检索结果-南通市图书馆

Molybdenum and cadmium co-induce necroptosis through Th1/Th2 imbalance-mediated endoplasmic reticulum stress in duck ovaries

引用

Journal of Environmental Sciences 2024年第8期142卷 92-102页

作者： Ting Cui Xueyan Dai huiling guo Dianyun Wang Bingyan Huang Wenjing Pu Xuesheng Chu Caiying Zhang Jiangxi Provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045China

Cadmium(Cd)and excess molybdenum(Mo)pose serious threats to animal *** previous study has determined that Cd and/or Mo exposure can cause ovarian damage of ducks,while the specific mechanism is still *** further investigate the toxic mechanism of Cd and Mo co-exposure in the ovary,forty 8-day-old female ducks were randomly allocated into four groups for 16 weeks,and the doses of Cd and Mo in basic diet per kg were as follows:control group,Mo group(100 mg Mo),Cd group(4 mg Cd),and Mo+Cd group(100 mg Mo+4 mg Cd).Cadmium sulfate 8/3-hydrate(CdSO_(4)·8/3H_(2)O)and hexaammonium molybdate((NH_(4))_(6)Mo_(7)O_(24)·4H_(2)O)were the origins of Cd and Mo,*** the 16th week of the experiment,all ovary tissues were collected for the detection of related *** data indicated that Mo and/or Cd induced trace element disorders and Th1/Th2 balance to divert toward Th1 in the ovary,which activated endoplasmic reticulum(ER)stress and then provoked necroptosis through triggering RIPK1/RIPK3/MLKL signaling pathway,and eventually caused ovarian pathological injuries and necroptosis *** alterations of above indicators were most apparent in the joint *** all,this research illustrates that Mo and/or Cd exposure can initiate necroptosis through Th1/Th2 imbalance-modulated ER stress in duck ovaries,and Mo and Cd combined exposure aggravates ovarian *** research explores the molecular mechanism of necroptosis caused by Mo and/or Cd,which reveals that ER stress attenuation may be a therapeutic target to alleviate necroptosis.

关键词： Molybdenum Cadmium Th1/Th2 imbalance Endoplasmic reticulum stress Necroptosis Ovary

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Nucleating Agent on the Formation of C_4A_3S

引用

Journal of Wuhan University of Technology(Materials Science) 2012年第1期27卷 177-180页

作者： guo huiling XIE Junlin ZHANG Shu XU Qi Key Laboratory for Silicate Materials Science and Engineering of Ministry of Education Wuhan University of TechnologyWuhan 430070China

The reference test methods are carried out parallelly, by means of chemical analysis, X-ray diffraction, differential scanning calorimetry-thermogravimetry, scanning electron microscopy and polarized optical microscope to study the formation of C4A3S in the presence and absence of nucleating agent. The results show that nucleating agent with high calcium and low heat consumption as tricalcium silicate （C3S） promotes the formation of C4A3S and increases desulfurization degree obviously. During calcining raw meals doped with C3S, the grain sizes of C4A3S are larger compared with that without C3S. And at the same calcining level, the mass loss and the heat consumption belonged to CaCO3 decomposition is reduced.

关键词： desulfurization C4A3S, nucleating agent C3S

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and DNA Adsorption of Poly(2-Vinyl-4,6-Diamino-1,3,5-Triazine)Coated Polystyrene Microspheres

引用

Journal of Wuhan University of Technology(Materials Science) 2018年第4期33卷 999-1006页

作者：黄雷王小涛 XIE Xun XIE Weihong LI Xuefeng GONG Xinghou LONG Shijun guo huiling 刘最芳 Hubei Provincial Key Laboratory of Green Materials for Light Industry School of Materials and Engineering Hubei University of Technology Collaborative Innovation Center of Green Light-weight Materials and Processing Hubei University of Technology School of Food and Biological Engineering Hubei University of Technology

To take advantage of the polymer＇s special properties, we synthesized PVDAT coated polystyrene（PVDAT@PS） microspheres through semi-continuous precipitation polymerization, and demonstrated the possibility of controlling the size of microspheres by using different sized PS cores. Mechanism of the microsphere synthesis was investigated. Preliminary application studies indicated that the synthesized microspheres adsorbed double-stranded DNAs（dsDNAs） comprising A-T base pairs in pH7.4 phosphate buffered saline, and the adsorption capacity was in a range of 3.28 mg to 5.58 mg per gram PVDAT@PS microspheres depending on A-T base pair percentage and chain length of the dsDNAs.

关键词： 2-vinyl-4,6-diamino-l,3,5-triazine PVDAT@PS DNA adsorption semi-continuousprecipitation polymerization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Conserved noncoding sequences correlate with distant gene contacts in Arabidopsis and Brassica

引用

Journal of Integrative Plant Biology 2023年第6期65卷 1467-1478页

作者： Lei Zhang Jian Wu Jianli Liang Runmao Lin Chao Sun Qirui Dai Lupeng Zhang huiling guo Ranze Zhao Xiaowu Wang State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China Research Institute of Forestry Chinese Academy of ForestryBeijing 100091China

Physical contact between genes distant on chromosomes is a potentially important way for genes to coordinate their *** investigate the potential importance of distant contacts,we performed high-throughput chromatin conformation capture(Hi-C)experiments on leaf nuclei isolated from Brassica rapa and Brassica *** then combined our results with published Hi-C data from Arabidopsis *** found that distant genes come into physical contact and do so preferentially between the proximal promoter of one gene and the downstream region of another *** with higher numbers of conserved noncoding sequences(CNSs)nearby were more likely to have contact with distant *** more CNSs came higher numbers of transcription factor binding sites and more histone modifications associated with the *** addition,for the genes we studied,distant contacting genes with CNSs were more likely to be transcriptionally *** observations suggest that CNSs may enrich active histone modifications and recruit transcription factors,correlating with distant contacts to ensure coordinated *** study advances our knowledge of gene contacts and provides insights into the relationship between CNSs and distant gene contacts in plants.

关键词： Arabidopsis Brassica conserved noncoding sequences distant gene contacts Hi-C

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein ubiquitination in ovarian cancer immunotherapy:The progress and therapeutic strategy

引用

Genes & Diseases 2024年第6期11卷 273-294页

作者： huiling guo Jianwei Wei Yuyan Zhang Li Wang Junhu Wan Weiwei Wang Ling Gao Jiajing Li Ting Sun Liwei Ma Department of Clinical Laboratory The First Affliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Key Clinical Laboratory of Henan Province ZhengzhouHenan 450052China Department of Neurosurgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Gynecologic Oncology The Affliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450052China

Ovarian cancer is a common cancer for females,and the incidence and mortality rates are on the *** treatment strategies have been developed for ovarian cancer,including chemotherapy and immunotherapy,but they are often ineffective and prone to drug *** ubiquitination is an important class of post-translation modifications that have been found to be associated with various human diseases and cancer *** studies have revealed that protein ubiquitination is involved in the progression of ovarian cancer and plays an important role in the tumor immune ***,the com-bination of ubiquitinase/deubiquitinase inhibitors and cancer immunotherapy approaches can effectively reduce treatment resistance and improve treatment efficacy,which provides new ideas for cancer ***,we review the role of protein ubiquitination in relation to ovarian cancer immunotherapy and recent advances in the use of ubiquitinase/deubiquitinase inhibitorsin combil ationwitncaner mmunotherapy.

关键词： Deubiquitination Immune-related molecules Immunotherapy Ovarian cancer Ubiquitination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbonaceous Nanofibers-titanium Dioxide Nanocomposites: Synthesis and Use as a Platform for Removal of Dye Pollutants

引用

Journal of Wuhan University of Technology(Materials Science) 2019年第2期34卷 303-307页

作者：郭洪影 JIANG Shan WANG Chaoyuan LI Shenwan FENG Jianjian 孙红梅 ZHU Hongda guo huiling LIU Mingxing SUN Honghao School of Bioengineering and Food Key Laboratory of Fermentation Engineering (Ministry of Education) Key Laboratory of Industrial Microbiology in Hubei National ‘‘111'' Center for Cellular Regulation and Molecular Pharmaceutics Hubei Provincial Cooperative Innovation Center of Industrial Fermentation Hubei University of Technology

A mild chemistry route was developed to prepare carbonaceous nanofibers-titanium dioxide(CNF-TiO_2) nanocomposites for removal of dye pollutants. In the process of the template-directed hydrothermal carbonization(HTC), ultrathin Te nanowires were adopted as templates and glucose as the carbon source, and TiO_2 was decorated on CNF via the hydrolysis of tetrabutyltitanate in the presence of CNF in ethanol. The as-prepared materials were characterized by scanning electron microscopy(SEM), transmission electron microscopy(TEM), energy-dispersive X-ray(EDX) and X-ray diffraction(XRD). SEM and TEM observations displayed that TiO_2 nanoparticles were anchored on the CNF. EDX and XRD data confirmed that the assynthesized samples were CNF-TiO_2, and TiO_2 belonged to anatase titania. Taking advantage of combined benefits of carbonaceous nanofibers and titanium dioxide, these CNF-TiO_2 nanocomposites exhibited higher removal efficiency in a short time and showed good reusability. It was showed that over 97% of Rhodamine B could be removed in 15 min without generating the solid and liquid wastes. The removal efficiency of dyes was still over 80% after reuse in five cycles. All the results demonstrate that the as-prepared CNF-TiO_2 composites are effective materials for fast and effective removal of dye pollutants and thus can provide a new platform for dye decontamination.

关键词： carbon materials nanocomposites dye pollutants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study

引用

Neuroscience Bulletin 2024年第6期40卷 683-694页

作者： Jingyu Yang huiling guo Aoling Cai Junjie Zheng Juan Liu Yao Xiao Sihua Ren Dandan Sun Jia Duan Tongtong Zhao Jingwei Tang Xizhe Zhang Rongxin Zhu Jie Wang Fei Wang Early Intervention Unit Department of PsychiatryAffiliated Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China School of Biomedical Engineering and Informatics NanjingMedical UniversityNanjing 211166China The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University Changzhou Second People’s HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Department of Radiology First Hospital of China Medical UniversityShenyang 110002China Department of Cardiac Function The People’s Hospital of China Medical University and the People’s Hospital of Liaoning ProvinceShenyang 110067China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430064China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Functional Brain Imaging Institute of Nanjing Medical University Nanjing 210029China

Early-onset mental disorders are associated with disrupted neurodevelopmental processes during *** methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induced,mimics the abnormal neurodevelopment associated with early-onset mental disorders from an etiological *** conducted longitudinal structural magnetic resonance imaging(MRI)scans during childhood,adolescence,and adulthood in MAM rats to identify specific brain regions and critical windows for ***,the effect of repetitive transcranial magnetic stimulation(rTMS)intervention on the target brain region during the critical window was *** addition,the efficacy of this intervention paradigm was tested in a group of adolescent patients with early-onset mental disorders(diagnosed with major depressive disorder or bipolar disorder)to evaluate its clinical translational *** results demonstrated that,compared to the control group,the MAM rats exhibited significantly lower striatal volume from childhood to adulthood(all P0.05)but was significantly lower than the control group from adolescence to adulthood(both P0.05).In the clinical trial,adolescents with early-onset mental disorders showed a significant increase in hippocampal volume after rTMS treatment compared to baseline(P<0.01),and these volumetric changes were associated with improvement in depressive symptoms(r=−0.524,P=0.018).These findings highlight the potential of targeting aberrant hippocampal development during adolescence as a viable intervent

关键词： Early-onset Mental disorder Neurodevelopment Animal model Hippocampus Repetitive transcranial magnetic stimulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Molecular Structure on the Performance of Polyacrylic Acid Superplasticizer

引用

Journal of Wuhan University of Technology(Materials Science) 2007年第2期22卷 245-249页

作者：张荣国雷家珩 Department of Applied Chemistry Wuhan University of Technology

The effects of structure parameters, such as molecular structure, segment kinds, molecular weight, and organic functional groups, on the performance of polyacrylic acid superplasticizer were discussed. According to the differences of chain sections, functional groups, eic, polyacrylic acid superplasticizer could be divided into A, B, C three parts. Among them, A chain section included sulfonic acid groups, B chain section carboxyl groups, C chain section polyester. Polyacrylic acid superplasticizers with different matching of A, B, C chain sections, different length of C chain section and different molecular weights were synthesized by acrylic acid, polyethylene glycol, sodium methyl allylsulfonate; the relation between the molecular structure and perfolxnance was also studied. The expetimental results indicate that the water-reduction ratio increases obviously with the increment of the proportion of sodium methyl allylsulfonate chain section in the molecular; the slump retention increases greatly with the increment of the proportion of acrylic acid chain section; the dispersion of cement particles increases with the increment of the chain length of polyethylene glycol; when the molecular weight is in the range of 5000, the dispersion and slump retentibity increase with the increment of the average molecular weight of polymers.

关键词： polyacrylic acid superplasticizer cement concrete structure and performance anion surface-active agent molecule structural design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

于“情”于“理”:失能老人家庭照护危机研究

引用

云南民族大学学报（哲学社会科学版） 2024年第5期41卷 64-71页

作者：郭慧玲华东政法大学社会发展学院上海201620

应用情理社会理论从照护者角度出发分析失能老人家庭照护危机的形成与应对。家庭照护是当前老人照护的主导模式,而女性在老人家庭照护者中占七成。个案研究发现,在中国式情理社会中,女性照料者的照护决策、行为和感受取决于“情”“理... 详细信息

应用情理社会理论从照护者角度出发分析失能老人家庭照护危机的形成与应对。家庭照护是当前老人照护的主导模式,而女性在老人家庭照护者中占七成。个案研究发现,在中国式情理社会中,女性照料者的照护决策、行为和感受取决于“情”“理”状况;以“情”为核心的联结感决定照护责任承担主观意愿,作为“理”之关键的其他责任重要性决定照护责任承担的客观条件;在联结感强且其他责任较少的情况下,照护承担带来较强的意义感和价值感,而在其他情况下,照护承担可能为照护者带来较多的压力;同时,“情”和“理”的松动和变化也造成新的照护危机和心理危机。鉴于照护承担意愿和条件多样性,应调整社会政策及相关举措协助、促成或替代女性照护者进行失能老人家庭照护。

关键词：联结感情理社会失能老人家庭照护女性照护者

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

社会建构论心理学:轮廓、流派和局限

引用

心理学探新 2015年第5期35卷 387-392页

作者：郭慧玲华东政法大学社会发展学院上海201620

20世纪70年代,传统实验心理学日益遭受诟病,社会建构论心理学作为其主要批判者之一进入人们的视野。其中,温和派沿着事物是否具有意义负荷的分界线在社会世界和物质世界之间做出区分,代表人物是哈尔。哈尔的社会建构论比较中规中矩,缺... 详细信息

20世纪70年代,传统实验心理学日益遭受诟病,社会建构论心理学作为其主要批判者之一进入人们的视野。其中,温和派沿着事物是否具有意义负荷的分界线在社会世界和物质世界之间做出区分,代表人物是哈尔。哈尔的社会建构论比较中规中矩,缺乏对一些更为敏感的领域的探讨。激进派社会建构论热情拥抱后现代思想,代表人物是格根。激进派在批判传统实验心理学的同时也摧毁自己的立论根基,其话语的指涉物充满不确定性,这是其思想难以在广泛范围内长期维持的原因。

关键词：社会建构论心理学格根哈尔温和派激进派

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：