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Rituximab Treatment Strategy for Patients with Diffuse Large B-Cell Lymphoma after First-line Therapy： A Systematic Review and Meta-Analysis

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Chinese Medical Journal 2015年第3期128卷 378-383页

作者： Yuan-Rong Ren Yong-Dong Jin Zhi-hui zhang li li Ping Wu Department of Medical Oncology Sichuan Cancer Hospital and Institute Chengdu Sichuan 610000 China

Background： Rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone （CHOP） significantly prolonged event-free survival in first-line chemotherapy for patients with diffuse large B-cell lymphoma （DLBCL）. But relapse and refractory DLBC L occur frequently. Although rituximab is effective, its role in salvage therapy after autologous transplant remains unclear. Maintenance therapy with rituximab in responding patients after first line chemotherapy may be a useful novel approach capable of eradicating minimal residual disease and to bring survival benefit. This systematic review and meta-analysis evaluated the effects of rituximab maintenance treatment and salvage therapy of patients with DLBCL. Methods： We performed a systematic review and meta-analysis of randomized controlled trials and compared rituximab maintenance or salvage therapy at relapse with observation. We searched the Cochrane library, PubMed, EMBASE, conference proceedings, databases of ongoing trials, and references of published trials. Two reviewers independently assessed the quality of the trials and extracted data. Hazard ratios for time-to-event data were estimated and pooled. Results： Seven trials including 1470 DLBCL patients were included in this systematic review and recta-analysis. Patients treated with maintenance rituximab have better overall survival （OS） and event-tree survival （EFS） than patients in the observation arm, but there was no statistical significance. Patients who received rituximab salvage therapy for relapse or refractory DLBCL have statistically significantly better OS [HR of death = 0.72, 95% CI （0.55-0.94）, P - 0.02], progression-free survival （PFS） [HR - 0.61,95% CI（0.52-0.72）, P 〈 0.05], odds ratio （OR） [RR = 1.26, 95% CI（1.07-1,47）, P = 0.004] than patients in the observation arm. The rate of infection-related adverse events was higher with rituximab treatment [RR = 1.37, 95% CI = （ 1.14 - 1.65） P =0.001 ]. Conclusions： After first-line c

关键词： Diffuse Large B Cell Lymphoma Meta-analysis: Review Rituximab

Preoperative Evaluation and Midterm Outcomes after the Surgical Correction of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery in 50 Infants and Children

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Chinese Medical Journal 2017年第23期130卷 2816-2822页

作者： hui-li zhang Shou-Jun li Xu Wang Jun Yah Zhong-Dong Hua Department of Cardiac Surgery Fuwai Hospital Chinese Academy of Medical Science and Peking Union Medical College National Center for Cardiovascular Diseases Beijing 100037 China

Background： Anomalous origin of the left coronary artery （LCA） from the pulmonary artery （ALCAPA） is a rather rare congenital anomaly that has a profound effect on heart function. This study aimed to retrospectively illustrate the perioperative clinical features, therapy experience, and midterm outcomes after surgical correction, and to determine the value of left ventricular ejection fraction （LVEF） and myocardial viability in differentiating critically ill patients among infants and children with ALCAPA. Methods： From April 1999 to March 2013, infants and children patients diagnosed with ALCAPA in Beijing Fuwai Hospital were analyzed. Clinical data of patients were summarized and retrospectively analyzed. All patients were divided into two groups according to LVEF level （Group 1： LVEF 〉50%, or Group 2： LVEF ≤50%） to compare perioperative and follow-up variables. Effect of myocardial viability evaluated according to myocardial perfusion/18F-fluorodeoxyglucose （FDG） imaging on the clinical variables was also analyzed. Results： A total of 50 patients with ALCAPA （male/female： 29/21; median age： 3.1 years [range： 4 months to 18 years]） were included. Younger age, lower weight, intercoronary collaterals （ICC） dysplasia, ratio of the proximal right coronary artery diameter to the aortic root diameter 〈0.2, and larger cardiothoracic ratio （CTR） were more frequently found in Group 2 than those in Group 1. Forty-seven patients underwent cardiac surgery. The times of cross-clamp and cardiopulmonary bypass were not different between the two groups; however, the duration of mechanical ventilation and postoperative Intensive Care Unit stay were longer in Group 2 than those in Group 1. Follow-ups were possible in 38 patients （80.9%）; median time： 84.5 months （range： 49 months to 216 months）. There was one late sudden death with simple ligation of the LCA at 8 months after surgery. No severe complications and reoperation occurred. The relationship of the grades of myocardial via

关键词： Follow-up Studies: Left Coronary Artery (LCA) fromthe Pulmonmy Artery Myocardial Ischemia: Surgical Procedures

Phthalate Exposure and Human Semen Quality in Shanghai:A Cross-sectional Study

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Biomedical and Environmental Sciences 2006年第3期19卷 205-209页

作者： YUN-hui zhang li-XING ZHENG BING-HENG CHEN Department of Environmental Health School of Public Health Fudan University Shanghai 200032 China

Objective To monitor the level of phthalates in human semen samples and to analyze the relationship between phthalate levels and semen parameters. Methods Concentrations of three kinds of commonly used phthalates （di-ethyl phthalate, DEP; di-n-butyl phthalate, DBP; di-2-ethylhexyl phthalate, DEHP） were measured using reversed-phase HPLC. Semen parameters were measured by computer aided sperm analysis （CASA）. Results The three phthalates were detected in most of the biological samples, with median levels of 0.30 mg/L （0.08-1.32 mg/L） in semen specimens. There was a significant positive association between liquefied time of semen and phthalate concentrations of semen. The correlation coefficient was 0.456 for DEP, 0.475 for DBP, and 0.457 for DEHP, respectively. There was no significant difference between phthalate concentrations of semen and sperm density or livability, though the correlation coefficients were negative. Conclusion These results suggest that people who reside in Shanghai are exposed to phthalates, especially to DBP and DEHP. Although the level of phthalates is relatively mild, an association of phthalate levels and reduced quality of human semen has been shown in the present study.

关键词： Environmental endocrine disruptor Phthalates Reversed-phase HPLC Biological samples

Systematic evaluation and Meta-analysis of acupuncture and collaterals cupping therapy for Knee Osteoarthritis

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TMR Modern Herbal Medicine 2019年第1期2卷 36-47页

作者： li-hui zhang Yong-Chen Zhao College of Chinese Medicine Hebei UniversityBaodingHebeiChina Affiliated Hospital of Hebei university BaodingHebeiChina

Objective:In order to obtain the best treatment program for Knee Osteoarthritis(KOA),to alleviate the pain of patients with KOA,and to systematically evaluate the efficacy of acupuncture cupping therapy for ***:we used computer to search the databases of CNKI(1989-2018.10),Wanfang(1989-2018.10),VIP(1989-2018.10),PubMed(1966-2018.10),EMbase(1986-2018.10)and Cochrane library(the 3rd issue of 2018).And the literature quality was evaluated by Jadad ***:A total of 19 eligible RCT studies were included,and a total of 2,088 patients participated in the eligible clinical ***-analysis results showed that the total effective rate OR combination=2.85[OR=3.98,95%CI(2.98,5.32),Plity clinical trials are still needed to verify.

关键词： acupuncture and collaterals cupping therapy Traditional Chinese Medicine Knee Osteoarthritis Meta-analysis Systematic evaluation

Formation of a DMM-EM2 Mixing Trend in Continental Intraplate Basalts by Variable Degrees of Melting of Hybrid Mantle Controlled by the lithospheric lid

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Journal of Earth Science 2023年

作者： Xun Yu Gang Zeng Xiao-Jun Wang Fa-Jun Sun hui-li zhang State Key Laboratory of Marine Geology School of Ocean and Earth Science Tongji University State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University State Key Laboratory of Continental Dynamics Department of Geology Northwest University Department of Environmental Science and Technology University of Maryland

Continental intraplate basalts form by partial melting of the mantle, and can provide important constraints on mantle heterogeneity. However, due to the thick overlying continental lithosphere, the origins of the geochemical characteristics of continental intraplate basalts are *** this study, we examined the geochemistry of Cenozoic basalts in southeast China. These basalts which are divided into four volcanic belts exhibit a DMM-EM2 mixing trend and spatial variations in Pb isotopes from inland(i.e., thick lithosphere) to coastal(i.e., thin lithosphere) regions. In contrast to the Pb isotopic variations, there are no spatial variations in Sr-Nd-Hf isotopes. Marked correlations between Pb isotopes and major elements(i.e., MgO and SiO2) suggest the continental lithospheric lid controlled their petrogenesis. Nonetheless, other factors are needed to explain the variations in Ti/Ti* and Hf/Hf* ratios, and Nd-Hf isotopes of the southeast China basalts. The increasing Pb isotope ratios from the inner to coastal regions are associated with decreases in CaO/Al2O3ratios and increases in FC3MS(FeOT/CaO–3×MgO/SiO2; in wt.%) values, indicating contributions from non-peridotite components in the mantle sources. The similarly depleted Nd-Hf isotopic compositions of the basalts from the three inner belts indicate these basalts have a similar origin, whereas the more enriched isotopic features of the basalts from the outer belt suggest their mantle source contains older recycled oceanic crust. Thus,source(i. e., lithological) heterogeneity also had a significant role in controlling the geochemistry of these basalts. The DMM-EM2 mixing trend defined by the Pb isotopic compositions of continental intraplate basalts from southeast China was generated by variable degrees of melting of heterogeneous mantle that was controlled by the thickness of the continental lithospheric lid(i. e., the melting pressure). This caused variable extents of melting of enriched components in

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Coronary spasm, a pathogenic trigger of vulnerable plaque rupture

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Chinese Medical Journal 2011年第23期124卷 4071-4078页

作者： WANG li-xin LU Shu-zheng zhang Wei-jun SONG Xian-tao CHEN hui zhang li-jie Department of Cardiology Beijing Anzhen Hospital Capital University of Medical Sciences Beijing 100029 China

Objective This coronary artery spasm review aimed to explore the most possible pathogenic trigger mechanism of vulnerable plaque rupture. Data sources Data used in this coronary artery spasm review were mainly from Medline and Pubmed in English. Study selection These reports from major review on coronary artery spasm .and these research included coronary artery conception, pathogenesis of spasm, mechanisms of plaque rupture, epidemiological evidence, clinical manifestation and the relationship between coronary artery spasm and vulnerable plaque rupture. Results Coronary artery spasm is somehow related to the presence of atherosclerotic intima disease in the coronary artery. However, chronic low-grade inflammation causes coronary vessel smooth muscle cell hypersensitivity, which can directely cause coronary artery spasm. Myocardial infarction and sudden cardiac death may be initiated by a sudden intense localized contraction of coronary artery smooth muscle. Conclusion Coronary artery spasm may be one trigger that can initiate and exacerbate vulnerable plaque rupture.

关键词： coronary spasm vulnerable plaque rupture pathogenic trigger

Efficacy of blood-letting puncture and cupping in the treatment of periarthritis of shoulder:a systematic review

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TMR Integrative Medicine 2018年第4期2卷 175-191页

作者： li-hui zhang li-Xin Wang Qian Cui Guo-Wei zhang College of Chinese Medicine Hebei UniversityBaodingHebei provinceChina

Objective:To systematically evaluate the clinical efficacy and safety of blood-letting puncture and cupping in the treatment of periarthritis of ***:We electronically searched databases including CNKI,VIP,PubMed,WanFang Data,EMbase Cochrane library and to collect randomized controlled trials(RCTs)and quasi-randomized controlled trials about blood-letting puncture and cupping for periarthritis of shoulder and evaluated the quality of the documents collected by the Cochrane collaboration,provided by Review Manager 5 software for statistical *** the quality of the included trials was assessed using the Jadad scale and GRADE system was used to score the quality and grade ***:Thirty RCTs involving 2556 patients were *** results of meta-analysis showed that:Total effective rate OR=6.21[OR=6.21,95%CI(4.69,8.21),Plimited quality of the included studies,more high quality studies are needed to verify the above conclusion.

关键词： Traditional Chinese Medicine Blood-letting Puncture and Cupping Periarthritis of shoulder Meta-analysis Systematic review GRADE system

Autophagy in synaptic development,function,and pathology

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Neuroscience Bulletin 2015年第4期31卷 416-426页

作者： Dan-Na Shen li-hui zhang Er-Qing Wei Yi Yang Department of Pharmacology Hangzhou Key Laboratory of Medical NeurobiologySchool of MedicineHangzhou Normal University Department of Pharmacology Zhejiang University School of Medicine

In the nervous system, neurons contact each other to form neuronal circuits and drive behavior, relying heavily on synaptic connections. The proper development and growth of synapses allows functional transmission of electrical information between neurons or between neurons and muscle fibers. Defects in synapse-formation or development lead to many diseases. Autophagy, a major determinant of protein turnover, is an essential process that takes place in developing synapses. During the induction of autophagy, proteins and cytoplasmic components are encapsulated in autophagosomes, which fuse with lysosomes to form autolysosomes. The cargoes are subsequently degraded and recycled. However, aberrant autophagic activity may lead to synaptic dysfunction, which is a common pathological characteristic in several disorders. Here, we review the current understanding of autophagy in regulating synaptic development and function. In addition, autophagy-related synaptic dysfunction in human diseases is also summarized.

关键词： autophagy synaptogenesis synaptic elimination synaptic function synaptic pathology

Overexpression of heme oxygenasel protects smooth muscle cells against oxidative injury and inhibits cell proliferation

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Cell Research 2002年第2期12卷 123-132页

作者： MIN zhang, BAO hui zhang, li CHEN, WEI AN1 Institute of Sports Medicine, The Third Hospital, Peking University, Beijing 100083, China 2Department of Cell Biology, Capital University of Medical Sciences, Beijing 100054, China 1Institute of Sports Medicine The Third Hospital Peking University Beijing 100083 China 1Institute of Sports Medicine The Third Hospital Peking University Beijing 100083 China 2Department of Cell Biology Capital University of Medical Sciences Beijing 100054 China 2Department of Cell Biology Capital University of Medical Sciences Beijing 100054 China

To investigate whether the expression of exogenous heme oxygenase-1 (HO-1) gene within vascular smooth muscle cells (VSMC) could protect the cells from free radical attack and inhibit cell proliferation, we established an in vitro transfection of human HO-1 gene into rat VSMC mediated by a retroviral vector. The results showed that the profound expression of HO-1 protein as well as HO activity was 1.8- and 2.0-fold increased respectively in the transfected cells compared to the non-transfected ones. The treatment of VSMC with different concentrations of H2O2 led to the remarkable cell damage as indicated by survival rate and LDH leakage. However, the resistance of the HO-1 transfected VSMC against H2O2 was significantly raised. This protective effect was dramatically diminished when the transfected VSMC were pretreated with ZnPP-IX, a specific inhibitor of HO, for 24 h. In addition, we found that the growth potential of the transfected cells was significantly inhibited directly by increased activity of H

关键词： Heme oxygenase retroviral vector free radical cell proliferation vascular smooth muscle cells.