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Long-term results of liver transplantation for over 60 years old patients with hepatitis B virus-related end-stage liver disease

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 501-507页

作者： Shu-Hong yi hui-min yi Bin-Sheng Fu Chi Xu min-Ru Li Qi Zhang Yang Yang Gui-Hua Chen Liver Transplant Center Third Affiliated Hospitaland Transplantation Research Institute Sun Yat-Sen University

BACKGROUND： Hepatitis B virus（HBV）-related end-stage liver disease is the leading indication for liver transplantation in China, but long-term results of liver transplantation in patients aged over 60 years are not clear. The present study was to reveal the natural history of liver recipients with hepatitis B older than60 ***： The recipients who had received liver transplantation between December 2003 and December 2005 were divided into two groups： those equal or older than 60 years（older group,n60） and those younger than 60 years（younger group, n305）.Risk factors for poor long-term outcome in patients aged over 60 years were also ***： Except for age and preexisting chronic disease（P0.05）,no significant differences were observed in perioperative characteristics between the two groups. There was also no significant difference in HBV and hepatocellular carcinoma recurrence（P0.05）. The actuarial 1-, 3-, 5- and 8-year survival rates were 81.6%, 71.6%, 66.7% and 63.3% respectively for the older group vs 84.9%, 77.7%, 70.8% and 65.6% for the younger group（P0.05）. Multivariate analyses showed that pre-liver transplant renal insufficiency was a risk factor for poor outcome in the older group（odds ratio=3.615, P0.014）.CONCLUSIONS： Liver transplantation is safe and feasible for patients with HBV-related end-stage liver disease aged over 60years. Older patients with renal insufficiency should undergo transplantation earlier than younger patients.

关键词： ge hepatitis B virus liver transplantation renal insufficiency long-term

A three-factor preoperative scoring model predicts risk of recurrence after liver resection or transplantation in hepatocellular carcinoma patients with preserved liver function

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 477-484页

作者： Yang Li Dan-Yun Ruan hui-min yi Guo-ying Wang Yang Yang Nan Jiang Department of Liver Surgery The Third Affiliated Hospital of Sun Yat-Sen University Department of Medical Oncology The Third Affiliated Hospital of Sun Yat-Sen University

BACKGROUND： No staging systems of hepatocellular carcinoma（HCC） are tailored for assessing recurrence risk. We sought to establish a recurrence risk scoring system to predict recurrence of HCC patients receiving surgical curative treatment（liver resection or transplantation）.METHODS： We retrospectively studied 286 HCC patients with preserved liver function receiving liver resection（n=184） or transplantation（n=102）. Independent risk factors were identified to construct the recurrence risk scoring model. The recurrence free survival and discriminatory ability of the model were analyzed. RESULTS： Total tumor volume, HBs Ag status, plasma fibrinogen level were included as independent prognostic factors for recurrence-free survival and used for constructing a 3-factor recurrence risk scoring model. The scoring model was as follows： 0.758×HBs Ag status（negative： 0; positive： 1）＋0.387×plasma fibrinogen level（≤3.24 g/L： 0; 〉3.24 g/L： 1）＋0.633×total tumor volume（≤107.5 cm3： 0; 〉107.5 cm3： 1）. The cutoff value was set to 1.02, and we defined the patients with the score ≤1.02 as a low risk group and those with the score 〉1.02 as a high risk group. The 3-year recurrence-free survival rate was significantly higher in the low risk group compared with that in the high risk group（67.9% vs 41.3%, P〈0.001）. In the subgroup analysis, liver transplantation patients had a better3-year recurrence-free survival rate than the liver resection patients in the low risk group（80.0% vs 64.0%, P〈0.01）. Additionally for patients underwent liver transplantation, we compared the recurrence risk model with the Milan criteria in the prediction of recurrence, and the 3-year recurrence survival rates were similar（80.0% vs 79.3%, P=0.906）.CONCLUSION： Our recurrence risk scoring model is effective in categorizing recurrence risks and in predicting recurrencefree survival of HCC before potential surgical curative treatment.

关键词： hepatocellular carcinoma liver resection liver transplantation total tumor volume plasma fibrinogen

Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol

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Chinese Chemical Letters 2011年第7期22卷 765-767页

作者： Xu Qin Li Yun Xu Yang Wei Li Wang Bin Hu hui min Xue Tian yi Zhang Xue Tao Zhang Department of Chemistry University of Science and Technology Beijing Beijing 100083 China

A practical chemical synthesis of L-camitine （1） has been accomplished from （R）-3-chloro-1,2-propanediol （（R）-4）, which is a main by-product originated from （R,R）-Salen Co（III） catalyzed hydrolytic kinetic resolution （HKR） of （±）-epichlorohydrin. （R）-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite （（R）-S）. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.

关键词： L-Camitine Cyclic sulfite (R)-3-Chloro-1,2-propanediol

Experience in Peri-operative care of patients with Hepatopulmonary Syndrome after Orthotropic Liver Transplantation

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Experience in Peri-operative care of patients with Hepatopul...

Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

2013中国器官移植大会

作者： hui-min yi Shuhong yi Yang YANG Gen-shu WANG Gui-hua CHEN The Third Affiliated Hospital of Sun Yat-sen University

Objective To summarize the experience in peri-operative care of patients with Hepatopulmonary Syndrome after Orthotropic Liver Transplantation. Methods 36 cases of HPS from Mar of 2004 to Oct of 2012 underwent OLT in the Third Affiliated Hospital of Sun Yatsen *** the 36 recipients,26 were performed OLT from 2004 to 2006 who did not receive selective digestive decontamination(SDD),extensive oxygen therapy,and extensive airway and gastrointestinal tract care.10 were performed OLT from 2007

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： yi-Qing Shen Qiu-Wan Wei yi-Ren Tian Yun-Zhi Ling min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

AP1000核电汽轮机中调门内两相流动特性数值模拟

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汽轮机技术 2017年第1期59卷 43-46页

作者：贺惠民张晓毅国网冀北节能服务有限公司北京100045

利用FLUENT对某AP1000核电汽轮机中压阀内的两相流动进行数值模拟。分别对调节阀在90°、40°、10°3种开度下的两相流与单相流流场比较分析,并对阀门压损以及影响压损的因素进行研究。结果表明:两相流在阀内的最大流速低于同等开度下... 详细信息

利用FLUENT对某AP1000核电汽轮机中压阀内的两相流动进行数值模拟。分别对调节阀在90°、40°、10°3种开度下的两相流与单相流流场比较分析,并对阀门压损以及影响压损的因素进行研究。结果表明:两相流在阀内的最大流速低于同等开度下单相流的最大流速,湿蒸汽两相流随开度的压损变化规律与单相流相似,但两相流的压损将近为单相流的两倍;蒸汽中水滴粒径大小对压力损失的影响较小,而蒸汽含水率对阀门压损影响非常大。

关键词：核电汽轮机中压阀门流场压力损失数值模拟

Orthotopic liver transplantation for the treatment of end-stage autoimmune liver disease:a single-center experience

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Fatal hemophagocytic syndrome after orthotopic liver transplantation:a report of two cases

2013中国器官移植大会

作者： Bin-sheng Fu Shu-hong yi Hua Li Tong Zhang hui-min yi Nan Jiang Gen-shu Wang Jian Zhang Chi Xu Yang Yang Gui-hua Chen Liver Transplant Center Third Affiliated Hospital of Sun Yat-sen University Transplantation Research Institute of Sun Yat-sen University Organ Transplantation Research Center of Guangdong Province

Objective To evaluate the effect of liver transplantation for end-stage autoimmune liver disease(ESALD)and summarize the clinical experience of liver transplantation in the treatment of ESALD. Methods The clinical records of 1 1 cases of ESALD who underwent liver transplantation from September 2003 to July 2009 were analyzed *** them,there were 2 male and 9 female patients(median age,44.2 8.7 years),who underwent modified piggyback liver transplantation with venacavaplasty because of primary biliary cirrhrosis(8 cases),autoimmune hepatitis(2 cases),and primary sclerosing cholangitis(1 case).All patients were treated with immunosuppressive agents including tacrolimus(or cyclosporine A)

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Fatal hemophagocytic syndrome after orthotopic liver transpl...

磁珠固定多抗预测最大吸附活性识别阳性突变体

2013中国器官移植大会

作者： Bin-sheng Fu Hua Li Shu-hong yi Tong Zhang hui-min yi Nan Jiang Gen-shu Wang Jian Zhang Chi Xu Yang Yang Gui-hua Chen Liver Transplant Center Third Affiliated Hospital of Sun Yat-sen University Transplantation Research Institute of Sun Yat-sen University Organ Transplantation Research Center of Guangdong Province

Objective Hemophagocytic syndrome(HPS)is a serious hematological disorder caused by activated T lymphocytes in immunologically compromised *** analyze the clinical characteristics,risk factors,diagnosis,and prognosis of hemophagocyfic syndrome(HPS)after liver transplantation(LT). Methods Among 813 patients who underwent orthotopic liver transplantation between September 2003 and December 2012,HPS developed in two patients(0.24%)on the 36th and 14th postoperative day,*** courses of these patients were evaluated. Results The cause of HPS was unknown in two *** patients had high fever,splenomegaly,pancytopenia,coagulopathy, hypertriglyceridemia,hyperferritinemia,and hemophagocytosis in bone *** diagnosis of HPS was established based on clinical

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西安交通大学学报（医学版） 2017年第5期38卷 753-757,767页

作者：种慧敏冯一然杨晓兰廖飞重庆医科大学检验医学院临床检验诊断学教育部重点实验室重庆400016

目的考察磁珠固定多抗吸附细胞裂解液中酶/突变体,分析吸附酶活性对样品蛋白量响应曲线预测最大吸附活性(Vs)用于比较识别阳性突变体的可靠性。方法纯化重组表达大肠杆菌碱性磷酸酶(ECAP)及绿脓杆菌芳香硫酸酯酶(PAAS)为免疫原;兔抗血清... 详细信息

目的考察磁珠固定多抗吸附细胞裂解液中酶/突变体,分析吸附酶活性对样品蛋白量响应曲线预测最大吸附活性(Vs)用于比较识别阳性突变体的可靠性。方法纯化重组表达大肠杆菌碱性磷酸酶(ECAP)及绿脓杆菌芳香硫酸酯酶(PAAS)为免疫原;兔抗血清用33%硫酸铵分级和DEAE-纤维素层析纯化得多抗。磁珠羧基活化后固定多抗;用对硝基酚显色底物,碱终止后测定405nm吸收增量反映酶活性;分析吸附响应曲线预测Vs。结果多抗磁珠吸附酶的容量约2.0mg/g磁珠。ECAP比活性超过PAAS比活性70倍。ECAP突变体R168K较野生型比活性提高约50%,用2.5μg多抗磁珠反应10min即可预测Vs识别此阳性突变体;用PAAS突变体G138S为起始酶,用10μg多抗磁珠测定吸附酶反应20min后吸收预测Vs,能识别活性提高20%以上的PAAS弱阳性突变体。结论只要被吸附酶活性能可靠测定,优化磁珠固定多抗的用量能预测低活性酶/突变体Vs进行比较识别阳性突变体。

关键词：多抗突变体最大吸附活性预测磁珠