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Immunotherapy in combination with chemotherapy for Peutz-Jeghers syndrome with advanced cervical cancer:A case report

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 480-487页

作者： Xiang-Cheng Hu Chen-Xiao Gan hui-min zheng Xue-Ping Wu Wen-Sheng Pan Department of Gastroenterology Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastroenterology Zhejiang Provincial People’s hospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Peutz-Jeghers syndrome(PJS)is a rare autosomal dominant disorder,and female patients may develop gynecologic *** prognosis for such patients is poor and the specific pathogenesis remains ***,there are currently no uniform treatment *** SUMMARY Herein,we introduce the case of a 45-year-old female who was diagnosed with PJS for 45 years and cervical cancer for 3 *** pathological examination showed metastases in the right external iliac lymph *** patient was initially treated with a combination of doxorubicin and carboplatin chemotherapy and pelvic magnetic resonance showed that the metastases had ***,we performed whole exome sequencing in this patient and identified the relevant causative *** addition to the chemotherapy regimen,sindilizumab was administered and the patient was followed *** 4 cycles of treatment,the metastases were substantially reduced and were not enlarged after six months of *** case report suggests that patients with PJS combined with cervical cancer may have a sustained response to immunecombination chemotherapy *** Clinicians should be aware of the importance of immunotherapy in patients with PJS combined with advanced cervical cancer.

关键词： Peutz-Jeghers syndrome Cervical cancer Programmed cell death protein 1 Chemotherapy Case report

Efficacy and safety of acupuncture on the treatment of functional constipation: Study protocol for a randomized controlled trial

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 145-152页

作者： Ping YIN Ning-yang GAO Bo DONG hui-min zheng Ze-qin CHEN Xuan YIN Jun-yi WU Yan CAO Shi-fen XU Shanghai Municipal Hospital of Traditional Chinese Medicine. Shanghai University of TCM Shanghai 200071 China Sliuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating ***:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled ***-two eligible patients will be randomly assigned to the intervention group(acupuncture)or the control group(sham acupuncture).All treatment will be given 26 sessions of acupuncture or sham acupuncture over 8 weeks(5 times per week in the first 2 weeks,3 times per week during weeks 3-6,and 2 times per week during weeks 7 and 8).Each treatment will last for 20 *** primary outcome is the change in mean complete spontaneous bowel movements(CSBMs)per *** secondary out?comes are patient assessment of constipation quality of life questionnaire(PAC-QOL),self-rating anxiety scale(SAS),and the dosage of the *** adverse events will be recorded in detail and managed by corresponding researchers as quickly as *** will be evaluated at baseline(1 week before treatment),2 weeks after intervention begins,6 weeks after intervention begins,8 weeks after intervention begins,4 weeks follow-up,and 12 weeks ***:The results of this study will provide the evidence of the efficacy and safety of acupuncture as a traditional treatment methods for functional *** registration:Chinese Clinical Trial Registry,*** on 23 May 2017.

关键词： Acupuncture Functional constipation Randomized controlled trial (RCT) Protocol

Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-min Zeng Di-Wei zheng Ting Pan Xing-Lan Ding Yun Zhang Chi-hui Yang Si-Xue Cheng Xian-zheng Zhang Key Laboratory of Biomedical Polymers of ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Systematic Acupuncture Explains Acupuncture at Baihui(GV20) and Fengchi(GB20) Targeting the Inflammatory Response to Regulate Migraine

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Journal of Traditional Chinese Medicine 2025年

作者： min Yu zheng Meifeng SUN Ju PENG Zetong CAO Zhixian HUANG Xiaohua Medical College of Acu-Moxi and Rehabilitation， Guangzhou University of Chinese Medicine Department of Rehabilitation Medicine， the Affiliated Panyu Central Hospital of Guangzhou Medical University

Objective: To take Baihui (GV20) and Fengchi (GB20) targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating ***: The target information of Baihui (GV20) and Fengchi (GB20) was retrieved， and after intersection with migraine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， Reactome， and UniProt Keywords were used for functional enrichment. After selecting the main pathway， rats were selected and nitroglycerin was used for modeling， and the behavioral scores， inflammatory factors， heme oxygenase 1 (HMOX1)， protein kinase B (AKT1)， signal transducer and activator of transcription 3 (STAT3)， phosphorylated extracellular signal-regulated kinase 1/2 (P-ERK1/ERK2) and other states of the rats in the acupuncture， twisting， and electroacupuncture groups were ***: A total of 135 Baihui (GV20) targets and 27 Fengchi (GB20) targets were collected. A total of 73 target information were obtained after the intersection of these targets in migraine. These 73 targets have three main pathways: hypoxia-inducible factor 1 (HIF-1) signaling pathway， signaling by interleukins and inflammatory response. The main targets in the pathway were verified and found that interleukin-1 beta (IL-1β)， interleukin-6 (IL-6)， tumor necrosis factor-alpha (TNF-α) and HMOX1， AKT1， STAT3， P-ERK1/ERK2 can be regulated by Baihui (GV20) and Fengchi (GB20).Conclusion: Baihui (GV20) and Fengchi (GB20) can regulate migraine by regulating inflammatory factors and HMOX1， AKT1， STAT3， P-ERK1/ERK2 and other changes in HIF-1 signaling pathway， Signaling by Interleukins and Inflammatory response pathways. Based on systems biology and network pharmacology， and with the model of "acupoint-target-disease"， explore the research methods of systematic acupuncture and moxibustion. We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-hui zheng Bo Shao Chao-min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

DNA analysis of a pedigree with Myotonic Dystrophy in Songiang county Shanghai

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中国临床神经科学 2000年第Z1期8卷 88-页

作者： hui-min zheng hui-jun Xie She Qing Zhang Dept. Of Neurology Changhai Hospital The Second Military Medical University Shanghai200433 Dept. Of Neurology Changhai Hospital The Second Military Medical University Shanghai200433 Dept. Of Neurology Changhai Hospital The Second Military Medical University Shanghai200433

Objective To make the molecular analysis of a pedigree with myotonic dystrophy (DM) in Songjiang county Shanghai China, and to observe the connection between CTG trinucleotide repeat number and clinical features in a pedigreee with DM. Beckground Previous reports of CTG repeat numbers in a pedigree with DM was less in China. The study showed normal and expanded CTG repeat numbers in a Chinese patients with DM. Methods CTG trinucleotide repeat numbers were analyzed by using Long Expand TM Template PCR system. Results Four of eight clinical patients had expanded DM allele, the other four had no expanded CTG copies. Seven of eight suspicious DM cases had expanded CTG repeat numbers and were therefore genetically diagnosed DM, and an asymptomatic individual was dianosed a doubted DM patient by DNA analysis. High risk of DM in six of seven individuals was ruled out, and a clinical doubted DM individual was ascertained a normal person by molecular analysis. A positive correlation was found between early onset and expanded CTG repeat number in six parent(or grandparent)/child pairs, but in the pair No Ⅱ2/NoⅣ7 CTG repeat numbers were reduced from 3100 in the grandmother to 175 in her grandson and there was no anticipation phenomenon. Discussion it is possible that these patients represent a form of allelic heterogeneity for DM. Conclusion The measurement of CTG repeat number can help to ascertain the diagnosis of DM.

关键词： trinucleotide repeat molecular analysis myotonic dystrophy clinical features Chinese patients diagnosis of early onset form of

Let-7a负性调控人肾上皮细胞293T中UHRF1基因的表达

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西南大学学报（自然科学版） 2017年第7期39卷 77-83页

作者：文利彭睿孙艳武天慧彭惠民张政重庆医科大学细胞生物学及遗传学教研室重庆400016 重庆医科大学生物信息学教研室重庆400016 重庆医科大学实验教学中心重庆400016

目的:探讨人肾上皮细胞293T中let-7a对靶基因UHRF1的负性调控作用.方法:运用生物信息学技术对let-7a靶基因进行预测和分析.构建含有UHRF1 3'UTR全长的野生型(pmiR-RB-UHRF1-3'UTR-wt)和突变型荧光素酶报告质粒(pmiR-RB-UHRF1-3'UTR-mut),分别将pmiR-RB-UHRF1-3'UTR-wt,pmiR-RB-UHRF1-3'UTRmut,pmiR-RB-REPORT vector与let-7amimics或mimics control共转染293T细胞,双荧光素酶报告系统检测转染后293T细胞的荧光素酶表达水平.293T细胞分别转染let-7amimics和inhibitor,western blot和real-time RT PCR检测UHRF1基因的表达.结果:生物信息学结果显示let-7a有48个预测靶基因,包括UHRF1,HMGA2,MAPK6等,主要涉及microRNA在肿瘤、细胞周期、PI3K-AKT、p53等信号通路.其中UHRF1 3'UTR含有一个let-7a的结合位点,且在多个物种中呈高度保守.进一步双荧光素酶检测发现,共转染let-7amimics和pmiR-RBUHRF1-3'UTR-wt的293T细胞荧光素酶活性显著降低(p<0.01).Western blot和real-time RT PCR结果显示转染let-7amimics的293T细胞UHRF1表达降低,而转染let-7ainhibitor的293T细胞UHRF1表达增高.结论:人肾上皮细胞293T中let-7a能通过与UHRF13'UTR靶向结合,负性调控UHRF1的表达.

关键词：微RNA UHRF1 基因表达

The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng Liu Chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling