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Science Bulletin 2019年第12期64卷 823-835页

作者： Bowen Yang Tong Liu huijie guo Shiyi Xiao Lei Zhou Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication Shanghai UniversityShanghai 200444China State Key Laboratory of Surface Physics Key Laboratory of Micro and Nano Photonic StructuresPhysics DepartmentFudan UniversityShanghai 200433China Shanghai Institute for Advanced Communication and Data Science Shanghai UniversityShanghai 200444China

Transmissive metasurfaces have provided an efficient platform to manipulate electromagnetic(EM)waves, but previously adopted multilayer meta-atoms are too thick and/or the design approach fully relies on brute-force simulations without physical understandings. Here, based on coupled-mode theory(CMT) analyses on multilayer meta-atoms of distinct types, it is found that meta-atoms of a specific type only allows the phase coverage over a particular range, thus suitable for polarization-control ***, combinations of meta-atoms with distinct types are necessary for building ultra-thin wavefront-control meta-devices requiring 360° phase coverage. Based on these physical understandings,high-efficiency meta-atoms are designed/fabricated, and used to construct three typical meta-devices,including quarter-and half-wave plates and a beam deflector. Our results elucidate the physics underlying the interplay between thicknesses and performances of transmissive metasurfaces, which can guide the realizations of miniaturized transmissive meta-devices in different frequency domains.

关键词： Metasurface Transparent window Wave plate Beam deflector

Tailoring the lineshapes of coupled plasmonic systems based on a theory derived from first principles

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Light(Science & Applications) 2020年第1期9卷 510-520页

作者： Jing Lin Meng Qiu Xiyue Zhang huijie guo Qingnan Cai Shiyi Xiao Qiong He Lei Zhou State Key Laboratory of Surface Physics Key Laboratory of Micro and Nano Photonic Structures(Ministry of Education)and Department of PhysicsFudan UniversityShanghai 200433China Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai Institute for Advanced Communication and Data ScienceShanghai UniversityShanghai 200444China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

Coupled photonic systems exhibit intriguing optical responses attracting intensive attention,but available theoretical tools either cannot reveal the underlying physics or are empirical in ***,we derive a rigorous theoretical framework from first principles(i.e.,Maxwell’s equations),with all parameters directly computable via wave function integrations,to study coupled photonic systems containing multiple *** calculations against Mie theory reveal the physical meanings of the parameters defined in our theory and their mutual *** testing our theory numerically and experimentally on a realistic plasmonic system,we show how to utilize it to freely tailor the lineshape of a coupled system,involving two plasmonic resonators exhibiting arbitrary radiative losses,particularly how to create a completely“dark”mode with vanishing radiative loss(e.g.,a bound state in continuum).All theoretical predictions are quantitatively verified by our experiments at near-infrared *** results not only help understand the profound physics in such coupled photonic systems,but also offer a powerful tool for fast designing functional devices to meet diversified application requests.

关键词： theory principles radiative

基于UG12.0自动编程的复杂槽类零件数控铣削仿真与加工

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机电工程技术 2024年第1期53卷 185-188页

作者：姚辉苗郭慧杰王雪英王成帅山西水利职业技术学院太原030032 新乡职业技术学院河南新乡453000 山西能源学院太原030600 中国矿业大学(北京) 北京100083 山西省能源职业学校(山西省能源职工教育中心) 太原030012

计算机辅助设计与制造技术是制造业的趋势和方向。对于轮廓形状复杂的零件,手动数控编程技术呈现出适应能力差,一定程度制约我国制造业质量水平的快速发展。以复杂槽类零件特征分析为基础,采用UG12.0 CAD模块开展复杂槽类零件三维建模,... 详细信息

计算机辅助设计与制造技术是制造业的趋势和方向。对于轮廓形状复杂的零件,手动数控编程技术呈现出适应能力差,一定程度制约我国制造业质量水平的快速发展。以复杂槽类零件特征分析为基础,采用UG12.0 CAD模块开展复杂槽类零件三维建模,应用CAM模块设置刀具、建立坐标系、创建几何体、建立加工工序、设置刀轨参数及切削层参数,开展复杂槽类零件自动编程,使用仿真加工功能验证程序的正确性,后处理导出569型Oi mate MD加工中心能识别的处理器为“FANUC-BJ”的程序。将程序导入数控系统,安装毛坯和刀具,对刀找中心点,将两把刀具的长度补偿输入参数表中,最后进行加工生产。实践表明,对于复杂槽类零件,采用UG12.0进行自动编程、数控铣削仿真和生产加工是可行的。

关键词： UG12.0 自动编程仿真数控铣削

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桂林市养老机构老年人卫生服务需要与利用研究

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中国农村卫生事业管理 2024年第1期44卷 19-25页

作者：黄雨薇赵文静郭惠杰汤琳琳郭振友桂林医学院公共卫生学院广西桂林541199 桂林医学院人文与管理学院广西桂林541199

目的了解养老机构老年人卫生服务需要及利用情况现状,分析影响养老机构老年人卫生服务需要及利用的因素,进而不断提升养老机构老年人的生命质量。方法用自制的调查问卷,采用一对一访谈法进行现场问卷调查,通过EpiData 3.1和SPSS 25.0... 详细信息

目的了解养老机构老年人卫生服务需要及利用情况现状,分析影响养老机构老年人卫生服务需要及利用的因素,进而不断提升养老机构老年人的生命质量。方法用自制的调查问卷,采用一对一访谈法进行现场问卷调查,通过EpiData 3.1和SPSS 25.0软件对资料进行整理与统计分析。结果共调查15家养老机构的421名老年人。被调查养老机构老年人的两周患病率为28.57%,慢性病的患病率为52.09%,慢性病中患病率排前五位的分别是高血压、尘肺病、心脏病、脑血管疾病、糖尿病,两周患病就诊比例为76.36%,两周应就诊未就诊的比例为23.64%。慢性病住院率为42.21%,调查前一年内出现医生诊断需住院而未住院的比例为15.00%,应就诊未就诊或应住院而未住院的主要原因为经济原因、无有效措施、自感病轻。超过半数的老年人就诊住院选择综合性的二、三级医院。Logistic回归分析结果显示,婚姻状况、性别、经济来源、受教育程度影响养老机构老年人的卫生服务需要及利用。结论养老机构老年人卫生服务需要相对较低,卫生服务利用程度偏低,且利用的医疗机构流向存在着不合理现象。养老机构应加强重点老年人群卫生服务需要和利用的健康管理,不断完善养老机构医疗服务与保障体系,将养老机构医疗服务纳入医疗保障范围,并将养老机构纳入医联体、医共体建设体系中。此外,养老机构还应加强相关职业病的治疗和健康管理。

关键词：养老机构老年人卫生服务需要卫生服务利用

2012—2021年我国医疗卫生资源配置的空间差异与动态演变

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华南预防医学 2024年第3期50卷 205-210页

作者：王馨蝶夏英华曹蓉郭辉杰吴为何群南方医科大学公共卫生学院广东广州510515 广东省疾病预防控制中心广东省公共卫生研究院

目的分析我国医疗卫生资源配置的空间差异和动态演进情况。方法利用2012—2021年我国31个省份(直辖市、自治区)的医疗卫生资源数据,评价指标选取医疗卫生财力、物力、人力和服务资源的4项指标:人均卫生费用、每千人医疗卫生机构数、每... 详细信息

目的分析我国医疗卫生资源配置的空间差异和动态演进情况。方法利用2012—2021年我国31个省份(直辖市、自治区)的医疗卫生资源数据,评价指标选取医疗卫生财力、物力、人力和服务资源的4项指标:人均卫生费用、每千人医疗卫生机构数、每千人卫生技术人员数和医师每日担负诊疗人次数,使用全局熵值法计算各省历年配置水平指数,应用Dagum基尼系数和核密度估计方法分析我国医疗卫生资源配置水平的区域差异和动态演进特征。结果Dagum基尼系数结果显示,2012—2021年间我国医疗卫生资源配置水平基尼系数由0.1805上升至0.1972,后波动下降至0.1187。核密度估计结果显示,核密度曲线中心位置随年份的增加从0.2左右逐渐右移,稳定在0.3左右。结论我国医疗资源配置水平逐年提高,资源配置空间总体差距整体上逐年缩小。各地区仍存在不平衡的发展现状和差异化的资源配置水平,影响总体区域差距的主要因素是区域间差距。

关键词：资源配置水平空间差异动态演进 Dagum基尼系数核密度估计法

Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 485-498页

作者： Xiaocheng LI Yaqing XIAO Pengfei LI Yayun ZHU Yonghong guo huijie BIAN Zheng LI Laboratory for Functional Glycomics College of Life SciencesNorthwest UniversityXi’an 710069China National Translational Science Center for Molecular Medicine Department of Cell BiologyFourth Military Medical UniversityXi’an 710032China Medical Experiment Center Shaanxi University of Chinese MedicineXianyang 712046China The Infectious Disease Department Gongli HospitalPudong New AreaShanghai 200135China

End-stage liver diseases,such as cirrhosis and liver cancer caused by hepatitis B,are often combined with hepatic encephalopathy(HE);ammonia poisoning is posited as one of its main pathogenesis *** is closely related to autophagy,but the molecular mechanism of ammonia’s regulatory effect on autophagy in HE remains *** is an essential form of *** the nervous system,abnormal sialylation affects various physiological processes,such as neural development and synapse ***3 β-galactoside α2,3-sialyltransferase 6(ST3GAL6)is one of the significant glycosyltransferases responsible for addingα2,3-linked sialic acid to substrates and generating glycan *** found that the expression of ST3GAL6 was upregulated in the brains of mice with HE and in astrocytes after ammonia induction,and the expression levels of α2,3-sialylated glycans and autophagy-related proteins microtubule-associated protein light chain 3(LC3)and Beclin-1 were upregulated in ammonia-induced *** findings suggest that ST3GAL6 is related to autophagy in ***,we aimed to determine the regulatory relationship between ST3GAL6 and *** found that silencing ST3GAL6 and blocking or degrading α2,3-sialylated glycans by way of Maackia amurensis lectin-II(MAL-II)and neuraminidase can inhibit *** addition,silencing the expression of ST3GAL6 can downregulate the expression of heat shock proteinβ8(HSPB8)and Bcl2-associated athanogene 3(BAG3).Notably,the overexpression of HSPB8 partially restored the reduced autophagy levels caused by silencing ST3GAL6 *** results indicate that ST3GAL6 regulates autophagy through the HSPB8-BAG3 complex.

关键词： Hepatic encephalopathy Hyperammonemia Autophagy ST3β-galactosideα2,3-sialyltransferase 6(ST3GAL6) Heat shock proteinβ8(HSPB8)

Morphology of bacterial flora in root canals associated with apical abscesses

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Chinese Medical Journal 2014年第18期127卷 3254-3258页

作者： guo huijie Gao Chengzhi Zhang Chengfei Zheng Shuying Yue Lin Department of Stomatology People's Hospital Peking University Beijing 100044 China Electron Microscopy Labrotary (Zheng SY) People's Hospital Peking University Beijing 100044 China Electron Microscopy Labrotary People's Hospital Peking University Beijing 100044 China Comprehensive Dental Care Endodontics Faculty of DentistryUniversity of Hong Kong Hong Kong China Department of Cariology Endodontology and Operative DentistryPeking University School and Hospital of Stomatology Beijing100081 China

Background Apical abscess is an inflammatory process in the peri-radicular tissues caused by biofilms in the necrotic root canal systems. Therefore, a comprehensive analysis of the bacterial colonization is required for a better understanding of the pathogenesis. This study aimed to investigate the patterns of bacterial infection of root canals of teeth with apical abscesses and to determine whether histological and microbiological findings correlated with clinical conditions. Methods Eighteen samples from 18 teeth with apical pathological lesions were analyzed. Nine patients with acute apical abscesses experienced severe pain, and nine patients were asymptomatic with a sinus tract. After extraction, each affected root was divided into two halves. One half was processed for histobacteriologic analysis and examined using light microscopy, and the other half was analyzed using scanning electron microscopy （SEM） to determine the patterns of microbial colonization of the root canals. Results The appearance of each sample subjected to SEM was consistent with the histobacteriologic findings despite the presence or absence of clinical symptoms. Intraradicular biofilms comprising cocci, rods, and/or filaments of amorphous materials were observed in the apical third of the main root canals in all samples. The bacterial biofilms covering the main root canal walls also penetrated the dentinal tubules to varying depths. The morphologies of biofilms varied, and a unique pattern of intraradicular infection was not identified. Conclusion Intraradicular infections formed complex and variable multispecies biofilms and their presence did not correlate with clinical symptoms.

关键词： apical abscess biofilm clinical symptoms dentinal tubules endodontic infection

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卫星/伪卫星/惯性组合着舰导引算法

系统工程与电子技术 2017年第2期39卷 391-397页

作者：王玮郭慧杰孟跃北京航空航天大学仪器科学与光电工程学院北京100191

针对舰载机安全着舰对高精度、高可靠性着舰导引系统的迫切需求,研究了卫星/伪卫星/惯性组合着舰导引技术,基于几何精度因子(geometric dilution of precision,GDOP)计算提出了伪卫星在舰船上的布设方案,并设计了其导航电文结构。研究... 详细信息

针对舰载机安全着舰对高精度、高可靠性着舰导引系统的迫切需求,研究了卫星/伪卫星/惯性组合着舰导引技术,基于几何精度因子(geometric dilution of precision,GDOP)计算提出了伪卫星在舰船上的布设方案,并设计了其导航电文结构。研究了卫星/伪卫星/惯性组合着舰导引算法,利用卫星及伪卫星的双差分载波相位信息,采用改进的模糊度最小二乘去相关平差(least-squares ambiguity decorrelation adjustment,LAMBDA)迭代算法解算其双差分整周模糊度,并基于舰载机运动模型建立滤波方程解算出舰机相对运动信息,再与惯导数据进行信息融合得到高精度的导引信息。仿真结果表明,提出的卫星/伪卫星/惯性着舰导引技术横向定位误差在0.3m以内,纵向定位误差在0.1m以内,高度定位误差在0.3m以内,可以满足舰载机着舰的要求,与卫星/惯性组合导引相比,该组合方式大大提高了垂直方向的定位精度,这对于确保安全着舰极为重要。并且,提出的着舰导引技术不仅精度高,而且工作连续可靠、抗干扰能力强,对保障舰载机着舰安全有重要的意义。

关键词：卫星导航伪卫星惯性导航系统组合导航着舰导引

Autophagy Alleviates Cold Exposure-induced Tight Junction Injury in Murine Ileum

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Biomedical and Environmental Sciences 2024年第7期37卷 800-804页

作者： Jingru guo Jing Xu Leichong Chen huijie Hu Junshu Nie Jianbin Yuan Li Ma Jingjing Lu Hong Ji Bin Xu Key Laboratory of Bovine Disease Control in Northeast China Ministry of Agriculture and Rural affairsHeilongjiang Provincial Key Laboratory of Prevention and Control of Bovine DiseasesCollege of Animal Science and Veterinary MedicineHeilongjiang Bayi Agricultural UniversityDaqing 163319HeilongjiangChina

Cold exposure is a pervasive stressor in the polar and subpolar regions,exerting both acute and chronic effects on *** environmental factor is known to induce physiological stress,compromise immune response efficacy,and increase susceptibility to various *** cold exposure,characterized by repetitive nonconsecutive exposure to suboptimal temperatures over an extended duration.

关键词： acute exposure susceptibility

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一种增强型虹膜图像质量评价算法

光电子技术 2019年第1期39卷 26-29页

作者：郭慧杰北京无线电计量测试研究所北京100854

提出了一种增强型虹膜图像质量评价算法,针对远距离移动中虹膜识别系统采集的受干扰虹膜图像,通过量化单帧图像感兴趣区域的清晰度、可用度和对比度等质量指标,计算序列图像的联合加权质量得分,对虹膜图像序列的可用性进行评价,有效筛... 详细信息

提出了一种增强型虹膜图像质量评价算法,针对远距离移动中虹膜识别系统采集的受干扰虹膜图像,通过量化单帧图像感兴趣区域的清晰度、可用度和对比度等质量指标,计算序列图像的联合加权质量得分,对虹膜图像序列的可用性进行评价,有效筛除获取的低质虹膜图像序列。实验表明,该算法提升了虹膜识别系统图像质量评价的准确性和可靠性,从而能有效提升系统的鲁棒性和识别效率。

关键词：虹膜识别质量评价序列图像质量得分