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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-lin jiang hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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深度学习在心力衰竭检测中的应用综述

计算机科学与探索 2025年第1期19卷 65-78页

作者：王永威魏德健曹慧姜良山东中医药大学智能与信息工程学院济南250355

随着生物医学技术的发展,利用生物信号进行心力衰竭的早期诊断已成为提高患者生存率和降低治疗成本的关键策略。在此背景下,深度学习技术的迅猛发展为心力衰竭检测开辟了新路径。系统地综述了深度学习在心力衰竭检测中的最新进展和应用... 详细信息

随着生物医学技术的发展,利用生物信号进行心力衰竭的早期诊断已成为提高患者生存率和降低治疗成本的关键策略。在此背景下,深度学习技术的迅猛发展为心力衰竭检测开辟了新路径。系统地综述了深度学习在心力衰竭检测中的最新进展和应用。概述了心力衰竭检测涉及的主要生物医学信号和公开数据集。详细分析了深度学习在心力衰竭诊断领域的应用及其发展,特别是对卷积神经网络和长短期记忆网络处理心电图、心率变异性、心音等关键生物医学信号的能力进行了深入分析,总结了这些技术的优势、局限性,并对各类模型性能进行了比较。探讨了通过融合多种人工智能技术所构建的混合模型在提升检测精度和模型泛化能力方面的潜力,以及如何利用模型的可解释性来增加检测过程的透明度,提升医生的信任度。最后总结了当前研究存在的不足,并对未来研究方向提出展望,强调了跨学科合作在推动心力衰竭检测技术进步中的重要性。

关键词：心力衰竭生物医学信号深度学习卷积神经网络循环神经网络混合模型

Dynamic softening and microstructural evolution during hot deformation of Al-Cu-Mg-Zr alloys with different homogenization cooling rates

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Rare Metals 2021年第3期40卷 626-634页

作者： Guo-Wei Bo Guan Wang Fu-lin jiang Can Liu Rong Chen hui Zhang College of Materials Science and Engineering Hunan UniversityChangsha410082China School of Mechanical Engineering Ningxia UniversityYinchuan 750021China

An Al-Cu-Mg-Zr alloy,which obtained different homogenization cooling rates by changing the heattreated sample size,was compressed to various strains at the deformation temperature of 300℃ and strain rate of 0.01 s^(-1).The results showed that the homogenization cooling rate had strong effects on the hot deformation behavior of the *** flow stress and relative dynamic softening rate of the alloy were significantly higher under a high cooling rate(HCR) than those under a low cooling rate(LCR).Furthermore,based on X-ray diffraction,scanning electron microscopy,transmission electron microscopy,and thermodynamic equilibrium phase calculation,the substructure evolution in the grain interior,morphology,and spatial distribution of the precipitates were studied to determine the differences in the flow softening *** main softening mechanism could be summarized as dynamic recovery and precipitation coarsening for the LCR alloy and dynamic precipitation for the HCR alloy.

关键词： Al-Cu-Mg-Zr alloy Homogenization Hot compression Flow softening Dynamic precipitation

B-Spline-Based Curve Fitting to Cam Pitch Curve Using Reinforcement Learning

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Intelligent Automation & Soft Computing 2023年第5期36卷 2145-2164页

作者： Zhiwei lin Tianding Chen Yingtao jiang hui Wang Shuqin lin Ming Zhu School of Physics and Information Engineering Minnan Normal UniversityZhang ZhouFujian363000China Department of Electrical and Computer Engineering University of NevadaLas VegasNV89154USA

Directly applying the B-spline interpolation function to process plate cams in a computer numerical control(CNC)system may produce verbose tool-path codes and unsmooth *** paper is devoted to addressing the problem of B-splineﬁtting for cam pitch *** that the B-spline curve needs to meet the motion law of the follower to approximate the pitch curve,we use the radial error to quantify the effects of theﬁtting B-spline curve and the pitch *** problem thus boils down to solving a difﬁcult global optimization problem toﬁnd the numbers and positions of the control points or data points of the B-spline curve such that the cumulative radial error between theﬁtting curve and the original curve is minimized,and this problem is attempted in this paper with a double deep Q-network(DDQN)reinforcement learning(RL)algorithm with data points ***ﬁcally,the RL envir-onment,actions set and current states set are designed to facilitate the search of the data points,along with the design of the reward function and the initialization of the neural *** experimental results show that when the angle division value of the actions set isﬁxed,the proposed algorithm can maximize the number of data points of the B-spline curve,and accurately place these data points to the right positions,with the minimum average of radial *** work establishes the theoretical foundation for studying splineﬁtting using the RL method.

关键词： B-splineﬁtting radial error DDQN RL algorithm global optimal policy

A TWO-STAGE ESTIMATION ALGORITHM FOR A TYPE OF CURRENT STATUS DATA

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Journal of Systems Science & Complexity 2012年第3期25卷 556-566页

作者： hui ZHAO Ningning jiang School of Mathematics and Statistics Central China Normal University Institute of Systems Science Academy of Mathematics and Systems ScienceChinese Academy of Sciences

Success-failure life tests are widely used in reliability engineering research to evaluate the storage life of products, where the observed data are the current status data, usually summarized as the form of ＂binomial life data＂. For this type of data, this paper proposes a two-stage algorithm to estimate some commonly used lifetime distributions. This Mgorithm is automatic, intuitively appealing and simple to implement. Simulation studies show that compared with some existing methods, the proposed algorithm is more stable and efficient, especially in small sample situations, and it can also be extended to deM with some complicated lifetime distributions.

关键词： Current status data nonparametric maximum likelihood estimation success-failure lifetest.

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(Plin2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased Plin2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting Plin2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Super-high bed sintering for iron ores:problems ascertainment

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Journal of Iron and Steel Research International 2024年第5期31卷 1063-1070页

作者： Liang-ping Xu hui-bo Liu Yu-chao Zhao Qiang Zhong Zhong-lin Dong Guang-hui Li Tao jiang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina

Super-high bed sintering process is an important development direction of iron ore sintering for its lower emission and higher ***,there is a lack of deep understanding of the uneven quality of super-high bed sintering products,and the deterioration of reduction disintegration performance,the thickening of hearth layer and the reduction in energy-saving effect are perplexing enterprises and *** ascertain the problems of super-high bed sintering,ten sintering machines with the areas of 265,280,360,550 and 660 m^(2)and bed depth above 900 mm were sampled and *** results showed that problems were mainly shown in the unevenness of chemical composition,macrostructure,mechanical strength and metallurgical *** chemical composition exhibits severe segregation in both horizontal and vertical directions,with basicity segregation reaching as high as *** uneven macrostructure of sinter is reflected in a 10%difference in porosity and mechanical strength increase in 16%–19%along the vertical *** reducibility and reduction disintegration performance gradually deteriorate along the bed depth,with a difference of 10.5%in reducibility and 7.3%in RDI−0.5 mm(reduction disintegration index of sinter with size smaller than 0.5 mm).

关键词： Super-high bed sintering Uneven sinter performance Segregation Agglomeration Iron ore

Filling up complex spectral regions through non-Hermitian disordered chains

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Chinese Physics B 2022年第5期31卷 1-9页

作者： hui jiang Ching Hua Lee Department of Physics National University of SingaporeSingapore 117551Republic of Singapore

Eigenspectra that fill regions in the complex plane have been intriguing to many,inspiring research from random matrix theory to esoteric semi-infinite bounded non-Hermitian *** this work,we propose a simple and robust ansatz for constructing models whose eigenspectra fill up generic prescribed *** approach utilizes specially designed non-Hermitian random couplings that allow the co-existence of eigenstates with a continuum of localization lengths,mathematically emulating the effects of semi-infinite *** some of these couplings are necessarily long-ranged,they are still far more local than what is possible with known random matrix *** ansatz can be feasibly implemented in physical platforms such as classical and quantum circuits,and harbors very high tolerance to imperfections due to its stochastic nature.

关键词： non-Hermitian skin effect disordered chain disorder localization non-Hermitian spectra

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World Journal of Clinical Cases 2022年第28期10卷 10097-10108页

作者： Dong-Mei Liu ling Yan Li Wang hui-hui lin Xia-Yan jiang School of Nursing Anhui Medical CollegeHefei 230062Anhui ProvinceChina

BACKGROUND Dementia is a severe neurological and psychological disease that occurs in older adults *** knowledge and attitude of medical-vocational college students play an important role in supporting primary healthcare *** To investigate the level of knowledge,contact experience,and attitudes toward dementia among medical-vocational college students in *** A cross-sectional survey was conducted,and 3-year medical and medical-related students from eight vocational colleges in Anhui province were *** contact experience,attitudes,and knowledge level of students toward dementia were assessed using a questionnaire designed according to the Chinese version of the Alzheimer’s Disease Knowledge Scale(ADKS).RESULTS A total of 2444 medical and medical-related students completed the survey,of whom 86.7% of respondents had interests and concerns regarding Alzheimer’s disease(AD),and 29.2% of respondents had experiences of contact with dementia *** attitudes toward dementia were *** 35.4% of students were interested in participating in the caregiving of dementia *** mean score of students’ knowledge about AD as assessed by the ADKS was 21.16(standard deviation,3.43) out of *** Dementia-related knowledge of medical-vocational college students was at a medium level,and their overall attitudes toward dementia were negative.

关键词： Medical-vocational college students Dementia Contact experience Attitude Knowledge Caregiving