathione synthase （GS） and S- containing antioxidation enzyme genes, which detoxified Cd2＋. It is suggested that （to cope with the toxicity of Cd, BSM and their co-contamination） the S uptake and assimilation pathway was activated in rice roots by increased expression of related genes, thus enhancing the supply of organic S for synthesis of Cd or BSM resistance-related substances.

关键词： rice cadmium bensulfuron-methyl sulfur assimilation

The Notch Signaling Pathway in Vascular Niche Promotes Stemness of Breast Cancer Cells through ZEB1

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The Notch Signaling Pathway in Vascular Niche Promotes Stemn...

Research on the Eigenvalues of Graphs and Mixed Graphs

第十一届全国免疫学学术大会

作者： jiang huimin Nankai University

Aim: Cancer stem cells(CSCs) are account for cancer initiation, progression, and recurrence. ZEB1 has been identified to promote the generation of breast CSCs(brCSCs). However, the cellular and molecular mechanisms upstream of ZEB1 function in tumorigenesis remain largely obscure. So we extended to examine the upstream components and their regulatory effects involved in ZEB1-mediated br CSC ***: Sphere formation and flow cytometry were used to detect ZEB1-indcued CSC frequencies in breast cancer cells. Luciferase assays were performed to screen siRNAs library on their influence on ZEB1 expression. Luciferase and chromatin immunoprecipitation(CHIP) assays were used to elucidate the molecular mechanism by which Notch activation regulates ZEB1 transcription. Co-cultures using human umbilical vein endothelial cells(HUVECs) and breast cancer cells in nude mouse tumor xenografts were used to investigate endothelial niche-enhanced tumor stemness in a Notch/ZEB1-dependent ***: We found that ectopic expression of ZEB1 in breast cancer cells promoted the sphere formation, and the CD44CD24 br CSC population. Interference of the Notch receptors, especially Notch1, was identified inhibitory to ZEB1 expression. Moreover, the results of luciferase and CHIP assays showed that Notch activation leaded to NICD(Notch intracellular domain) translocation into the nucleus, where it induces the promoter activity of ZEB1 by binding to the canonical notch response elements, eventually resulting in up-regulation of ZEB1 expression. The co-culture system using HUVECs and breast cancer cells further revealed that the expression of Notch ligands(Jag1) in HUVECs were significantly up-regulated, accompanied with the increase of br CSC ***: Our data demonstrated that endothelial cells nurture tumor initiating and CSC properties of breast cancer by providing Jag1, which effect is mediated via the regulation of ZEB1. Thus, targeting ZEB1 is expected to achi

关键词： Notch ZEB1 CSCs stemness self-renewal

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International Journal of Technology Management 2015年第1期 109-110页

作者： Zhihui Ma huimin jiang College of Sciences Shihezi University Shihezi XinJiang 832003 China

This paper first elaborates the research situation and progress of Laplace characteristics and the eigenvalues value of graphs. The second is given an upper bound of characteristic value of a kind of special graph using the properties of similar matrices. At the same time, a new upper bound of Laplace characteristic values are given using properties of Laplace matrix and the similarity matrix, to improve the existing results. Then, we use the example of the upper bound of our results are more precise than some previous results. Finally the use Laplace non- zero eigenvalues of graph properties to give a bound expressions using the degree of square with a number of edges and the graph of the number, number of connected component expression map, it reflected the relationship between eigenvalues and the amount of Laplace.

关键词： Graph eigenvalue Nonsingular unicyclic mixed graph

Lymphangiogenesis contributes to exercise-induced physiological cardiac growth

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Journal of Sport and Health Science 2022年第4期11卷 466-478页

作者： Yihua Bei Zhenzhen Huang Xing Feng Lin Li Meng Wei Yujiao Zhu Shuqin Liu Chen Chen Mingming Yin huimin jiang Junjie Xiao Cardiac Regeneration and Ageing Lab Institute of Geriatrics(Shanghai University)Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Shanghai Engineering Research Center of Organ Repair School of Life ScienceShanghai UniversityShanghai 200444China Clinical Laboratory Center Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

Background:Promoting cardiac lymphangiogenesis exerts beneficial effects for the *** can induce physiological cardiac growth with cardiomyocyte hypertrophy and increased proliferation markers in ***,it remains unclear whether and how lymphangiogenesis contributes to exercise-induced physiological cardiac *** aimed to investigate the role and mechanism of lymphangiogenesis in exercise-induced physiological cardiac ***:Adult C57 BL6/J mice were subjected to 3 weeks of swimming exercise to induce physiological cardiac *** treatment with vascular endothelial growth factor receptor 3(VEGFR3) inhibitor SAR1 3 1 675 was used to investigate whether cardiac lymphangiogenesis was required for exercise-induced physiological cardiac growth by VEGFR3 ***,human dermal lymphatic endothelial cell(LEC)-conditioned medium was collected to culture isolated neonatal rat cardiomyocytes to determine whether and how LECs could influence cardiomyocyte proliferation and ***:Swimming exercise induced physiological cardiac growth accompanied by a remarkable increase of cardiac lymphangiogenesis as evidenced by increased density of lymphatic vessel endothelial hyaluronic acid receptor 1-positive lymphatic vessels in the heart and upregulated LYVE-1 and Podoplanin expressions ***3 was upregulated in the exercised heart,while VEGFR3 inhibitor SAR131675 attenuated exercise-induced physiological cardiac growth as evidenced by blunted myocardial hypertrophy and reduced proliferation marker Ki67 in cardiomyocytes,which was correlated with reduced lymphatic vessel density and downregulated LYVE-1 and Podoplanin in the heart upon ***,LEC-conditioned medium promoted both hypertrophy and proliferation of cardiomyocytes and contained higher levels of insulinlike growth factor-1 and the extracellular protein Reelin,while LEC-conditioned medium from LECs treated with SAR131675 blocked these e

关键词： Cardiac lymphatics Exercise Physiological cardiac hypertrophy Proliferation VEGFR3

氯化汞对鲤幼鱼鳃组织抗氧化系统和组织损伤研究

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生态毒理学报 2014年第5期9卷 998-1003页

作者：姜会民山东高校十二五规划重点实验室"动物生理与生化及应用"重点实验室菏泽274015

在急性毒性试验的基础上,设定0.052 mg·L-1(SL)、0.13 mg·L-1(SM)、0.26 mg·L-1(SH)三个汞离子染毒浓度和一个对照组(SC)研究无机汞污染对黄河鲤幼鱼鳃组织过氧化物酶(POD)活性和(丙二醛)MDA含量以及鳃组织损伤的影响。实验结果显示:... 详细信息

在急性毒性试验的基础上,设定0.052 mg·L-1(SL)、0.13 mg·L-1(SM)、0.26 mg·L-1(SH)三个汞离子染毒浓度和一个对照组(SC)研究无机汞污染对黄河鲤幼鱼鳃组织过氧化物酶(POD)活性和(丙二醛)MDA含量以及鳃组织损伤的影响。实验结果显示:POD活性随氯化汞浓度的增加先上升后下降,当浓度为0.26 mg·L-1时POD活性显著的低于对照组(p<0.05);实验组MDA含量均显著高于对照组(p<0.05);实验组鳃组织可见鳃小片肿胀,基部增生,上皮细胞脱落,泌氯细胞增多,细胞核溶解及金属沉积。试验结果表明氯化汞对鲤鳃组织结构和抗氧化系统具有明显的损伤。

关键词：氯化汞鳃过氧化物酶丙二醛组织损伤

Magnetic resonance imaging diagnosis of acute Guillain-Barré syndrome in children

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Neural Regeneration Research 2011年第20期6卷 1564-1569页

作者： Zhongjun Hou Xiaojun Yu huimin jiang Xi Li Bingyi Cao Yaotang Chen Jiao Chen Gamma Knife Department Second Affiliated Hospital of Guangzhou Medical College Guangzhou 510260 Guangdong Province China Department of Neurological Rehabilitation Guangzhou Children's Hospital Guangzhou 510320 Guangdong Province China

The present study examined 24 children with acute Guillain-Barre syndrome using magnetic resonance imaging （MRI） plain scans and fat-suppressed enhanced Tl-weighted imaging （T1WI） scans. Axial MRI plain scans centering on the medullary conus were positive in nine patients （38%）. These displayed variable thickening involving the cauda equina with isointensity on T1WI and isointensity or slight hyperintensity on T2WI. False negatives were obtained in patients with cervical and cranial nerve symptoms. Contrast enhancement of T1WI with fat suppression was positive in all patients in the cauda equina with varied thickening and enhancement centering on the medullary conus. Five patients （36%） were positive in the cervical nerves and 3 patients （50%） were positive in the cranial nerves. These patients had corresponding cervical and cranial nerve symptoms, respectively. Patients with serious clinical symptoms in the lower limbs exhibited obvious involvement of the cauda equina by MRI. Statistical analysis revealed a positive correlation between the extent of enlargement of the cauda equina, centering on the medullary conus, and cerebrospinal fluid protein concentration.

关键词： children acute Guillain-Barre syndrome diagnosis magnetic resonance imaging