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Natural variation in MORE GRAINS 1 regulates grain number and grain weight in rice

Journal of Integrative Plant Biology 2024年第7期66卷 1440-1458页

作者： Yingchun Han Qianfeng Hu Nuo Gong huimin yan Najeeb Ullah Khan yanxiu Du Hongzheng Sun Quanzhi Zhao Wanxi Peng Zichao Li Zhanying Zhang Junzhou Li Henan Key Laboratory of Rice Molecular Breeding and High Efﬁciency Production College of AgronomyHenan Agricultural UniversityZhengzhou 450046China Beijing Key Laboratory of Crop Genetic Improvement College of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Rice Industrial Technology Research Institute Guizhou UniversityGuiyang 550025China School of Forestry Henan Agricultural UniversityZhengzhou 450046China

Grain yield is determined mainly by grain number and grain *** this study,we identified and characterized MORE GRAINS1(MOG1),a gene associated with grain number and grain weight in rice(Oryza sativa L.),through map-based *** of MOG1 increased grain yield by 18.6%-22.3%under field *** determined that MOG1,a bHLH transcription factor,interacts with OsbHLH107 and directly activates the expression of LONELY GUY(LOG),which encodes a cytokinin-activating enzyme and the cell expansion gene EXPANSIN-LIKE1(EXPLA1),positively regulating grain number per panicle and grain *** variations in the promoter and coding regions of MOG1 between Hap-LNW and Hap-HNW alleles resulted in changes in MOG1 expression level and transcriptional activation,leading to functional *** analysis revealed that Hap-HNW,which results in a greater number and heavier grains,has undergone strong selection but has been poorly utilized in modern lowland rice *** summary,the MOG1-OsbHLH107 complex activates LOG and EXPLA1 expression to promote cell expansion and division of young panicles through the cytokinin pathway,thereby increasing grain number and grain *** findings suggest that Hap-HNW could be used in strategies to breed high-yielding temperate japonica lowland rice.

关键词： grain number grain weight MOG1 natural variation rice

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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian Li Mengxin Xu Jingyi yang Li Zhou Lin Liu Min Li Shasha Wang Mei-Qin Liu Zhixiang Huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen huimin yan Yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

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NEXMIF基因新发变异致West综合征患儿1例的临床及遗传学分析

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中华医学遗传学杂志 2024年第6期41卷 725-729页

作者：何文梁妍闫会敏万林杨光解放军总医院第一医学中心儿科北京100853

目的:探讨1例NEXMIF基因变异所致West综合征患儿的临床特征及基因变异情况。方法:以1例2021年3月就诊于解放军总医院第一医学中心儿科的患儿作为研究对象。收集患儿的临床资料,对患儿及其父母进行全外显子组测序,对候选变异进行Sanger... 详细信息

目的:探讨1例NEXMIF基因变异所致West综合征患儿的临床特征及基因变异情况。方法:以1例2021年3月就诊于解放军总医院第一医学中心儿科的患儿作为研究对象。收集患儿的临床资料,对患儿及其父母进行全外显子组测序,对候选变异进行Sanger测序验证及致病性分析。总结患儿的治疗情况。结果:患儿为男性,出生4个月时无明显诱因出现成串痉挛发作,视频脑电图提示异常,高度失律,监测到数次成串痉挛发作。头颅磁共振成像提示额顶部脑外间隙增宽。查体发现患儿不会竖头、追听、追视,小头畸形,身高<1 SD,在当地医院诊断为West综合征,予泼尼松口服3个月后癫痫发作得到控制,调整为托吡酯片口服,已有7个月未发作。测序发现患儿携带NEXMIF基因c.982_c.983delTT(p.L328Dfs*23)新发无义变异。结论:对以严重发育落后甚至倒退为首发症状、癫痫发作难以控制且伴有异常面容的West综合征患儿,需警惕NEXMIF基因变异。基因检测有助于早期诊断及治疗。

关键词： NEXMIF基因 KIAA2022基因 West综合征癫痫智力障碍

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酮咯酸氨丁三醇注射液联合枸橼酸舒芬太尼注射液在全膝关节置换术后患者静脉自控镇痛中的应用效果

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中国民康医学 2024年第6期36卷 58-60页

作者：颜惠敏谈金凤苏州明基医院药剂科江苏苏州215000

目的:观察酮咯酸氨丁三醇注射液联合枸橼酸舒芬太尼注射液在全膝关节置换术后患者静脉自控镇痛中的应用效果。方法:选取2020年1月至2022年1月该院收治的120例全膝关节置换术后患者进行前瞻性研究,按照随机数字表法将其分为观察组(n=60)... 详细信息

目的:观察酮咯酸氨丁三醇注射液联合枸橼酸舒芬太尼注射液在全膝关节置换术后患者静脉自控镇痛中的应用效果。方法:选取2020年1月至2022年1月该院收治的120例全膝关节置换术后患者进行前瞻性研究,按照随机数字表法将其分为观察组(n=60)和对照组(n=60)。两组术后均行静脉自控镇痛,对照组用药为枸橼酸舒芬太尼注射液,观察组用药为酮咯酸氨丁三醇注射液联合枸橼酸舒芬太尼注射液,比较两组疼痛视觉模拟评分法(VAS)评分、血清炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]水平、简易精神状态量表(MMSE)评分和不良反应发生率。结果:术后2、4、8、24、48 h,两组静息与活动(咳嗽)状态下VAS评分组间比较,差异均无统计学意义(P>0.05);术后24 h,两组血清IL-6、hs-CRP、TNF-α水平高于术前,但观察组低于对照组,差异均有统计学意义(P<0.05);术后4、8 h,观察组MMSE评分均高于对照组,差异有统计学意义(P<0.05);术后48 h,观察组不良反应发生率为21.67%,低于对照组的43.33%,差异有统计学意义(P<0.05)。结论:酮咯酸氨丁三醇注射液联合枸橼酸舒芬太尼注射液用于全膝关节置换术后患者静脉自控镇痛可提高其MMSE评分,降低其不良反应发生率和炎性因子水平,效果优于单纯枸橼酸舒芬太尼注射液静脉自控镇痛。

关键词：全膝关节置换术术后静脉自控镇痛酮咯酸氨丁三醇枸橼酸舒芬太尼 MMSE评分炎性因子

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一类带Hardy项的p-Laplace方程正解的先验估计

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延边大学学报（自然科学版） 2024年第1期50卷 23-30页

作者：闫慧敏谢君辉湖北民族大学数学与统计学院湖北恩施445000

研究了一类带Hardy项椭圆型p-Laplace方-Δ_(p)u=u^(q)|x|^(a)+h(x,u,■u)解的先验估计,其中3 详细信息

研究了一类带Hardy项椭圆型p-Laplace方-Δ_(p)u=u^(q)|x|^(a)+h(x,u,■u)解的先验估计,其中3

关键词： p-Laplace方程 Hardy项先验估计 Doubling引理 Liouville定理

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Spatio-temporal Pattern of Ecosystem Pressure in Countries Along the Belt and Road: Combining Remote Sensing Data and Statistical Data

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Chinese Geographical Science 2022年第5期32卷 745-758页

作者： DU Wenpeng yan huimin FENG Zhiming ZHANG Chao yanG yanzhao Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Building a Green Silk Road by integrating the Sustainable Development Goals(SDGs) is one of the Belt and Road Initiative(BRI) visions, but the BRI faces enormous challenge that is the conflict between economic development and ecological *** the current scale and trend of the impact of human activities on the ecosystem is the preliminary work to ensure that human activities do not exceed the ecological carrying capacity under the BRI. This study evaluated the ecosystem pressure in countries along the Belt and Road(B&R) from 2000–2017 based on the supply-consumption balance relationship of ecological resources. Net primary productivity(NPP) is taken as the measure of ecological resources, and the supply level and consumption intensity of ecological resources is estimated based on remote sensing data and statistical data, respectively. Results show that thirteen countries with overconsumed ecological resources concentrated in the West Asia/Middle East. Although the intensity of the ecological resource consumption correlated with ecological resource endowments, the ecosystem pressure was determined by social development dependence on the ecological resources at the same ecological resource endowments level. Nearly 80% of countries along the B&R suffered from significantly increased(P < 0.05) ecosystem pressure during 2000–2017, since most of the countries along the B&R were developing countries,and their economic development was highly dependent on ecological resources. Some West Asia/Middle East countries successfully mitigated the ecosystem pressure by importing feed for livestock. Likewise, the Southeast Asian islands benefitted from the import of agricultural products. The results highlight that the BRI should reduce the dependence of social development demands on local ecological resources by international trade for ensuring the increasing ecosystem pressure trend within the ecological carrying capacity.

关键词： Green Silk Road ecosystem pressure net primary productivity(NPP) ecological carrying capacity remote sensing

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某超大型双燃料动力集装箱船LNG燃料舱布置方案分析

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上海船舶运输科学研究所学报 2024年第2期47卷 21-26页

作者：鄢慧敏袁红良翁振勇丁超沪东中华造船(集团)有限公司上海200129

以某新巴拿马型15000~16000 TEU级别液化天然气(Liquefied Natural Gas,LNG)动力集装箱船建造项目为背景,对超大型双燃料动力集装箱船LNG燃料舱布置方案进行研究。通过对比不同LNG燃料舱的结构尺寸和布置位置,并从燃料舱的晃荡载荷、船... 详细信息

以某新巴拿马型15000~16000 TEU级别液化天然气(Liquefied Natural Gas,LNG)动力集装箱船建造项目为背景,对超大型双燃料动力集装箱船LNG燃料舱布置方案进行研究。通过对比不同LNG燃料舱的结构尺寸和布置位置,并从燃料舱的晃荡载荷、船舶的装载能力和稳性等方面进行分析论证,得到一种成熟可靠的超大型双燃料集装箱船LNG燃料舱布置方案。在该方案中,LNG燃料舱的宽度不超过船宽的56%,且其整体或前半段位于上层建筑下方。与市场上常见的燃料舱布置方案相比,该方案不仅能提升船舶的空间利用率,而且能在保障船舶续航能力的同时,提升LNG燃料舱的抗液货晃荡能力,增加船舶的集装箱装载量。

关键词：双燃料动力集装箱船液化天然气(LNG)燃料舱晃荡载荷布置方案稳性分析

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Polydopamine/polyethyleneimine co-crosslinked graphene oxide for the enhanced tribological performance of epoxy resin coatings

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Journal of Materials Science & Technology 2023年第5期136卷 13-20页

作者： Shaofeng Zhou Jin yan Jialin Chen huimin yan Yin Zhang Jin Huang Guizhe Zhao Qiaoxin Zhang Yaqing Liu Shanxi Province Key Laboratory of Functional Nanocomposites and School of Materials Science and EngineeringNorth University of ChinaTaiyuan 030051China School of Mechanical and Electronic Engineering Wuhan University of TechnologyWuhan 430070China Queen Marry University of London Engineering School Northwestern Polytechnical UniversityXi’an 710129China Southwest Technology and Engineering Research Institute Chongqing 400039China School of Chemistry and Chemical Engineering and Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function ManufacturingSouthwest UniversityChongqing 400715China

To enhance the wear resistance of graphene oxide(GO)nano-filled epoxy resin(EP)coatings with ex-cellent dispersion,GO were modified using a co-crosslinking strategy between polydopamine(PDA)and polyethyleneimine(PEI)through an environmentally friendly,simple and low-cost ***-density amino-branched PEI and highly adhesive PDA formed covalent bond cross-links with GO(PDA/PEI-GO)through the Michael addition and Schiffbase *** the introduction of amino active sites,the PDA self-polymerization reaction time was significantly shorted from 24 to 6 *** covalently cross-linked network increased the lamellar spacing of GO and enhanced the interfacial bonds between the PDA/PEI-GO lamellae and EP *** to the improved dispersion and surface activity of GO,the PDA/PEI-GO nano-filled EP coating exhibited excellent wear *** friction with GCr15 stainless steel ball,the average friction coefficient and wear rate of the coating were reduced by 31.9%and 62.7%,respectively,compared to the pure EP *** addition,the wear mechanism of the PDA/PEI-GO/EP coating changed from adhesive and fatigue wear to abrasive wear,and it maintained good wear resistance by forming a GO lubrication transfer film on the counterpart ***,this study may provide a new strategy for improving the dispersion of graphene in wear-resistant polymer materials for practical applications.

关键词： Graphene oxide Co-crosslinking Epoxy coatings Tribological properties

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An mRNA vaccine encoding Chikungunya virus E2-E1 protein elicits robust neutralizing antibody responses and CTL immune responses

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Virologica Sinica 2022年第2期37卷 266-276页

作者： Ningning Ge Jin Sun Zhihua Liu Jiayi Shu huimin yan Zhihua Kou Yu Wei Xia Jin CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Shanghai Public Health Clinical Center Fudan UniversityShanghai 200540China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China

Arthropod-borne chikungunya virus(CHIKV)infection can cause a debilitating arthritic disease in ***,there are no specific antiviral drugs and effective licensed vaccines against CHIKV available for clinical ***,we developed an m RNA-lipid nanoparticle(m RNA-LNP)vaccine expressing CHIKV E2-E1 antigen,and compared its immunogenicity with soluble recombinant protein s E2-E1 antigen expressed in S2 *** comparison,we first showed that recombinant protein antigens mixed with aluminum adjuvant elicit strong antigenspecific humoral immune response and a moderate cellular immune response in C57BL/6 ***,s E2-E1vaccine stimulated 12-23 folds more neutralizing antibodies than s E1 vaccine and s E2 ***,when E2-E1 gene was delivered by an m RNA-LNP vaccine,not only the better magnitude of neutralizing antibody responses was induced,but also greater cellular immune responses were generated,especially for CD8+T cell ***,E2-E1-LNP induced CD8~+T cells can perform cytotoxic effect in *** its better immunogenicity and convenience of preparation,we suggest that more attention should be placed to develop CHIKV E2-E1-LNP m RNA vaccine.

关键词： Chikungunya virus(CHIKV) mRNA vaccine Neutralizing antibody Cytotoxic T-lymphocytes(CTL)

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超声耦合加热制备明胶稳定的水包油型乳液的研究

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食品与发酵工业 2024年第6期50卷 78-83页

作者：胡恩民姚秀宁许钰琴方顺李雪晴严慧敏樊智豪叶敏戚军熊国远李超贾敬敏农业农村部江淮农产品精深加工与资源利用重点实验室安徽省农产品加工工程实验室安徽农业大学茶与食品科技学院安徽合肥230036 雨润集团肉品质量控制与新资源创制全国重点实验室江苏南京210041 宿州市符离集刘老二烧鸡有限公司安徽宿州234101

热加工可导致水包油型乳液失稳,因此利用热加工制备乳液对拓展乳液在热加工领域的应用具有重要意义。该文主要通过对乳液粒径、乳析指数、显微结构、Zeta电位和界面蛋白负载量等指标的测定,研究热超声时间(0、20、40、60 min)对乳液稳... 详细信息

热加工可导致水包油型乳液失稳,因此利用热加工制备乳液对拓展乳液在热加工领域的应用具有重要意义。该文主要通过对乳液粒径、乳析指数、显微结构、Zeta电位和界面蛋白负载量等指标的测定,研究热超声时间(0、20、40、60 min)对乳液稳定性的影响。研究结果表明,超声耦合加热可以形成对热稳定的明胶稳定的水包油型乳液。随着超声时间延长到40 min,乳析指数降低到82.40%、乳液稳定系数增加至62.60%;随着热超声时间进一步延长,乳析指数增加,乳液稳定系数下降。这些结果表明热超声40 min可形成热稳定的乳液,此时乳液体积平均粒径最低,为1.00μm,油滴微观大小与粒径结果相一致。进一步研究发现热超声40 min制备的乳液的界面蛋白负载量最高(7.35 mg/m^(2)),虽然此时Zeta电位的绝对值降低至16.69 mV,表明热超声40 min形成稳定乳液的关键因素是界面蛋白引起的空间位阻作用而非静电斥力。

关键词：明胶乳液界面结构乳化性热超声

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