检索结果-南通市图书馆

Non-coding RNAs in acute ischemic stroke:from brain to periphery

Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang huiling sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

区块链技术在广播电视信号监测中的应用

引用

电视技术 2024年第7期48卷 218-221页

作者：孙慧灵西藏广播影视节目传输中心西藏拉萨850000

随着信息技术的不断发展,广播电视信号监测技术得到了空前的进步。作为一种新型的技术手段,区块链技术在广播电视信号监测中具有广泛的应用前景。深入分析区块链技术应用原理,探讨区块链技术在广播电视信号监测中的具体应用,旨在为广播... 详细信息

随着信息技术的不断发展,广播电视信号监测技术得到了空前的进步。作为一种新型的技术手段,区块链技术在广播电视信号监测中具有广泛的应用前景。深入分析区块链技术应用原理,探讨区块链技术在广播电视信号监测中的具体应用,旨在为广播电视行业提供一种新的技术手段和管理模式。

关键词：区块链技术广播电视信号监测分布式架构

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

用于音视频传输的高效压缩编码系统的设计和实现

引用

中国科技纵横 2024年第4期 93-95页

作者：孙慧灵西藏广播影视节目传输中心西藏拉萨 850000

提升广播电视主流媒体的影响力和竞争力,更好地满足人民群众对美好视听生活的新需求、新期待,达到国家广电总局高清、超高清制播能力要求,关键在于节目信号的传输.为实现高效、稳定、安全的音视频传输,设计并实现一个高效压缩编码系统... 详细信息

提升广播电视主流媒体的影响力和竞争力,更好地满足人民群众对美好视听生活的新需求、新期待,达到国家广电总局高清、超高清制播能力要求,关键在于节目信号的传输.为实现高效、稳定、安全的音视频传输,设计并实现一个高效压缩编码系统成为具有重要研究价值的课题.现行标清广播电视普遍使用的音视频压缩编码技术为H.264、MEPG-2等,难以满足日益增长的音视频数据量实时、高质量传输的需求.因此,需要设计和实现一种高效、灵活、可扩展的压缩编码系统,以满足音视频传输需求.

关键词：广播电视节目传输高效编码系统

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

数据实证引领区域教育督导评价改革

引用

中小学校长 2024年第3期 6-10页

作者：孙慧玲吕莉莉上海市闵行区教育测评与研究中心

教育数字化是开辟教育发展新赛道和塑造教育发展新优势的重要突破口,教育督导评价的数字化变革是教育数字化变革重要组成部分。围绕“为了每一位孩子健康快乐成长”核心教育理念,上海市闵行区大胆进行基于数字实证的区域教育督导评价改... 详细信息

教育数字化是开辟教育发展新赛道和塑造教育发展新优势的重要突破口,教育督导评价的数字化变革是教育数字化变革重要组成部分。围绕“为了每一位孩子健康快乐成长”核心教育理念,上海市闵行区大胆进行基于数字实证的区域教育督导评价改革实践,在构建区域数字化教育督导评价指标体系、形成“四维一体”区域数字化教育督导评价系统、分析挖掘区域教育督导评价数据、借助督导评价数据服务区域教育决策精准化、服务学校管理改进、服务师生全面发展等方面积极探索与创新,成效明显。

关键词：数据实证教育督导评价区域实践

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

负压封闭引流与外科常规换药对腹部术后伤口愈合不良的疗效观察

引用

联勤军事医学 2024年第5期38卷 397-401页

作者：徐诺孙慧伶吴荣高小玉张晓翠毕华中部战区总医院普通外科湖北武汉430070 武汉科技大学医学部

目的探究负压封闭引流(vacuum sealing drainage, VSD)与伤口常规换药对腹部术后伤口愈合不良的临床疗效。方法选取2020-08-01/2023-09-30日作者医院普通外科225例腹部术后伤口愈合不良患者进行回顾性研究。根据伤口换药方式,将患者分... 详细信息

目的探究负压封闭引流(vacuum sealing drainage, VSD)与伤口常规换药对腹部术后伤口愈合不良的临床疗效。方法选取2020-08-01/2023-09-30日作者医院普通外科225例腹部术后伤口愈合不良患者进行回顾性研究。根据伤口换药方式,将患者分为VSD组(n=110)和常规伤口换药组(n=115)。比较两组腹部术后伤口愈合不良患者的临床疗效、住院天数、换药次数、换药天数、Ⅱ期清创缝合时间、血清学炎症指标。结果 225例腹部术后伤口愈合不良患者中,伤口出现脂肪液化或组织坏死110例(VSD组53例、常规伤口换药组57例),大量脓液或深部脓腔80例(VSD组42例、常规伤口换药组38例),切口裂开35例(VSD组15例、常规伤口换药组20例)。两组腹部术后伤口愈合不良患者的基线资料比较差异无统计学意义(P>0.05)。VSD组腹部术后伤口愈合不良患者中,伤口出现脂肪液化或组织坏死、大量脓液或深部脓腔、切口裂开的患者的临床疗效总有效率明显高于常规伤口换药组,住院天数、换药天数、换药次数、Ⅱ期清创缝合时间均少于常规伤口换药组,差异均有统计学意义(P均<0.05)。换药后,两组腹部术后伤口愈合不良患者伤口出现脂肪液化或组织坏死、大量脓液或深部脓腔、切口裂开的患者的白细胞(white blood cell, WBC)、中性粒细胞(neutrophil, NEU)、白细胞介素6(interleukin 6,IL-6)、降钙素原(procalcitonin, PCT)、C-反应蛋白(C-reactive protein, CRP)水平较换药前均明显下降,且VSD组低于常规换药组(P均<0.05)。结论与常规伤口换药相比,应用VSD伤口换药有利于加快腹部术后伤口愈合不良患者伤口恢复,降低感染发生率,有效缩短创面Ⅱ期清创缝合时间,改善患者血清炎症指标,促进术后恢复,值得临床推广应用。

关键词：负压封闭引流手术部位感染腹部手术伤口愈合不良临床疗效

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Spatiotemporal Distribution Characteristics of Cloud Types and Phases in the Arctic Based on CloudSat and CALIPSO Cloud Classification Products

引用

Advances in Atmospheric Sciences 2024年第2期41卷 310-324页

作者： Yue sun huiling YANG Hui XIAO Liang FENG Wei CHENG Libo ZHOU Weixi SHU Jingzhe sun Key Laboratory of Cloud-Precipitation Physics and Severe Storms(LACS) and Department of Lower Atmospheric Observation Research(LAOR)Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth Sciences University of Chinese Academy of Sciences(UCAS)Beijing 100049China Beijing Institute of Applied Meteorology Beijing 100029China

The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud types(high cloud, altostratus, altocumulus, stratus, stratocumulus, cumulus, nimbostratus, and deep convection) and three phases(ice,mixed, and water) in the Arctic. Possible reasons for the observed interannual variability are also discussed. The main conclusions are as follows:(1) More water clouds occur on the Atlantic side, and more ice clouds occur over continents.(2)The average spatial and seasonal distributions of cloud types show three patterns: high clouds and most cumuliform clouds are concentrated in low-latitude locations and peak in summer;altostratus and nimbostratus are concentrated over and around continents and are less abundant in summer;stratocumulus and stratus are concentrated near the inner Arctic and peak during spring and autumn.(3) Regional averaged interannual frequencies of ice clouds and altostratus clouds significantly decrease, while those of water clouds, altocumulus, and cumulus clouds increase significantly.(4) Significant features of the linear trends of cloud frequencies are mainly located over ocean areas.(5) The monthly water cloud frequency anomalies are positively correlated with air temperature in most of the troposphere, while those for ice clouds are negatively correlated.(6) The decrease in altostratus clouds is associated with the weakening of the Arctic front due to Arctic warming, while increased water vapor transport into the Arctic and higher atmospheric instability lead to more cumulus and altocumulus clouds.

关键词： CloudSat and CALIPSO cloud type cloud phase temporal and spatial distribution interannual variation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

LncRNA SNHG16 promotes colorectal cancer proliferation by regulating ABCB1 expression through sponging miR-214-3p

引用

The Journal of Biomedical Research 2022年第4期36卷 231-241页

作者： Pei Tan Mu Xu Junjie Nie Jian Qin Xiangxiang Liu huiling sun Shukui Wang Yuqin Pan General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China School of Medicine Southeast UniversityNanjingJiangsu 210009China Jiangsu Collaborative Innovation Center on Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsu 211100China

Mounting evidence indicates that long non-coding RNAs(lncRNAs)have critical roles in colorectal cancer(CRC)progression,providing many potential diagnostic biomarkers,prognostic biomarkers,and treatment ***,we sought to investigate the role and underlying regulatory mechanism of lncRNA small nucleolar RNA host gene 16(SNHG16)in *** expressions of SNHG16 in CRC were identified by RNA-sequencing and quantitative reverse transcription *** functions of SNHG16 were explored by a series of in vitro and in vivo assays(colony formation assay,flow cytometry assay,and xenograft model).Bioinformatics analysis,RNA fluorescence in situ hybridization and luciferase reporter assay were used to investigate the regulatory mechanism of effects of ***16 was found to be significantly elevated in human CRC tissues and cell *** studies suggested that SNHG16 promoted CRC cell growth both in vitro and in ***,we identified that SNHG16 is expressed predominantly in the ***16 could interact with miR-214-3p and up-regulated its target *** study indicated that SNHG16 plays an oncogenic role in CRC,suggesting it could be a novel biomarker and therapeutic target in CRC.

关键词： SNHG16 ATP-binding cassette subfamily B member 1 microRNA colorectal cancer ceRNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fatigue Analysis and Life Prediction of Dumpers with Cumulative Fatigue Damage Approach

引用

上海交通大学学报 2004年第Z2期38卷 96-100页

作者： LI Shouju LIU Yingxi sun huiling State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology Dalian116024 China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology Dalian116024 China Department of Engineering Mechanics Dalian University of Technology Dalian116024China

A fatigue damage model is developed for evaluating accumulative fatigue damage of dumpers. The loading spectrums acted on dumpers are created according to measured strain data in field. The finite element analysis is carried out for assessing stress distribution and strength characteristics of dumpers. Fatigue damage indexes and service life are calculated by a modified Palmgren-Miner rule. The investigation shows that fatigue notch factor has a significant influence on the calculation of fatigue damage of dumpers.

关键词： fatigue life prediction dumper miner's rule finite element analysis loading spectrums

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on exosome mediated miR-1229 as metastasis markers of colorectal cancer and its mechanism

Study on exosome mediated miR-1229 as metastasis markers of ...

引用

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学...

作者： huiling sun Shukui Wang Nanjing First Hospital Nanjing Medical University

Background:Existing evidence has shown that miRNAs are involved in carcinogenesis and cancer progression through regulating the expression of their target genes,and that exosome-mediated miRNAs play an important role in cancer progression and metastasis,suggesting that miRNAs in exosomes may be potential biomarker in ***:To elucidate the role of miR-1229 in exosomes in CRC,we performed quantitative real-time PCR(qRT-PCR),western blot and immunohistochemical(IHC) assays,FISH,Transwell migration/invasion(with Matrigel) assays,in vitro scratch assay,luciferase reporter assay,Western blot and RT-qPCR analysis in *** vivo,LoVo tumor-bearing mice and liver metastasis mice model were ***:Preliminary studies of our group observed that miR-1229 in exosomes was significantly downregulated in serum and tissue samples of colorectal cancer(CRC) with *** target genes of miR-1229,IGF2 and IGF2BP3 were markedly overexpressed in tissue samples of CRC metastasis,and promoted the proliferation,invasion and metastasis of cancer cells,indicating that exosome-mediated miR-1229 has a potential clinical value as a biomarker to predict CRC *** this research project,serum and tissue samples of CRC with or without metastasis is collected to investigate the value of exosome-mediated miR-1229,in the early diagnosis and prognosis of CRC metastasis;the regulation of IGF2/IGF2BP3 and downstream signaling pathway is investigated to determine the role of signaling pathway in vascular permeability,proliferation,invasion and metastasis of cancer cells in vivo and in vitro;and the mechanisms underlying CRC metastasis is explored as ***:This study will provide clinicians with new insights on clinical diagnosis and the molecular pathogenesis of CRC metastasis.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

NUMERICAL CALCULATIONS OF GASEOUS REACTING FLOWS IN A MODEL OF GAS TURBINE COMBUSTORS

引用

Chinese Journal of Aeronautics 1991年第1期6卷 26-34页

作者： Yan Chuanjun, Tang Ming, Zhu huiling and sun HuixianNorthwestern Polytechnical University Northwestern Polytechnical Univ

This paper describes the numerical calculations of gaseous reaction flows in a model of gas turbine combustors. The profiles of hydrodynamic and thermodynamic patterns in a three-dimensional combustor model are obtained by solving the governing differential transport equations. The well-established numerical prediction algorithm SIMPLE, the modified k-ε turbulence model and k-ε-g turbulent diffusion flame model have been adopted in computations. The β function has been selected as probability density function. The effect of combustion process on flow patterns has been investigated. The calculated results have been verified by experiments. They are in remarkably good agreement.

关键词： NUMERICAL CALCULATIONS OF GASEOUS REACTING FLOWS IN A MODEL OF GAS TURBINE COMBUSTORS GAS Flow work

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：