检索结果-南通市图书馆

Height and body mass index trajectories from 1975 to 2015 and prevalence of stunting,underweight and obesity in 2016 among children in Chinese cities:findings from five rounds of a national survey

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第4期20卷 404-412页

作者： Xin‑Nan Zong hui li Ya‑qin Zhang Department of Growth and Development Capital Institute of PediatricsBeijing 100020China

Background A more comprehensive assessment of growth and nutrition in children is required in China due to rapid socioeconomic *** aimed to investigate height and body mass index(BMI)trajectories from 1975 to 2015 and the prevalence of stunting and obesity in 2016 among children in Chinese *** A total of 904,263 children from birth to 6.9 years were collected from a series of nationally representative surveys in *** and BMI trajectories and prevalence of stunting,underweight,overweight and obesity were *** The average height level of Chinese urban children under 7 years presented a positive secular trend from 1975 to 2015;however,a slowing tendency occurred in 2005‒*** apparent increase was observed at the 5th,50th and 95th percentiles of BMI in urban children aged 3 years and older,with a more prominent increase at the 95th *** total prevalence of stunting and underweight under 7 years was 1.4%and 2.0%,*** total prevalence of overweight and obesity under 7 years was 12.6%and 4.3%,respectively,with 12.7%and 4.9%for boys,12.6%and 3.6%for girls,12.1%and 4.0%in urban areas and 13.1%and 4.5%in suburban rural *** The average height level of Chinese urban children has reached World Health Organization child growth standards since 2005 and presented a slowing tendency in secular trend in 2005‒*** attention and efforts and public health interventions should be urgently made to combat overweight and obesity among preschool children.

关键词： Body mass index Children Height Obesity Stunting

Cancer organoids:A platform in basic and translational research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 614-632页

作者： Xin Ma qin Wang Guozheng li hui li Shouping Xu Da Pang Department of Breast Surgery Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Sino-Russian Medical Research Center Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Heilongjiang Academy of Medical Sciences HarbinHeilongjiang 150086China Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China) College of Pharmacy of Harbin Medical UniversityHarbinHeilongjiang 150086China

An accumulation of previous work has established organoids as good preclinical models of human tumors,facilitating translation from basic research to clinical *** are changing the paradigm of preclinical cancer research because they can recapitulate the heterogeneity and pathophysiology of human cancers and more closely approximate the complex tissue environment and structure found in clinical tumors than in vitro cell lines and animal ***,the potential applications of cancer organoids remain to be comprehensively *** the review,we firstly describe what is currently known about cancer organoid culture and then discuss in depth the basic mechanisms,including tumorigenesis and tumor metastasis,and describe recent advances in patient-derived tumor organoids(PDOs)for drug screening and immunological ***,the present challenges faced by organoid technology in clinical practice and its prospects are *** review highlights that organoids may offer a novel therapeutic strategy for cancer research.

关键词： Drug assays Immunotherapy Mechanism research Organoids Precision medicine

Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第11期8卷 5383-5393页

作者： Yan liu Yi-hui Shao Jun-meng Zhang Ying Wang Mei Zhou hui-qin li Cong-cong Zhang Pei-jie Yu Shi-juan Gao Xue-rui Wang li-xin Jia Chun-mei Piao Jie Du Yu-lin li Beijing Anzhen Hospital Capital Medical UniversityThe Key Laboratory of Remodeling-Related Cardiovascular DiseasesMinistry of EducationBeijing Collaborative Innovative Research Center for Cardiovascular DiseasesBeijing Institute of Heart Lung and Blood Vessel DiseasesBeijing100029China

Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction(MI).Caspase-recruitment domain family member 9(CARD9)acts as an adapter that mediates the transduction of pro-inflammatory signaling cascades in innate immunity;however,its role in cardiac injury and repair post-MI remains *** found that Card9 was one of the most upregulated Card genes in the ischemic myocardium of ***9 expression increased considerably 1 day post-MI and declined by day 7 ***,CARD9 was mainly expressed in F4/80-positive ***9 knockout(KO)led to left ventricular function improvement and infarct scar size reduction in mice 28 days ***,Card9 KO suppressed cardiomyocyte apoptosis in the border region and attenuated matrix metalloproteinase(MMP)*** sequencing revealed that Card9 KO significantly suppressed lipocalin 2(Lcn2)expression *** LCN2 and the receptor solute carrier family 22 member 17(SL22A17)were detected in ***,we demonstrated that Card9 overexpression increased LCN2 expression,while Card9 KO inhibited necrotic cell-induced LCN2 upregulation in macrophages,likely through NF-κ***2 KO showed beneficial effects post-MI,and recombinant LCN2 diminished the protective effects of Card9 KO in ***2 KO reduced MMP9 post-MI,and Lcn2 overexpression increased Mmp9 expression in ***22a17 knockdown in macrophages reduced MMP9 release with recombinant LCN2 *** conclusion,our results demonstrate that macrophage CARD9 mediates the deterioration of cardiac function and adverse remodeling post-MI via LCN2.

关键词： CARD9 protective immunity

Characteristics of transfer zones under the influence of preexisting faults and regional stress transformation:Wenchang A subsag,Zhujiang River Mouth Basin,northern South China Sea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Oceanology and limnology 2024年第3期42卷 744-759页

作者： Wei li Mingyue CAO Meifang MENG Caiwei FAN hui li Jia li Wanqiu WU Ruiqing qin Xingan li Yiming liU State Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580China School of Geosciences China University of Petroleum(East China)Qingdao 266580China Zhanjiang Branch China National Offshore Oil Corporation CompanyZhanjiang 524057China

A transfer zone in rift basins preserves important information on regional tectonic evolution and plays significant roles in hydrocarbon *** on the systematic analysis of 3D seismic data and hydrocarbon accumulation conditions,the geometry,kinematics,and reservoir control of a large synthetic overlapping transfer zone in the south of the Wenchang A subsag in the Zhujiang(Pearl)River Mouth basin were *** indicate that the development and evolution of the transfer zone was controlled by the interaction between pre-existing faults and regional stress *** intense rifting of the main faults of the transfer zone controlled the development of source rocks and faultcontrolled slope break *** strike-slip overprint since the Oligocene is conducive to the formation of a large-scale fault-anticline trap,and the secondary faults in the transfer zone contribute to the hydrocarbon *** conjugate intersection area of the NE-and NW-trending faults offers more opportunity for hydrocarbon migration and accumulation.

关键词： transfer zone pre-existing fault regional stress transformation Cenozoic Wenchang A Subsag Zhujiang(Pearl)River Mouth Basin

Asymmetric Transfer Hydrogenation of Stable NH Imines for the Synthesis of Enantiopure α-Chiral Primary Amines

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第18期42卷 2211-2216页

作者： Mangang Zhang hui li Keqin Wu Nianxin Rong Shaoquan lin Hua Yang qin Yin College of Chemistry and Chemical Engineering Central South UniversityChangshaHunan 410083China Faculty of Pharmaceutical Sciences Shenzhen University of Advanced TechnologyShenzhenGuangdong 518055China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhenGuangdong 518055China

Although it offers a direct route to access synthetically valuableα-chiral primary amines,asymmetric transfer hydrogenation of NH imines has been rarely studied,due in large part to the inaccessibility and instability of NH ***,we report a Rh-catalyzed asymmetric transfer hydrogenation of a kind of novel and stable NH imines which are prepared via condensation of easily available sulfonylated 2'-aminoacetophenones with NH3 in *** this method,enantioenriched chiral 2-(1-aminoalkyl)anilines,which are privileged pharmacore groups,have been synthesized with good functional group compatibility,and with up to 99%ee.A gram-scale reaction using 0.2 mol%of catalyst has been successfully performed to highlight the ***,the products can be derivatized into enantiopure bioactive molecules as well as chiral tridentate ligands for metal catalysis.

关键词： Asymmetric transfer hydrogenation Asymmetric hydrogenation α-Chiral primary amine NH imines 2-(1-Aminoalkyl)anilines

Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2024年第4期39卷 699-701页

作者： Jinzhu Feng Zeyu Pu Rong li Yuzhuang li Xuewen qin hui Zhang Yiwen Zhang Institute of Human Virology Department of Pathogen Biology and BiosecurityKey Laboratory of Tropical Disease Control of Ministry of EducationZhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China

Dear Editor,As mass vaccination has been accomplished worldwide and a growing number of individuals have already been infected by SARS-CoV-2,understanding the incidence of subsequent re-infection is urgently required for comprehending the transmission dynamics of COVID-19(Bobrovitz et al.,2023).Additionally,current SARS-CoV-2 variants cause widespread escape from the neutralizing antibody(nAb)elicited by current ***,durable neutralization and memory B cell responses can be predicted by rapid CD4t T cell responses,particularly strong circulating T follicular helper(cTfh)cell responses,in individuals infected with SARS-CoV-2(Gong et al.,2020;Boppana et al.,2021;Narowski et al.,2022).Although nAb titers are known as predictors of protection against SARS-CoV-2 variants(Khoury et al.,2021),identifying more potential factors that could predict the risk of re-infection following primary infection and vaccination has become quite important in shaping prevention strategies(Chemaitelly et al.,2023).

关键词： infection prevention subsequent

Associative Tasks Computing Offloading Scheme in Internet of Medical Things with Deep Reinforcement Learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2024年第4期21卷 38-52页

作者： Jiang Fan qin Junwei liu Lei Tian hui School of Communications and Information Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

The Internet of Medical Things(Io MT) is regarded as a critical technology for intelligent healthcare in the foreseeable 6G era. Nevertheless, due to the limited computing power capability of edge devices and task-related coupling relationships, Io MT faces unprecedented challenges. Considering the associative connections among tasks, this paper proposes a computing offloading policy for multiple-user devices(UDs) considering device-to-device(D2D) communication and a multi-access edge computing(MEC)technique under the scenario of Io MT. Specifically,to minimize the total delay and energy consumption concerning the requirement of Io MT, we first analyze and model the detailed local execution, MEC execution, D2D execution, and associated tasks offloading exchange model. Consequently, the associated tasks’ offloading scheme of multi-UDs is formulated as a mixed-integer nonconvex optimization problem. Considering the advantages of deep reinforcement learning(DRL) in processing tasks related to coupling relationships, a Double DQN based associative tasks computing offloading(DDATO) algorithm is then proposed to obtain the optimal solution, which can make the best offloading decision under the condition that tasks of UDs are associative. Furthermore, to reduce the complexity of the DDATO algorithm, the cacheaided procedure is intentionally introduced before the data training process. This avoids redundant offloading and computing procedures concerning tasks that previously have already been cached by other UDs. In addition, we use a dynamic ε-greedy strategy in the action selection section of the algorithm, thus preventing the algorithm from falling into a locally optimal solution. Simulation results demonstrate that compared with other existing methods for associative task models concerning different structures in the Io MT network, the proposed algorithm can lower the total cost more effectively and efficiently while also providing a tradeoff between delay and energy co

关键词： associative tasks cache-aided procedure double deep Q-network Internet of Medical Things(IoMT) multi-access edge computing(MEC)

Developing a novel quantitative parameter for characterizing spatial distribution of fish following exposure to chemicals and wastewater:Behavioral Gini coefficient

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第7期141卷 129-138页

作者： Xuanyue Chen Yuanyuan li Zhanfen qin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

While the spatial distribution pattern of fish is increasingly used for toxicological test o chemicals or wastewater,no ideal parameter is available for quantitative assessment of spa tial distribution,especially uneven distribution with multiple ***,to develop a quantitative assessment parameter for spatial distribution,the zebrafish were exposed to ethanol,pentylenetetrazole(PTZ),paraquat dichloride(paraquat)and wastewater,followed by a behavioral test in a narrow *** data was acquired and analyzed by id Tracker and *** comparing the effects of all treatments on behavior parameters we confirmed that the spatial distribution was more easily altered rather than general loco motor parameters,e.g.0.7-70 mg/L PTZ and 5-20 mg/L paraquat being effective for altering spatial distribution but having little effects on general locomotor *** on the heatmap,i.e.,the cumulative proportion of grids and that of frequency in grids,we calcu lated the behavioral Gini coefficient(G_(b))for quantitative assessment of fish spatial distri *** Gini coefficient ranged from zero to 1,with larger values meaning poorer even ness of spatial *** note,G_(b)showed smaller coefficient of variations(CV)with3%-19%between replicate tanks in all treatments than the highest frequency(4%-79%),dis playing well ***,G_(b)addressed the challenge of the complicated heatmap with multiple ***,the behavioral Gini coefficient we established is an idea parameter to quantitatively assess spatial distribution of fish shoal,which is expected to be applied in toxicity testing for chemicals and wastewater and automatic quality monitoring for surface water and aquaculture water.

关键词： Zebrafish Behavioral test Spatial distribution Behavioral Gini coefficient

Role of micro-Ca/In alloying in tailoring the microstructural characteristics and discharge performance of dilute Mg-Bi-Sn-based alloys as anodes for Mg-air batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第1期12卷 251-266页

作者： Fei-er Shangguan Wei-li Cheng Yu-hang Chen Ze-qin Cui hui Yu Hong-xia Wang li-fei Wang Hang li Hua Hou School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300132China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The influence of micro-Ca/In alloying on the microstructural charac teristics,electrochemical behaviors and discharge properties of extruded dilute Mg-0.5Bi-0.5Sn-based(wt.%)alloys as anodes for Mg-air batteries are *** grain size and texture intensity of the Mg-Bi-Sn-based alloys are significantly decreased after the Ca/In alloying,particularly for the In-containing *** that,in addition to nanoscale Mg_(3)Bi_(2)phase,a new microscale Mg_(2)Bi_(2)Ca phase forms in the Ca-containing *** electrochemical test results demonstrate that Ca/In micro-alloying can enhance the electrochemical *** In to alloy the Mg-Bi-Sn-based alloy is effective in restricting the cathodic hydrogen evolution(CHE)kinetics,leading to a low self-corrosion rate,while severe CHE occurred after Ca *** micro-alloying of Ca/In to Mg-Bi-Sn-based alloy strongly deteriorates the compactness of discharge products film and mitigates the"chunk effect"(CE),hence the cell voltage,anodic efficiency as well as discharge capacity are greatly *** In-containing alloy exhibits outstanding discharge performance under the combined effect of the modified microstructure and discharge products,thus making it a potential anode material for primary Mg-air battery.

关键词： Mg-air batteries Mg-Bi-Sn based alloys Electrochemical behaviors Discharge properties