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Immunotherapy-based novel nanoparticles in the treatment of gastrointestinal cancer: Trends and challenges

World Journal of Gastroenterology 2022年第37期28卷 5403-5419页

作者： Yi-Nan ding Ming Xue Qiu-Sha Tang Li-Jun Wang hui-yan ding Han Li Cheng-Cheng Gao Wei-Ping Yu Department of Pathophysiology College of MedicineSoutheast UniversityNanjing 210000Jiangsu ProvinceChina Department of Critical Care Medicine Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210000Jiangsu ProvinceChina Department of Tuberculosis The Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Radiology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Medical School Southeast UniversityNanjing 210009Jiangsu ProvinceChina

Gastrointestinal cancer(GIC)is the most common cancer with a poor ***,surgery is the main treatment for ***,the high rate of postoperative recurrence leads to a low five-year survival *** recent years,immunotherapy has received much *** the only immunotherapy drugs approved by the Food and Drug Administration(FDA),immune checkpoint blockade(ICB)drugs have great potential in cancer ***,the efficacy of ICB treatment is greatly limited by the low immunogenicity and immunosuppressive microenvironment of ***,the targets of immunotherapy have expanded from ICB to increasing tumor immunogenicity,increasing the recruitment and maturation of immune cells and reducing the proportion of inhibitory immune cells,such as M2-like macrophages,regulatory T cells and myeloid-derived suppressor ***,with the development of nanotechnology,a variety of nanoparticles have been approved by the FDA for clinical therapy,so novel nanodrug delivery systems have become a research focus for anticancer *** this review,we summarize recent advances in the application of immunotherapy-based nanoparticles in GICs,such as gastric cancer,hepatocellular carcinoma,colorectal cancer and pancreatic cancer,and described the existing challenges and future trends.

关键词： Gastrointestinal cancer Gastric cancer Hepatocellular carcinoma Colorectal cancer Pancreatic cancer Immunotherapy-based novel nanoparticles

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Recombinant scFv Antibodies against E Protein and N Protein of Severe Acute Respiratory Syndrome Virus

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Acta Biochimica et Biophysica Sinica 2004年第8期36卷 541-547页

作者： hui LIU , yan-Li ding, Wei HAN, Mei-Yun LIU, Rui-yang TIAN, Sheng-Li yanG, and Yi GONGShanghai Research Center of Biotechnology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences, Shanghai 200233, China Shanghai Research Center of Biotechnology Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai 200233 China. huiliu@***

Three single chain antibodies (scFv) against the proteins of severe acute respiratory syndrome coronavirus (SARS-CoV) were isolated by phage display from an scFv antibody library. Bio-panning was carried out against immobilized purified envelope (E) and nucleocapsid (N) proteins of SARS-CoV. Their binding activity and specificity to E or N protein of SARS-CoV were characterized by phage-ELISA. Two of them, B10 and C20, could recognize non-overlapping epitopes of the E protein according to the two-site binding test result. Clone A17 could recognize N protein. The sequence of the epitope or overlapping epitope of scFv antibody A17 was PTDSTDNNQNGGRNGARPKQRRPQ. The affinity (equilibrium dissociation constant, Kd) of SARS-CoV E protein was 5.7×10–8 M for B10 and 8.9×10–8 M for C20. The affinity of A17 for N protein was 2.1×10–6 M. All three scFv antibodies were purified with affinity chromatography and determined by Western blot.

关键词： SARS-CoV antibody scFv phage display affinity chromatography

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Associations of Saposin C,Src,and Androgen Receptor Upregulate Expression and Function of Androgen Receptor in Human Prostate Cancer Cells

Associations of Saposin C,Src,and Androgen Receptor Upregula...

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2008年全国生物化学与分子生物学学术大会

作者： hui-qing Yuan yan ding Xiao-ling Wang Ai-hui Xu Yuan-yuan Tian (Department of Biochemistry and Molecular Biology,School of Medicine,Shandong University,Jinan 250012,China)

Saposin C,one of the sphingolipid activator proteins involved in lysosomal hydrolysis of sphingolipids,is a novel androgen-response gene in prostate cancer *** is proposed that a putative G protein-coupled receptor interacts with saposin C and results in activation of saposin ***,we demonstrated that ectopic expres-

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独立学院专业综合实训实践教学研究——以制冷与空调专业为例

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科教文汇 2017年第8期 74-75页

作者：张辉丁艳中国矿业大学徐海学院江苏徐州221008

独立学院实践教学是十分必要而且十分重要的教学环节,而专业综合实训是该专业必不可少的环节。通过实训,不但可以让学生对所学的理论知识进行巩固,而且可以培养学生的创新、创造能力以及综合分析和解决实际问题的能力。结合学院实际情况... 详细信息

独立学院实践教学是十分必要而且十分重要的教学环节,而专业综合实训是该专业必不可少的环节。通过实训,不但可以让学生对所学的理论知识进行巩固,而且可以培养学生的创新、创造能力以及综合分析和解决实际问题的能力。结合学院实际情况,总结了专业综合实训实践教学中存在的问题及不足,并且根据存在的问题对专业综合实训实践教学改革进行了探索,提出了改革的内容及具体的实施办法,为独立学院制冷与空调专业的专业综合实训实践教学提供新的模式,同时为其它专业的实践教学改革提供参考。

关键词：独立学院实践教学制冷与空调

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Cloning,genomic structure and expression analysis of flavonoid structural genes in upland cotton

Cloning,genomic structure and expression analysis of flavono...

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第十三届全国植物基因组学大会

作者： Man Jiang,Qian yan,hui ding,Shaofei Bo,yanjun Wang,Dan Yao,Mengmeng Miao,yan Pei,Yuehua Xiao~* lotechnology Research Center,Southwest University,Chongqing 400716,China

Flavonoids may play important roles in regulating the development of *** elucidate the molecular basis of the flavonoid biosynthesis in upland cotton,we cloned five 5 flavonoid synthase genes(Chalcone isomerase,CHI;Flavanone-3 - hydroxylase,F3H;Flavanone 3’5’ hydroxylase,F3’5’H;Dihydroflavonol 4-reductase,

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GhTT2-3A Encodes a R2R3-MYB Protein Controlling Proanthocyanidin Biosynthesis in Cotton Fiber

GhTT2-3A Encodes a R2R3-MYB Protein Controlling Proanthocyan...

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第十二届全国植物基因组学大会

作者： Qian yan,hui ding,Shaofei Bo,yangjun Wang,Man Jiang,Dan Yao,Mengmeng Miao,yan Pei,Yuehua Xiao~* Biotechnology Research Center,Southwest University,Chongqing 400716,China

Brown cotton is the most widely used naturally colored *** was reported that the brown pigment in cotton fiber belonged to proanthocyanidins(PAs).TT2 is a key regulator of PA pathway in *** this study,we cloned a TT2 homozygous gene(GhTT2-3) related to brown fiber trait,and analysed its biological functions by cotton genetic transformation. Sequence analyses showed that GhTT2-3A shared high sequence similarity(identity>50%) with the PA-related R2R3-MYB proteins,such as *** determining PA and GhTT2-3A expression levels in various tissues,and in fibers of different colors at different developmental stages,we revealed that high levels of PA and GhTT2-3A expression were simultaneously detected only in the developing brown *** a RIL

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MAD-AOS二元共聚物的制备及在浮选脱墨中的应用

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中国造纸 2017年第8期36卷 6-12页

作者：游群杰张昌辉马燕丁希陕西科技大学教育部轻化工助剂化学与技术重点实验室陕西西安710021

采用马来酸十二醇单酯(MAD)和α-烯烃磺酸钠(AOS)为原料,过硫酸铵(APS)为引发剂进行反应得到一系列MAD-AOS二元共聚物高分子表面活性剂,并对其脱墨性能进行研究,通过红外光谱(IR)对MAD-AOS二元共聚物的结构进行表征。用凝胶渗透色谱分析... 详细信息

采用马来酸十二醇单酯(MAD)和α-烯烃磺酸钠(AOS)为原料,过硫酸铵(APS)为引发剂进行反应得到一系列MAD-AOS二元共聚物高分子表面活性剂,并对其脱墨性能进行研究,通过红外光谱(IR)对MAD-AOS二元共聚物的结构进行表征。用凝胶渗透色谱分析仪(GPC)测得其相对分子质量及其分布,通过环境扫描电子显微镜(ESEM)对比其与复配脱墨剂及市售脱墨剂的脱墨效果。结果表明,当n(MAD)∶n(AOS)=1∶1,引发剂用量为2.5%(对单体总质量),聚合温度为85℃,聚合时间6 h时,MAD-AOS二元共聚物表面活性剂可达到较好的脱墨效果。将MAD-AOS二元共聚物与脂肪酸甲酯乙氧基化物(FMEE)按一定比例复配,在m(MAD-AOS)∶m(FMEE)=1∶1,复配脱墨剂用量为0.3%(其他助剂一定)时,脱墨浆白度可达72.2%,残余油墨量为44 mm^2/m^2。

关键词：马来酸十二醇单酯聚合物脱墨剂残余油墨量白度

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R2R3-MYB Gene GhPAP1 Promotes Efficient Anthocyanin Biosynthesis in Cotton,Tobacco and Poplar

R2R3-MYB Gene GhPAP1 Promotes Efficient Anthocyanin Biosynth...

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第十二届全国植物基因组学大会

作者： Shaofei Bo,Fan yang,Mengmeng Miao,yangjun Wang,Qian yan,hui ding,Man Jiang,Dan Yao,yan Pei,Yuehua Xiao~* Biotechnology Research Center,Southwest University,Chongqing 400716,China

Red plant is a traditional genetic marker trait in cotton,and is controlled by a single dominant gene(R1). It was found that R1 cotton accumulated high-level anthocyanin in various tissues,and the expression levels of anthocyanin synthase genes were significantly up-regulated compared to green plant cotton. Plant R2R3-MYB protein,such as PAP1 from Arabidopsis,is a key regulator of *** elucidate the molecular basis of anthocyanin regulation,we cloned a PAP1 homologous gene(GhPAP1) from R1 *** analysis showed that GhPAP1 encodes an anthocyanin-related R2R3-MYB *** ex-

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping ding Liyun Wu Songfeng E Qian He Nanyang Wang hui Zuo Zhengyang Zhou Feng ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： Zhou, Chengwang ding, Zhezheng Ying, Shengzhe Jiang, Hao Wang, yan Fang, Timing Zhang, You Sun, Bing Tang, Xiao Liu, Xiaomin Qingdao Univ Sch Text & Clothing Sch Chem & Chem Engn Qingdao 266071 Shandong Peoples R China Univ Technol Sydney Fac Sci Ctr Clean Energy Technol Sch Math & Phys Sci Ultimo NSW 2007 Australia Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

A double-layered protective film based on zinc-based coordination compound and ZnF2-rich solid electrolyte interphase layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** double-layered architecture can effectively modulate Zn2+ flux and suppress the zinc dendrite growth, thus facilitating the uniform zinc *** as-developed zinc-(dual) halogen batteries based on double-layered protective film can present high areal capacity and satisfactory cycling stability. Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources, intrinsic safety, and high theoretical capacity. Nevertheless, the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation. Herein, a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid (ZEA) artificial film and ZnF2-rich solid electrolyte interphase (SEI) layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization. The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer, therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode. Such double-layered architecture not only modulates Zn2+ flux and suppresses the zinc dendrite growth, but also blocks the direct contact between the metal anode and electrolyte, thus mitigating the corrosion from the active species. When employing optimized metal anodes and electrolytes, the as-developed zinc-(dual) halogen batteries present high areal capacity and satisfactory cycling stability. This work provides a new avenue for developing aqueous zinc-(dual) halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual) halogen batteries

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