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Research on the Association between Fear of Cancer Recurrence in Young Breast Cancer Patients and Adult Attachment and Self-Disclosure

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Psycho-Oncologie 2024年第3期18卷 169-179页

作者： huimin zheng Minghui Wang Miao Ye Department of Breast Cancer Surgery Jiangsu Cancer HospitalThe Affliated Cancer Hospital of Nanjing Medical UniversityJiangsu Institute of Cancer ResearchNanjing210009China

Background:Although fear of cancer recurrence(FCR)is the most important factor affecting the life quality of young breast cancer patients,and it may be affected by the patient’s personality,marital relationship and communication,there is a lack of research on the relationship between adult attachment,self-disclosure and FCR in *** study investigated the current situation of FCR in young breast cancer patients,its correlation with adult attachment and self-disclosure and its inﬂuencing factors,in order to predict the impact of adult attachment and self-disclosure of patients to spouse on ***:A survey was conducted on 126 breast cancer patients at our hospital using the General Information Questionnaire(GIQ),Fear of Progression Questionnaire-Short Form(FoP-Q-SF),Experiences in Close Relationships inventory(ECR),and Distress Disclosure Index(DDI).The study analyzed the status of FCR among young breast cancer patients and its correlation with adult attachment and self-disclosure,along with its inﬂuencing ***:Among the 126 young breast cancer patients,50 had a FoP-Q-SF score<34(normal group),while 76 had a FoP-Q-SF score≥34(FCR positive group),with an FCR incidence rate of 60.32%.Univariate analysis showed statistically signiﬁcant differences between the two groups in terms of FoP-Q-SF score,ECR score,attachment anxiety score,attachment avoidance score,DDI score,age,educational level,employment status,per capita monthly income,and treatment method(p<0.05).Correlation analysis revealed that FoP-Q-SF scores were positively correlated with attachment anxiety score,attachment avoidance score,ECR scores and negatively correlated with DDI scores(p<0.05).Linear regression analysis indicated that age,per capita monthly income,treatment method,attachment anxiety,attachment avoidance and self-disclosure level were negative predictors of FoP-Q-SF scores in young breast cancer patients(p<0.05).Conclusion:The incidence rate of FCR among young breast canc

关键词： Breast cancer fear of recurrence adult attachment self-disclosure

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Quantum software framework： a tentative study

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Frontiers of Computer Science 2013年第3期7卷 341-349页

作者： Nan WU Haixing HU Fangmin SONG huimin zheng Xiangdong LI State Key Laboratory for Novel Software Technology Nanjing University Nanjing 210093 China Department of Computer Science and Technology Nanjing University Nanjing 210093 China Department of Computer Science The Graduate School The City University of New York New York 10016 USA

In this paper we conduct a tentative study on the requirements and the structure for a quantum computer at the software level. From the software point of view, we describe the methodology used to minimize the decoherence. We con- struct the quantum instruction set for the higher-level computation. We also study the criteria for designing the quantum programming languages.

关键词： quantum software quantum computation quantum programming language

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The Difficulties and Obstacles of Socialized Service in University Library

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Journal of Contemporary Educational Research 2018年第6期2卷 29-32页

作者： huimin zheng Zhongyuan University of Technology Library Zhengzhou 450007China

University library plays an important role in serving all lecturers and students as it is a place where books and other information resources are collected and gathered for the purposes of reading and *** time goes by,university libraries have gradually open to the public to fully make use of its function as an educational and social *** socialized service of university library has the advantages of promoting cultural virtue and moral integrity to the ***,there remain many issues during the development of socialized service in the university ***,analyzing the difficulties and obstacles faced in socialized services of the university library,this paper aims to provide countermeasures to solve the problems.

关键词： University library socialized service difficulty obstacle countermeasure

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Exploration on the Construction of Mobile Library Service Quality Optimization Model

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Journal of Contemporary Educational Research 2019年第6期3卷 39-42页

作者： huimin zheng Zhongyuan University of Technology Library Zhengzhou450007China

The emergence of science and technology and big data has promoted the emergence of major resource *** libraries have emerged as the world *** have put forward high requirements for service quality in the process of using mobile *** service quality is one of the important topics of mobile libraries *** our paper the mobile library service quality optimization model is constructed from three aspects,including the starting point of the optimization model,the optimization content,and the final *** keeping up with the pace of the times,we will meet the needs of users and enhance user satisfaction in order to promote the development and advancement of mobile libraries.

关键词： Mobile library Service quality Service model

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Performance of LED with mixed wavelengths or two-phase culture on the growth and lipid accumulation of Chlorella pyrenoidosa

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International Journal of Agricultural and Biological Engineering 2021年第1期14卷 90-96页

作者： Bingquan Chu Jiewei Zhao huimin zheng Jinyan Gong Kai Chen Suwan Zhang Gongnian Xiao Yong He College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou 310023China

Chlorella pyrenoidosa,a type of lipid-rich green algae,features broad prospects for application in such fields as healthy foods,biodiesel and so *** light-utilizing efficiency of the cells is a critical factor that influences the biomass and lipid contents of photoautotrophic *** illumination wavelengths hinder microalgal *** patterns about the impacts of mixed light emitting diode(LED)wavelengths or two-phase culture over the growth and lipid accumulation of Chlorella pyrenoidosa were *** the different LED wavelengths(white,purple,blue,green,yellow and red)at the light intensity of 200μmol/m2·s tested,red and green gave maximum biomass and lipid contents,*** on the discovery,two-phase(red was illuminated for 12 d in the first phase,and then shifted to green light for 8 d in the second phase,R→G)or mixed LED(R:G=3:7 or R:G=7:3)culture protocol was adopted for the high lipid-accumulation of Chlorella *** results indicated that the lipid contents of Chlorella pyrenoidosa treated with two-phase(R→G)or mixed LED culture was significantly higher than that of white light with the same intensity(p<0.05),and the highest lipid-accumulation rate was 26.37 mg/L·d in the two-phase *** acid(FA)analysis showed that 13 types FAs were detected and unsaturated FAs were over 50%(w/w).26.8%-27.7%(w/w)palmitic acid(C16:0)was the major saturated FA,while the largest proportions of monounsaturated FA and polyunsaturated FA were oleic acid(C18:1)and linoleic acid(C18:2),***,although no difference in the FA composition of Chlorella pyrenoidosa treated with different protocols was found,the absolute content did differ significantly,coinciding with that of the total ***,the ratio of unsaturated FAs in Chlorella pyrenoidosa was significantly increased under the mixed LED(R:G=7:3)(p<0.05).

关键词： Chlorella pyrenoidosa mixed LED wavelength two-phase biomass lipid fatty acid

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The mechanism of dentine hypersensitivity:Stimuli-induced directional cation transport through dentinal tubules

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Nano Research 2023年第1期16卷 991-998页

作者： Nuo Chen Jingjing Deng Shengjie Jiang Xiang-Yu Kong Teng Zhou Kai Zhao Zuohui Xiao huimin zheng Weipeng Chen Congcong Zhu Xinyu Liu Liping Wen Yan Wei Xuliang Deng Lei Jiang Beijing Laboratory of Biomedical Materials Department of Geriatric DentistryPeking University School and Hospital of StomatologyBeijing 100081China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Mechanical and Electrical Engineering College Hainan UniversityHainan 570228China School of Future Technology University of Chinese Academy of Sciences Beijing 100049China

Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains *** long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain ***,no experimental evidence supports the ***,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine *** in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine ***,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine ***,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical *** proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure.

关键词： dentine hypersensitivity cation transport dentinal tubules Ionic-current-rectification

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Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies

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Journal of Molecular Cell Biology 2020年第9期12卷 688-699页

作者： Lei Cao Xianyou Xia Yu Kong Fengqin Jia Bo Yuan Rui Li Qian Li YuxinWang Mingrui Cui Zhongye Dai huimin zheng Jesper Christensen Yuan Zhou Xudong Wu Collaborative Innovation Center of Tianjin for Medical Epigenetics Tianjin Key Laboratory of Medical EpigeneticsKey Laboratory of Immune Microenvironment and Disease(Ministry of Education)Department of Cell BiologyTianjin Medical UniversityTianjin 300070China National Demonstration Center for Experimental Basic Medical Science Education Tianjin Medical UniversityTianjin 300070China Department of Prosthodontics School and Hospital of StomatologyTianjin Medical UniversityTianjin 300070China Biotech Research and Innovation Centre and Centre for Epigenetics University of Copenhagen2200 CopenhagenDenmark State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

Mutations of epigenetic regulators are pervasive in human ***1 is frequently mutated in myeloid *** previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A(H2AK119ub1),a Polycomb repressive ***,a complete mechanistic understanding of ASXL1 in transcriptional regulation and tumor suppression remains to be ***,we find that depletion of Asxl1 confers murine 32D cells to IL3-independent growth at least partly due to sustained activation of PI3K/AKT ***,Asxl1 is critical for the transcriptional activation of Pten,a key negative regulator of AKT *** we confirm that Asxl1 is specifically enriched and required for H2AK119 deubiquitylation at the Pten ***,ASXL1 and PTEN expression levels are positively correlated in human blood cells and ASXL1 mutations are associated with lower expression levels of PTEN in human myeloid ***,malignant cells with ASXL1 downregulation or mutations exhibit higher sensitivity to the AKT inhibitor ***,this study has linked the PTEN/AKT signaling axis to deregulated epigenetic changes in myeloid *** also provides a rationale for mechanism-based therapy for patients with ASXL1 mutations.

关键词： tumor suppressor Polycomb H2A ubiquitylation PTEN AKT

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Application of an analytic hierarchy process to hydrocarbon accumulation coefficient estimation

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Petroleum Science 2010年第3期7卷 337-346页

作者： Gao Yongjin Liu Lifeng Liu huimin zheng Feifei Wu Li Zhou Jingjing Qu Dongfang State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum Beijing 102249 China Geoscience Research Institute Shengli Oilfield SINOPEC Dongying 257061 China Laboratory of Integrated Geology and Geophysics Research China University of Petroleum Beijing 102249 China

The hydrocarbon accumulation coefficient is a key parameter in resources evaluation by genetic techniques. Methods of obtaining its value scientifically have always been an important factor influencing evaluation credibility. In this paper, the hydrocarbon accumulation system is evaluated quantitatively by establishing a hierarchy structure model based on an analytical hierarchy process. The hydrocarbon accumulation system of a higher exploration degree is selected as a calibration area and its hydrocarbon accumulation coefficient can be calculated using methods of hydrocarbon generation potential and reservoir-scale sequence. The hydrocarbon accumulation coefficient of a petroleum accumulation system can be gained by analogy of reservoir forming comprehensive evaluation results with the calibration area. The hydrocarbon accumulation coefficient of each petroleum accumulation system in the upper reservoir-forming combination of the Liaohe Western Sag can be obtained with this method. Practice shows that using the analytical hierarchy process to quantitatively evaluate the hydrocarbon accumulation system and then quantitatively predict the hydrocarbon accumulation coefficient decreases the influence of human factors in resources evaluation, and makes the resources assessment more objective and closer to the actual geological condition.

关键词： Hydrocarbon accumulation coefficient analytical hierarchy process hydrocarbon resourceevaluation hydrocarbon accumulation system Liaohe Western Sag

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两种麻醉方式用于小儿腹腔镜手术的效果比较

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中国基层医药 2020年第3期27卷 263-266页

作者：郑惠敏宁波大学医学院附属医院麻醉科 315020

目的比较两种麻醉方式用于小儿腹腔镜手术的效果及其对应激反应、血流动力学的影响。方法选取宁波大学医学院附属医院2016年11月至2017年11月行腹腔镜手术的患儿100例,采用病床奇偶数分为两组,对照组50例行全身麻醉,观察组50例行瑞芬太... 详细信息

目的比较两种麻醉方式用于小儿腹腔镜手术的效果及其对应激反应、血流动力学的影响。方法选取宁波大学医学院附属医院2016年11月至2017年11月行腹腔镜手术的患儿100例,采用病床奇偶数分为两组,对照组50例行全身麻醉,观察组50例行瑞芬太尼复合丙泊酚全凭静脉麻醉,比较两组麻醉效果及应激反应、血流动力学指标。结果观察组术后清醒时间[(31.48±4.19)min]、睫毛反射消失时间[(2.32±1.62)min]、自主呼吸恢复时间[(1.96±1.45)min]、不良反应发生率[4.00%(2/50)]、麻醉中Ramsay评分[(3.69±0.43)分]、麻醉中疼痛评分[(1.96±1.42)分]、术后立即Ramsay评分[(2.11±0.82)分]、术后立即疼痛评分[(2.31±0.43)分]均优于对照组(t=15.623、1.436、5.436,χ2=5.432,t=1.187、1.528、2.136、2.431,均P<0.05),观察组各时间段平均动脉压、心率及术后立即的应激反应(皮质醇、血糖、氧分压、平均动脉压)指标均优于对照组(均P<0.05)。结论全身麻醉在小儿腹腔镜手术中风险较大,可延长意识清醒时间,而瑞芬太尼复合丙泊酚全凭静脉麻醉在小儿腹腔镜手术中,可稳定血流动力学指标,减轻应激反应,提高麻醉安全性。

关键词：麻醉,全身麻醉,静脉腹腔镜应激反应血流动力学疗效安全性儿童

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肿瘤翻译调控机制及其靶向药物的研究进展

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中国现代应用药学 2023年第20期40卷 2897-2908页

作者：郑慧敏徐易尘浙江大学药学院浙江大学医学院附属第二医院

mRNA翻译是蛋白合成的最终调控环节，是细胞发挥功能、增殖以及适应环境的重要分子基础。肿瘤中mRNA翻译调控的异常活跃不仅能介导促癌蛋白的持续合成以保障肿瘤细胞的高速增殖，亦能促进某些关键蛋白的灵活表达协助肿瘤细胞快速适应多... 详细信息

mRNA翻译是蛋白合成的最终调控环节，是细胞发挥功能、增殖以及适应环境的重要分子基础。肿瘤中mRNA翻译调控的异常活跃不仅能介导促癌蛋白的持续合成以保障肿瘤细胞的高速增殖，亦能促进某些关键蛋白的灵活表达协助肿瘤细胞快速适应多变的微环境，甚至是肿瘤抵抗抗肿瘤药物打击、产生耐药的重要手段。因此，靶向翻译调控不仅能够遏制肿瘤的发生发展，亦可改善肿瘤耐药。本文简述mRNA翻译调控网络的重要调控因子和通路，探讨肿瘤异常激活翻译以合成促癌蛋白的方式，并总结现有翻译靶向药物的研究进展和临床使用情况。

关键词：肿瘤翻译调控翻译抑制剂

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