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Trends of Mortality in End-Stage Liver Disease—China,2008–2020

China CDC weekly 2023年第30期5卷 657-663,I0001-I0009页

作者： Xiaoxiao Wang huixin liu Jinlei Qi Fangfang Zeng Lijun Wang Peng Yin Feng liu Hongbo Li Yunning liu Jiangmei liu Lai Wei Xiaofeng Liang Yu Wang Huiying Rao Maigeng Zhou Peking University People’s Hospital Peking University Hepatology InstituteBeijingChina Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases Beijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina Peking University People’s Hospital Department of Clinical Epidemiology and BiostatisticsBeijingChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhou CityGuangdong ProvinceChina Disease Control and Prevention Institute of Jinan University Guangzhou CityGuangdong ProvinceChina Jinan University-BioKangtai Vaccine Institute Jinan UniversityGuangzhou CityGuangdong ProvinceChina China Center for Economic Research National School of DevelopmentPeking UniversityBeijingChina Beijing Tsinghua Changgung Hospital Tsinghua UniversityBeijingChina Chinese Foundation for Hepatitis Prevention and Control BeijingChina.

Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics.

关键词： prevention stratified burden

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Horizontal structure of convergent wind shear associated with sporadic E layers over East Asia

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Earth and Planetary Physics 2023年第5期7卷 548-557页

作者： LiHui Qiu Xian Lu Tao Yu Yosuke Yamazaki huixin liu Yang-Yi Sun HaoNan Wu XiaoMin Zuo XiangXiang Yan Yan Yu YiFan Qi Institute of Geophysics&Geomatics China University of GeosciencesWuhan 430074China Department of Physics and Astronomy Clemson UniversityClemsonSC 29631USA Leibniz institute of Atmospheric Physics at the University of Rostock 18225 KühlungsbornGermany Department of Earth and Planetary Sciences Kyushu UniversityFukuoka 8190395Japan School of Mathematics and Physics China University of GeosciencesWuhan 430074China

At present,the main detection instruments for observing sporadic E(Es)layers are ground-based radars,dense networks of ground-based global navigation satellite system(GNSS)receivers,and GNSS radio occultation,but they cannot capture the whole picture of the horizontal structure of Es layers.This study employs the Whole Atmosphere Community Climate Model with thermosphere and ionosphere eXtension model(WACCM-X 2.1)to derive the horizontal structure of the ion convergence region(HSICR)to explore the shapes of the large-scale Es layers over East Asia for the period from June 1 to August 31,2008.The simulation produced the various shapes of the HSICRs elongated in the northwest-southeast,northeast-southwest,or composed of individual small patches.The close connection between Es layer critical frequency(foEs)and vertical ion convergence indicates that the HSICR is a good candidate for revealing and explaining the horizontal structure of the large-scale Es layers.

关键词： sporadic E layer horizontal structure wind shear WACCM-X model

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Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1194-1201页

作者： Xiaoying Zhang Miao Miao Ruijun Zhang Xu liu Xiaozhen Zhao Miao Shao Tian liu Yuebo Jin Jiali Chen huixin liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li Department of Rheumatology and Immunology Peking University People’s Hospital100044 BeijingChina Department of Rheumatology and Immunology The First Affiliated Hospital of Wannan Medical College241000 WuhuAnhuiChina Department of Clinical Epidemiology and Biostatistics Peking University People’s Hospital100044 BeijingChina Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis(BZ0135) BeijingChina Peking-Tsinghua Center for Life Sciences BeijingChina State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina

Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504.

关键词： patients placebo methotrexate

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基于校准窗口集成与耦合市场特征的可解释双层日前电价预测

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中国电机工程学报 2024年第4期44卷 1272-1285,I0003页

作者：刘慧鑫沈晓东魏泽涛刘友波刘俊勇白元宝四川大学电气工程学院四川省成都市610065 四川能投综合能源公司四川省成都市611130

随着电力市场之间耦合程度不断加深,只局限于单个市场内部的传统特征集不足以支撑高精度预测的需求。而且模型预测性能对校准窗口的选择敏感,而传统电价预测仅使用一个固定时间长度的数据集,同时预测模型的“黑盒”结构导致预测结果在... 详细信息

随着电力市场之间耦合程度不断加深,只局限于单个市场内部的传统特征集不足以支撑高精度预测的需求。而且模型预测性能对校准窗口的选择敏感,而传统电价预测仅使用一个固定时间长度的数据集,同时预测模型的“黑盒”结构导致预测结果在工程应用中可信度偏低。针对上述问题,该文提出一种考虑校准窗口集成与耦合市场特征的可解释双层日前电价预测框架。内层框架为基于改进自适应噪声完备集合经验模态分解(improved complete ensemble empirical mode decomposition,ICEEMDAN)的择优预测,首先分解原始电价序列,然后应用Lasso估计回归(lassoestimated autoregressive,LEAR)、长期和短期时间序列网络(long-term and short-term time-series networks,LSTNet)、卷积神经网络-长短记忆神经网络(convolutionalneuralnetworks-longshort termmemory,CNN-LSTM)、移动平均(autoregressive integrated moving average,ARIMA)和核极限学习机(kernel extreme learning machines,KELM)模型预测子序列并选择最优预测算法。外层框架为基于贝叶斯模型平均(bayes modelaveraging,BMA)的校准窗口集成预测,针对每个不同校准窗口长度数据集下的预测分配权重并集成得到预测电价。最后,通过可解释方法沙普利加性解释模型(shapley additiveexplanations,SHAP)分析耦合市场特征如何影响预测电价。该文通过北欧电力市场数据集的算例分析证明了所提算法的优越性和校准窗口集成方案的有效性。

关键词：校准窗口集成耦合市场特征双层预测框架改进自适应噪声完备集合经验模态分解(ICEEMDAN) 贝叶斯模型平均(BMA) 沙普利加性解释模型(SHAP)

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热机械处理对Al-Cu-Mg合金显微组织和力学性能的调控机理

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中国有色金属学报 2024年第1期34卷 50-62页

作者：王琮琳刘辉新郑亚亚王昆陈志国中南大学材料科学与工程学院长沙410083 湖南人文科技学院材料工程系娄底417000

采用X射线衍射仪(XRD)、透射电子显微镜(TEM)、拉伸力学性能测试以及疲劳裂纹扩展速率测试等手段探究热机械处理工艺对Al-Cu-Mg合金显微组织及宏观性能的影响。结果表明:热机械处理工艺可以使Al-Cu-Mg合金获得良好的强塑性配合,其中,采... 详细信息

采用X射线衍射仪(XRD)、透射电子显微镜(TEM)、拉伸力学性能测试以及疲劳裂纹扩展速率测试等手段探究热机械处理工艺对Al-Cu-Mg合金显微组织及宏观性能的影响。结果表明:热机械处理工艺可以使Al-Cu-Mg合金获得良好的强塑性配合,其中,采用25%变形量的固溶热轧+30%变形量的深冷非对称轧制(1.2异速比)+100℃、6 h的人工时效处理时,Al-Cu-Mg合金的伸长率可达10.1%;抗拉强度和屈服强度达到了517.2和448.3 MPa,分别比常规T6态的Al-Cu-Mg合金高74.8和98.6 MPa。热机械处理工艺使合金中出现大量位错缠结及细小S析出相,高强度的Goss织构和大量剪切织构通过影响疲劳裂纹的偏折提升合金的疲劳性能。

关键词： Al-Cu-Mg合金热机械处理拉伸力学性能显微组织疲劳裂纹扩展速率

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淀粉基气凝胶的制备、改性与应用

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中国食品学报 2024年第1期24卷 455-465页

作者：卢慧馨钟成鹏罗舜菁叶江平刘成梅南昌大学食品学院南昌330047

淀粉基气凝胶是一种密度低、比表面积大、孔隙率高的三维多孔网络新型轻质材料。淀粉基气凝胶的制备过程简单、清洁,是将淀粉糊化和回生制备水凝胶后脱水干燥而得。本文探讨影响气凝胶性能的主要因素,如淀粉来源、淀粉浓度、糊化温度、... 详细信息

淀粉基气凝胶是一种密度低、比表面积大、孔隙率高的三维多孔网络新型轻质材料。淀粉基气凝胶的制备过程简单、清洁,是将淀粉糊化和回生制备水凝胶后脱水干燥而得。本文探讨影响气凝胶性能的主要因素,如淀粉来源、淀粉浓度、糊化温度、回生条件和干燥方式。阐述淀粉基气凝胶的改性方法,如交联处理、复合改性、表面涂层等,以及改性后淀粉基气凝胶的应用。目前有关淀粉基气凝胶的应用研究主要围绕食品营养和生物医药方面,其在隔热材料、环境污染处理等领域存在应用潜力。本文对构建高品质的淀粉基气凝胶,拓展其应用具有重要意义。

关键词：淀粉气凝胶生物基制备改性应用

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电热应力对硅油产气特性协同效应的实验研究

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高压电器 2024年第1期60卷 100-107,117页

作者：连鸿松郑东升刘慧鑫赖永华李长云国网福建省电力有限公司电力科学研究院福州350007 山东省科技大学山东青岛266590

实验室中常采用加速老化方法获得硅油的老化试样,并根据试样中溶解气体组分及体积分数判断硅绝缘油的老化状态,但当前实验中仅能施加热应力或电应力,不能较好地反映硅油的真实工况。为解决这这一问题,文中开展了电热应力对硅油产气特性... 详细信息

实验室中常采用加速老化方法获得硅油的老化试样,并根据试样中溶解气体组分及体积分数判断硅绝缘油的老化状态,但当前实验中仅能施加热应力或电应力,不能较好地反映硅油的真实工况。为解决这这一问题,文中开展了电热应力对硅油产气特性协同效应的实验研究。文中针对PMX-200型硅油,在200℃、25 kV下设计了硅油的热电老化、电热老化和电热联合老化等3组加速老化实验,通过对试样中的气体组分及体积分数分析,发现热电老化方式与电热联合老化方式下试样中溶解气体组分及体积分数最为接近,误差在7.41%~16.86%之间。文中结果表明实验中可用热电老化方式模拟硅油的实际老化条件。同时,文中结合ReaxFF力场,从原子水平上分析了硅油的热老化及电热老化机理。文中所得结论可为硅油的加速老化实验提供理论基础。

关键词：电硅绝缘油热电联合老化产气特征协同效应

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Prevalence and risk evaluation of cardiovascular disease in the newly diagnosed prostate cancer population in China: A nationwide, multi-center, population-based cross-sectional study

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中华医学杂志(英文版) 2024年第11期137卷 2024 Apr 12页

作者： Zhang Weiyu liu huixin liu Ming Ying Shi Yuan Renbin Zeng Hao Zhang Zhenting Han Sujun Si Zhannan Hu Bin Wen Simeng Xu Pengcheng Yu Weimin Chen Hui Wang Liang Lin Zhitao Dai Tao Lin Yunzhi Xu Tao Hospital Tianjin China Department of Urology Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China National Cancer Center Beijing China National Clinical Research Center for Cancer Beijing China Department of Urology Liaoning Cancer Hospital Shenyang Liaoning China Department of Urology The Second Hospital of Tianjin Medical University Tianjin China Tianjin Institute of Urology Tianjin Medical University Tianjin China Department of Urology Lu’an Affiliated Hospital of Anhui Medical University Lu’an Anhui China Department of Urology Renmin Hospital of Wuhan University Wuhan Hubei China Department of Urology Harbin Medical University Affiliated Cancer Hospital Harbin Heilongjiang China Department of Urology Peking University People’s Hospital Beijing China Department of Urology The Second Hospital of Dalian Medical University Dalian Liaoning China Department of Urology Surgery Fujian Cancer Hospital Fuzhou Fujian China Department of Urology Surgery Hunan Cancer Hospital Changsha Hunan China Department of Urology Surgery The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian China Department of Clinical Epidemiology and Biostatistics Peking University People’s Hospital Beijing China Department of Urology Beijing Hospital National Center of Gerontology Beijing China Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China Department of Urology Wuhan Union Hospital Huazhong University of Science &amp Technology Wuhan Hubei China Department of Urology The Third People’s Hospital of Chengdu Chengdu Sichuan China Department of Urology West China Hospital of Sichuan University Chengdu Sichuan China Department of Urologic Oncology Tianjin Medical University Cancer Institute &amp

Background: Cardiovascular disease (CVD) has emerged as the leading cause of death from prostate cancer (PCa) in recent decades, bringing a great disease burden worldwide. Men with preexisting CVD have an increased risk for major adverse cardiovascular events when treated with androgen deprivation therapy (ADT). The present study aimed to explore the prevalence and risk evaluation of CVD among people with newly diagnosed PCa in China.Methods: Clinical data of newly diagnosed PCa patients were retrospectively collected from 34 centers in China from 2010 to 2022 through convenience sampling. CVD was defined as myocardial infarction, arrhythmia, heart failure, stroke, ischemic heart disease, and others. CVD risk was estimated by calculating Framingham risk scores (FRS). Patients were accordingly divided into low-, medium-, and high-risk groups.χ2 or Fisher’s exact test was used for comparison of categorical variables.Results: A total of 4253 patients were enrolled in the present study. A total of 27.0% (1147/4253) of patients had comorbid PCa and CVD, and 7.2% (307/4253) had two or more CVDs. The enrolled population was distributed in six regions of China, and approximately 71.0% (3019/4253) of patients lived in urban areas. With imaging and pathological evaluation, most PCa patients were diagnosed at an advanced stage, with 20.5% (871/4253) locally progressing and 20.5% (871/4253) showing metastasis. Most of them initiated prostatectomy (46.6%, 1983/4253) or regimens involving ADT therapy (45.7%, 1944/4253) for prostate cancer. In the present PCa cohort, 43.1% (1832/4253) of patients had hypertension, and half of them had poorly controlled blood pressure. With FRS stratification, as expected, a higher risk of CVD was related to aging and metabolic disturbance. However, we also found that patients with treatment involving ADT presented an originally higher risk of CVD than those without ADT. This was in accordance with clinical practice, i.e., aged patients or patients at advanced oncological stages were inclined to

关键词： Prostate cancer Castration Cardiovascular disease Prevalence Cardiovascular risk

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超、特高压交流线路反时限零序过流后备保护的整定建议

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电力自动化设备 2024年第1期44卷 217-224页

作者：刘阳陈祥文王玉龙李会新李勇王英英国家电网有限公司华中分部湖北武汉430077 柳焕章劳模创新工作室湖北武汉430077 南京南瑞继保电气有限公司江苏南京211102

针对国家电网“六统一”线路保护装置,提出了超、特高压交流线路反时限零序过流保护的整定原则。反时限零序过流保护在保证灵敏性方面并无困难,整定原则的核心问题是解决选择性和速动性的矛盾。根据该保护的原理和逻辑提出了转折电流的... 详细信息

针对国家电网“六统一”线路保护装置,提出了超、特高压交流线路反时限零序过流保护的整定原则。反时限零序过流保护在保证灵敏性方面并无困难,整定原则的核心问题是解决选择性和速动性的矛盾。根据该保护的原理和逻辑提出了转折电流的概念以及接地距离保护与反时限零序过流保护的配合原则;充分考虑配合时间定值和最小时间定值对保护动作特性的影响,综合超、特高压电网实际短路电流水平和接地距离保护的过渡电阻耐受能力,将反时限零序过流保护低电流区的选择性与接地距离保护高电流区的选择性进行结合,提升了对接地故障全域电流范围的选择性切除能力;提出了方向元件投退原则。通过对某省级电网进行算例分析,验证了整定原则的有效性,该整定原则已经在实际电网中进行了应用。

关键词：反时限零序过流保护定时限零序过流保护继电保护高阻接地故障超、特高压交流线路选择性速动性整定原则

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Pregnancy outcomes after fertility preservation in women with endometrial carcinoma and atypical endometrial hyperplasia:A systematic review and meta-analysis

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 190-196页

作者： Zerui Xiao Ziyi Song Jianliu Wang huixin liu Qun Lu Department of Obstetrics and Gynecology Peking University People’s HospitalChina Department of Clinical Epidemiology Peking University People's HospitalChina

Objective:The objective of the study was to compare the effects of assisted reproductive technology(ART)and spontaneous pregnancy on pregnancy outcomes in women with endometrial carcinoma(EC)and atypical endometrial hyperplasia(AEH)following fertility-sparing treatments.Methods:Relevant studies published through July 2020 were identified from PubMed and Web of Science literature searches.The pregnancy outcomes of ART and spontaneous pregnancy were summarized and compared for women with complete remission of EC/AEH after fertility-sparing treatments.A subgroup analysis was performed based on whether patients had received in vitro fertilization and embryo transfer(IVF-ET)treatment.The complete remission and recurrence rates of EC/AEH following fertility-sparing treatments were estimated.The effect of pregnancy on recurrence rates of EC/AEH was also calculated.Results:Sixteen observational studies reporting pregnancy outcomes or recurrence with ART or spontaneous pregnancy for women with EC/AEH after fertility-sparing treatments were included.The complete remission rate of EC/AEH was 81.5%(95%CI,78%–85%).Compared with spontaneous pregnancy,the pregnancy rate of ART was significantly higher(66.8%vs.43.7%,OR=2.64,95%CI 1.71–4.05,P<0.00001,I^(2)=14%).Subgroup analysis showed that the pregnancy rate of IVF-ET was significantly higher than that of spontaneous pregnancy(62.7%vs.35.1%,OR=2.85,95%CI 1.44-5.63,P=0.003,I^(2)=29%).The live birth rate of ART was significantly higher than that of spontaneous pregnancy(75.3%vs.47.8%,OR=3.96,95%CI1.76-8.77,P=0.0009,I^(2)=45%).The recurrence rate of EC/AEH was 31%(95%CI 24%–39%).Clinical pregnancy could reduce the recurrence rate of EC/AEH,but there was no significant evidence of an association.Conclusions:ART,especially IVF-ET,could significantly improve pregnancy outcomes in women with EC/AEH receiving fertility-sparing treatments.Following complete remission,ART treatment might be a better option for women with EC/AEH than spontaneous pregnancy.

关键词： Endometrial carcinoma Atypical endometrial hyperplasia Fertility sparing treatment Assisted reproductive technology In vitro fertilization and embryo transfer

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