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Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 35-42页

作者： Li-Li Miao Jing-Wen Wang hui-hui liu Shuai Gao yu-Chen Fan Kai Wang Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Hepatology Shandong UniversityJinan 250012China

Background: Glycine dehydrogenase(GLDC) plays an important role in the initiation and proliferation of several human cancers. In this study, we aimed to detect the methylation status of GLDC promoter and its diagnostic value for hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC). Methods: We enrolled 197 patients, 111 with HBV-HCC, 51 with chronic hepatitis B(CHB), and 35 healthy controls(HCs). The methylation status of GLDC promoter in peripheral mononuclear cells(PBMCs) was identified by methylation specific polymerase chain reaction(MSP). The mRNA expression was examined using real-time quantitative polymerase chain reaction(q PCR). Results: The methylation frequency of the GLDC promoter was significantly lower in HBV-HCC patients(27.0%) compared to that in CHB patients(68.6%) and HCs(74.3%)( P < 0.001). The methylated group had lower alanine aminotransferase level( P = 0.035) and lower rates of tumor node metastasis(TNM) Ⅲ/Ⅳ( P = 0.043) and T3/T4( P = 0.026). TNM stage was identified to be an independent factor for GLDC promoter methylation. GLDC mRNA levels in CHB patients and HCs were significantly lower than those in HBV-HCC patients( P = 0.022 and P < 0.001, respectively). GLDC mRNA levels were significantly higher in HBV-HCC patients with unmethylated GLDC promoters than those with methylated GLDC promoters( P = 0.003). The diagnostic accuracy of alpha-fetoprotein(AFP) combined with GLDC promoter methylation for HBV-HCC was improved compared with that of AFP alone(AUC: 0.782 vs. 0.630, P < 0.001). In addition, GLDC promoter methylation was an independent predictor for overall survival of HBV-HCC patients( P = 0.038). Conclusions: The methylation frequency of GLDC promoter was lower in PBMCs from HBV-HCC patients than that from patients with CHB and HCs. The combination of AFP and GLDC promoter hypomethylation significantly improved the diagnostic accuracy of HBV-HCC.

关键词： Hepatocellular carcinoma Glycine dehydrogenase DNA methylation Peripheral blood mononuclear cells

Dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates

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Opto-Electronic Advances 2024年第1期7卷 36-46页

作者： yuncheng liu Ke Xu Xuhao Fan Xinger Wang Xuan yu Wei Xiong hui Gao Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

Interactive holography offers unmatched levels of immersion and user engagement in the field of future *** of the substantial progress has been made in dynamic meta-holography,the realization of real-time,highly smooth interactive holography remains a significant challenge due to the computational and display frame rate *** this study,we introduced a dynamic interactive bitwise meta-holography with ultra-high computational and display frame *** our knowledge,this is the first reported practical dynamic interactive metasurface holographic *** spa-tially divided the metasurface device into multiple distinct channels,each projecting a reconstructed *** switching states of these channels were mapped to bitwise operations on a set of bit values,which avoids complex holo-gram computations,enabling an ultra-high computational frame *** approach achieves a computational frame rate of 800 kHz and a display frame rate of 23 kHz on a low-power Raspberry Pi computational *** to this methodology,we demonstrated an interactive dynamic holographic Tetris game system that allows interactive gameplay,color display,and on-the-fly hologram *** technology presents an inspiration for advanced dynamic meta-holography,which is promising for a broad range of applications including advanced human-computer interaction,real-time 3D visualization,and next-generation virtual and augmented reality systems.

关键词： interactive display meta-holography bitwise operation ultra-high frame rate

Improving creep strength of the fine-grained heat-affected zone of novel 9Cr martensitic heat-resistant steel via modified thermo-mechanical treatment

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 1037-1047页

作者： Jingwen Zhang Liming yu Yongchang liu Ran Ding Chenxi liu Zongqing Ma huijun Li Qiuzhi Gao hui Wang State Key Lab of Hydraulic Engineering Simulation and Safety Tianjin Key Lab of Composite and Functional MaterialsTianjin UniversityTianjin 300072China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

The infamous type Ⅳ failure within the fine-grained heat-affected zone (FGHAZ) in G115 steel weldments seriously threatens the safe operation of ultra-supercritical (USC) power *** this work,the traditional thermo-mechanical treatment was modified via the replacement of hot-rolling with cold rolling,i.e.,normalizing,cold rolling,and tempering (NCT),which was developed to improve the creep strength of the FGHAZ in G115 steel *** NCT treatment effectively promoted the dissolution of preformed M_(23)C_(6)particles and relieved the boundary segregation of C and Cr during welding thermal cycling,which accelerated the dispersed reprecipitation of M_(23)C_(6) particles within the fresh reaustenitized grains during post-weld heat *** addition,the precipitation of Cu-rich phases and MX particles was promoted evidently due to the deformation-induced *** a result,the interacting actions between precipitates,dislocations,and boundaries during creep were reinforced *** this strategy,the creep rupture life of the FGHAZ in G115 steel weldments can be prolonged by 18.6%,which can further push the application of G115 steel in USC power plants.

关键词： G115 steel fine-grained heat-affected zone creep strength element segregation nano-sized precipitates

Small but mighty:Empowering sodium/potassium-ion battery performance with S-doped SnO_(2) quantum dots embedded in N,S codoped carbon fiber network

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Carbon Energy 2024年第5期6卷 186-200页

作者： Shengnan He hui Wu Shuang Li Ke liu Yaxiong Yang Hongge Pan Xuebin yu Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'anChina Department of Materials Science Fudan UniversityShanghaiChina Wanxiang A123 Systems Corporation HangzhouChina School of Material Science and Engineering Shanghai UniversityShanghaiChina

SnO_(2) has been extensively investigated as an anode material for sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs)due to its high Na/K storage capacity,high abundance,and low ***,the sluggish reaction kinetics,low electronic conductivity,and large volume changes during charge and discharge hinder the practical applications of SnO_(2)-based electrodes for SIBs and *** rational structures with fast charge/ion transfer and robust stability is important to overcoming these ***,S-doped SnO_(2)(S-SnO_(2))quantum dots(QDs)(≈3 nm)encapsulated in an N,S codoped carbon fiber networks(S-SnO_(2)-CFN)are rationally fabricated using a sequential freeze-drying,calcination,and S-doping *** analysis and density functional theory calculations reveal that the integration of S-SnO_(2) QDs with N,S codoped carbon fiber network remarkably decreases the adsorption energies of Na/K atoms in the interlayer of SnO_(2)-CFN,and the S doping can increase the conductivity of SnO_(2),thereby enhancing the ion transfer *** synergistic interaction between S-SnO_(2) QDs and N,S codoped carbon fiber network results in a composite with fast Na+/K+storage and extraordinary long-term ***,the S-SnO_(2)-CFN delivers high rate capacities of 141.0 mAh g^(−1) at 20 A g^(−1) in SIBs and 102.8 mAh g^(−1) at 10 A g^(−1) in ***,it delivers ultra-stable sodium storage up to 10,000 cycles at 5 A g^(−1) and potassium storage up to 5000 cycles at 2 A g^(−1).This study provides insights into constructing metal oxide-based carbon fiber network structures for high-performance electrochemical energy storage and conversion devices.

关键词： carbon fiber network heteroatom doping potassium-ion battery sodium-ion battery S-SnO_(2)quantum dot

Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： Shan-Shan Jin Si-Nong Wang Yan-Yan Huang Jing-yu Zhang Peng liu hui yu Hong-Dong Zhang yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

Deep Learning-Based Secure Transmission Strategy with Sensor-Transmission-Computing Linkage for Power Internet of Things

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Computers, Materials & Continua 2024年第3期78卷 3267-3282页

作者： Bin Li Linghui Kong Xiangyi Zhang Bochuo Kou hui yu Bowen liu State Grid Beijing Urban District Power Supply Company Beijing100034China

The automatic collection of power grid situation information, along with real-time multimedia interaction between the front and back ends during the accident handling process, has generated a massive amount of power grid data. While wireless communication offers a convenient channel for grid terminal access and data transmission, it is important to note that the bandwidth of wireless communication is limited. Additionally, the broadcast nature of wireless transmission raises concerns about the potential for unauthorized eavesdropping during data transmission. To address these challenges and achieve reliable, secure, and real-time transmission of power grid data, an intelligent security transmission strategy with sensor-transmission-computing linkage is proposed in this paper. The primary objective of this strategy is to maximize the confidentiality capacity of the system. To tackle this, an optimization problem is formulated, taking into consideration interruption probability and interception probability as constraints. To efficiently solve this optimization problem, a low-complexity algorithm rooted in deep reinforcement learning is designed, which aims to derive a suboptimal solution for the problem at hand. Ultimately, through simulation results, the validity of the proposed strategy in guaranteed communication security, stability, and timeliness is substantiated. The results confirm that the proposed intelligent security transmission strategy significantly contributes to the safeguarding of communication integrity, system stability, and timely data delivery.

关键词： Secure transmission deep learning power Internet of Things sensor-transmission-computing

Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in a Chinese Cohort

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Neuroscience Bulletin 2020年第7期36卷 696-704页

作者： Wei-Wei Li Zhen Wang Dong-yu Fan Ying-Ying Shen Dong-Wan Chen hui-yun Li Ling Li Heng Yang yu-hui liu Xian-Le Bu Wang-Sheng Jin Fan Zeng Zhi-Qiang Xu Jin-Tai yu Li-Yong Chen Yan-Jiang Wang Department of Neurology and Centre for Clinical Neuroscience Duping HospitalThird Military Medical UniversityChongqing 400042China Department of Anaesthesiology Daping HospitalThird Military Medical UniversityChongqing 400042China Chongqing Key Laboratory of Aging and Diseases Chongqing 400042China Centre for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Department of Neurology Huashan HospitalFudan UniversityShanghai 200040China

To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer’s disease(sAD)and pathological biomarkers in cerebrospinal fluid(CSF),462 sAD patients and 463 age-matched cognitively normal(CN)controls were genotyped for 35 singlenucleotide polymorphisms(SNPs)that are significantly associated with ***,the alleles found to be associated with sAD were used to build polygenic risk score(PRS)models to represent the genetic *** operating characteristic(ROC)analyses and the Cox proportional hazards model were used to evaluate the predictive value of PRS for the sAD risk and age at *** measured the CSF levels of Aβ42,Aβ42/Aβ40,total tau(T-tau),and phosphorylated tau(P-tau)in a subgroup(60 sAD and 200 CN participants),and analyzed their relationships with the *** found that 14 SNPs,including SNPs in the APOE,BIN1,CD33,EPHA1,SORL1,and TOMM40 genes,were associated with sAD risk in our *** PRS models built with these SNPs showed potential for discriminating sAD patients from CN controls,and were able to predict the incidence rate of sAD and age at ***,the PRSs were correlated with the CSF levels of Aβ42,Aβ42/Aβ40,T-tau,and *** study suggests that PRS models hold promise for assessing the genetic risk and development of *** genetic risk profiles vary among populations,large-scale genome-wide sequencing studies are urgently needed to identify the genetic risk loci of sAD in Chinese populations to build accurate PRS models for clinical practice.

关键词： Alzheimer's disease Single nucleotide polymorphism Polygenic risk score Cerebrospinal fluid Biomarker Amyloid-beta Tau

Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy

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Science China Chemistry 2024年第7期67卷 2412-2422页

作者： yu Chen yu Guo Jiaoli Wang Ruiting liu Xiaohai Yang Kemin Wang Ying Pu hui Shi Jin Huang Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China National Clinical Research Center for Geriatric Disorders Department of GeriatricsXiangya HospitalCentral South UniversityChangsha 410008China

DNAzyme-based gene therapy faces some challenges including cell penetration,activity limitation,and co-delivery ***-assembled DNA nanomedicine has attracted widespread attention due to its many *** is urgent to develop a universal DNA degradation strategy for precise programmable drug ***,we reported a self-catabolic DNAzyme nanospheres(SCNS),which could simultaneously achieve cell penetration,activity enhancement,and co-delivery *** SCNS were assembled through Y-DNA stepwise hybridization with each other,which were then loaded with aptamer(Apt),doxorubicin(Dox),and zinc oxide nanoparticles(ZnO NPs).The acid-triggered dissociation of ZnO NPs leads to the generation of Zn^(2+)ions cofactors for immediately self-catabolic DNAzyme *** the disassembly of the SCNS,three types of anticancer treatments would be activated,which include Zn^(2+)involved reactive oxygen species(ROS),Dox-induced chemotherapy,and DNAzyme-based gene *** experimental results show that the nanoplatform(Apt-SCNS-Dox-ZnO)has a good tumor-killing effect and minimal side *** a smart self-driven drug delivery nanoplatform,it is anticipated to displace extraordinary potential in biomedicine and bioengineering.

关键词： DNAzyme nanosphere ZnO NPs ROS Dox anticancer therapy

Energy Economic Dispatch for Photovoltaic-Storage via Distributed Event-Triggered Surplus Algorithm

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Energy Engineering 2024年第9期121卷 2621-2637页

作者： Kaicheng liu Chen Liang Naiyue Wu Xiaoyang Dong hui yu China Electric Power Research Institute Beijing100192China Electric Power Research Institute of State Grid Gansu Electric Power Company Lanzhou730000China State Key Laboratory of Power Grid Safety Beijing100084China

This paper presents a novel approach to economic dispatch in smart grids equipped with diverse energy *** method integrates features including photovoltaic(PV)systems,energy storage coupling,varied energy roles,and energy supply and demand *** systemmodel is developed by considering energy devices as versatile units capable of fulfilling various functionalities and playing multiple roles *** strike a balance between optimality and feasibility,renewable energy resources are modeled with considerations for forecasting errors,Gaussian distribution,and penalty ***,this study introduces a distributed event-triggered surplus algorithm designed to address the economic dispatch problem by minimizing production *** in surplus theory and finite time projection,the algorithm effectively rectifies network imbalances caused by directed graphs and addresses local inequality *** algorithm greatly reduces the communication burden through event triggering ***,both theoretical proofs and numerical simulations verify the convergence and event-triggered nature of the algorithm.

关键词： Fully distributed algorithm economic dispatch directed graph renewable energy resource