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Role of CD36 in central nervous system diseases

Neural Regeneration Research 2024年第3期19卷 512-518页

作者： Min Feng Qiang Zhou huimin xie Chang Liu Mengru Zheng Shuyu Zhang Songlin Zhou Jian Zhao School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Department of Orthopedic Oncology Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Stomatology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Medical College of Nantong University NantongJiangsu ProvinceChina

CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic ***36 was recently found to be widely expressed in various cell types in the nervous system,including endothelial cells,pericytes,astrocytes,and ***36 mediates a number of regulatory processes,such as endothelial dysfunction,oxidative stress,mitochondrial dysfunction,and inflammatory responses,which are involved in many central nervous system diseases,such as stroke,Alzheimer’s disease,Parkinson’s disease,and spinal cord ***36 antagonists can suppress CD36 expression or prevent CD36 binding to its ligand,thereby achieving inhibition of CD36-mediated pathways or ***,we reviewed the mechanisms of action of CD36 antagonists,such as Salvianolic acid B,tanshinone IIA,curcumin,sulfosuccinimidyl oleate,antioxidants,and small-molecule ***,we predicted the structures of binding sites between CD36 and *** sites can provide targets for more efficient and safer CD36 antagonists for the treatment of central nervous system diseases.

关键词： animal experiments antagonists CD36 antagonist central nervous system diseases clinical trial curcumin microRNA salvianolic acid B small-molecule drugs sulfosuccinimidyl oleate

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RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration

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Neural Regeneration Research 2024年第8期19卷 1812-1821页

作者： Xinyang Zhou Yehua Lv huimin xie Yan Li Chang Liu Mengru Zheng Ronghua Wu Songlin Zhou Xiaosong Gu Jingjing Li Daguo Mi Suzhou Medical College of Soochow University SuzhouJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Orthopedic Nantong Traditional Chinese Medicine HospitalNantongJiangsu ProvinceChina Nantong Stomatological Hospital Affiliated to Nantong University NantongJiangsu ProvinceChina Department of General Practice Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after *** non-coding RNAs(IncRNAs)have been reported to play a crucial role in axonal *** r,the role of the IncRNA-microRNAmessenger RNA(mRNA)-competitive endogenous RNA(ceRNA)network in exosome-mediated axonal regeneration remains *** this study,we performed RNA transcriptome sequencing analysis to assess mRNA expression patterns in exosomes produced by cultured fibroblasts(FC-EXOs)and Schwann cells(SCEXOs).Diffe rential gene expression analysis,Gene Ontology analysis,Kyoto Encyclopedia of Genes and Genomes analysis,and protein-protein intera ction network analysis were used to explo re the functions and related pathways of RNAs isolated from FC-EXOs and *** found that the ribosome-related central gene Rps5 was enriched in FC-EXOs and SC-EXOs,which suggests that it may promote axonal *** addition,using the miRWalk and Starbase prediction databases,we constructed a regulatory network of ceRNAs targeting Rps5,including 27 microRNAs and five *** ceRNA regulatory network,which included Ftx and Miat,revealed that exsosome-derived Rps5 inhibits scar formation and promotes axonal regeneration and functional recovery after nerve *** findings suggest that exosomes derived from fibro blast and Schwann cells could be used to treat injuries of peripheral nervous system.

关键词： ceRNA network exosomes fibroblast cells Gene Ontology(GO) Kyoto Encyclopedia of Genes and Genomes(KEGG) protein-protein interaction(PPI)networks RNA-seq Schwann cells

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Characterization for elastic constants of fused deposition modelling-fabricated materials based on the virtual fields method and digital image correlation

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Acta Mechanica Sinica 2017年第6期33卷 1075-1083页

作者： Quankun Cao huimin xie AML Department of Engineering Mechanics Tsinghua University Beijing 100084 China

Fused deposition modelling(FDM), a widely used rapid prototyping process, is a promising technique in manufacturing engineering. In this work, a method for characterizing elastic constants of FDM-fabricated materials is proposed. First of all, according to the manufacturing process of FDM, orthotropic constitutive model is used to describe the mechanical behavior. Then the virtual fields method(VFM) is applied to characterize all the mechanical parameters(Q, Q, Q, Q) using the full-field strain,which is measured by digital image correlation(DIC). Since the principal axis of the FDM-fabricated structure is sometimes unknown due to the complexity of the manufacturing process, a disk in diametrical compression is used as the load configuration so that the loading angle can be changed conveniently. To verify the feasibility of the proposed method, finite element method(FEM) simulation is conducted to obtain the strain field of the disk. The simulation results show that higher accuracy can be achieved when the loading angle is close to 30?. Finally, a disk fabricated by FDM was used for the experiment. By rotating the disk, several tests with different loading angles were conducted. To determine the position of the principal axis in each test, two groups of parameters(Q, Q, Q, Q) are calculated by two different groups of virtual fields. Then the corresponding loading angle can be determined by minimizing the deviation between two groups of the parameters. After that, the four constants(Q, Q, Q, Q) were determined from the test with an angle of 27?.

关键词： Fused deposition modelling Virtual fields method Digital image correlation Orthotropic constitutive model Disk compression

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In situ SEM-DIC technique and its application to characterize the high-temperature fatigue crack closure effect

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Science China(Technological Sciences) 2020年第2期63卷 265-276页

作者： YIN YuanJie xie huimin HE Wei Key Laboratory of Applied Mechanics School of Aerospace EngineeringTsinghua UniversityBeijing 100084China

In situ high-temperature(maximum: 650°C) experiments for fatigue crack growth on single edge-notched GH4169 superalloy specimens have been performed in scanning electron microscopy(SEM). In order to investigate the crack closure behavior,digital image correlation(DIC) method was applied to measure the full-field displacement and strain fields around the crack *** deformation carrier(speckle) was fabricated on the polished specimen surface with Zr O2 powders having a good hightemperature resistance, and the speckle patterns were recorded during the fatigue test by SEM. In consideration of the distortion of SEM images, the unabridged model and the bicubic model were used to correct the spatial distortion, and the distortion parameters can be determined by a calibration test. It is shown that the unabridged model makes a better contribution towards improving SEM-DIC measurement accuracy. Based on the deformation field, the mode Ι stress intensity factor range ?K and the crack opening displacement(COD) can be calculated for evaluating the crack closure effect. Additionally, the crack propagation was monitored using SEM and optical microscope. It indicates that the cracks grew initially in trans-granular mode at room temperature and 650°C, then propagated in both trans-granular and inter-granular modes.

关键词： SEM-DIC stress intensity factor crack closure high-temperature fatigue

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Constitutive parameters identification of thermal barrier coatings using the virtual fields method

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Acta Mechanica Sinica 2019年第1期35卷 78-87,I0003页

作者： Mengmeng Zhou huimin xie Luming Li School of Aerospace Engineering Tsinghua UniversityBeijing 100084China

Thermal barrier coatings (TBCs) are widely applied in thermal components to protect metallic components. Owing to the complex layered structure of TBCs and difficult preparation of coating, the mechanical characterization of TBCs should be of primary importance. With regard to TBCs, this study deals with the constitutive parameters identification of bi-material. Considering the complex construction and boundary of bi material, the virtual fields method (VFM) was employed in this study. A methodology based on the optimized virtual fields method combined with moire interferometry was proposed for the constitutive parameters identification of bi-material. The feasibility of this method is verified using simulated deformation fields of a two-layer material subjected to three point ben ding loading. As an application, the deformation fields of the TBC specimens were measured by moire interferometry. Then, lhe mechanical parameters of the coating were identified by the proposed method. The identification results indicate that Young's modulus of the TBC top coating is 89.91 GPa, and its Poisson's ratio is 0.23.

关键词： Virtual Fields Method Thermal barrier coatings Mechanical parameters identification Moiré interferometry

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Identification of the elastic stiffness of composites using the virtual fields method and digital image correlation

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Acta Mechanica Sinica 2015年第2期31卷 173-180页

作者： Lebin Jiang Baoqiao Guo huimin xie Department of Engineering Mechanics Tsinghua University State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

This paper presents an effective methodology for characterizing the mechanical parameters of composites using digital image correlation combined with the virtual fields *** using a three-point bending test configuration,this method can identify all mechanical parameters of the material with merely a single *** results verified that this method is especially effective for characterizing composite *** this study,the method is applied to measure the orthotropic elastic parameters of fiber-reinforced polymer-matrix composites before and after the hygrothermal aging *** results indicate that the hygrothermal aging environment significantly influences the mechanical property of a *** components of the parameters in the direction of the fiber bundle decreased *** the accuracy analysis,we found that the actual measurement accuracy is sensitive to a shift of the horizontal edges and rotation of the vertical edges.

关键词： DIC VFM Characterization Composite

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RECENT PROGRESS IN RESIDUAL STRESS MEASUREMENT TECHNIQUES

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Acta Mechanica Solida Sinica 2013年第6期26卷 570-583页

作者： Xianfu Huang Zhanwei Liu huimin xie School of Aerospace Engineering Beijing Institute of Technology AML Department of Engineering MechanicsTsinghua University

Residual stress measurement is of critical significance to in-service security and the reliability of engineering components, and has been an active area of scientific interest. This paper offers a review o[ several prominent mechanical release methods for residual stress measurement and recent developments, focusing on the hole-drilling method combined with advanced optical sensing. Some promising trends for mechanical release methods are also analyzed.

关键词： residual stress, mechanical release method, hole drilling, moiré interferometry, holography ESPI, digital image correlation

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Simulation of residual stresses and their effects on thermal barrier coating systems using finite element method

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Science China(Physics,Mechanics & Astronomy) 2015年第3期58卷 49-58页

作者： ZHU JianGuo CHEN Wei xie huimin Faculty of Civil Engineering and Mechanics Jiangsu University School of Naval Architecture and Ocean Engineering Jiangsu University of Science and Technology Key Laboratory of Applied Mechanics (AML) Department of Engineering Mechanics Tsinghua University

Thermal barrier coating(TBC)systems are widely used in industrial gas-turbine ***,premature failures have impaired the use of TBCs and cut down their lifetime,which requires a better understanding of their failure *** the present study,experimental studies of isothermal cycling are firstly carried out with the observation and estimation of *** to the experimental results,a finite element model is established for the analysis of stress perpendicular to the TBC/BC *** residual stress distributions in TBC are obtained to reflect the influence of mechanical properties,oxidation,and interfacial *** calculated results show that the maximum tensile stress concentration appears at the peak of TBC and continues to increase with thermal *** of the microstructural characteristics of plasma-sprayed TBCs,cracks initialize in tensile stress concentration(TSC)regions at the peaks of TBC and propagate along the TBC/BC interface resulting in the spallation of ***,the inclusion of creep is crucial to failure prediction and is more important than the inclusion of sintering in the simulation.

关键词： residual stress failure mechanism finite element method thermal barrier coating

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High-temperature fatigue crack propagation study of superalloy GH4169 by single-lens 3D digital image correlation

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Science China(Technological Sciences) 2020年第4期63卷 693-704页

作者： YIN YuanJie HE Wei xie huimin WU LiFu Key Laboratory of Applied Mechanics School of Aerospace EngineeringTsinghua UniversityBeijing 100084China

The characterization of fatigue crack propagation behavior is crucial for performance and reliability evaluation of aerospace *** this study,high-temperature(maximum:650℃)fatigue crack propagation experiments of Ni-based superalloy GH4169 were *** bi-prism-based single-lens 3D digital image correlation(BSL 3D DIC)technique was used to insitu measure the displacement and strain fields near fatigue crack *** on the deformation information,the modeΙstress intensity factor range△K and the crack opening displacement(COD)were determined for characterizing the crack closure *** the major fatigue crack growth model,the parameters of modified Paris’law were obtained based on the effective stress intensity factor range△Keff and the fatigue crack propagation rate(FCPR).Additionally,two kinds of J integrals,JP(path integral method)and JK(stress intensity factor K method),were used to evaluate the small-scale yielding approximation.

关键词： high-temperature fatigue Paris'law crack closure BSL 3D DIC

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Gold modified microelectrode for direct tetracycline detection

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Frontiers of Environmental Science & Engineering 2012年第3期6卷 313-319页

作者： Hongtao WANG huimin ZHAO xie QUAN Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) School of Environmental Science and Technology Dalian University of Technology Dalian 116024 China

The residues of tetracycline antibiotics in water have attracted many concerns due to their harmful impact to human health. This paper reports an electrochemical sensor for the determination of tetracycline (TC) by the microelectrode, which was fabricated by electrodeposited gold colloids on tungsten tip. Cyclic voltammerty was used to study the electrochemical behavior of TC on the microelectrode. Well anodic wave was obtained at about 1.5 V in acidic solutions. Electrochemical determination of tetracycline was investigated using microelectrode by cyclic voltammetry. Under optimized conditions, the calibration curves for TC were obtained. The oxidation peak currents were linearly related to TC concentrations in the range of 1–10 mg·L?1 and 10–100 mg·L?1, respectively. The detection limit was 0.09 mg·L?1 (S/N = 3).

关键词： microelectrode tungsten tip gold colloids tetracycline

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