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Effects and possible mechanisms of dexmedetomidine on post-operative cognitive dysfunction

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中华医学杂志（英文版） 2023年第19期136卷 2392-2394页

作者： huijuan he Manhua Zhu Yupeng Lyu Yuan Yuan Yong Qi China 315000 China 315000

To the Editor: Post-operative cognitive dysfunction (POCD) is described as a series of changes in the neurocognitive conditions and behaviors of patients, which occur within several weeks or even months after anesthesia and surgery. POCD occurs in 20% to 50% of patients, resulting in burden on patients, and exerting a significant social and economic impact. Although an increased understanding of the effects of neuroinflammation and oxidative stress after surgery and anesthesia have clarified the underlying pathophysiology of POCD, many questions remain to be answered. At present, the treatment of POCD mainly focuses on prevention strategies, early identification, and perioperative risk factor management; and an effective treatment is still lacking. Dexmedetomidine (Dex) is a novel and highly selective α2 adrenergic receptor agonist. Perioperative Dex treatment can significantly reduce the incidence of POCD and inflammation, and it can improve postoperative neurocognitive function. Dex may inhibit the massive release of high mobility group protein B1 (HMGB1) by acting on the α2 adrenergic receptor to activate the PI3K/Akt signaling pathway, thus reducing the binding of HMGB1 with Toll-like receptor 4 and other membrane proteins, thus playing an anti-inflammatory role. Dex can also enhance HMGB1-induced cognitive decline in inflammatory mice via vagal nerve stimulation. HMGB1 is released extracellularly after cell activation, stress, injury, or death and can promote an inflammatory response. High HMGB1 expression is associated with the occurrence of POCD. The inflammatory immune response may play an important role in the pathogenesis of POCD. Regulatory T (Treg) cells are key regulatory cells involved in inflammation and play an important role in immune tolerance and ***1can downregulate the immune function of Treg cells by decreasing the expression of marker molecules on their surface and inhibiting cytokine secretion. Extracellular HMGB1 also intensifie

关键词： REGULATORY T-CELLS ACUTE LUNG INJURY

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养老院护士安宁疗护课程的构建与培训实践

护理学杂志 2024年第11期39卷 85-89页

作者：覃郅原王向荣卢俊芳贺惠娟郑三一李小伟湖北中医药大学护理学院湖北武汉430065 宜昌市中心人民医院/三峡大学附属中心人民医院湖北省中医院/湖北中医药大学附属医院

目的构建养老院护士安宁疗护培训课程,评价培训效果。方法基于Watson人性照护理论与德尔菲法构建养老院护士安宁疗护培训课程体系,编撰成培训手册后用于35名养老院护士培训。培训前后进行理论操作考核,测评人文关怀行为。结果构建的培... 详细信息

目的构建养老院护士安宁疗护培训课程,评价培训效果。方法基于Watson人性照护理论与德尔菲法构建养老院护士安宁疗护培训课程体系,编撰成培训手册后用于35名养老院护士培训。培训前后进行理论操作考核,测评人文关怀行为。结果构建的培训课程体系包括5项一级指标、27项二级指标和34项三级指标;培训手册为6个章节共20学时。培训后护士的理论操作考核成绩及人文关怀行为得分显著高于培训前(均P<0.05)。结论构建的培训课程适用性良好,用于养老院护士的安宁疗护培训效果显著。

关键词：护士养老院安宁疗护课程构建培训体系人文关怀关怀行为教学实践

Parallel Physics-Informed Neural Networks Method with Regularization Strategies for the Forward-Inverse Problems of the Variable Coefficient Modified KdV Equation

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Journal of Systems Science & Complexity 2024年第2期37卷 511-544页

作者： ZHOU huijuan School of Science Shanghai Maritime UniversityShanghai 201306China

This paper mainly introduces the parallel physics-informed neural networks(PPINNs)method with regularization strategies to solve the data-driven forward-inverse problems of the variable coefficient modified Korteweg-de Vries(VC-MKdV)*** the forward problem of the VC-MKdV equation,the authors use the traditional PINN method to obtain satisfactory data-driven soliton solutions and provide a detailed analysis of the impact of network width and depth on solving accuracy and ***,the author finds that the traditional PINN method outperforms the one with locally adaptive activation functions in solving the data-driven forward problems of the VC-MKdV *** for the data-driven inverse problem of the VC-MKdV equation,the author introduces a parallel neural networks to separately train the solution function and coefficient function,successfully addressing the function discovery problem of the VC-MKdV *** further enhance the network’s generalization ability and noise robustness,the author incorporates two regularization strategies into the *** amount of numerical experimental data in this paper demonstrates that the PPINNs method can effectively address the function discovery problem of the VC-MKdV equation,and the inclusion of appropriate regularization strategies in the PPINNs can improves its performance.

关键词： Data-driven forward-inverse problems parallel physics-informed neural networks regularization strategies variable coefficient modified KdV equation

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密室逃脱教学法在护理临床思维训练模块实训中的应用

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护理学杂志 2024年第15期39卷 69-73页

作者：王双庆王向荣乔桂圆贺惠娟祝鑫红赵玉覃郅原李小伟湖北中医药大学护理学院湖北武汉430070

目的探讨密室逃脱教学法在护理临床思维训练模块实训中的应用效果。方法选取我院2020级4个护理学本科班护生作为研究对象,通过抽签的方法分为观察组80人和对照组82人,对照组采用案例教学法及自主训练进行授课,观察组在对照组的基础上,... 详细信息

目的探讨密室逃脱教学法在护理临床思维训练模块实训中的应用效果。方法选取我院2020级4个护理学本科班护生作为研究对象,通过抽签的方法分为观察组80人和对照组82人,对照组采用案例教学法及自主训练进行授课,观察组在对照组的基础上,在操作训练中增加4次密室逃脱教学训练。结果观察组课程考核成绩、批判性思维能力和人文关怀能力评分显著高于对照组(均P<0.05),且4次闯关耗时依次缩短(P<0.05)。结论密室逃脱教学法在护理临床思维训练模块实训中具有较好的应用效果,有助于提高护生的操作水平、评判性思维能力和人文关怀能力。

关键词：护理本科生密室逃脱护理临床思维训练标准化病人评判性思维人文关怀游戏教学护理教育

赛教融合背景下护生临床思维能力培养的教学设计

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中华医学教育探索杂志 2024年第3期23卷 419-423页

作者：侯雪蓓乔桂圆贺惠娟祝鑫红杨芬付庆蓉湖北中医药大学护理学院武汉430065 湖北中医药大学附属医院推拿科/康复医学科武汉430061

护理技能竞赛是临床护理发展的风向标,竞赛所展示的教学理念、命题形式及评价体系等都对护理教学有很强的借鉴性。本文介绍了在赛教融合背景下,在护理综合实训中借鉴STEM[科学(Science)、技术(Technology)、工程(Engineering)、数学(Mat... 详细信息

护理技能竞赛是临床护理发展的风向标,竞赛所展示的教学理念、命题形式及评价体系等都对护理教学有很强的借鉴性。本文介绍了在赛教融合背景下,在护理综合实训中借鉴STEM[科学(Science)、技术(Technology)、工程(Engineering)、数学(Mathematics)四门学科英文首字母的缩写]教育理念将护理专业相关课程根据要解决的问题及目标进行知识选取和整合,以临床病例为载体或主线创建现实问题情景,再以Tanner临床判断模式引导学生对病例进行综合分析,帮助学生培养临床思维能力和综合实践能力,旨在缩小在校学习内容与临床护理工作的差距,帮助护生尽快适应临床实习。

关键词：赛教融合护生临床判断模式临床思维能力

High-Efficiency Photo-Induced Charge Transfer for SERS Sensing in N-Doped 3D-Graphene on Si heterojunction

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Energy & Environmental Materials 2024年第2期7卷 272-280页

作者： Guanglin Zhang Jie Sun Genwang Wei Shan Zhang Zhengyi he huijuan Wu Bingkun Wang Siwei Yang Guqiao Ding Zhiduo Liu Zhiwen Jin Caichao Ye Gang Wang Department of Microelectronic Science and Engineering School of Physical Science and Technology Ningbo University Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Shenzhen University Academy for Advanced Interdisciplinary Studies & Department of Materials Science and Engineering Guangdong Provincial Key Laboratory of Computational Science and Material Design Southern University of Science and Technology State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE) School of Physics Beijing Institute of Technology School of Physical Science and Technology & Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou University

Nitrogen-doped three-dimensional graphene（N-doped 3D-graphene） is a graphene derivative with excellent adsorption capacity, large specific surface area, high porosity, and optoelectronic properties. herein, N-doped 3Dgraphene/Si heterojunctions were grown in situ directly on silicon（Si）substrates via plasma-assisted chemical vapor deposition（PACVD）, which is promising for surface-enhanced Raman scattering（SERS） substrates candidates. Combined analyses of theoretical simulation, incorporating N atoms in 3D-graphene are beneficial to increase the electronic state density of the system and enhance the charge transfer between the substrate and the target molecules. The enhancement of the optical and electric fields benefits from the stronger light-matter interaction improved by the natural nano-resonator structure of N-doped 3D-graphene. The as-prepared SERS substrates based on N-doped 3D-graphene/Si heterojunctions achieve ultralow detection for various molecules: 10-8M for methylene blue（MB） and10-9M for crystal violet（CRV） with rhodamine（R6G） of 10-10M. In practical detected, 10-8M thiram was precisely detected in apple peel extract. The results indicate that N-doped 3D-graphene/Si heterojunctions based-SERS substrates have promising applications in low-concentration molecular detection and food safety.

关键词： charge transfer DFT simulation N-doped 3D-graphene SERS Thiram detection

Recent Advances of Imide-Functionalized Polymer Donors for Non-fullerene Solar Cells

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Chinese Journal of Chemistry 2024年第15期42卷 1759-1780页

作者： huijuan Wang Songmin Mo Dongyan Li Qinghe Wu Department of Chemistry and Key(Guangdong-Hong Kong Joint)Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Shantou UniversityShantouGuangdong 515063China

In recent years,there has been a shift towards using non-fullerene electron acceptors in organic solar cells(osCs)as a replacement for fullerene *** change requires polymer donors that possess compatible physical properties,such as absorption range,HoMo energy level,miscibility,and ***,the high cost and poor batch-to-batch reproducibility of polymer donors also hinder future large-scale *** emphasize the need to explore alternative types of polymer *** imide-functionalized building units possess several key attributes that make their polymers highly promising for non-fullerene *** attributes include ease of synthesis,strong electron-withdrawing ability,rigid and co-planar structure,and the ability to easily tune solubility through imide side *** this review,we summarized the synthetic routes of imide building units,and the structural evolution of imide-functionalized polymer donors by focusing on the effects of polymer structure on their physical,optoelectronic,and photovoltaic *** hope that this mini-review will serve as a catalyst for future research on imide-functionalized polymers toward high-performance,cost-effective,and durable organic solar cells(oscs).

关键词： Imide Polymer donors Organic solar cells Synthetic routes Polymer structure evolution

Sulfur vacancies and heterogeneous interfaces promote high performance sodium storage of bimetallic chalcogenide hollow nanospheres

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Journal of Energy Chemistry 2024年第8期95卷 596-610,I0013页

作者： Shiyue Cao Xiaoting Xu Qiming Liu huijuan Zhu Ting Hu Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina

Transition metal sulfides have high theoretical capacities and are considered as potential anode materials for sodium-ion ***,due to low inherent conductivity and significant volume expansion,the electrochemical performance is greatly *** this study,a nickel/manganese sulfide material(Ni_(0.96)S_(x)/MnS_(y)-NC)with adjustable sulfur vacancies and heterogeneous hollow spheres was prepared using a simple *** introduction of a concentration-adjustable sulfur vacancy enables the generation of a heterogeneous interface between bimetallic sulfide and sulfur *** interface collectively creates an internal electric field,improving the mobility of electrons and ions,increasing the number of electrochemically active sites,and further optimizing the performance of Na~+*** direction of electron flow is confirmed by Density functional theory(DFT)*** hollow nano-spherical material provides a buffer for expansion,facilitating rapid transfer *** innovative discovery involves the interaction between the ether-based electrolyte and copper foil,leading to the formation of Cu_9S_5,which grafts the active material and copper current collector,reinforcing mechanical *** results in a new heterostructure of Cu_9S_5 with Ni_(0.96)S_(x)/MnS_(y),contributing to the stabilization of structural integrity for long-cycle ***,Ni_(0.96)S_(x)/MnS_(y)-NC exhibits excellent electrochemical properties following our modification *** stability performance,Ni0_(.96)S_(x)/MnS_(y)-NC demonstrates an average decay rate of 0.00944%after 10,000 cycles at an extremely high current density of 10000 mA g^(-1),A full cell with a high capacity of 304.2 mA h g^(-1)was also successfully assembled by using Na_(3)V_(2)(PO_(4))_(3)/C as the *** study explores a novel strategy for interface/vacancy co-modification in the fabrication of high-performance sodium-ion batteries electrode.

关键词： Sulfur vacancies heterogeneous interface Interactions Sodium ion batteries

Promoting Environmental Risk Assessment and Control of Emerging Contaminants in China

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Engineering 2024年第6期37卷 13-17页

作者： Bin Wang Qian Sui huijuan Liu Gang Yu Jiuhui Qu School of Environment Tsinghua UniversityBeijing 100084China School of Resources and Environmental Engineering East China University of Science and TechnologyShanghai 200237China Advanced Interdisciplinary Institute of Environmental and Ecology Beijing Normal UniversityZhuhai 519000China

*** In recent years,China has carried out an extensive preventative battle against air,water,and soil pollution,and the nation’s environmental quality-as reflected by conventional pollutant indicators—has significantly *** the same time,the issue of emerging contaminants(ECs)is beginning to receive increasing *** generally refer to newly discovered or noticeable pollutants that pose risks to the ecological environment or human *** they have not been included in environmental management,or existing management measures are insufficient to effectively prevent and control their *** ECs of greatest concern generally include persistent organic pollutants(POPs),endocrine-disrupting chemicals(EDCs),pharmaceuticals and personal care products(PPCPs),and *** four categories of ECs are not entirely separate,as they interrelate with each other(Fig.1).Chemical production and product usage are the main sources of *** is the world’s largest producer and consumer of bulk chemicals,and the production value of China’s chemical industry is predicted to reach 50%of the global total by 2030[1].Scientific control of ECs based on their environmental risk assessment is a necessary way to support the prevention and legal governance of ECs.

关键词： legal entirely prevention