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Damage characterization of shale under uniaxial compression by acoustic emission monitoring

Frontiers of Earth Science 2021年第4期15卷 817-830页

作者： huijun lu Ru ZHANG Li REN Anlin ZHANG Yiming YANG Xiaopeng LI State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource&HydropowerSichuan UniversityChengdu 610065China Key Laboratory of Deep Earth Science and Engineering(Ministry of Education) Sichuan UniversityChengdu 610065China

Understanding the damage behavior and cracking mechanism of brittle shale is crucial for hydraulic fracturing *** this research,uniaxial compression tests are conducted on shale samples with different bedding plane orientations,and acoustic emission monitoring is implemented *** results indicate that the apparent elastic modulus increases with increasing bedding *** the bedding orienta-tions of 45°and 90°,the lateral deformation is anisotropic due to the bedding structure,revealing the anisotropic Poisson effect.A shear failure surface and tensile failure surfaces form parallel to the bedding plane for bedding orientations of 45°and 90°,*** the bedding orientation of 0°,shear failure mainly occurs through the bedding ***,the damage mechanism of shale is investigated by crack classification based on AE *** is found that crack initiation is induced by the generation of shear cracks for the bedding orientation of 45°,whereas by the generation of tensile cracks for other bedding *** to damage attributable to different type cracks,shear cracks dominate the damage behavior for bedding orientations of 0°and 45°,whereas tensile cracks dominate the damage behavior for bedding orientation of 90°.Finally,the information entropy is calculated by AE energy.A low value of information entropy,approximately 0.36,predicts failure with a low degree of instability for the bedding orientation of 0°,whereas a high value of information entropy,more than 1.5,predicts failure with a high degree of instability for other bedding *** finding indicates that the failure behavior is gradual progressive damage for bedding orientation of 0°,whereas sudden damage dominates failure behavior for other bedding orientations.

关键词： shale damage characterization uniaxial compression acoustic emission

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犬髓外浆细胞瘤的组织病理学诊断和免疫组织化学分析

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中国兽医杂志 2025年第1期61卷 1-6页

作者：张竞李伊萌石俊超马莹贺文琦陆慧君吉林大学动物医学学院吉林长春130062 长春市西部新城公园绿地管理中心吉林长春130062

髓外浆细胞瘤(EMP)在犬中属于相对罕见的肿瘤,为了明确犬EMP的组织病理学和免疫标志物表达特征,本试验采用苏木精-伊红(H. E.)染色和刚果红染色法对患犬的皮肤肿物进行组织病理学诊断,进一步使用EMP免疫标志物配对盒基因5(PAX5)、白细... 详细信息

髓外浆细胞瘤(EMP)在犬中属于相对罕见的肿瘤,为了明确犬EMP的组织病理学和免疫标志物表达特征,本试验采用苏木精-伊红(H. E.)染色和刚果红染色法对患犬的皮肤肿物进行组织病理学诊断,进一步使用EMP免疫标志物配对盒基因5(PAX5)、白细胞分化抗原20(CD20)、白细胞分化抗原79a(CD79a)、多发性骨髓瘤基因1(MUM1)和犬免疫球蛋白G(Canine IgG)进行免疫组织化学(IHC)染色,并总结免疫标志物表达特征。结果显示,2例病例的肿物均无包膜结构,并与周围组织边界清晰,肿瘤细胞呈浆细胞样或浆母细胞样特征,病例2肿物内见淀粉样沉积。病例1肿瘤细胞免疫标志物PAX5、CD20和MUM1呈阴性,CD79a和Canine IgG呈阳性;病例2肿瘤细胞免疫标志物PAX5呈阴性,CD20、CD79a、MUM1和Canine IgG呈阳性。结果表明,通过组织病理学检查结合IHC染色结果,确诊2例病例均为犬皮肤型EMP。本试验为犬EMP的精确诊断提供重要的病理学依据,具有重要的参考价值。

关键词：犬髓外浆细胞瘤(EMP) 组织病理学免疫组织化学鉴别诊断

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Endovascular repair of thoracic aortic dissection associated with right-sided aortic arch：report of four cases

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The Journal of Biomedical Research 2017年第1期31卷 74-78页

作者： Ye Yuan Yi Zhao Mi Zhang huijun lu Department of Vascular Surgery Wuxi People＇s Hospital Affiliated with Nanjing Medical University Wuxi Jiangsu 214023 China

Aortic dissection involving a right-sided aortic arch（RAA）is extremely rare with an incidence in adults of 0.04%to 0.1%^（[1]）.Thoracic aortic dissection associated with RAA is even a more uncommon and life-threatening *** complicated aortic dissection,conventional open surgical repair is considered a standard therapy^（[2]）.However,

关键词： Endovascular repair of thoracic aortic dissection associated with right-sided aortic arch RAA RCCA

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9种犬圆形细胞肿瘤鉴别诊断方法的建立和应用

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中国兽医杂志 2025年第1期61卷 7-13页

作者：张竞马莹甄理刘政魏建伟贺文琦陆慧君吉林大学动物医学学院吉林长春130062 河北省乡村振兴促进中心河北石家庄050011 吉林大学人兽共患病研究所吉林长春130062

犬圆形细胞肿瘤(RCT)的鉴别诊断是犬肿瘤病理诊断的难点,且目前犬商用鉴别诊断试剂多为进口,价格高或无购买渠道。为了解决这一难题,本试验选择针对9种犬RCT鉴别诊断的18种免疫标志物抗体和1种特异性染料进行染色分析,并优化染色方法。... 详细信息

犬圆形细胞肿瘤(RCT)的鉴别诊断是犬肿瘤病理诊断的难点,且目前犬商用鉴别诊断试剂多为进口,价格高或无购买渠道。为了解决这一难题,本试验选择针对9种犬RCT鉴别诊断的18种免疫标志物抗体和1种特异性染料进行染色分析,并优化染色方法。结果显示,筛选获得组织细胞瘤免疫标志物抗体离子化钙结合适配分子1(Iba 1)、T细胞淋巴瘤免疫标志物抗体白细胞分化抗原3(CD3)、B细胞淋巴瘤免疫标志物抗体白细胞分化抗原20(CD20)、肥大细胞瘤特异性染料甲苯胺蓝(T blue)等13种有效的犬RCT免疫标志物抗体和1种染料;应用优化后的染色方法对临床14例犬RCT病例进行诊断,取得了良好的诊断效果。本试验为犬RCT鉴别诊断提供了经济有效的抗体组合和染色方法。

关键词：犬圆形细胞肿瘤(RCT) 免疫组织化学免疫标志物鉴别诊断

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4例犬恶性黑色素瘤病理学和PNL-2免疫组织化学染色检查

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中国兽医杂志 2025年第1期61卷 19-24页

作者：贾茜涵石俊超张竞马莹刘政陆慧君贺文琦吉林大学动物医学学院吉林长春130062

为了对4例疑似犬肿瘤的临床病例进行确诊,本文对临床送检的4例疑似犬肿瘤的肿物样本进行组织切片制作,经苏木精-伊红(H.E.)染色后,镜下可见增生的细胞排列呈束状、片状、巢状和螺纹状等,细胞呈梭形或多角形,部分细胞胞浆内含有黑色素颗... 详细信息

为了对4例疑似犬肿瘤的临床病例进行确诊,本文对临床送检的4例疑似犬肿瘤的肿物样本进行组织切片制作,经苏木精-伊红(H.E.)染色后,镜下可见增生的细胞排列呈束状、片状、巢状和螺纹状等,细胞呈梭形或多角形,部分细胞胞浆内含有黑色素颗粒,符合黑色素细胞肿瘤的特征;为了进一步观察细胞形态并对肿物进行确诊,使用黑色素瘤相关抗原(PNL-2)对肿瘤细胞进行免疫组织化学(IHC)染色,并用二氨基联苯胺(DAB)和3-氨基-9-乙基卡唑(AEC)显色液对其显色,结果均为恶性黑色素瘤(MM)。本试验通过对肿物的细胞形态学特征和IHC染色结果综合分析,将4例病例诊断为MM。试验结果不仅为犬MM的病理诊断提供参考,还为比较医学中MM的确诊提供参考依据。

关键词：犬恶性黑色素瘤(MM) 苏木精-伊红(H.E.) 免疫组织化学(IHC) 黑色素瘤相关抗原(PNL-2)

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Hydraulic fracturing behaviors of shale under coupled stress and temperature conditions simulating different burial depths

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International Journal of Mining Science and Technology 2024年第6期34卷 783-797页

作者： Qin Zhou Zheming Zhu Wei Liu huijun lu Zidong Fan Xiaofang Nie Cunbao Li Jun Wang Li Ren MOE Key Laboratory of Deep Earth Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Downhole Operating Company CNPC Chuanqing Drilling and Exploration Engineering Co.Ltd.Shenzhen 518060China School of Architecture and Civil Engineering Xihua UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Shenzhen UniversityShenzhen 518060China

Fracture propagation in shale under in situ conditions is a critical but poorly understood mechanical process in hydraulic fracturing for deep shale gas reservoirs. To address this, hydraulic fracturing experiments were conducted on hollow double-wing crack specimens of the Longmaxi shale under conditions simulating the ground surface(confining pressure σ_(cp)=0, room temperature(Tr)) and at depths of 1600 m(σ_(cp)=40 MPa, Ti=70 ℃) and 3300 m(σ_(cp)=80 MPa, high temperature Ti=110 ℃) in the study *** in situ stress was found to significantly increase fracture toughness through constrained microcracking and particle frictional bridging mechanisms. Increasing the temperature enhances rather than weakens the fracture resistance because it increases the grain debonding length, which dissipates more plastic energy and enlarges grains to close microdefects and generate compressive stress to inhibit microcracking. Interestingly, the fracture toughness anisotropy in the shale was found to be nearly constant across burial depths, despite reported variations with increasing confining pressure. Heated water was not found to be as important as the in situ environment in influencing shale fracture. These findings emphasize the need to test the fracture toughness of deep shales under coupled in situ stress and temperature conditions rather than focusing on either in situ stress or temperature alone.

关键词： Hydraulic fracturing Fracture toughness Shale Anisotropy Deep rock mechanics

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Mechanical behaviors of mylonitic granite and granitic protomylonite in a deep ductile shear zone

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2663-2677页

作者： Lanbin Zhang Ru Zhang Li Ren Zhilong Zhang Zetian Zhang Dong Wang Xinzhong Wang huijun lu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China MOE Key Laboratory of Deep Earth Science and Engineering Sichuan UniversityChengdu610065China China Railway Eryuan Engineering Group Company Ltd.Chengdu610065China School of Architecture and Civil Engineering Xihua UniversityChengdu610065China

For projects near the tectonic belt,mylonite of varying metamorphic degrees may be *** matrix proportion of rock reflects its internal microscopic characteristics,thus it is beneficial for engineering geology to study the effect of the matrix proportion on the mechanical properties and rupture behaviors of *** of mylonitic granite and granitic protomylonite with varying matrix proportions were obtained from a ductile shear zone for a series of uniaxial compression and acoustic emission(AE)*** results showed that with the increase in matrix proportion,the average strength and elastic modulus of the samples increased,and the rock sample with the largest matrix proportion exhibited the maximum peak stress of 244.42 MPa,which was 45.86%greater than the average peak stress of the rock samples with the smallest matrix *** the rock samples with larger matrix proportion,their mechanical parameters exhibited greater dispersion and the large-scale appearance of AE events occurred earlier,showing a relatively gradual failure *** samples had larger accumulated AE parameter values and greater degree of *** contrast,for samples with smaller matrix proportions,the large-scale appearance of AE events occurred close to the peak stress,indicating that the occurrence of damage and fractures was centralized and *** samples had lower accumulated AE parameter values and fewer cracks after ***,for the rock samples with more matrix proportion,the average variance of the b-value was 1.1,which was lower than that of rock samples with the smallest matrix proportion(the average variance of the b-value was 3.7).Furthermore,it can be predicted that under certain stress,the failure depth around a tunnel is generally smaller when the strength of rock samples with larger matrix proportion is greater.

关键词： Mylonite Matrix proportion Mechanical properties Acoustic emission(AE) Rupture behaviors

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Exact Tail Asymptotics for a Queueing System with a Retrial Orbit and Batch Service

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Applied Mathematics 2024年第6期15卷 406-420页

作者： huijun lu Huling Middle School Yanan China

This paper discusses a queueing system with a retrial orbit and batch service, in which the quantity of customers’ rooms in the queue is finite and the space of retrial orbit is infinite. When the server starts serving, it serves all customers in the queue in a single batch, which is the so-called batch service. If a new customer or a retrial customer finds all the customers’ rooms are occupied, he will decide whether or not to join the retrial orbit. By using the censoring technique and the matrix analysis method, we first obtain the decay function of the stationary distribution for the quantity of customers in the retrial orbit and the quantity of customers in the queue. Then based on the form of decay rate function and the Karamata Tauberian theorem, we finally get the exact tail asymptotics of the stationary distribution.

关键词： Exact Tail Asymptotics Batch Service Censoring Technique Matrix Analysis Method Karamata Tauberian Theorem

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Efficacy of seasonal pandemic influenza hemagglutinin DNA vaccines delivered by electroporation against aseasonal H1N1 virus challenge in mice

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Science China(Life Sciences) 2011年第4期54卷 293-299页

作者： TAN Lei lu huijun ZHANG Dan WANG KaiYan TIAN MingYao LIU CunXia LIU YanYu HU Bo JIN NingYi Genetic Engineering Laboratory of PLA Academy of Military Medical Sciences of PLA Changchun 130062 China College of Animal Science and Veterinary Medicine Jilin University Changchun 130062 China Agricultural College of Yanbian University Yanji 133400 China

Prophylactic DNA vaccines against the influenza virus are promising alternatives to conventional vaccines. In this study, we generated two candidate gene-based influenza vaccines encoding either the seasonal or pandemic hemagglutinin antigen （HA） from the strains A/New Caledonia/20/99 （HIN1）（pV1AS） and A/Califorrtia/04/2009 （H1N1）（pVEH1）, respectively. After verifying antigen expression, the immunogenicity of the vaccines delivered intramuscularly with electroporation was tested in a mouse model. Sera of immunized animals were tested in hemagglutination inhibition assays and by ELISA for the presence of HA-specific antibodies. HA-specific T-cells were also measured in IFN-γ ELISpot assays. The protective efficacy of the candidate influenza vaccines was evaluated by measuring mortality rates and body weight after a challenge with 100 LD50 of mouse-adapted A/New Caledonia/20/99 （H1N1）. Mice immunized with either one of the two vaccines showed significantly higher T cell and humoral immune responses （P〈0.05） than the pVAX1 control group. Additionally, the pV1A5 vaccine effec- tively protected the mice against a lethal homologous mouse-adapted virus challenge with a survival rate of 100% compared with a 40% survival rate in the pVEH1 vaccinated group （P〈0.05）. Our study indicates that the seasonal influenza DNA vac- cine completely protects against the homologous A/New Caledonia/20/99 virus （H1N1）, while the pandemic influenza DNA vaccine only partially protects against this virus.

关键词： seasonal influenza pandemic influenza hemagglutinin DNA vaccine electroporation H1N1 influenza virus

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Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2

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Science Bulletin 2019年第3期64卷 180-188页

作者： Ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu Zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian huijun lu Ningyi Jin Chengyu Jiang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Peking Union Medical College Tsinghua University China Academy of Chinese Medicine Sciences Interdisciplinary Nanoscience Center (iNANO) Department of Engineering Aarhus University Genetic Engineering Laboratory Institute of Military Veterinary Academy of Military Medical Sciences

Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals.

关键词： Influenza TUDCA M2 proton channel Virus entry Cell-penetrating peptide Oligomerization inhibitor

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