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牛角瓜纤维研究现状及应用

针织工业 2023年第6期 14-19页

作者：方国平胡惠民上海帕兰朵纺织科技发展有限公司上海200437 上海魔树生物科技有限公司上海201803

论述新型天然植物牛角瓜及其纤维在种植、纤维特性、纺纱等方面的研究概要,阐述其在生物医药、新材料等领域的应用。并详细介绍牛角瓜纤维目前的种植现状和纺织现状。阐述牛角瓜纤维创新历程及国内外对该纤维的评价。分析目前牛角瓜纤... 详细信息

论述新型天然植物牛角瓜及其纤维在种植、纤维特性、纺纱等方面的研究概要,阐述其在生物医药、新材料等领域的应用。并详细介绍牛角瓜纤维目前的种植现状和纺织现状。阐述牛角瓜纤维创新历程及国内外对该纤维的评价。分析目前牛角瓜纤维研究和推广过程中存在的问题及原因,提出应建立国内牛角瓜新型产业研究体系,并表明了自己的想法和意见。

关键词：牛角瓜牛角瓜纤维牛角瓜产业应用前景

Internal incentives and operations strategies for the watersaving supply chain with cap-and-trade regulation

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Frontiers of Engineering Management 2019年第1期6卷 87-101页

作者： Zhisong CHEN Li fang huimin WANG Business School Nanjing Normal University Nanjing 210023 China Stem School of Business New York University New York NY 10012 USA State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 China Business School Hohai University Nanjing 211100 China College of Management and Economics Tianjin University Tianjin 300072 China

Faced with the rapid development of modem industries of agriculture, manufacturing, and services, water resources are becoming increasingly scarce. Industries with high water consumption are generally regulated by the government's water cap-and-trade (CAT) regulation to solve the contradiction between the limited water supply and the rapid growing water demand. Supply chain equilibrium and coordination models under the benchmark scenario without water saving and CAT regulation, watersaving supply chain equilibrium and coordination models under the scenario without/with CAT regulation are developed, analyzed and compared. The corresponding numerical and sensitivity analyses for all models are conducted and compared, and the managerial insights and policy recommendations are summarized in this article. The results indicate that (1) Conducting water saving could improve effectively the operational performance of the water-saving supply chain under the scenario without/with CAT regulation.(2) The coordination strategy based on the revenue sharing contract could efficiently coordinate the water-saving supply chain, enhance water consumption reduction rate, and improve the operational performance of the water-saving supply chain.(3) The implementation of CAT regulation enhances effectively water-consumptio reduction in the water-saving supply chain and improves the operational performance of water-saving supply chain.(4) Simultaneous implementation of CAT regulation by the government and adopting coordination strategy by the water-saving supply chain would be superior to any other scenarios/strategies.(5) A suitable water cap based on the industrial average water consumption and historical water consumption data are beneficial for constructing reasonable and effective incentive mechanism.(6) A higher marginal trade price could induce more reduction in water consumption and create better operational performance for the manufacturer and water-saving supply chain, both under the equilibrium and coordination strategies.

关键词： water-saving supply chain equilibrium coordination internal incentive cap and trade regulation

机器学习定位特发性室性心律失常起源的前瞻性研究

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中华心律失常学杂志 2024年第2期28卷 125-130页

作者：傅国华郑建伟徐茵储慧民卓伟东王彬浩郁一波高昉丰明俊杜先锋孙一钧裘欣慧宁波大学附属第一医院心律失常诊疗中心宁波315000 上海科心医学生物技术有限公司上海200000

目的评估高精度机器学习算法软件定位特发性室性心律失常(IVA)起源的准确性。方法本研究为观察性描述性研究。入选2023年8月至10月在宁波大学附属第一医院心律失常诊疗中心行IVA导管射频消融术(RFCA)的患者,术前通过高精度机器学习算法... 详细信息

目的评估高精度机器学习算法软件定位特发性室性心律失常(IVA)起源的准确性。方法本研究为观察性描述性研究。入选2023年8月至10月在宁波大学附属第一医院心律失常诊疗中心行IVA导管射频消融术(RFCA)的患者,术前通过高精度机器学习算法软件预测IVA起源位置,与最终行RFCA成功的起源位置比较。结果38例患者于术前进行起源位置预测,其中2例患者消融失败,最后共纳入首次成功行RFCA的36例IVA患者,其中男15例,年龄(53.1±9.6)岁。35例患者预测准确,1例IVA起源左心室顶部(Summit)内膜面的患者预测失败,软件预测准确率为97.22%(34/35)。经过(3.1±0.3)个月随访,所有患者均达到长期消融成功标准。该机器学习算法软件预测IVA起源的受试者工作特征曲线下的面积、敏感度、特异度、F1评分、准确率分别为97%、97%、100%、96%、99%。结论高精度机器学习算法软件定位IVA起源有效、精准。

关键词：人工智能特发性室性心律失常机器学习射频导管消融心电图

Morphological Characteristics and Seed Physiochemical Properties of Two Giant Embryo Mutants in Rice

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Rice science 2020年第2期27卷 81-85页

作者： ZHANG Long LI Ning fang huimin ZHAO Linglong GUO Ke ZHANG Jing LIU Qiaoquan JIANG Ling WEI Cunxu Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of the Ministry of Education Yangzhou UniversityYangzhou 225009China Co-Innovation Center for Modern Production Technology of Grain Crops of Jiangsu Province/Joint International Research Laboratory of Agriculture&Agri-Product Safety of the Ministry of Education Yangzhou UniversityYangzhou 225009China College of Guangling Yangzhou UniversityYangzhou 225009China State Key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research CenterNanjing Agricultural UniversityNanjing 210095China

Rice(Oryza sativa L.)is one of the most important cereal crops and the staple food for over half of the world’s population.Under the efforts of breeders,the quality of rice has been becoming better in recent years,and basically meets the growing life requirements of people.However,the major micronutrients in seeds are gradually decreasing in many rice cultivars,which is highly relevant to chronic diseases and micronutrient deficiencies and influences the health of children and women in the developing countries(Wahlqvist et al,1999;Zhang et al,2005).Therefore,how to increase the nutritional quality in rice has attracted growing attention in recent years.

关键词： crops cultivar cereal

The Late Palaeozoic Rifting on Hainan Island, China

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Acta Geologica Sinica(English Edition) 1991年第4期65卷 341-355页

作者： Xia Bangdong Shi Guangyu fang Zhong Yu Jinhai Wang Ciyin Tao Xiancong Li huimin Department of Earth Sciences,Nanjing University, Nanjng Jiang Minxi Department of Earth Sciences Nanjing University Nanjing

There occurred rifting on Hainan Island in the Late Palaeozoic. Bimodal volcanic rocks composed ofbasalt and rhyolite developed in the Carboniferous. Widespread in the Late Palaeozoic formations are severallayers of fluvial intermontane conglomerates whose distribution is controlled by rift faults. The Late Palaeozoicdeposits dominaled by clastic rocks are, for a major part, of marine facies and of continental facies in the lowerand upper parts. Lithological and lithochemical studies indicate that the detrital rocks were formed in atectonic setting of continental rifting. The evolution of the rifting terminated at the stage of transition form anintra continental rift to an intercontinental one and the rift basin was a bay opening westward to the sea.

关键词： China The Late Palaeozoic Rifting on Hainan Island

Mechanism of Huatan Sanjie fang in improving goiter in Graves'disease mice based on the Hippo signaling pathway

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 289-295页

作者： huimin Yuan Wenxin Ma Yifei Song Hang Wang Shuxin Yan Silan Hao Xiaoyun Zhu Yang Tang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China

Objective:To explore the mechanism of Huatan Sanjie fang(HTSJ)in regulating goiter in Graves'disease(GD)mice by detecting key factors of the Hippo signaling pathway.Methods:A mouse model of GD was established by injecting Ad-TSHR289 adenovirus into the bilateral quadriceps femoris of female mice.Successful mouse models were then randomly divided into a model group,methimazole(MMI)group,and HTSJ group,and fed with deionized water,MMI(4.5 mg/kg per day),and HTSJ(35.10 g/kg per day),respectively,for 10 weeks.Histopathological changes of the thyroid gland were subsequently observed by hematoxylin-eosin staining.Radioimmunoassay was used to detect serum total thyroxine(T4)and thyrotrophin-receptor antibody(TRAb)levels.The relative expression of mRNA of Mst1,YAP,and TAZ were detected by quantitative real-time polymerase chain reaction,while the protein expression of Mst1,YAP,TAZ,pMst1,and pYAP were detected by western blot.Results:After 10 weeks of drug intervention,goiter and other pathological changes in the HTSJ group significantly improved compared with the model group,and the levels of serum T4 and TRAb significantly decreased(P=.002,P<.001,respectively).Decreased mRNA expression of Mst1,YAP,and TAZ,the key factors of the Hippo signaling transduction pathway,was also observed(P=.002,P=.022,P<.001,respectively).In contrast,protein expression of Mst1(P=.046),pMst1(P=.026),and p YAP(P=.004)increased,while protein expression of YAP and TAZ decreased(P=.041,P<.001,respectively).Conclusion:HTSJ can effectively improve goiter in GD mice through the Hippo signaling pathway.

关键词： Graves'disease Huatan Sanjie fang Goiter Hippo signaling pathway Organ size Graves'disease model methimazole YAP

Shale pore characteristics of Shahejie Formation: Implication for pore evolution of shale oil reservoirs in Dongying sag, north China

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Petroleum Research 2019年第2期4卷 113-124页

作者： Shun Zhang huimin Liu Min Wang Xinjin Liu Huilai Liu Youshu Bao Weiqing Wang Runze Li Xin Luo Zhengwei fang Research Institute of Petroleum Exploration and Development Sinopec Shengli Oilfield CompanyShandongDongying257022China Postdoctor Scientific Research Stations Sinopec Shengli Oilfield CompanyShandongDongying257000China Petroleum Development Center of Shengli Oilfield ShandongDongying257022China Petroleum Development Center of Shengli Oilfield Beijing100007China Chongqing Gas Field of PetroChina Southwest Oil&Gasfield Company Chongqing400021China

The pore characteristics of shale reservoirs in the lower submember of Member 3 to upper submember of Member 4 of Shahejie Formation in Dongying sag are analyzed,influences of mineral content and organic matter content on porosity and pore size are also investigated,and through the diagenetic thermal simulation experiment,the main pore evolution is further discussed.The results show that the pore structure of shale reservoirs is complex,the micron-nanometer pores can storage liquid hydrocarbons,and the free-phase crude oil is mainly distributed in intergranular dissolution pores of calcite,recrystallized intergranular pores,intergranular shrinkage fractures of clay mineral which have large pore size.Framework minerals and organic matter content directly influence porosity and pore size of shale reservoirs,relationship between porosity and content of felsic mineral as well as content of organic matter content is linear and positive,while relationship between content of carbonated mineral is negative.At the buried depth from 2500 to 3500 m,concentration of organic acid from hydrocarbon generation and expulsion of organic matter,increasing range of pressure coefficient,are well corresponding to highporosity intervals;pore formation in shale oil reservoirs are almost controlled by diagenetic evolution of clay minerals;framework storage spaces formed by carbonate grain crystals as well as intergranular and intergranular dissolution pores of carbonate increases porosity of shale oil reservoirs;local increase of porosity at the depth of 3500e3800 m is mainly caused by coupling of hydrocarbon-generating overpressure and dissolution,and size,distribution and connectivity of pores are enhanced obviously.

关键词： Shale oil Pore and fracture Diagenesis Clay mineral transformation Dissolution Recrystallization Hydrocarbon-generation and acid expulsion Paleogene Dongying sag

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脱发性疾病的发生机制及干细胞治疗研究进展

中华整形外科杂志 2022年第8期38卷 946-950页

作者：方慧敏汪振星孙家明华中科技大学同济医学院附属协和医院整形外科武汉市表浅器官再造与修复临床研究中心武汉430022

脱发性疾病主要由多种原因导致的毛囊干细胞增殖分化能力受损造成,毛囊微环境调节着毛囊干细胞的活化状态。外源性干细胞能够调节毛囊部位的微环境,通过多种途径调节毛囊内细胞的生长。该文综述了毛囊干细胞和毛囊微环境对于毛囊生长的... 详细信息

脱发性疾病主要由多种原因导致的毛囊干细胞增殖分化能力受损造成,毛囊微环境调节着毛囊干细胞的活化状态。外源性干细胞能够调节毛囊部位的微环境,通过多种途径调节毛囊内细胞的生长。该文综述了毛囊干细胞和毛囊微环境对于毛囊生长的调控,以及在脱发性疾病发生中的机制,介绍了外源性干细胞治疗在脱发性疾病中的临床应用进展。

关键词：干细胞脱发细胞微环境

Impact of dietary fat levels and fatty acid composition on milk fat synthesis in sows at peak lactation

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1134-1149页

作者： Li Zhe Uffe Krogh Charlotte Lauridsen Mette Olaf Nielsen Zhengfeng fang Peter Kappel Theil Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationAnimal Nutrition InstituteSichuan Agricultural University211 Huimin RoadWenjiang DistrictChengdu 611130China Department of Animal and Veterinary Sciences Aarhus UniversityFoulumDk‑8830 TjeleDenmark

Background Dietary fat is important for energy provision and immune function of lactating sows and their progeny.However,knowledge on the impact of fat on mammary transcription of lipogenic genes,de novo fat synthesis,and milk fatty acid(FA)output is sparse in sows.This study aimed to evaluate impacts of dietary fat levels and FA composition on these traits in sows.Forty second-parity sows(Danish Landrace×Yorkshire)were assigned to 1 of 5 dietary treatments from d 108 of gestation until weaning(d 28 of lactation):low-fat control diet(3%added animal fat);or 1 of 4 high-fat diets with 8%added fat:coconut oil(CO),fish oil(FO),sunflower oil(SO),or 4%octanoic acid plus 4%FO(OFO).Three approaches were taken to estimate de novo milk fat synthesis from glucose and body fat.Results Daily intake of FA was lowest in low-fat sows within fat levels(P<0.01)and in OFO and FO sows within highfat diets(P<0.01).Daily milk outputs of fat,FA,energy,and FA-derived carbon reflected to a large extent the intake of those.On average,estimates for de novo fat synthesis were 82 or 194 g/d from glucose according to method 1 or 2 and 255 g de novo+mobilized FA/d according to method 3.The low-fat diet increased mammary FAS expression(P<0.05)and de novo fat synthesis(method 1;P=0.13)within fat levels.The OFO diet increased de novo fat synthesis(method 1;P<0.05)and numerically upregulated mammary FAS expression compared to the other high-fat diets.Across diets,a daily intake of 440 g digestible FA minimized milk fat originating from glucose and mobilized body fat.Conclusions Sows fed diets with low-fat or octanoic acid,through upregulating FAS expression,increased mammary de novo fat synthesis whereas the milk FA output remained low in sows fed the low-fat diet or high-fat OFO or FO diets,indicating that dietary FA intake,dietary fat level,and body fat mobilization in concert determine de novo fat synthesis,amount and profiles of FA in milk.

关键词： Carbon metabolism De novo fat synthesis Dietary fatty acid Fat balance Mammary gene expression Mammary lipogenesis Milk fat production Piglet growth