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Nanoparticle-mediated corneal neovascularization treatments: Toward new generation of drug delivery systems

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Chinese Chemical Letters 2023年第3期34卷 90-99页

作者： huimin zhu Jingwen Yu Jinfa Ye Yiming Wu Jintao Pan Yingying Li Chuan Chen Li Zheng Gang Liu Chengchao Chu Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry Guangxi Medical UniversityNanning 530021China Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceXiamen UniversityXiamen 361102China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen Xiamen UniversityXiamen 361102China Department of Pharmacy Xiamen Medical CollegeXiamen 361023China Shenzhen Research Institute of Xiamen University Shenzhen 518057China

Corneal neovascularization(CNV) is one of the major factors for vision impairment and blindness worldwide. The current treatment for CNV focuses primarily on topical eyedrops of glucocorticoids,non-steroidal anti-inflammatory drugs, electro-coagulation and laser photo-coagulation. Unfortunately,coagulation-based treatment is restricted by corneal hemorrhage and iris atrophy. And drug treatments have limited therapeutic effects and a short duration of action. Nanoparticle-based drug delivery systems are widely applied due to their improved pharmacokinetics, optimized drug targeting and enhanced biocompatibility. In this article, we provide a comprehensive and systematic overview of the CNV nanodrug system, highlighting some of the recent advances in nanodrug design, preparation, and functional modification. Moreover, we discuss the challenges in the clinical translation and potential risks in CNV treatment. A greater effort is needed for the potential applications of nanotechnology in the field of ophthalmology.

关键词： Corneal neovascularization Nanoparticles Drug delivery system Anti-VEGF Supramolecular assembly

Epithelial-mesenchymal transition effect of fine particulate matter from the Yangtze River Delta region in China on human bronchial epithelial cells

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Journal of Environmental Sciences 2018年第4期30卷 155-164页

作者： Yulang Chi Qiansheng Huang Yi Lin Guozhu Ye huimin zhu Sijun Dong Center for Excellence in Urban Atmospheric Environment Institute of Urban Environment Chinese Academy of Sciences Key Lab of Urban Environment and Health Institute of Urban Environment Chinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences

Epidemiological studies have demonstrated that fine particulate matter（PM（2.5）） exposure causes airway inflammation, which may lead to lung cancer. The activation of epithelial–mesenchymal transition（EMT） is assumed to be a crucial step in lung tumor metastasis and development. We assessed the EMT effect of low concentrations（0, 0.1, 1.0, and 5.0 μg/m L）of PM（2.5） organic extract on a human bronchial epithelial cell line（BEAS-2 B）. PM（2.5） samples were collected from three cities（Shanghai, Ningbo, and Nanjing） in the Yangtze River Delta（YRD） region in autumn 2014. BEAS-2 B cells were exposed to the PM（2.5） extract to assess cell viability, invasion ability as well as the relative m RNA and protein expressions of EMT markers. Our findings revealed that BEAS-2 B cells changed from the epithelial to mesenchymal phenotype after exposure. In all groups, PM（2.5） exposure dose-dependently decreased the expression of E-cadherin and increased the expression of Vimentin. The key transcription factors, including ZEB1 and Slug, were significantly up-regulated upon exposure. These results indicated that the PM（2.5） organic extract induced different degrees of EMT progression in BEAS-2 B cells. The cell invasion ability increased in a concentration-dependent manner after 48 hr of treatment with the extract. This study offers a novel insight into the effects of PM（2.5） on EMT and the potential health risks associated with PM（2.5） in the YRD region.

关键词： PM2.5 BEAS-2B Epithelial–mesenchymal transition Cell invasion

医务社工在出院准备工作中的介入空间与现实挑战

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中国全科医学 2024年第21期27卷 2651-2656页

作者：孙振军朱慧敏华东理工大学社会与公共管理学院上海市200237 上海交通大学医学院附属第九人民医院门急诊管理处上海市200011

背景出院准备工作可以帮助患者顺利地从一个照护环境进入另一个照护环境。在国外医疗机构中,出院准备是医务社工的主要职责之一。而在我国目前医务社工介入出院准备工作相对较少。目的了解医务社工在出院准备工作领域的介入空间及面临... 详细信息

背景出院准备工作可以帮助患者顺利地从一个照护环境进入另一个照护环境。在国外医疗机构中,出院准备是医务社工的主要职责之一。而在我国目前医务社工介入出院准备工作相对较少。目的了解医务社工在出院准备工作领域的介入空间及面临的现实挑战,为完善出院准备社会工作提供参考依据。方法基于多学科视角,采用目的抽样法于2023年3—6月对20名医务人员(包括医生、护士、医务社工、医疗管理人员)进行深度访谈,借助Nvivo12.0软件,并运用Colaizzi七步分析法对访谈资料进行整理和分析。结果医务社工在出院准备服务领域主要开展心理社会评估、制订专业服务计划、提供社会工作干预、进行跟踪随访等,在积累一些本土实践经验的同时也面临许多现实性挑战,包括社会资源可及性不足、医社联动存在多重障碍、医院尚未建立常态化机制、多学科协作不够完善、社工人力资源短缺、综合能力有待提升等。结论通过倡导社会政策体系机制建设,搭建医院多学科合作平台建设,促进医务社工综合能力建设,推动我国出院准备社会工作服务的发展。

关键词：社会工作者出院准备多学科合作介入空间现实挑战

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Environmental risk assessment of selected organic chemicals based on TOC test and QSAR estimation models

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Journal of Environmental Sciences 2018年第2期30卷 23-31页

作者： Yulang Chi Huanteng Zhang Qiansheng Huang Yi Lin Guozhu Ye huimin zhu Sijun Dong Key Lab of Urban Environment and Health Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100049 China

Environmental risks of organic chemicals have been greatly determined by their persistence,bioaccumulation, and toxicity（PBT） and physicochemical properties. Major regulations in different countries and regions identify chemicals according to their bioconcentration factor（BCF） and octanol–water partition coefficient（Kow）, which frequently displays a substantial correlation with the sediment sorption coefficient（Koc）. Half-life or degradability is crucial for the persistence evaluation of chemicals. Quantitative structure activity relationship（QSAR） estimation models are indispensable for predicting environmental fate and health effects in the absence of field-or laboratory-based data. In this study, 39 chemicals of high concern were chosen for half-life testing based on total organic carbon（TOC） degradation,and two widely accepted and highly used QSAR estimation models（i.e., EPI Suite and PBT Profiler） were adopted for environmental risk evaluation. The experimental results and estimated data, as well as the two model-based results were compared, based on the water solubility, Kow, Koc, BCF and half-life. Environmental risk assessment of the selected compounds was achieved by combining experimental data and estimation models. It was concluded that both EPI Suite and PBT Profiler were fairly accurate in measuring the physicochemical properties and degradation half-lives for water, soil, and sediment.However, the half-lives between the experimental and the estimated results were still not absolutely consistent. This suggests deficiencies of the prediction models in some ways, and the necessity to combine the experimental data and predicted results for the evaluation of environmental fate and risks of pollutants.

关键词： QSAR Risk assessment Predictive toxicology TOC Physicochemical property

叙事之艺与伦理之思的有机交融——《麦克尤恩的小说创作及其伦理价值研究》述评

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山东外语教学 2024年第3期45卷 129-133页

作者：朱慧敏刘茂生广东外语外贸大学英语语言文化学院广东广州510420

尚必武教授于2023年出版的新著《麦克尤恩的小说创作及其伦理价值研究》深入探讨了英国作家伊恩·麦克尤恩的小说创作,聚焦于作品所呈现的叙事特色和伦理主题,是麦克尤恩研究的重要成果。该著作挖掘了麦克尤恩作品隐含在叙事艺术背后的... 详细信息

尚必武教授于2023年出版的新著《麦克尤恩的小说创作及其伦理价值研究》深入探讨了英国作家伊恩·麦克尤恩的小说创作,聚焦于作品所呈现的叙事特色和伦理主题,是麦克尤恩研究的重要成果。该著作挖掘了麦克尤恩作品隐含在叙事艺术背后的伦理内核,剖析了小说中的伦理问题和伦理困境。尚必武教授细致解读麦克尤恩作品,关注被学界所忽视的伦理关切,呈现其中的伦理诉求。该著极具学术深度,特色鲜明,表达了中国本土视角下的研究立场,实现了中外研究平等对话,是理解麦克尤恩作品、推动中外文学研究交流与互动的力作。

关键词：伊恩·麦克尤恩小说创作叙事艺术伦理思想伦理价值

Cell-derived extracellular matrix-coated silk fibroin scaffold for cardiogenesis of brown adipose stem cells through modulation of TGF-β pathway

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Regenerative Biomaterials 2020年第4期7卷 403-412页

作者： Wei Liu Yanfeng Sun Xiaohui Dong Qi Yin huimin zhu Siwei Li Jin Zhou Changyong Wang School of Life Science and Technology Harbin Institute of Technology92 West Dazhi StreetNan Gang DistrictHarbin 150080P.R.China Tissue Engineering Research Center Academy of Military Medical Sciences27 Taiping RoadBeijing 100850P.R.China Department of Neural Engineering and Biological Interdisciplinary Studies Institute of Military Cognition and Brain SciencesAcademy of Military Medical Sciences27 Taiping RoadBeijing 100850P.R.China Pediatric Clinical CancerThe Armed Police General Hospital69 Yongding RoadBeijing 100080P.R.China

The cell-derived extracellular matrix(ECM)-modified scaffolds have advantages of mimic tissue specificity and been thought to better mimic the native cellular microenvironment in vitro.ECM derived from cardiac fibroblasts(CFs)are considered as key elements that provide a natural cell growth microenvironment and change the fate of cardiomyocytes(CMs).Here,a new hybrid scaffold is designed based on silk fibroin(SF)scaffold and CFs-derived ECM.CFs were seeded on the SF scaffold for 10days culturing and decellularized to produce CFs-derived ECM-coated SF scaffold.The results showed that the cell-derived ECM-modified silk fibroin scaffold material contained collagen,laminin,fibronectin and other ECM components with myocardial-like properties.Further to explore its effects on brown adipose stem cells(BASCs)differentiation into CMs.We found that the CFderived ECM-coated scaffold also increased the expression of CM-specific proteins(e.***.cardiac troponin T and α-actinin)of BASCs.Notably,the b1-integrin-dependent transforming growth factor-β1 signaling pathway was also involved in the regulation of CF-derived ECM by promoting the differentiation of BASCs into CMs.Overall,these findings provide insights into the bionic manufacturing of engineered cardiac tissues(ECTs)and establish a theoretical basis for the construction of ECTs.

关键词： cell-derived extracellular matrix cardiac fibroblasts brown adipose stem cells silk fibroin scaffolds

ATP-responsive hollow nanocapsules for DOX/GOx delivery to enable tumor inhibition with suppressed P-glycoprotein

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Nano Research 2021年第1期14卷 222-231页

作者： huimin zhu Guodong Cao Yike Fu Chao Fang Qiang Chu Xiang Li Yulian Wu Gaorong Han State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Surgery Second Affiliated Hospital Zhejiang University School of Medicine Zhejiang UniversityHangzhou 310000China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200China

Multidrug resistance(MDR)restricts chemotherapy efficacy due to P-glycoprotein(P-gp)mediated drug efflux,whereas current approaches to suppressing P-gp expression suffer from intrinsic challenges,such as low transfection,high toxicity and poor specificity.Here,hollow ferric-tannic acid complex nanocapsules(HFe-TA),which can be effectively degraded by the reaction with adenosine triphosphate(ATP),are synthesized for the delivery of glucose oxidase(GOx)and doxorubicin(DOX)for tumor treatment.The findings indicate that the intracellular ATP is significantly decreased due to the combined effect of HFe-TA degradation and GOx-mediated glucose consumption.Along with this ATP down-regulation,P-gp expression of tumor cells is suppressed remarkably,which in turn promotes the intracellular accumulation and anticancer efficacy of DOX.In addition,the production of•OH by Fe ions released from HFe-TA is promoted by the by-products of the oxidation of glucose process by GOx.In consequence,HFe-TA nanocapsules loaded with DOX and GOx enable significant inhibition effect to tumors both in vitro and in vivo due to the synergistic effect of cascade reactions.This study has therefore provided an alternative therapeutic platform for effective tumor inhibition with the potential in overcoming intrinsic MDR.

关键词： adenosine triphosphate(ATP)-responsive P-glycoprotein(P-gp)suppression nanocapsules multi-model tumor therapy

基于Python+ESP32的微波系统蓄电池组智能健康监测系统

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广播与电视技术 2024年第1期51卷 120-122页

作者：朱慧敏广东省广播电视技术中心东莞电视转播台广东510000

蓄电池组在确保微波系统传输安全中扮演着至关重要的角色。为了确保蓄电池组的可靠性,对其进行维护和健康监测是至关重要的。本文详细介绍了东莞微波站基于Python+ESP32的微波系统蓄电池组健康监测系统,并在此基础上进行了引申。基于现... 详细信息

蓄电池组在确保微波系统传输安全中扮演着至关重要的角色。为了确保蓄电池组的可靠性,对其进行维护和健康监测是至关重要的。本文详细介绍了东莞微波站基于Python+ESP32的微波系统蓄电池组健康监测系统,并在此基础上进行了引申。基于现有的微波IP化改造,设计实现了一个基于微波IP的全省微波系统蓄电池健康状况系统,为智能高山台站的智慧化迈出了重要的一步。

关键词：微波传输蓄电池组健康监测智能高山台站

Piperlongumine Inhibits Zika Virus Replication In vitro and Promotes Up-Regulation of HO-1 Expression, Suggesting An Implication of Oxidative Stress

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Virologica Sinica 2021年第3期36卷 510-520页

作者： Weizhi Lu Linjuan Shi Jing Gao huimin zhu Ying Hua Jintai Cai Xianbo Wu Chengsong Wan Wei Zhao Bao Zhang Biosafety Level-3 Lab School of Public HealthSouthern Medical UniversityGuangzhou 510515China Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515China

Owing to the widespread distribution of mosquitoes capable of transmitting Zika virus, lack of clinical vaccines and treatments, and poor immunity of populations to new infectious diseases, Zika virus has become a global public health concern. Recent studies have found that Zika virus can continuously infect human brain microvascular endothelial cells.These cells are the primary components of the blood–brain barrier of the cerebral cortex, and further infection of brain tissue may cause severe damage such as encephalitis and fetal pituitary disease. The present study found that a biologically active base, piperlongumine(PL), inhibited Zika virus replication in human brain microvascular endothelial cells, Vero cells, and human umbilical vein endothelial cells. PL also significantly increased heme oxygenase-1(HO-1) gene expression, while silencing HO-1 expression and using the reactive oxygen species scavenger, N-acetylcysteine, attenuated the inhibitory effect of PL on Zika virus replication. These results suggest that PL induces oxidative stress in cells by increasing reactive oxygen species. This, in turn, induces an increase in HO-1 expression, thereby inhibiting Zika virus replication. These findings provide novel clues for drug research on the prevention and treatment of Zika virus.

关键词： Piperlongumine Heme oxygenase-1(HO-1) Reactive oxygen species Zika virus(ZIKV) Human brain microvascular endothelial cells