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Biomedical and Environmental Sciences 2021年第9期34卷 693-704页

作者： DUAN Wen Hua JIN Li Ya CAI Zu Chao lim David FENG Zhi hui Department of Occupational Health and Occupational Medicine School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina School of Health Sciences Western Sydney UniversityCampbelltown 2560Australia

Objective The aim of this study was to explore the effects of 2-hexyl-4-pentylenic acid(HPTA)in combination with radiotherapy(RT)on distant unirradiated breast *** Using a rat model of chemical carcinogen(7,12-dimethylbenz[a]anthracene,DMBA)-induced breast cancer,tumor volume was monitored and treatment response was evaluated by performing HE staining,immunohistochemistry,immunofluorescence,q RT-PCR,and western blot *** The results demonstrated that HPTA in combination with RT significantly delayed the growth of distant,unirradiated breast *** mechanism of action included tumor-associated macrophage(TAM)infiltration into distant tumor tissues,M1 polarization,and inhibition of tumor angiogenesis by IFN-γ.Conclusion The results suggest that the combination of HPTA with RT has an abscopal effect on distant tumors via M1-polarized TAMs,and HPTA may be considered as a new therapeutic for amplifying the efficacy of local RT for non-targeted breast tumors.

关键词： Breast cancer Abscopal effect 2-hexyl-4-pentylenic acid(HPTA) Radiotherapy(RT) Tumor-associated macrophages(TAMs) Polarization Angiogenesis

Importance of proper ventilator support and pulmonary rehabilitation in obese patients with heart failure:Two case reports

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World Journal of Clinical Cases 2023年第13期11卷 3029-3037页

作者： Eun-Hee lim Sung-Hee Park Yu hui Won Physical Medicine and Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Physical Medicine and Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Research Institute of Clinical Medicine of Jeonbuk National University Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND The optimal treatment for heart failure(HF)is a combination of appropriate *** the disease using only medical therapy is difficult in patients with HF,severe hypercapnia,and *** patients should first receive ventilator support followed by pulmonary rehabilitation(PR).CASE SUMMARY We report two cases in which arterial blood gas(ABG)improved and PR was possible with appropriate ventilator *** patients with extreme obesity complaining of worsening dyspnea–a 47-year-old woman and a 36-year-old man both diagnosed with HF–were hospitalized because of severe hypercapnia and *** proper medical treatment,hypercapnia and desaturation resolved in neither case,and both patients were transferred to the rehabilitation department for *** the time of the first consultation,the patients were bedridden because of *** demand was successfully reduced once noninvasive ventilation was *** the patients’dyspnea gradually improved to the point where they could be weaned off the ventilator during the daytime,they started engaging in functional training and aerobic *** 4 mo of followup,both patients were able to perform activities of daily living and maintain their lower body weight and normalized ABG *** Symptoms of patients with obesity and HF may improve once ABG levels are normalized through ventilator support and implementation of PR.

关键词： Noninvasive ventilation Heart failure Obesity Rehabilitation Dyspnea Case report

Mast Cell-Derived Exosomes at the Stimulated Acupoints Activating the Neuro-immune Regulation

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Chinese Journal of Integrative Medicine 2017年第11期23卷 878-880页

作者： CHEN Bo LI Ming-yue GUO Yi ZHAO Xue lim hui-min Calista Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine Tianjin(300193)China Department of Clinical Practice Teaching Tianjin University of Traditional Chinese MedicineTianjin(300193)China

Exosomes are cell-derived vesicles that take part in intercellular signaling. Research has shown that acupuncture is closely related to affecting the functions of the mast cells in the local region of the acupoint, and stimulating the afferent nerve. Mast cells have a connection with the conduction within the meridians, and play an important role in immuno-regulation. The ＇synapse-like＇ connection between the mast cells and nerve endings is the basis for the exchange of information between these two tissues. Exosome mediates mast exchange of information between mast cells and the nerves, starting the process of neuro-immuno regulation. Therefore, we propose that mast cell-derived exosomes mediate the neuro-immuno regulation at the local site of acupuncture, and this is one of the key factors resulting in the effectiveness of acupuncture.

关键词： mast cell-derived exosomes acupuncture neuro-immuno regulation

Visual quality assessment after presbyopic laser in-situ keratomileusis

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 462-469页

作者： Dong hui lim Eui-Sang Chung Myoung Joon Kim Tae-Young Chung Department of Ophthalmology Samsung Medical Center Sungkyunkwan University School of Medicine Department of Preventive Medicine Graduate School the Catholic University of Korea Department of Ophthalmology University of Ulsan College of MedicineAsan Medical Center

AIM： To assess visual quality after presbyopia correction using an aspheric ablation profile and a micro-monovision protocol. METHODS： This is a retrospective interventional study. Fifty-four eyes of 27 patients （mean age, 50.2±7.5y） who underwent presbyopia correction with an aspheric micro-monovision protocol were enrolled. The values of modulation transfer function （MTF） cutoff frequency, Strehl ratio, objective scattering index （OSI） and accommodation range were quantitatively assessed using the HD analyzer. Preoperative and postoperative contrast sensitivity （CS） at far （2.5 m） and near （40 cm） distance and higher-order aberrations （HOAs） were analyzed. Subjective visual satisfaction was evaluated by self-reported questionnaire regarding optical visual symptoms. RESULTS： One year after presbyopia correction, no significant differences were found in the MTF cutoff frequency, Strehl ratio and OSI, however, the lID analyzer accommodation range significantly differed postoperatively （P=0.004）. Postoperative CS at 12 and 18 cpd at near showed statistically significant improvement （P=0.020 and 0.008, respectively）. Visual performance by self-reported questionnaire revealed satisfactory results in terms of subjective visual quality improvement. CONCLUSION： Objective optical quality parameters show good visual outcomes. Subjective visual quality assessed by self-reported questionnaire in the presbyopia correction group show satisfactory results.

关键词： presbyopia correction laser blended vision visual quality LASIK

Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer

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World Journal of Clinical Cases 2022年第28期10卷 10066-10076页

作者： Hee Ryeong Jang hui-Young Lee Seo-Young Song Kyu-Hyoung lim Department of Internal Medicine Kangwon National University HospitalKangwon National University School of MedicineChuncheon-siGangwon-do 24289South Korea

BACKGROUND The 5-fluorouracil-based chemotherapy combined with oxaliplatin or irinotecan is usually used in colorectal cancer(CRC).The addition of a targeted agent(TA) to this combination chemotherapy is currently the standard treatment for metastatic ***,the efficacy and safety of combination chemotherapy for metastatic CRC in patients aged above 80 years has yet to be *** To assess the clinical outcomes and feasibility of combination chemotherapy using a TA in extremely elderly patients with *** Eligibility criteria were:(1) Age above 80 years;(2) Metastatic colorectal cancer;(3) Palliative chemotherapy na?ve;(4) Eastern Cooperative Oncology Group performance status 0-1;and(5) Adequate organ *** received at least one dose of combination chemotherapy with or without *** was evaluated every 8 *** Of 30 patients,the median age of 15 patients treated with TA was 83.0 years and that of those without TA was 81.3 *** median progression-free survival(PFS) and overall survival(OS) in patients treated with TA were 7.4 mo and 15.4 mo,respectively,compared with 4.4 mo and 15.6 mo,respectively,in patients treated without *** was no significant difference in PFS(P:0.193) and OS(P:0.748) between patients treated with and without *** grade 3/4 hematologic toxicities were anemia(16.7%) and neutropenia(10.0%).After disease progression,the median OS of patients who were treated with and without salvage chemotherapy were 23.5 mo and 7.0 mo,respectively,suggesting significant difference in OS(P = 0.001).CONCLUSION Combination chemotherapy with TA for metastatic CRC may be considered feasible in patients aged above 80 years,when with careful *** chemotherapy can help improve OS in some selected of these elderly patients.

关键词： Combination chemotherapy Targeted agent Colorectal cancer Salvage chemotherapy Elderly patient

“房子”与“身份”——奈保尔《毕司沃斯先生的房子》

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外国语文研究 2024年第2期10卷 32-40页

作者：林宛莹厦门大学外文学院

奈保尔的小说《毕司沃斯先生的房子》书写了主人公毕司沃斯终生追求“房子”的奇特现象。本文运用文学伦理学批评方法,探讨了小说中主人公毕司沃斯追求“房子”的原因,揭示了毕司沃斯追求“房子”与“身份”探寻之间的密切关系。本文认... 详细信息

奈保尔的小说《毕司沃斯先生的房子》书写了主人公毕司沃斯终生追求“房子”的奇特现象。本文运用文学伦理学批评方法,探讨了小说中主人公毕司沃斯追求“房子”的原因,揭示了毕司沃斯追求“房子”与“身份”探寻之间的密切关系。本文认为,毕司沃斯试图通过获得房子来确立自己作为儿子、女婿、丈夫和父亲的伦理身份,从而实现他的存在价值和人生意义。在这一意义上,小说中通过揭示“房子”与“身份”的关系也展现了空间的伦理意义。通过对空间伦理的关注,本文强调了小说中的“房子”不仅仅是房子,它在本质的意义上具有“独立自主”“个人尊严”“人生成就”“责任与义务”的伦理价值。

关键词：奈保尔《毕司沃斯先生的房子》身份文学伦理学批评

Synthesis of Al-doped ZnO Nanorods via Microemulsion Method and Their Application as a CO Gas Sensor

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Journal of Materials Science & Technology 2015年第6期31卷 639-644页

作者： Sang Kyoo lim Seong hui Hong Sung-Ho Hwang Won Mi Choi Soonhyun Kim Hyunwoong Park Min Gi Jeong Division of Nano & Bio Technology Daegu Gyeongbuk Institute of Science and Technology(DGIST) School of Energy Engineering Kyungpook National University Department of Advanced Organic Materials Engineering Yeungnam University

Aluminum doped ZnO(AZO) nanorods were synthesized by microemulsion method with different types of *** phase and the morphology of the above nanorods were investigated by scanning electron microscopy(SEM) and X-ray diffraction(XRD).SEM observations showed that the ZnO nanorods had diameters around about 50—200 nm and lengths up to several *** CO gas sensing properties of the AZO nanorods were tested at operating temperatures of 200,300,350 and 400 ℃.It was found that AZO nanorods based sensor exhibited the highest sensitivity to CO at 350℃.

关键词： Zinc oxide Nanorod Microemulsion Aluminum CO and g

lim结构蛋白激酶1在肾透明细胞癌中的表达及其对肿瘤细胞增殖和迁移能力的影响

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医药论坛杂志 2024年第7期45卷 699-704页

作者：郭文慧袁红昌新乡医学院第一附属医院临床药学学部河南新乡453000

目的本研究旨在探讨lim结构蛋白激酶1(lim domain kinase 1,limK1)在肾透明细胞癌(clear cell renal cell carcinoma,ccRCC)中的表达及其对肿瘤细胞增殖、迁移能力的影响。方法数据获取时间为2023年2月。通过癌症基因组图谱数据库TCGA获... 详细信息

目的本研究旨在探讨lim结构蛋白激酶1(lim domain kinase 1,limK1)在肾透明细胞癌(clear cell renal cell carcinoma,ccRCC)中的表达及其对肿瘤细胞增殖、迁移能力的影响。方法数据获取时间为2023年2月。通过癌症基因组图谱数据库TCGA获取ccRCC患者的转录组数据和临床信息,采用生存分析、单因素和多因素分析评估limK1对ccRCC患者预后的影响。利用功能富集分析预测limK1参与ccRCC病理过程的分子信号通路。通过RT-qPCR技术检测limK1在ccRCC细胞系中的表达水平,利用基因干扰技术敲减limK1在786-O细胞系中的表达。采用CCK8实验、划痕愈合实验的方法综合评估limK1对细胞增殖和迁移的影响。结果来自公共数据库的结果表明,在ccRCC组织中limK1呈现高表达(PlimK1是ccRCC患者的独立预后危险因素。功能富集分析揭示了limK1表达升高可能通过T细胞受体信号、P53信号、Toll样受体信号和JAK/STAT信号通路参与ccRCC的病理进程。实验结果表明,limK1在ccRCC细胞系中的表达水平增高,敲减limK1的表达能够抑制786-O细胞的增殖和迁移能力(PlimK1是ccRCC患者不良预后的潜在诊断标志物,可通过调控肿瘤细胞增殖和侵袭等特性影响ccRCC的发生与发展。

关键词：肾透明细胞癌 limK1 恶性生物学行为

Characterizations of organic compounds in diesel exhaust particulates

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Journal of Environmental Sciences 2015年第8期27卷 171-183页

作者： Jaehyun lim Cheolsoo lim Sangkyun Kim Jihyung Hong Division of Global Environment Research National Institute of Environmental Research Department of Climate and Air Quality Research National Institute of Environmental Research

To characterize how the speed and load of a medium-duty diesel engine affected the organic compounds in diesel particle matter（PM） below 1 μm, four driving conditions were examined. At all four driving conditions, concentration of identifiable organic compounds in PM ultrafine（34–94 nm） and accumulation（94–1000 nm） modes ranged from 2.9 to 5.7 μg/m3 and 9.5 to 16.4 μg/m3, respectively. As a function of driving conditions, the non-oxygencontaining organics exhibited a reversed concentration trend to the oxygen-containing organics. The identified organic compounds were classified into eleven classes： alkanes,alkenes, alkynes, aromatic hydrocarbons, carboxylic acids, esters, ketones, alcohols, ethers,nitrogen-containing compounds, and sulfur-containing compounds. At all driving conditions,alkane class consistently showed the highest concentration（8.3 to 18.0 μg/m3） followed by carboxylic acid, esters, ketones and alcohols. Twelve polycyclic aromatic hydrocarbons（PAHs）were identified with a total concentration ranging from 37.9 to 174.8 ng/m3. In addition, nine nitrogen-containing polycyclic aromatic compounds（NPACs） were identified with a total concentration ranging from 7.0 to 10.3 ng/m3. The most abundant PAH（phenanthrene）and NPACs（7,8-benzoquinoline and 3-nitrophenanthrene） comprise a similar molecular（3 aromatic-ring） structure under the highest engine speed and engine load.

关键词： Diesel particle matter Organic compounds Polycyclic aromatic hydrocarbons Nitrogen-containing polycyclic aromatic compounds

Intelligent Prescription-Generating Models of Traditional Chinese Medicine Based on Deep Learning

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World Journal of Traditional Chinese Medicine 2021年第3期7卷 361-369页

作者： Qing-Yang Shi Li-Zi Tan lim Lian Seng hui-Jun Wang Department of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina Department of Traditional Chinese Medicine Malaysia Chinese Medical AssociationKuala LumpurMalaysia

Objective:This study aimed to construct an intelligent prescription-generating(IPG)model based on deep-learning natural language processing(NLP)technology for multiple prescriptions in Chinese *** and Methods:We selected the Treatise on Febrile Diseases and the Synopsis of Golden Chamber as basic datasets with EDA data augmentation,and the Yellow Emperor’s Canon of Internal Medicine,the Classic of the Miraculous Pivot,and the Classic on Medical Problems as supplementary datasets for *** selected the word-embedding model based on the Imperial Collection of Four,the bidirectional encoder representations from transformers(BERT)model based on the Chinese Wikipedia,and the robustly optimized BERT approach(RoBERTa)model based on the Chinese Wikipedia and a general *** addition,the BERT model was fine-tuned using the supplementary datasets to generate a Traditional Chinese Medicine-BERT *** IPG models were constructed based on the pretraining strategy and experiments were *** of precision,recall,and F1-score were used to assess the model *** on the trained models,we extracted and visualized the semantic features of some typical texts from treatise on febrile diseases and investigated the ***:Among all the trained models,the RoBERTa-large model performed the best,with a test set precision of 92.22%,recall of 86.71%,and F1-score of 89.38%and 10-fold cross-validation precision of 94.5%±2.5%,recall of 90.47%±4.1%,and F1-score of 92.38%±2.8%.The semantic feature extraction results based on this model showed that the model was intelligently stratified based on different meanings such that the within-layer’s patterns showed the associations of symptom–symptoms,disease–symptoms,and symptom–punctuations,while the between-layer’s patterns showed a progressive or dynamic symptom and disease ***:Deep-learning-based NLP technology significantly improves the performance of IPG mo

关键词： Ancient books of Chinese medicine bidirectional encoder representations from transformers deep learning intelligent prescription-generating models pretrained models