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Manure substitution improves maize yield by promoting soil fertility and mediating the microbial community in lime concretion black soil

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Journal of Integrative Agriculture 2024年第2期23卷 698-710页

作者： Minghui Cao Yan Duan Minghao Li Caiguo Tang Wenjie Kan Jiangye Li huilan zhang Wenling Zhong Lifang Wu The Center for Ion Beam Bioengineering&Green Agriculture Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Zhongke Taihe Experimental Station Taihe 236626China Institute of Resources and Environment Jiangsu Academy of Agricultural SciencesNanjing 210014China

Synthetic nitrogen(N)fertilizer has made a great contribution to the improvement of soil fertility and productivity,but excessive application of synthetic N fertilizer may cause agroecosystem risks,such as soil acidification,groundwater contamination and biodiversity reduction.Meanwhile,organic substitution has received increasing attention for its ecologically and environmentally friendly and productivity benefits.However,the linkages between manure substitution,crop yield and the underlying microbial mechanisms remain uncertain.To bridge this gap,a three-year field experiment was conducted with five fertilization regimes:i)Control,non-fertilization;CF,conventional synthetic fertilizer application;CF_(1/2)M_(1/2),1/2 N input via synthetic fertilizer and 1/2 N input via manure;CF_(1/4)M_(3/4),1/4 N input synthetic fertilizer and 3/4 N input via manure;M,manure application.All fertilization treatments were designed to have equal N input.Our results showed that all manure substituted treatments achieved high soil fertility indexes(SFI)and productivities by increasing the soil organic carbon(SOC),total N(TN)and available phosphorus(AP)concentrations,and by altering the bacterial community diversity and composition compared with CF.SOC,AP,and the soil C:N ratio were mainly responsible for microbial community variations.The co-occurrence network revealed that SOC and AP had strong positive associations with Rhodospirillales and Burkholderiales,while TN and C:N ratio had positive and negative associations with Micromonosporaceae,respectively.These specific taxa are implicated in soil macroelement turnover.Random Forest analysis predicted that both biotic(bacterial composition and Micromonosporaceae)and abiotic(AP,SOC,SFI,and TN)factors had significant effects on crop yield.The present work strengthens our understanding of the effects of manure substitution on crop yield and provides theoretical support for optimizing fertilization strategies.

关键词： fertilization manure substitution soil fertility maize yield bacterial community

A trial of pirfenidone in hospitalized adult patients with severe coronavirus disease 2019

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Chinese Medical Journal 2022年第3期135卷 368-370页

作者： Fengqin zhang Yanqiu Wei Li He huilan zhang Qiongjie Hu Huihui Yue Jianhan He Huaping Da Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 10029China Peking University Health Science Center Beijing 100029China Department of Respiratory and Critical Care Medicine Jingzhou Central HospitalJingzhouHubei 434200China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesBeijing 100029China

To the Editor:Coronavirus disease 2019(COVID-19),which broke out in 2019,has become a global pandemic.Similar to severe acute respiratory syndrome coronavirus(SARS-CoV)in 2003,SARS-CoV-2 could cause acute lung injury and cytokine storms characterized by the increased interleukin(IL)-8,IL-6,and tumor necrosis factorα(TNF-α).[1]Perspective studies in those survivors from the severe acute respiratory syndrome(SARS)epidemic in 2003 revealed that those SARS patients manifested varying degrees of pulmonary interstitial fibrosis.[2]Similarly,patients with severe COVID-19 are also featured by the diffuse alveolar damage along with alveolar interstitial fibrosis.[3]

关键词： patients acute respiratory

Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

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Frontiers of Medicine 2008年第1期2卷 11-14页

作者： huilan zhang Daowen WANG Cardiovascular Department of Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Using the plasma aldosterone concentration to plasma renin activity ratio(PAC/PRA ratio)as the screening test of choice for primary aldosteronism in hypertensive patients,we studied the clinical character-istics and the diagnostic value of PAC/PRA ratio in primary aldosteronism.The plasma aldosterone concen-tration(PAC)and plasma renin activity(PRA)levels were measured by radioimmunoassay in 902 hypertensive patients from out-patient clinics or hospitals.One hundred and twenty-six suspected primary aldosteronism patients whose PAC/PRA ratio was>25 ng/dL/ng/mL/hr had a lamellar computed tomography(CT)scan in the adrenal gland and follow-up visits.The proportion of primary aldosteronism in hypertensive patients was 14%(126/902).There were 54 patients with unilateral or bilateral hyperplasia and 25 patients with adenoma according to the CT scan.39%(49/126)of the patients with primary aldosteronism had hypokalemia.Twenty-five patients received surgical treatment.The efficacy and cure rates were 100%(25/25)and 48%(12/25),respect-ively.The effective rate of aldactone and the single-drug cure rate were 89%(48/54)and 24%(13/54),respectively.Primary aldosteronism affects over 10%of hypertensive patients in China.The PAC/PRA ratio can be considered as a routine screening test in hypertensives,especially resistant hypertensive patients and a high PAC/PRA ratio is an invaluable index in primary aldosteronism diagnosis.

关键词： hypertension primary aldosteronism aldos-terone renin

1985—2021年青藏高原典型湖泊水文特征及关键影响因素

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水土保持学报 2024年第3期38卷 140-149页

作者：张嘉琪张会兰刘雪妍北京林业大学水土保持学院北京100083 北京林业大学重庆缙云三峡库区森林生态系统国家定位观测研究站重庆400711

[目的]青藏高原的湖泊是气候变化的重要指示器,其扩张或缩减亦对青藏高原自然环境产生重要影响。[方法]选取位于青藏高原不同气候子区的3个典型湖泊(青海湖、羊卓雍错、乌兰乌拉湖),采用遥感监测手段,研究3个典型湖泊1985—2021年水文... 详细信息

[目的]青藏高原的湖泊是气候变化的重要指示器,其扩张或缩减亦对青藏高原自然环境产生重要影响。[方法]选取位于青藏高原不同气候子区的3个典型湖泊(青海湖、羊卓雍错、乌兰乌拉湖),采用遥感监测手段,研究3个典型湖泊1985—2021年水文特征的时空变化规律,揭示关键气候因子的作用,并进一步探讨冰川和冻土对典型湖泊的影响。[结果]研究期间,青海湖的面积和水位呈显著上升趋势,面积增长238.68 km^(2),水位增长1.32 m,空间上则向东西方向扩张;羊卓雍错湖泊面积呈先波动上升后减少趋势,面积和水位分别减少16.31 km^(2)和3.25 m,在空间上整体由四周向中心的萎缩态势;乌兰乌拉湖面积和水位呈显著上升趋势,分别增长125.57 km^(2)和8.12 m,扩张区域主要集中在南部。[结论]在暖湿化环境下,降水增多和冰川冻土加速融化导致的湖泊扩张是青藏高原最为突出的环境变化特征,其中,降水量变化是影响青海湖和羊湖面积变化的关键因素,且面积变化和降水量具有滞后性;而乌兰乌拉湖水位上升的主要原因是气温升高引起冻土的季节融化。探索青藏高原湖泊面积的变化,对深入研究全球气候变化及地表水资源评估具有重要指导意义。

关键词：青藏高原湖泊面积变化水位冰川冻土

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基于SWAT模型的涪江流域土地利用变化的水沙响应研究

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水土保持研究 2024年第3期31卷 79-89,100页

作者：刘雪妍张会兰罗泽宇张嘉琪安妮北京林业大学水土保持学院北京100083 重庆缙云山三峡库区森林生态系统国家定位观测研究站重庆400711

[目的]分析涪江流域水沙对土地利用类型变化的响应情况,为流域水土资源规划管理和生态环境建设提供科学依据。[方法]应用SWAT分布式水文模型,采用情景模拟方法构建3期自然情景以及3种极端情景,分析流域1990—2010年的土地利用变化情况... 详细信息

[目的]分析涪江流域水沙对土地利用类型变化的响应情况,为流域水土资源规划管理和生态环境建设提供科学依据。[方法]应用SWAT分布式水文模型,采用情景模拟方法构建3期自然情景以及3种极端情景,分析流域1990—2010年的土地利用变化情况以及量化不同土地利用类型对流域水沙的作用程度。[结果](1) 1999—2010年,流域上游以林草地为主,约占流域总面积的46%;中下游主要为农业用地和居民用地,耕地占流域总面积的51%左右;居民用地与未利用地扩张率分别为95.86%和434.43%。自然情景下,流域径流变化率小于5%,侵蚀产沙变化率小于15%。(2) SWAT模型在涪江流域具有较强的适用性,径流率定期和验证期的R~2和NSE分别为0.86,0.85;0.80,0.78,泥沙分别为0.68,0.67;0.68,0.43。情景模拟分析得出具体土地利用类型对径流的影响程度:林地>草地>未利用地,相对于基准期,林地覆被情景减少了35.66%的产流量。对流域侵蚀产沙的影响程度:未利用地>林地>草地,未利用地情景下增加了56.74%的侵蚀产沙量,林地和草地情景分别减少了43.57%和30.04%。(3)基于随机森林算法的自变量影响程度重要性排序结果表明:影响产流量的前3个土地利用类型是耕地、林地、草地,权重系数分别为2.057,2.030,1.148;影响侵蚀产沙量的是草地、耕地、林地,权重系数分别为1.753,1.208,1.003。[结论]除耕地外,径流对林地变化的响应最显著,侵蚀产沙量对草地变化的响应最显著,当土地利用类型向林草地转化时,对流域具有显著减水减沙效果。该研究可为涪江流域未来土地利用结构优化和水土资源的合理规划提供科学依据。

关键词：土地利用变化 SWAT模型情景分析随机森林算法涪江流域

1,8-二川芎嗪基大黄酸与牛血清白蛋白相互作用研究

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分析科学学报 2024年第3期40卷 337-343页

作者：闫恳张燕燕卞在东张辉兰黄鹏倪佳黄和平安徽中医药大学药学院安徽合肥230038 中药研究与开发安徽省重点实验室安徽合肥230012

本文采用紫外光谱法、荧光光谱法、圆二色谱法、电化学分析法和分子对接技术,对1,8-二川芎嗪基大黄酸(DBR)与牛血清白蛋白(BSA)的相互作用机制进行了研究。结果表明DBR和BSA间存在强相互作用,在温度290、300、310 K时,两者间的结合常数K... 详细信息

本文采用紫外光谱法、荧光光谱法、圆二色谱法、电化学分析法和分子对接技术,对1,8-二川芎嗪基大黄酸(DBR)与牛血清白蛋白(BSA)的相互作用机制进行了研究。结果表明DBR和BSA间存在强相互作用,在温度290、300、310 K时,两者间的结合常数Ka的数量级达10^(5),结合位点数为1.1,表明两者之间有着较强的相互作用并形成1∶1复合物;Kq两者的猝灭常数值分别为5.5924×10^(12)、4.9853×10^(12)、4.1665×10^(12)L·mol^(-1)·s^(-1),推测猝灭方式为静态猝灭。根据F9rster的非辐射能量转移机制求算出给体与受体间的结合距离r=4.8 nm、能量转移效率E=0.5793,推测两者之间存在非辐射能量转移;通过计算该体系的热力学参数得到ΔH<0,ΔS<0,ΔG<0,表明二者作用力类型为氢键和范德华力。另外,随着DBR的加入BSA的构象发生了改变,BSA的α-螺旋结构从60.55%减少到58.5%;电化学分析法表明两者形成了非电活性的超分子化合物;分子对接模拟结果推测出DBR分子进入了BSA分子的疏水腔内,其结合位置位于domainⅠA亚域。

关键词： 1 8-二川芎嗪基大黄酸牛血清白蛋白光谱法电化学法分子对接

Transcriptome analysis suggests mechanisms for a novel flowering type: Cleistogamous wheat

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The Crop Journal 2020年第2期8卷 313-326页

作者： Caiguo Tang Minghao Li Minghui Cao Ruiju Lu huilan zhang Chenghong Liu Shengwei Huang Pingping zhang Hao Hu Weiwei Zhao Lifang Wu Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031AnhuiChina School of Life Sciences University of Science and Technology of ChinaHefei 230027AnhuiChina Biotech Research Institute Shanghai Academy of Agricultural SciencesShanghai 201106China School of Life Sciences Anhui UniversityHefei 230601AnhuiChina Taihe Experimental Station Hefei Institutes of Physical ScienceChinese Academy of SciencesTaihe 236626AnhuiChina

Wheat is one of the most important staple crops worldwide.Fusarium head blight severely reduces wheat yield and quality.Cultivation of a novel type of cleistogamous wheat mutant,ZK001,which was created by static magnetic field treatment,is a new strategy for controlling Fusarium head blight.However,little is known about the mechanism of cleistogamy in wheat.The present study demonstrated that anthers of ZK001 were retained on the glumes at all flowering stages,whereas those of YM18 were extruded from the paleae and lemmae.There was a clear difference in the morphological characteristics of lodicules between YM18 and ZK001.Lodicule calcium and potassium contents were significantly higher in YM18 than in ZK001 from white to yellow anther stages.In Fusarium head blight resistance,the diseased kernel rate and deoxynivalenol content of ZK001 were markedly lower than those of YM18 and QM725.Comparative transcriptome analysis of YM18 and ZK001 was performed to identify regulatory mechanisms of cleistogamy.The main differentially expressed genes identified in the spikelets of YM18 and ZK001 at the green anther stage were associated with cell walls,carbohydrates,phytohormones,water channel,and ion binding,transport,and homeostasis.These differentially expressed genes may play an important role in regulating cellular homeostasis,osmotic pressure,and lodicule development.The results indicate that ZK001 lost the ability to push the lemmae and paleae apart during the flowering stage because of the thin lodicules.ZK001 was speculated to provide structural barriers for Fusarium head blight during the flowering stage.The thin lodicule of ZK001 results from low levels of soluble sugar,calcium ions,and potassium ions in the lodicules.These levels are regulated by differentially expressed genes.

关键词： blight crops Wheat

半夏泻心汤化学成分、药理作用的研究进展及质量标志物的预测

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世界中医药 2024年第5期19卷 719-726页

作者：王若玲霍静娴张辉兰黄和平黄鹏汪电雷张彩云安徽中医药大学药学院合肥230012

半夏泻心汤(BXD)是记载于《伤寒论》中的经典名方之一,具有调和肝脾、寒热平调、消痞散结之功效。研究发现BXD具有保护胃肠道黏膜、抗胃肠道肿瘤、调节肠道菌群、降血糖、改善胰岛素抵抗、调节神经递质、抗抑郁等作用。通过对BXD的化学... 详细信息

半夏泻心汤(BXD)是记载于《伤寒论》中的经典名方之一,具有调和肝脾、寒热平调、消痞散结之功效。研究发现BXD具有保护胃肠道黏膜、抗胃肠道肿瘤、调节肠道菌群、降血糖、改善胰岛素抵抗、调节神经递质、抗抑郁等作用。通过对BXD的化学成分、药理作用研究进展进行归纳、总结与分析,并基于中药质量标志物(Q-marker)的传递与溯源、特有性、有效性、可测性及复方配伍环境对BXD的Q-marker进行预测分析,发现表小檗碱、黄连碱、巴马汀、小檗碱、黄芩苷、甘草酸、6-姜辣素、β-谷甾醇可作为BXD的Q-marker,以此为建立BXD及其复方制剂的质量控制体系和全过程质量溯源体系提供科学参考依据。

关键词：半夏泻心汤化学成分质量分析药理作用质量标志物

基于VOSviewer和CiteSpace的开心散研究现状及热点可视化分析

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国际中医中药杂志 2024年第4期46卷 506-513页

作者：张辉兰王若玲文峻黄鹏张彩云付俐安徽中医药大学药学院合肥230012 中药研究与开发安徽省重点实验室合肥230012 安徽省食品药品检验研究院业务部合肥230000

目的探讨开心散的研究现状及热点。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)、PubMed及Web of Science建库至2023年1月10日发表的开心散研究文献。... 详细信息

目的探讨开心散的研究现状及热点。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)、PubMed及Web of Science建库至2023年1月10日发表的开心散研究文献。采用CiteSpace 6.2.R2和VOSviewer 1.6.16软件对纳入文献的文献类型、来源期刊、发文量、作者、机构、关键词等数据进行可视化分析。结果纳入文献235篇,以中文期刊论文为主,涉及来源期刊87种,其中《中国中药杂志》和J.Ethnopharmacol发文较多。开心散年发文量整体呈上升趋势,涉及505位作者,形成了以刘屏、姜艳艳等为核心的研究团队;纳入文献作者来自99家研究机构,机构间的合作以地理区域相同和相近单位、中医药大学及其附属医院为主;关键词共现聚类网络、关键词共现时间网络和关键词突现分析结果表明,开心散主要活性成分组成(人参皂苷类、茯苓酸、细辛醚类、酮类和寡糖酯类)、检测方法(HPLC及液质联用)、开心散药理作用(抗老年痴呆、抗抑郁)、作用机制及临床应用是当前研究热点和发展动向。结论开心散的研究多集中于AD、抑郁症等疾病作用机制和临床研究,其中开心散主要活性成分研究是近年热点内容,而药理作用机制及临床应用等发展趋势较好,基于组方活性成分与功效相关性可能成为开心散研究新的热点方向。

关键词：散剂(中药) 开心散研究现状研究热点文献计量学可视化分析