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Visual differences in topography-guided versus wavefront-optimized LASIK in the treatment of myopia: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1602-1609页

作者： Peng-Cheng Hu Li Li xian-hui wu Yan-Qing Li Ke-Wei Li Department of Ophthalmology the Second Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400010China Department of Ophthalmology the First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016China

AIM: To investigate the potential differences between topography-guided(TG) and wavefront-optimized(WFO) laser in situ keratomileusis(LASIK) for the treatment of ***: A systematic literature search was performed to determine relevant trials comparing LASIK with TG and WFO from the time of library construction to August 2020, and The PubMed, Cochrane, Web of Science, EMBASE and Chinese databases(i.e. CNKI, CBM, WAN FANG and VIP) were accessed. The data on visual acuity, refractive status and wavefront aberration were retrieved and evaluated from three to six months after surgery. STATA(version 14.0) software was used for statistical analysis. A cumulative Meta-analysis was simultaneously ***: Eleven studies with a total of 1425 eyes were incorporated. No statistically significant differences were evident between TG and WFO ablation in the proportion of eyes achieving an uncorrected distance visual acuity(UCVA) of 20/20 or better(P=0.377), gaining one line or more(P=0.05), postoperative cylinder(P=0.40), vertical coma(P=0.593) and horizontal coma(P=0.957). After TG ablation, the proportion of the patients’ eyes of which postoperative refraction is within ±0.5 diopter of the target refraction was significantly higher than that undergoes WFO(P=0.003). As opposed to the WFO group, manifest refraction spherical equivalent(MRSE;P=0.000) was lower, and UCVA(P=0.005) was better in the TG group. The higher-order aberrations(HOAs;P=0.000), spherical aberration(P=0.000) and coma(P=0.000) were significantly lower in TG group. The cumulative Meta-analysis illustrated that the proportion of eyes achieving UCVA of 20/20 or better, postoperative refraction within ±0.5 diopter, and MRSE has steady between the two ***: Both TG-LASIK and WFO-LASIK are safe, effective, and predictable for correcting myopia. TG-LASIK may produce fewer aberration and is more precise than WFO-LASIK.

关键词： Meta-analysis corneal topography wavefront aberration laser in situ keratomileusis myopia

Quantum metrology with a non-Markovian qubit system

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Chinese Physics B 2018年第12期27卷 172-176页

作者： Jiang Huang Wen-Qing Shi Yu-Ping Xie Guo-Bao Xu hui-xian wu College of Electronics and Information Engineering Guangdong Ocean University

The dynamics of the quantum Fisher information(QFI) of phase parameter estimation in a non-Markovian dissipative qubit system is investigated within the structure of single and double Lorentzian spectra. We use the time-convolutionless method with fourth-order perturbation expansion to obtain the general forms of QFI for the qubit system in terms of a non-Markovian master equation. We find that the phase parameter estimation can be enhanced in our model within both single and double Lorentzian spectra. What is more, the detuning and spectral width are two significant factors affecting the enhancement of parameter-estimation precision.

关键词： quantum metrology quantum Fisher information time-convolutionless parameter estimation

Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： xian-Rong wu Xiao-Hong He Yong-Fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

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一种电动执行器控制系统设计与应用

仪表技术与传感器 2017年第4期 83-87页

作者：赵慧娴吴新伟内蒙古机电职业技术学院内蒙古呼和浩特010070 内蒙古电力建设工程有限公司内蒙古包头014030

针对电动执行器的速度、位置控制问题,提出了一种基于数字信号处理器TMS320F2812的电动执行器控制系统。硬件方面,基于专用控制芯片PMM8713PT设计了步进电机驱动电路;结合CAN控制器SJA1000和驱动器82C250设计了CAN总线电路;利用霍尔传... 详细信息

针对电动执行器的速度、位置控制问题,提出了一种基于数字信号处理器TMS320F2812的电动执行器控制系统。硬件方面,基于专用控制芯片PMM8713PT设计了步进电机驱动电路;结合CAN控制器SJA1000和驱动器82C250设计了CAN总线电路;利用霍尔传感器和光电编码器实现了电机速度、位置的检测。软件方面,介绍了控制系统主程序,提出了一种基于积分分离PID算法的步进电机速度和位置控制方法。以电动执行器轨迹跟踪为例,展开应用研究。实际轨迹和给定轨迹基本吻合,实验结果验证了所述基于DSP的电动执行器控制系统的可行性和有效性。

关键词：电动执行器数字信号处理器控制系统步进电机

芳烃-氟代芳烃和氢键作用调控的树枝状分子自组装及其液晶性质

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高分子学报 2017年第2期27卷 329-333页

作者：王章远吴惠娴倪犇博马玉国北京大学化学与分子工程学院北京100871

通过收敛法合成了母核为亚胺键连接的芳环与氟代芳环,外围为3,4,5-三(正十二烷氧基)苯基亚甲基的第一代树枝状亚胺分子,并对其热致液晶行为和聚集体结构进行了研究.示差扫描量热和热台偏光光学显微镜研究表明该亚胺分子在93?C到118?C的... 详细信息

通过收敛法合成了母核为亚胺键连接的芳环与氟代芳环,外围为3,4,5-三(正十二烷氧基)苯基亚甲基的第一代树枝状亚胺分子,并对其热致液晶行为和聚集体结构进行了研究.示差扫描量热和热台偏光光学显微镜研究表明该亚胺分子在93?C到118?C的温度范围内为具有双折射的液晶相.X-射线衍射结果表明该亚胺分子的液晶相为斜柱状结构(a=4.90 nm,b=3.51 nm,γ=110?).芳环-氟代芳环的面对面交替堆积和氢键驱动亚胺分子形成了柱状聚集体,分子外围的柔性十二烷氧基链的无序伸展,与母核聚集体发生微相分离,促使了亚胺分子斜柱状液晶相的形成.

关键词：树枝状分子液晶芳烃-氟代芳烃相互作用氢键

Kappa角在眼科手术中的临床应用及研究进展

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国际眼科杂志 2023年第5期23卷 778-782页

作者：李彦青李立伍先慧重庆医科大学附属第二医院眼科重庆市400010

人眼具有多种轴线和角度,其中Kappa角是反映人眼居中性的重要指标,在眼科手术中应用广泛。术前正确的评估与应用Kappa角,有利于恢复术后最佳视觉质量。μ弦是近几年为了更好地表达Kappa角而出现的一个新术语。临床上这两个概念未被很好... 详细信息

人眼具有多种轴线和角度,其中Kappa角是反映人眼居中性的重要指标,在眼科手术中应用广泛。术前正确的评估与应用Kappa角,有利于恢复术后最佳视觉质量。μ弦是近几年为了更好地表达Kappa角而出现的一个新术语。临床上这两个概念未被很好地理解,限制了其实用性。因此,为了更好地理解Kappa角和μ弦,本文分别阐述了两者的定义和联系。同时,总结了Kappa角在斜视手术中的应用,探讨了在角膜屈光手术中补偿大Kappa角的方法以及在超声乳化联合多焦点人工晶状体(MIOL)植入术中参考Kappa角预测术后MIOL居中性的临床意义,以期为临床工作提供一定的参考。

关键词： Kappa角 μ弦斜视手术角膜屈光手术白内障手术

Pentamethylquercetin ameliorates renal fibrosis by suppression of TGF-β/Smads signaling in diabetic GK rats

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Pentamethylquercetin ameliorates renal fibrosis by suppressi...

中国药理学会第十一次全国学术会议

作者： XIN Xin,LI xian-hui,wu Jian-zhao,JIN Man-wen (Department of Pharmacology,Basic Medical School,Tongji Medical College,Huazhong University of Science and Technology,wuhan 430030,China)

OBJECTIVE The effect of pentamathylquercetin(PMQ) on renal fibrosis in diabetic GK rats was investigated. METHODS Male GK rats and age-matched male Wistar rats were *** rats were divided into four groups which were fed by normal or drug-containing food,resulting in daily PMQ intake of 0,5,10 or 20 mg·kg,respectively,for 16 *** the end of the experimental period,urine was collected for 24 h from rats kept in metabolic *** the rats were sacrificed to obtain kidneys and blood *** changes of kidney weight/body weight(KW/BW),urine albumin excretion rate(UAER) and creatinine clearance rate(Ccr) were *** morphology of glomeruli was observed by Masson ***,immunohistochemistry was carried out to measure TGF-β,Smad7 and collagenⅣ,TGF-βwas also measured by enzyme linked immunosorbent assay (ELISA).RESULTS Compared with Wistar rats,the levels of KW/BW(from5.35 to9.15),UAER(from 46.1 to 49.8 mg/24 h),Ccr(from 0.43 to 0.67 ml·min),glomerular fibrosis(increased 95.3%),TGF-β(increased 33.7%for immunohistochemistry and 48.2%for ELISA) and collagenⅣ(increased 25.9%) were markedly enlarged in the model group,while the Smad7 level was reduced(by 16.1%).However,the renal fibrosis was ameliorated with suppression of TGF-β/Smads signaling after PMQ treatment. Take the group of PMQ 10 mg·kg for *** levels of KW/BW(from 9.15 to 7.99),UAER(from 49.8 to 40.2 mg/ 24 h),Ccr(from 0.67 to 0.49 ml·min),glomerular fibrosis(decreased 61.8%),TGF-β(decreased 8.3%for immunohisto-chemistry and 58.9%for ELISA),collagenⅣ(decreased 28.7%).Smad7 level was increased(by 33.4%).CONCLUSION TGF-β/Smads signaling has been activated in the kidney of GK rats,which showed typical renal dysfunction and *** treatment with PMQ,this signaling was suppressed and renal fibrosis was significantly *** effect of PMQ may be a result of increased Smad7.

关键词： pentamethylquercetin renal fibrosis TGF-β/Smads

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巴氯芬治疗顽固性呃逆

中国新药与临床杂志 2001年第6期20卷 432-433页

作者：陈协辉吴贤仁汕头大学医学院第一附属医院内二科广东汕头515041

目的 :观察巴氯芬对顽固性呃逆的疗效。方法 :80例顽固性呃逆病人分为 2组 ,其中治疗组42例 (男性 2 8例 ,女性 14例 ,年龄 48a±s 8a)采用巴氯芬治疗。最小剂量是 10mg ,bid。最大剂量为 15mg ,tid。小剂量开始 ,逐步递增。疗程 4d。3 ... 详细信息

目的 :观察巴氯芬对顽固性呃逆的疗效。方法 :80例顽固性呃逆病人分为 2组 ,其中治疗组42例 (男性 2 8例 ,女性 14例 ,年龄 48a±s 8a)采用巴氯芬治疗。最小剂量是 10mg ,bid。最大剂量为 15mg ,tid。小剂量开始 ,逐步递增。疗程 4d。3 8例对照组 (男性 2 4例 ,女性 14例 ,年龄 44a± 11a)采用氯丙嗪、苯妥英、硝苯地平、东莨菪碱等常规治疗。结果 :治疗组总有效率 98% ,对照组总有效率 5 8% (P <0 .0 5 ) ,治疗组服药d 1起效率 86% ,对照组服药d 1起效率 2 1% (P <0 .0 1) ,治疗组疗程明显缩短 (P <0 .0 1) ,不良反应少。结论 :巴氯芬是治疗顽固性呃逆较为有效的药物。

关键词：巴氯芬氯丙嗪呃逆药物疗法治疗

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes