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On the Application of Mixed Models of Probability and Convex Set for Time-Variant Reliability Analysis

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1981-1999页

作者： Fangyi Li Dachang Zhu huimin Shi Center for Research on Leading Technology of Special Equipment School of Mechanical and Electric EngineeringGuangzhou UniversityGuangzhou510006China

In time-variant reliability problems,there are a lot of uncertain variables from different ***,it is important to consider these uncertainties in *** addition,time-variant reliability problems typically involve a complexmultilevel nested optimization problem,which can result in an enormous amount of *** this end,this paper studies the time-variant reliability evaluation of structures with stochastic and bounded uncertainties using a mixed probability and convex set *** this method,the stochastic process of a limit-state function with mixed uncertain parameters is first discretized and then converted into a timeindependent reliability ***,to solve the double nested optimization problem in hybrid reliability calculation,an efficient iterative scheme is designed in standard uncertainty space to determine the most probable point(MPP).The limit state function is linearized at these points,and an innovative random variable is defined to solve the equivalent static reliability analysis *** effectiveness of the proposed method is verified by two benchmark numerical examples and a practical engineering problem.

关键词： Mixed uncertainty probability model convex model time-variant reliability analysis

Stimulating Start-up Investment Through Government-Sponsored Venture Capital: Theory and Chinese Evidence

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Journal of Systems Science & Complexity 2024年第5期37卷 2021-2053页

作者： NI Xuanming ZHENG Tiantian GAO Feng ZHAO huimin School of Software and Microelectronics Peking University School of Economics and Management Tsinghua University School of Business Sun Yat-sen University

Government-sponsored venture capital(GVC) has been used to support financially constrained start-ups as an important policy tool in China. Typically, to motivate the social capital to invest in start-ups, GVC provides subsidies for them to bridge the funding gap in the early-stage venture capital market. However, the effect and mechanism of GVC affecting social capital investment have not been clearly studied. In this paper, the authors not only develop a game model to analyze this issue in theory, but conduct an empirical study by analyzing the 14741 records matched by propensity score matching(PSM) of Chinese venture capital market data from 2011 to 2021. The proposed findings are as the follows. Firstly, the subsidies offered by GVC will simultaneously increase the returns and risks of investments in start-ups of social capital with more volatile incentive effect of GVC. The incentive effect of GVC is only effective when the returns resulting from the subsidies outweigh the risks they introduce. In the context of the Chinese venture capital market, the incentive effect of GVC is effective. Secondly, the incentive effect of GVC is more pronounced in high-tech industries, which can be attributed to the signaling effect facilitated by GVC. In this context, the subsidy mainly helps social capital to bear the costs associated with screening potential investments. Thirdly, the incentive effect of GVC is more significant in underdeveloped venture capital markets, which can be explained by the “virtuous cycle” effect, in which GVC plays a pioneering role in establishing a more robust early-stage market trading system. By examining these three points, this study contributes to a better understanding of how GVC can effectively guide social capital investment, especially in the Chinese landscape.

关键词： Government-sponsored venture capital fund incentive effect social capital subsidy venture capital

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跆拳道技术教学微课程手段与效果的实证研究

成都体育学院学报 2018年第5期44卷 96-99,126页

作者：杜慧敏成都体育学院四川成都610041

通过对微课程在跆拳道技术教学中的应用情况与应用效果进行实证分析,以其为跆拳道技术教学创新提供理论依据与实践指导。研究结果表明:微课程教学在跆拳道技术教学中的应用效果较好,有利于提高学生的跆拳道技术学习效能和学习兴趣;有利... 详细信息

通过对微课程在跆拳道技术教学中的应用情况与应用效果进行实证分析,以其为跆拳道技术教学创新提供理论依据与实践指导。研究结果表明:微课程教学在跆拳道技术教学中的应用效果较好,有利于提高学生的跆拳道技术学习效能和学习兴趣;有利于加强师生之间的互动和交流;有利于提升跆拳道教师的教学水平。

关键词：跆拳道微课程应用效果实证研究

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图书馆文化的结构及其作用机制

图书馆杂志 2003年第10期22卷 8-10页

作者：杜慧敏南京审计学院图书馆 210029

现代社会的发展,对图书馆文化建设有着重要影响。本文运用文化人类学和社会学的理论分析框架,对图书馆文化的结构及其作用机制进行了初步的探讨。

关键词：图书馆文化文化结构文化人类学社会学图书馆价值观图书馆精神图书馆心理图书馆道德馆员素质

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

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Signal Transduction and Targeted Therapy 2024年第1期9卷 326-337页

作者： You Zhai Yicong du Guanzhang Li Mingchen Yu huimin Hu Changqing Pan Di Wang Zhongfang Shi Xu Yan Xuesong Li Tao Jiang Wei Zhang Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingPR China Department of Urology Peking University First HospitalInstitute of UrologyPeking UniversityNational Urological Cancer CenterBeijingPR China Department of Pathophysiology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China China National Clinical Research Center for Neurological Diseases BeijingPR China Center of Brain Tumor Beijing Institute for Brain DisordersBeijingPR China Research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijingPR China Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingPR China

Chimeric antigen receptor(CAR)T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid *** instances of rapid tumor remissions have been observed in animal models and clinical trials,tumor relapses occur with multiple therapeutic resistance ***,while the mechanisms underlying the long-term therapeutic resistance are well-known,short-term adaptation remains less ***,more views shed light on short-term adaptation and hold that it provides an opportunity window for long-term *** this study,we explore a previously unreported mechanism in which tumor cells employ trogocytosis to acquire CAR molecules from CAR-T cells,a reversal of previously documented *** mechanism results in the depletion of CAR molecules and subsequent CAR-T cell dysfunction,also leading to short-term antigen loss and antigen *** type of intercellular communication is independent of CAR downstream signaling,CAR-T cell condition,target antigen,and tumor cell ***,it is mainly dependent on antigen density and CAR sensitivity,and is associated with tumor cell cholesterol *** mitigation of this trogocytosis-induced CAR molecule transfer can be achieved by adaptively administering CAR-T cells with antigen density-individualized CAR ***,our study reveals a dynamic process of CAR molecule transfer and refining the framework of clinical CAR-T therapy for solid tumors.

关键词： Together instance depletion

Effect of Epoxy Resin on the Properties of Recycled Asphalt

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1149-1155页

作者： YANG Ruochong CHEN huimin YANG Jun School of Transportation Southeast UniversityNanjing 211189China

To promote the recycling of reclaimed asphalt pavement(RAP),epoxy resin was used to prepare the epoxy-recycled asphalt *** effect of epoxy resin on the properties of aged asphalt binder was investigated based on the tensile test,flexural creep test,and laser scanning confocal *** curing characteristics and the mechanical performance of recycled asphalt with different epoxy contents were *** results show that the low-temperature performance,ductility,and strength of the aged asphalt binder were significantly improved when the epoxy content reached 40%.The curing time of epoxy-recycled asphalt should be at least 4 d to ensure the formation of good internal spatial network structure.

关键词： RAP epoxy resin aged asphalt mechanical performance

“Survival”and“death”in Céline’s novels

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Language and Semiotic Studies 2024年第2期10卷 153-166页

作者： huimin duan Soochow University SuzhouChina

Louis-Ferdinand Céline,a French writer of the twentieth century,was an important author during the two world wars in *** works,set against the backdrop of these wars,depict the various aspects of human nature during wartime.“Survival”and“Death”are important themes discussed in Céline’s *** the background of wars,“survival”becomes the instinct of characters in Céline’s works,but the threat of death is always *** the perspective of a doctor,Céline materializes“survival”and“death,”using metaphors such as“devouring,”“decomposition,”and“corrosion”to illustrate the viewpoint of“death on the installment plan,”vividly depicting the“imagination”and“fear”between“survival”and“death,”presenting the disasters and sufferings caused by wars,and expressing strong antiwar sentiments within a pessimistic view of life and *** using semiotic isotope as a tool,we study the thematic generation process of“survival and death,”analyzing the“surface-level image paths”of the text through the“discourse images,”and then delving into the deeper layers of the text to discover the inherent and shared nuclear seme features of these images and their repetition of information,namely semiotic isotope.

关键词： Céline semiotic isotope survival death imagination fear

Natural variation in MORE GRAINS 1 regulates grain number and grain weight in rice

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Journal of Integrative Plant Biology 2024年第7期66卷 1440-1458页

作者： Yingchun Han Qianfeng Hu Nuo Gong huimin Yan Najeeb Ullah Khan Yanxiu du Hongzheng Sun Quanzhi Zhao Wanxi Peng Zichao Li Zhanying Zhang Junzhou Li Henan Key Laboratory of Rice Molecular Breeding and High Efﬁciency Production College of AgronomyHenan Agricultural UniversityZhengzhou 450046China Beijing Key Laboratory of Crop Genetic Improvement College of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Rice Industrial Technology Research Institute Guizhou UniversityGuiyang 550025China School of Forestry Henan Agricultural UniversityZhengzhou 450046China

Grain yield is determined mainly by grain number and grain *** this study,we identified and characterized MORE GRAINS1(MOG1),a gene associated with grain number and grain weight in rice(Oryza sativa L.),through map-based *** of MOG1 increased grain yield by 18.6%-22.3%under field *** determined that MOG1,a bHLH transcription factor,interacts with OsbHLH107 and directly activates the expression of LONELY GUY(LOG),which encodes a cytokinin-activating enzyme and the cell expansion gene EXPANSIN-LIKE1(EXPLA1),positively regulating grain number per panicle and grain *** variations in the promoter and coding regions of MOG1 between Hap-LNW and Hap-HNW alleles resulted in changes in MOG1 expression level and transcriptional activation,leading to functional *** analysis revealed that Hap-HNW,which results in a greater number and heavier grains,has undergone strong selection but has been poorly utilized in modern lowland rice *** summary,the MOG1-OsbHLH107 complex activates LOG and EXPLA1 expression to promote cell expansion and division of young panicles through the cytokinin pathway,thereby increasing grain number and grain *** findings suggest that Hap-HNW could be used in strategies to breed high-yielding temperate japonica lowland rice.

关键词： grain number grain weight MOG1 natural variation rice

Multi-Scale Fusion Model Based on Gated Recurrent Unit for Enhancing Prediction Accuracy of State-of-Charge in Battery Energy Storage Systems

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 405-414页

作者： Hao Liu Fengwei Liang Tianyu Hu Jichao Hong huimin Ma School of Computer and Communication Engineering University of Science and Technology BeijingBeijingChina School of Mechanical Engineering University of Science and Technology BeijingBeijingChina IEEE

Accurate prediction of the state-of-charge(SOC)of battery energy storage system(BESS)is critical for its safety and lifespan in electric *** overcome the imbalance of existing methods between multi-scale feature fusion and global feature extraction,this paper introduces a novel multi-scale fusion(MSF)model based on gated recurrent unit(GRU),which is specifically designed for complex multi-step SOC prediction in practical *** correlation analysis is first employed to identify SOC-related *** parameters are then input into a multi-layer GRU for point-wise feature ***,the parameters undergo patching before entering a dual-stage multi-layer GRU,thus enabling the model to capture nuanced information across varying time ***,by means of adaptive weight fusion and a fully connected network,multi-step SOC predictions are *** extensive validation over multiple days,it is illustrated that the proposed model achieves an absolute error of less than 1.5%in real-time SOC prediction.

关键词： Electric vehicle battery energy storage system(BESS) state-of-charge(SOC)prediction gated recurrent unit(GRU) multi-scale fusion(MSF).