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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

n6-methyladenosine(m^(6)A), the most prevalent and conserved RnA modification in eukaryotic cells, profoundly influences virtually all aspects of mRnA metabolism. mRnA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RnA methylation

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Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei Wang Mei-xia Tao Kai-Ming Mo Xu Chen Shu-Hua Zhong Elena S Shubina Guo-Hong ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.n.nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JnM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JnM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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Layered SnS sodium ion battery anodes synthesized near room temperature

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nano Research 2017年第12期10卷 4368-4377页

作者： Chuan xia Fan Zhang Hanfeng Liang Husam n. Alshareef Materials Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwa123955-6900 Saudi Arabia

In this report, we demonstrate a simple chemical bath deposition approach for the synthesis of layered SnS nanosheets （typically 6 nm or -10 layers thick） at very low temperature （40℃）. We successfully synthesized SnS/C hybrid electrodes using a solution-based carbon precursor coating with subsequent carbonization strategy. Our data showed that the ultrathin carbon shell was critical to the cycling stability of the SnS electrodes. As a result, the as-prepared binder-free SnS/C electrodes showed excellent performance as sodium ion battery anodes. Specifically, the SnS/C anodes delivered a reversible capacity as high as 792 mAh-g-1 after 100 cycles at a current density of 100 mA·g-1 They also had superior rate capability （431 mAh.g-1 at 3,000 mA.g-1） and stable long-term cycling performance under a high current density （345 mAh-g-1 after 500 cycles at 3 A.g-1）. Our approach opens up a new route to synthesize SnS-based hybrid materials at low temperatures for energy storage and other applications. Our process will be particularly useful for chalcogenide matrix materials that are sensitive to high temperatures during solution synthesis.

关键词： SnS sodium ion battery anode one-step synthesis

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Thermal analysis of the Rindler-Schwarzschild black hole via corrected entropy

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Communications in Theoretical Physics 2024年第9期76卷 95-106页

作者： Allah Ditta xia Tiecheng Riasat Ali AliÖvgün Department of Mathematics Shanghai University and Newtouch Center for Mathematics of Shanghai UniversityShanghai200444China Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprus via Mersin 10Turkiye

In this study,we investigate the thermodynamic characteristics of the Rindler–Schwarzschild black hole *** analysis encompasses the examination of energy emission,Gibbs free energy,and thermal *** calculate various quantities such as the Hawking temperature,geometric mass,and heat capacity to assess the local and global thermodynamic *** temperature of the black hole is determined using the first law of thermodynamics,while the energy emission rate is evaluated as *** computing the Gibbs free energy,we explore the phase transition behavior exhibited by Rindler–Schwarzschild black hole,specifically examining the swallowing ***,we derive the corrected entropy to investigate the influence of thermal fluctuations on small and large black ***,we compare the impact of correction terms on the thermodynamic system by comparing the results obtained for large black holes and small black holes.

关键词： black holes thermodynamics thermal fluctuations heat capacity Gibbs free energy energy emission Rindler–Schwarzschild black hole

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绿色环保聚酯增塑剂聚己二酸-1,2-丙二醇酯对聚氯乙烯性能的影响

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皮革科学与工程 2025年第1期35卷 23-28页

作者：刘霞黄华莹徐启奎四川化工职业技术学院四川泸州646300 四川泸天化创新研究院有限公司四川泸州646300

采用绿色环保的聚己二酸-1,2-丙二醇酯(PPA)作为增塑剂,对聚氯乙烯(PVC)进行增塑改性,研究了PPA对PVC力学性能、硬度、加工流动性、耐热性和耐溶剂迁移性能的影响,并与邻苯二甲酸二辛酯(DOP)增塑剂增塑PVC的效果作了对比研究。结果表明,... 详细信息

采用绿色环保的聚己二酸-1,2-丙二醇酯(PPA)作为增塑剂,对聚氯乙烯(PVC)进行增塑改性,研究了PPA对PVC力学性能、硬度、加工流动性、耐热性和耐溶剂迁移性能的影响,并与邻苯二甲酸二辛酯(DOP)增塑剂增塑PVC的效果作了对比研究。结果表明,PPA和DOP对PVC均具有较好的增塑效果。随着增塑剂含量的增加(从40份增加至50份时),PPA/PVC/CaCO_(3)和DOP/PVC/CaCO_(3)复合材料的拉伸强度分别降低了3.25%和10.16%,质量损失50%时的温度分别为392.22℃和320.15℃,PPA/PVC/CaCO_(3)复合材料具有更高的力学性能和耐热性。此外,DOP/PVC/CaCO_(3)复合材料在乙醇、机油和正庚烷中的质量损失率分别为4.51%、0.52%和11.81%,而PPA/PVC/CaCO_(3)复合材料在溶剂中无明显的质量损失,具有优异的耐溶剂迁移性。因此,绿色环保聚酯增塑剂PPA不仅可以替代DOP增塑PVC,还在耐高温、耐溶剂迁移领域,具有更广阔的应用前景。

关键词：聚氯乙烯聚己二酸-1,2-丙二醇邻苯二甲酸二辛酯增塑剂力学性能复合材料

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Laser-induced oxidation assisted micro milling of high aspect ratio microgroove on WC-Co cemented carbide

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Chinese Journal of Aeronautics 2021年第4期34卷 465-475页

作者： Guolong ZHAO Hongjun xia Yang ZHAnG Liang LI ning HE Hans nφrgaard HAnSEn national Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Mechanical Engineering Technical University of DenmarkKgs.Lyngby 2800Denmark

Severe tool wear and poor surface quality are the main problems during micro machining of cemented *** this work,an innovative hybrid process of laser-induced oxidation assisted micro milling(LOMM)was proposed to solve the problems.A nanosecond laser was utilized to induce oxidation of the WC-20%Co material,producing loose oxide which was easy to *** micro machinability of the material was improved by laser-induced *** oxidation mechanisms of cemented carbide were studied.A microgroove with a depth of 2.5 mm and aspect ratio of 5 was fabricated *** milling force,surface quality and tool wear mechanisms were *** comparison,a microgroove was also fabricated with conventional micro milling(COMM)using identical milling *** revealed that in LOMM the milling force and tool wear rate were extremely low during removing the *** machined surface quality and dimensional accuracy achieved by LOMM were superior to those obtained by *** surface roughness Saof the microgroove bottom reached 88 nm in LOMM,while the cross-sectional geometry of the microgroove was a *** of the microgroove sidewall machined by LOMM was better than that by *** tool wear forms in LOMM were coating spalling and slight tool nose *** with COMM,the tool life in LOMM was prolonged *** indicates that the proposed hybrid process is an effective and efficient way to fabricate high aspect ratio micro-features with high dimensional accuracy.

关键词： Cemented carbide High aspect ratio Laser-induced oxidation Micro milling Microgroove Tool wear

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Entransy dissipation minimization for generalized heat exchange processes

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Science China(Technological Sciences) 2016年第10期59卷 1507-1516页

作者： xia ShaoJun Institute of Thermal Science and Power Engineering Naval University of EngineeringWuhan 430033China Military Key Laboratory for naval Ship Power Engineering Naval University of EngineeringWuhan 430033China College of Power Engineering Naval University of EngineeringWuhan 430033China

This paper investigates the MED （Minimum Entransy Dissipation） optimization of heat transfer processes with the generalized heat transfer law q ∝ （A（T^n））m. For the fixed amount of heat transfer, the optimal temperature paths for the MED are obtained The results show that the strategy of the MED with generalized convective law q ∝ （△T）^m is that the temperature difference keeps constant, which is in accordance with the famous temperature-difference-field uniformity principle, while the strategy of the MED with linear phenomenological law q ∝ A（T^-1） is that the temperature ratio keeps constant. For special cases with Dulong-Petit law q ∝ （△T）^1.25 and an imaginary complex law q ∝ （△（T^4））^1.25, numerical examples are provided and further compared with the strategies of the MEG （Minimum Entropy Generation）, CHF （Constant Heat Flux） and CRT （Constant Reservoir Temperature） operations. Besides, influences of the change of the heat transfer amount on the optimization results with various heat resistance models are discussed in detail.

关键词： entransy theory finite time thermodynamics heat exchange process optimal temperature path generalized heattransfer law generalized thermodynamic optimization

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High-order numerical methods of fractional-order Stokes' first problem for heated generalized second grade fluid

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Applied Mathematics and Mechanics(English Edition) 2012年第1期33卷 65-80页

作者： Chao YE xia n-nan LUO Li-ping WEn School of Mathematics and Computational Science Xiangtan UniversityXiangtan 411105Hunan ProvinceP.R.China

The high-order implicit finite difference schemes for solving the fractional- order Stokes＇ first problem for a heated generalized second grade fluid with the Dirichlet boundary condition and the initial condition are given. The stability, solvability, and convergence of the numerical scheme are discussed via the Fourier analysis and the matrix analysis methods. An improved implicit scheme is also obtained. Finally, two numerical examples are given to demonstrate the effectiveness of the mentioned schemes

关键词： fractional-order Stokes' first problem implicit difference scheme solvability stability convergence

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On HERMITIAn POSITIVE DEFInITE SOLUTIOn OF nOnLInEAR MATRIX EQUATIOn X＋A^＊X^-2A=Q

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Journal of Computational Mathematics 2005年第5期23卷 513-526页

作者： xiao xia Guo ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 China

Based on the fixed-point theory, we study the existence and the uniqueness of the maximal Hermitian positive definite solution of the nonlinear matrix equation X＋A^＊X^-2A=Q, where Q is a square Hermitian positive definite matrix and A＊ is the conjugate transpose of the matrix A. We also demonstrate some essential properties and analyze the sensitivity of this solution. In addition, we derive computable error bounds about the approximations to the maximal Hermitian positive definite solution of the nonlinear matrix equation X＋A^＊X^-2A=Q. At last, we further generalize these results to the nonlinear matrix equation X＋A^＊X^-nA=Q, where n≥2 is a given positive integer.

关键词： nonlinear matrix equation Hermitian positive definite solution Sensitivity analysis Error bound

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Progress in non-viral localized delivery of siRnA therapeutics for pulmonary diseases

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1400-1428页

作者： Jingjing Gao Ziting xia Dilrasbonu Vohidova John Joseph James n.Luo nitin Joshi Center for nanomedicine Department of AnesthesiologyPerioperative and Pain MedicineBrigham and Women's HospitalBostonMA 02115USA Harvard Medical School BostonMA 02115USA Department of Surgery Brigham and Women's HospitalBostonMA 02115USA

Emerging therapies based on localized delivery of siRnA to lungs have opened up exciting possibilities for treatment of different lung *** delivery of siRnA to lungs has shown to result in severalfold higher lung accumulation than systemic route,while minimizing non-specific distribution in other ***,to date,only 2 clinical trials have explored localized delivery of siRnA for pulmonary *** we systematically reviewed recent advances in the field of pulmonary delivery of siRnA using non-viral *** firstly introduce the routes of local administration and analyze the anatomical and physiological barriers towards effective local delivery of siRnA in *** then discuss current progress in pulmonary delivery of siRnA for respiratory tract infections,chronic obstructive pulmonary diseases,acute lung injury,and lung cancer,list outstanding questions,and highlight directions for future *** expect this review to provide a comprehensive understanding of current advances in pulmonary delivery of siRnA.

关键词： siRnA non-viral delivery Injection routes Respiratory tract infections Particle pharmacokinetics Pulmonary inflammation Acute lung injury Lung cancer

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