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Evaluating quality of motion for unsupervised video object segmentation

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Optoelectronics Letters 2024年第6期20卷 379-384页

作者： CHENG Guanjun SONG huihui Jiangsu Key Laboratory of Big Data Analysis Technology Jiangsu Collaborative Innovation Center on Atmospheric Environment and Equipment TechnologyNanjing University of Information Science&TechnologyNanjing 210044China12

Current mainstream unsupervised video object segmentation(UVOS) approaches typically incorporate optical flow as motion information to locate the primary objects in coherent video frames. However, they fuse appearance and motion information without evaluating the quality of the optical flow. When poor-quality optical flow is used for the interaction with the appearance information, it introduces significant noise and leads to a decline in overall performance. To alleviate this issue, we first employ a quality evaluation module(QEM) to evaluate the optical flow. Then, we select high-quality optical flow as motion cues to fuse with the appearance information, which can prevent poor-quality optical flow from diverting the network's attention. Moreover, we design an appearance-guided fusion module(AGFM) to better integrate appearance and motion information. Extensive experiments on several widely utilized datasets, including DAVIS-16, FBMS-59, and You Tube-Objects, demonstrate that the proposed method outperforms existing methods.

关键词： Evaluating quality of motion for unsupervised video object segmentation

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Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 1-37页

作者： Yu Huang Hui Fan huihui Ti School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Province Precise Medicine Big Date of Traditional Chinese Medicine Engineering Technology Research Center Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

With the rapid development of the fields of tumor biology and immunology, tumor immunotherapy has been used in clinical practice and has demonstrated significant therapeutic potential, particularly for treating tumors that do not respond to standard treatment options. Despite its advances, immunotherapy still has limitations, such as poor clinical response rates and differences in individual patient responses, largely because tumor tissues have strong immunosuppressive microenvironments. Many tumors have a tumor microenvironment (TME) that is characterized by hypoxia, low pH, and substantial numbers of immunosuppressive cells, and these are the main factors limiting the efficacy of antitumor immunotherapy. The TME is crucial to the occurrence, growth, and metastasis of tumors. Therefore, numerous studies have been devoted to improving the effects of immunotherapy by remodeling the TME. Effective regulation of the TME and reversal of immunosuppressive conditions are effective strategies for improving tumor immunotherapy. The use of multidrug combinations to improve the TME is an efficient way to enhance antitumor immune efficacy. However, the inability to effectively target drugs decreases therapeutic effects and causes toxic side effects. Nanodrug delivery carriers have the advantageous ability to enhance drug bioavailability and improve drug targeting. Importantly, they can also regulate the TME and deliver large or small therapeutic molecules to decrease the inhibitory effect of the TME on immune cells. Therefore, nanomedicine has great potential for reprogramming immunosuppressive microenvironments and represents a new immunotherapeutic strategy. Therefore, this article reviews strategies for improving the TME and summarizes research on synergistic nanomedicine approaches that enhance the efficacy of tumor immunotherapy.

关键词： Tumor immunotherapy Tumor micr oenvir onment Nanomedicine Tumor repr ogramming

Product quality prediction based on RBF optimized by firefly algorithm

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Journal of Systems Engineering and Electronics 2024年第1期35卷 105-117页

作者： HAN huihui WANG Jian CHEN Sen YAN Manting College of Electronics and Information Engineering Tongji UniversityShanghai 201804China

With the development of information technology,a large number of product quality data in the entire manufacturing process is accumulated,but it is not explored and used effectively.The traditional product quality prediction models have many disadvantages,such as high complexity and low accuracy.To overcome the above problems,we propose an optimized data equalization method to pre-process dataset and design a simple but effective product quality prediction model:radial basis function model optimized by the firefly algorithm with Levy flight mechanism(RBFFALM).First,the new data equalization method is introduced to pre-process the dataset,which reduces the dimension of the data,removes redundant features,and improves the data distribution.Then the RBFFALFM is used to predict product quality.Comprehensive expe riments conducted on real-world product quality datasets validate that the new model RBFFALFM combining with the new data pre-processing method outperforms other previous me thods on predicting product quality.

关键词： product quality prediction data pre-processing radial basis function swarm intelligence optimization algorithm

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Parametric Optimization of Wheel Spoke Structure for Drag Reduction of an Ahmed Body

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 955-975页

作者： huihui Zhai Dongqi Jiao Haichao Zhou Institute of Electrical and Information Engineering Zhenjiang CollegeZhenjiang212028China School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang212013China

The wheels have a considerable influence on the aerodynamic properties and can contribute up to 25%of the total drag on modern vehicles.In this study,the effect of the wheel spoke structure on the aerodynamic performance of the isolated wheel is investigated.Subsequently,the 35°Ahmed body with an optimized spoke structure is used to analyze the flow behavior and the mechanism of drag reduction.The Fluent software is employed for this investigation,with an inlet velocity of 40 m/s.The accuracy of the numerical study is validated by comparing it with experimental results obtained from the classical Ahmed model.To gain a clearer understanding of the effects of the wheel spoke parameters on the aerodynamics of both the wheel and Ahmedmodel,and five design variables are proposed:the fillet angleα,the inside arc radius R1,the outside radius R2,and the same length of the chord L1 and L2.These variables characterize the wheel spoke structure.The Optimal Latin Hypercube designmethod is utilized to conduct the experimental design.Based on the simulation results of various wheel spoke designs,the Kriging model and the adaptive simulated annealing algorithm is selected to optimize the design parameters.The objective is to achieve the best combination for maximum drag reduction.It is indicated that the optimized spoke structure resulted in amaximum drag reduction of 5.7%and 4.7%for the drag coefficient of the isolated wheel and Ahmed body,respectively.The drag reduction is primarily attributed to changes in the flow state around the wheel,which suppressed separation bubbles.Additionally,it influenced the boundary layer thickness around the car body and reduced the turbulent kinetic energy in the wake flow.These effects collectively contributed to the observed drag reduction.

关键词： Ahmed body wheel spoke design parameter optimization drag reduction numerical simulation

Surface defect engineered-Mg-based implants enable the dual functions of superhydrophobic and synergetic photothermal/chemodynamic therapy

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Bioactive Materials 2023年第12期30卷 15-28页

作者： Dongdong Zhang Ru Xu Shuhan Chen huihui du Shi Qian Feng Peng Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhenChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055PR China Medical Research Institute Department of OrthopedicsGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern MedicalUniversityGuangzhou510080China GuangDong Engineering Technology Research Center of Functional Repair of Bone Defects and Biomaterials Guangzhou510080China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou310024China

Promoting metallic magnesium(Mg)-based implants to treat bone diseases in clinics,such as osteosarcoma and bacterial infection,remains a challenging topic.Herein,an iron hydroxide-based composite coating with a twostage nanosheet-like structure was fabricated on Mg alloy,and this was followed by a thermal reduction treatment to break some of the surface Fe–OH bonds.The coating demonstrated three positive changes in properties due to the defects.First,the removal of–OH made the coating superhydrophobic,and it had self-cleaning and antifouling properties.This is beneficial for keeping the implants clean and for anti-corrosion before implantation into the human body.Furthermore,the superhydrophobicity could be removed by immersing the implant in a 75%ethanol solution,to further facilitate biological action during service.Second,the color of the coating changed from yellow to brown-black,leading to an increase in the light absorption,which resulted in an excellent photothermal effect.Third,the defects increased the Fe2+content in the coating and highly improved peroxidase activity.Thus,the defect coating exhibited synergistic photothermal/chemodynamic therapeutic effects for bacteria and tumors.Moreover,the coating substantially enhanced the anti-corrosion and biocompatibility of the Mg alloys.Therefore,this study offers a novel multi-functional Mg-based implant for osteosarcoma therapy.

关键词： Magnesium-based implants Surface defects Superhydrophobic Anti-bacterial Anti-tumor

High success rate of fiberscope-monitored intubation via a supraglottic airway device BlockBusterTMin good device positioning: A prospective observational study

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中华医学杂志(英文版) 2024年第7期137卷 871-873页

作者： Hu Zhenfa Su Kai Miao huihui Gao Xue Xue Fushan Tian Ming Department of Anesthesiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Beijing Shijitan Hospital Beijing 100038

Deletion of the waaf gene affects O antigen synthesis and pathogenicity in Vibrio parahaemolyticus from shellfish

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Food Science and Human Wellness 2022年第2期11卷 418-426页

作者： Feng Zhao Guoying Ding Qilong Wang huihui du Guosheng Xiao Deqing Zhou College of biology and food engineering Chongqing Three Gorges UniversityWanzhou 404100China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesLaboratory for Marine Drugs and Bioproducts of Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China

Vibrio parahaemolyticus is the main cause of foodborne gastroenteritis,which is widely distributed in shellfish and other seafood.Most V.parahaemolyticus are nonpathogenic,and only a few types,such as serotype O3:K6,are pathogenic,which is also the most prevalent strain in Asia.However,the relationship between this serotype and pathogenicity has yet to be established.The waaf gene is located in the O antigen synthesis gene cluster.Thus,we constructed a waaf gene deletion mutant(i.e.,Δwaaf)of wild-type(WT)which isolated from shellfish serotype O3:K6 via chitin-mediated transformation technology.We then constructed theΔwaaf complementary strain(i.e.,C-△waaf)via the Escherichia coli S17λpir strain by conjugation.The basic physiological characteristics,adhesion to Caco2 cells,and pathogenicity of the WT,△waaf,and C-△waaf strains were compared.Growth curves showed no remarkable differences between the WT andΔwaaf strains.However,theΔwaaf strain non-reactive to O3 antisera and other 12 O-group antisera of V.parahaemolyticus.Moreover,the number of flgella and extracellular polysaccharides decreased,the adhesion decreased,and the pathogenicity weakened.These characteristics of the C-△waaf strain were similar to those of the WT strain These results indicated that the waaf gene is vital to the serotype in V.parahaemolyticus,and changes in O antigen could affect the pathogenicity of this bacterium.This study will be helpful to understand the pathogenic mechanism of V.parahaemolyticus.

关键词： Vibrio parahaemolyticus waaf gene LPS O antigen Pathogenicity

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Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy

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Journal of Materials Science & Technology 2023年第7期138卷 203-213页

作者： huihui du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan Shuhan Chen Feng Peng Shi Qian Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Medical Research Center Department of OrthopedicsGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Cixi Center of Biomaterials Surface Engineering Ningbo 315300China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou 310024China

Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS.

关键词： Mg alloy Fe_(3)O_(4)nanosheets Photothermal effect Chemodynamic therapy Antitumor

Accelerated reconstruction of ZIF-67 with significantly enhanced glucose detection sensitivity

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Nano Research 2024年第6期17卷 4737-4743页

作者： huihui Jin Weihao Zeng Wei Qian Lun Li Pengxia Ji Zhengying Li Daping He School of Information Engineering Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Research on metal-organic framework(MOF)-based non-enzymatic glucose sensors usually ignores the impact of the surface reconstruction degree of MOF on the activity of catalyzing glucose oxidation.In this work,we choose zeolitic imidazolate framework-67(ZIF-67),which is commonly used in glucose sensing,as a representative to investigate the influence of reconstruction degree on its structure and glucose catalytic performance.By employing the electrochemical activation strategy,the activity of ZIF-67 in catalyzing glucose gradually increased with the prolongation of the activation time,reaching the optimum after 2 h activation.The detection sensitivity of the activated ZIF-67 was 19 times higher than that of the initial ZIF-67,and the limit of detection(LOD)was lowered from 7 to 0.4μM.Our findings demonstrate that the oxidation degree of ZIF-67 deepened rapidly with continuously activation and was basically reconstructed to CoOOH after 2 h activation,accompanied by a morphological change from cuboctahedral to flower-like.Simultaneously,theoretical investigation revealed that ZIF-67 is not suitable as a stable glucose sensor electrode since the adsorbed glucose molecules hasten the dissociation of ligands and the breaking of Co-N bond in ZIF-67.Therefore,our work has important implications for the rational design of next-generation MOF-based glucose sensors.

关键词： zeolitic imidazolate framework-67(ZIF-67) glucose oxidation electrochemical activation reconstruction CoOOH