检索结果-南通市图书馆

Relationships between the North Pacific Oscillation and the typhoon/hurricane frequencies

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2007年第9期50卷 1409-1416页

作者： WANG huijun sun JianQi FAN Ke Institute of Atmospheric Physics (IAP) Chinese Academy of Sciences Beijing 100029 China Institute of Atmospheric Physics (IAP) Chinese Academy of Sciences Beijing 100029 China Institute of Atmospheric Physics (IAP) Chinese Academy of Sciences Beijing 100029 China

Relationships between the North Pacific Oscillation (NPO) and the typhoon as well as hurricane fre-quencies are documented. The correlation between NPO index in June-July-August-September and the annual typhoon number in the western North Pacific is 0.37 for the period of 1949―1998. The NPO is correlated with the annual hurricane number in the tropical Atlantic at -0.28 for the same period. The variability of NPO is found to be concurrent with the changes of the magnitude of vertical zonal wind shear, sea-level pressure patterns, as well as the sea surface temperature, which are physically asso- ciated with the typhoons and hurricanes genesis. The NPO associated atmospheric circulation vari- ability is analyzed to explain how NPO is linked with variability of the tropical atmospheric circulation in the western Pacific and the tropical Atlantic, via the atmospheric teleconnection.

关键词： Western North Pacific Typhoon, tropical Atlantic hurricane, North Pacific oscillation, typhoon/hurricane frequency

Topological-based bottleneck analysis and improvement strategies for traffic networks

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2009年第10期52卷 2814-2822页

作者： JianJun Wu ZiYou Gao huijun sun State Key Laboratory of Rail Traffic Control and Safety (Beijing Jiaotong University) Beijing 100044 China School of Traffic and Transportation Beijing Jiaotong University Beijing 100044 China MOE Key Laboratory for Urban Transportation Complex Systems Theory and Technology Beijing Jiaotong University Beijing 100044 China

A method is proposed to find key components of traffic networks with homogenous and heterogeneous topologies, in which heavier traffic flow is transported. One component, called the skeleton, is the minimum spanning tree (MST) based on the zero flow cost (ZCMST). The other component is the infinite incipient percolation cluster (IIC) which represents the spine of the traffic network. Then, a new method to analysis the property of the bottleneck in a large scale traffic network is given from a macroscopic and statistical viewpoint. Moreover, three effective strategies are proposed to alleviate traffic congestion. The significance of the findings is that one can significantly improve the global transport by enhancing the capacity in the ZCMST with a few links, while for improving the local traffic property, improving a tiny fraction of the traffic network in the IIC is effective. The result can be used to help traffic managers prevent and alleviate traffic congestion in time, guard against the formation of congestion bottleneck, and make appropriate policies for traffic demand management. Meanwhile, the method has very important theoretical significance and practical worthiness in optimizing traffic organization, traffic control, and disposal of emergency.

关键词： traffic congestion user equilibrium assignment heterogeneous and homogenous networks

Equilibrium model and algorithm of urban transit assignment based on augmented network

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2009年第11期52卷 3158-3167页

作者： SI BingFeng ZHONG Ming sun huijun GAO ZiYou Institute of System Science School of Traffic and TransportationBeijing Jiaotong UniversityBeijing 100044China Department of Civil Engineering University of New BrunswickFrederictonN.B.E3B 5A3Canada

The passenger flow assignment problem for the urban transit network is relatively complicated due to the complexity of the network structure and many factors influencing the passengers' route and line choices. In the past three decades, many models have been proposed to solve the passenger flow assignment problem. However, the common-line problem remains challenging in transit flow assignment. In this paper, the characteristics of the urban transit network is analysed and a new technique of augmented network is proposed to represent the urban transit system. The purpose is to eliminate the complex common-line problem when modeling transit passenger flow assignment. Through this augmentation technique, the urban transit system can be represented by an augmented network-it then behaves like a simple network and can be used as a generalized network for traffic assignment or network analysis. This paper presents a user equilibrium model for the urban transit assignment problem based on such a technique. A numerical example is also provided to illustrate the approach.

关键词： transit network flow assignment user equilibrium algorithm

Collaborative matching of ridesplitting and connection in the ridesourcing market

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2021年第5期1卷 517-533页

作者： Yafei Li huijun sun Ying Lv Key Laboratory of Transport Industry of Big Data Application Technologies for Comprehensive Transport Beijing Jiaotong UniversityMinistry of TransportBeijing 100044China

The emergence of ridesplitting as a form of ridesourcing reduces the use of vehicles on the *** connecting multiple ridesplitting orders and single orders to the sharing path,it can achieve higher sharing *** paper aims to further improve the vehicle sharing rate,and explore the impact of multi-mode sharing using the order data of Haikou,China provided by DiDi Chuxing.A shareability network combining the ridesplitting network and connection network is built based on the order *** propose the on-demand matching algorithm with four matching objectives to obtain the dispatching *** results show that the percentage of shared trips can reach 99%,the vehicle saving rate can reach 83%,and the average number of shared trips served by shared vehicles can reach about 6 with the time interval 20 min and maximum delay 300 *** the maximum delay is 300 s,the percentage of orders that can be shared by multiple modes is about 30%.The average delay,idling time and waiting time of shared orders are slightly higher than the corresponding maximum delay,and increase with the increase of the maximum delay,while the change of saving time is the *** proposed algorithm considers the impact of the maximum delay,which,compared with the maximum matching algorithm,has a significant improvement.

关键词： Ridesplitting Ridesourcing Shareability network Matching

Coupling analysis of passenger and train flows for a large-scale urban rail transit system

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Engineering Management 2023年第2期10卷 250-261页

作者： Ping ZHANG Xin YANG Jianjun WU huijun sun Yun WEI Ziyou GAO State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China Beijing Mass Transit Railway Operation Corp.Ltd. Beijing 100044China

Coupling analysis of passenger and train flows is an important approach in evaluating and optimizing the operation efficiency of large-scale urban rail transit(URT)*** study proposes a passenger–train interaction simulation approach to determine the coupling relationship between passenger and train *** the bases of time-varying origin–destination demand,train timetable,and network topology,the proposed approach can restore passenger behaviors in URT *** priority,queuing process with first-in-first-serve principle,and capacity constraints are considered in the proposed simulation *** approach can also obtain each passenger’s complete travel chain,which can be used to analyze(including but not limited to)various indicators discussed in this research to effectively support train schedule optimization and capacity evaluation for urban rail ***,the proposed model and its potential application are demonstrated via numerical experiments using real-world data from the Beijing URT system(i.e.,rail network with the world’s highest passenger ridership).

关键词： urban rail transit coupling analysis passenger–train interaction large-scale simulation

Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters(OATs)

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2019年第5期9卷 986-996页

作者： Xiaokui Huo Qiang Meng Changyuan Wang Yanna Zhu Zhihao Liu Xiaodong Ma Xiaochi Ma Jinyong Peng huijun sun Kexin Liu Department of Clinical Pharmacology College of PharmacyDalian Medical UniversityDalian116044China College(Institute)of Integrative Medicine Dalian Medical UniversityDalian116044China Provincial Key Laboratory for Pharmacokinetics and Transport Dalian Medical UniversityDalian116044China

Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I(DHP-I),was developed. In present study, the potential roles of renal organic anion transporters(OATs) in alleviating the nephrotoxicity of imipenem by cilastatin were investigated in vitro and in rabbits. Our results indicated that imipenem and cilastatin were substrates of h OAT1 and h OAT3. Cilastatin inhibited h OAT1/3-mediated transport of imipenem with IC50 values comparable to the clinical concentration, suggesting the potential to cause a clinical drug–drug interaction(DDI). Moreover,imipenem exhibited h OAT1/3-dependent cytotoxicity, which was alleviated by cilastatin and probenecid. Furthermore, cilastatin and probenecid ameliorated imipenem-induced rabbit acute kidney injury, and reduced the renal secretion of imipenem. Cilastatin and probenecid inhibited intracellular accumulation of imipenem and sequentially decreased the nephrocyte toxicity in rabbit primary proximal tubule cells. Renal OATs, besides DHP-I, was also the target of interaction between imipenem and cilastatin, and contributed to the nephrotoxicity of imipenem. This therefore gives in part the explanation about the mechanism by which cilastatin protected against imipenem-induced nephrotoxicity. Thus, OATs can potentially be used as a therapeutic target to avoid the renal adverse reaction of imipenem in clinic.

关键词： Imipenem Cilastatin Probenecid OATs h OAT1 h OAT3 Nephrotoxicity

A Sociological Account of the Translation,Promotion and Reception of Jia Pingwa’s Feidu Outside China

在线全文

学校读者我要写书评

暂无评论

Journal of Philosophy Study 2020年第6期10卷 372-382页

作者： sun huijun LI Ying Shanghai International Studies University ShanghaiChina

Feidu,a novel by Jia Pingwa,which is regarded as one of the most controversial fiction in China since 1993,has recently come back to the attention of the public in China because of the publication of its English version Ruined City:A Novel in 2016 in the *** present paper intends to investigate the different receptions of the novel in China and in countries,like Japan,France,and *** attention is given to its translation,promotion,and reception in America on the basis of analyses of the para-texts of the English version,such as the preface of the translator,the promotional words on the part of the American publisher,the endorsement of literary scholars both at home and abroad,and the comments on it by *** is found that:(1)The novel was enthusiastically accepted and highly acclaimed in France and Japan,which constitutes a sharp contrast with its reception among Chinese readers and scholars;(2)it got a chance to be translated into English and promoted to the readership 23 years after its publication owing to the efforts of“different agents”,among whom were the translator,the editor,the publisher and many influential scholars both at home and abroad;(3)Goldblatt,rather than others,was finally chosen as the translator of the book on account of the cultural,social,symbolic,and economic capitals he possesses;and(4)the state-sponsored English translation and publication of the book in America was part of China’s effort of introducing its contemporary literature outside ***,in its consecration in the dominant field of world literature,the novel met with obstacles,and its reception not very *** authors of the present paper draw on sociological perspectives proposed by Pierre Bourdieu for an explanatory account of the *** addition,Actor-Network Translation Studies(ANTS),a sociological framework for translation research proposed by Jonathan Stalling,is also introduced,and its important concepts turn out to have such explana

关键词： Ruined City:A novel English translation Howard Goldblatt agent field capital ANTS

Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 252-263页

作者： Yanna Zhu Xiaokui Huo Changyuan Wang Qiang Meng Zhihao Liu huijun sun Aiping Tan Xiaodong Ma Jinyong Peng Kexin Liu Department of Clinical Pharmacology College of PharmacyDalian Medical UniversityDalian 116044China College(Institute)of Integrative Medicine Dalian Medical UniversityDalian 116044China Provincial Key Laboratory for Pharmacokinetics and Transport Dalian Medical UniversityDalian 116044China Department of Pharmacy First Affiliated Hospital of Dalian Medical UniversityDalian 116011China

This study aimed to clarify that organic anion transporters(OATs)mediate the drug–drug interaction(DDI)between imipenem and *** co-administration with imipenem,the plasma concentrations and the plasma concentration-time curve(AUC)of cilastatin were significantly increased,while renal clearance and cumulative urinary excretion of cilastatin were *** the same time,imipenem significantly inhibited the uptake of cilastatin in rat kidney slices and in human OAT1(hOAT1)-HEK293 and human OAT3(hOAT3)-HEK293 ***,p-aminohippurate,and benzylpenicillin inhibited the uptake of imipenem and cilastatin in rat kidney slices and in hOAT1-and hOAT3-HEK 293 cells,*** uptakes of imipenem and cilastatin in hOAT1-and hOAT3-HEK 293 cells were significantly higher than that in mock-HEK-293 ***,the K m values of cilastatin were increased in the presence of imipenem with unchanged V max,indicating that imipenem inhibited the uptake of cilastatin in a competitive *** imipenem and cilastatin were co-administered,the level of imipenem was higher compared with imipenem alone both in vivo and in ***,cilastatin significantly inhibited the uptake of imipenem when dehydropeptidase-1(DPEP1)was silenced by RNAi technology in hOAT1-and hOAT3-HEK 293 *** conclusion,imipenem and cilastatin are the substrates of OAT1 and ***1 and OAT3 mediate the DDI between imipenem and ***,cilastatin also reduces the hydrolysis of imipenem by inhibiting the uptake of imipenem mediated by OAT1 and OAT3 in the kidney as a complement.

关键词： Imipenem/cilastatin Renal dipeptidase Organic anion transporters Drug-drug interaction

基于瓶颈模型的异质出行者早高峰出行问题研究

在线全文

学校读者我要写书评

暂无评论

系统工程理论与实践 2018年第4期38卷 1003-1012页

作者：郭晓孙会君北京交通大学交通运输学院交通系统科学与工程研究院

早高峰出行中道路瓶颈是造成交通拥堵的主要原因之一．本文针对存在高速公路（含有高承载力车道）和普通道路的瓶颈路段，研究了时间价值不同的出行者早高峰出行行为．基于瓶颈模型的均衡条件，推导了不同收费标准下，出行者改变出行方... 详细信息

早高峰出行中道路瓶颈是造成交通拥堵的主要原因之一．本文针对存在高速公路（含有高承载力车道）和普通道路的瓶颈路段，研究了时间价值不同的出行者早高峰出行行为．基于瓶颈模型的均衡条件，推导了不同收费标准下，出行者改变出行方式时个人早到惩罚的临界值．研究发现收费较低时，时间价值较低的出行者使用高承载力车辆的数量会增加．收费达到一定程度时，即使是时间价值较高的出行者也会选择高承载力车辆出行．数值算例也表明设置恰当的收费标准可以降低系统出行时间．

关键词：公路运输拥堵收费瓶颈模型高承载力车道