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Remarkable Wear Resistance in a Complex Concentrated Alloy with Nanohierarchical Architecture and Composition Undulation

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Research 2024年第1期2023卷 403-416页

作者： Yushan Geng Wenyuan chen hui Tan jun cheng Shengyu Zhu jun Yang Weimin Liu State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049PR China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264000PR China

Sustained wear damages on the sliding surfaces of alloys are generally the culprit responsible for the failure of various mechanical *** by high-entropy effects,here we deliberately deploy nanohierarchical architecture with composition undulation in a Ni50(AlNbTiV)_(50) complex concentrated alloy,which yields ultralow wear rate within the order of 10^(−7) to 10^(−6) mm^(3)/Nm between room temperature and 800℃.Such remarkable wear resistance heretofore represents one of the highest wear resistance reported for the bulk alloys or composites,and originates from the multi-type adaptive friction interface protection governed by intrinsically nano-coupled grains and *** cooperative heterostructure releases gradient frictional stress in stages upon wear at room temperature through the coexistence of multiple deformation pathways while activating a dense nanocrystalline glaze layer upon wear at 800℃ to minimize adhesive and oxidative *** work uncovers a practical avenue for tailoring wear properties with multicomponent heterostructures over a wide temperature range.

关键词： wear alloys friction

Role of polarization evolution in the hysteresis effect of Pb-based antiferroelecrtics

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Chinese Chemical Letters 2024年第4期35卷 516-519页

作者： Botao Gao He Qi hui Liu jun chen Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201899China Hainan University Haikou 570228China

The electric field-induced irreversible domain wall motion results in a ferroelectric(FE) hysteresis. In antiferroelectrics(AFEs), the irreversible phase transition is the main reason for the hysteresis effects, which plays an important role in energy storage performance. Compared to the well-demonstrated FE hysteresis,the structural mechanism of the hysteresis in AFE is not well understood. In this work, the underlying correlation between structure and the hysteresis effect is unveiled in Pb(Zr,Sn,Ti)O_(3) AFE system by using in-situ electrical biasing synchrotron X-ray diffraction. It is found that the AFE with a canting dipole configuration, which shows a continuous polarization rotation under the electric field, tends to have a small hysteresis effect. It presents a negligible phase transition, a small axis ratio, and electric field-induced lattice changing, small domain switching. All these features together lead to a slim hysteresis loop and a high energy storage efficiency. These results offer a deep insight into the structure-hysteresis relationship of AFEs and are helpful for the design of energy storage material.

关键词： Antiferroelectric Hysteresis effect Structure refinement Perovskite In situ synchrotron radiation

Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice

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Military Medical Research 2023年第5期10卷 599-619页

作者： Yun-Meng Bai Fan Yang Piao Luo Lu-Lin Xie jun-hui chen Yu-Dong Guan Hong-Chao Zhou Teng-Fei Xu hui-Wen Hao Bing chen Jia-hui Zhao Cai-Ling Liang Ling-Yun Dai Qing-Shan Geng Ji-Gang Wang Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People’s Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Urology Shenzhen People’s Hospitalthe First Affiliated HospitalSouthern University Science and Technologythe Second Clinical Medical CollegeJinan UniversityShenzhen 518020China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Center for Reproductive Medicine Dongguan Maternal and Child Health Care HospitalSouthern Medical UniversityDongguan 523125GuangdongChina

Background: Triclosan [5-chloro-2-(2,4-dichlorophenoxy) phenol, TCS], a common antimicrobial additive in many personal care and health care products, is frequently detected in human blood and urine. Therefore, it has been considered an emerging and potentially toxic pollutant in recent years. Long-term exposure to TCS has been suggested to exert endocrine disruption effects, and promote liver fibrogenesis and tumorigenesis. This study was aimed at clarifying the underlying cellular and molecular mechanisms of hepatotoxicity effect of TCS at the initiation ***: C57BL/6 mice were exposed to different dosages of TCS for 2 weeks and the organ toxicity was evaluated by various measurements including complete blood count, histological analysis and TCS quantification. Single cell RNA sequencing(scRNA-seq) was then carried out on TCS-or mock-treated mice livers to delineate the TCS-induced hepatotoxicity. The acquired single-cell transcriptomic data were analyzed from different aspects including differential gene expression, transcription factor(TF) regulatory network, pseudotime trajectory, and cellular communication, to systematically dissect the cellular and molecular events after TCS exposure. To verify the TCS-induced liver fibrosis,the expression levels of key fibrogenic proteins were examined by Western blotting, immunofluorescence, Masson’s trichrome and Sirius red stainings. In addition, normal hepatocyte cell MIHA and hepatic stellate cell LX-2 were used as in vitro cell models to experimentally validate the effects of TCS by immunological, proteomic and metabolomic ***: We established a relatively short term TCS exposure murine model and found the TCS mainly accumulated in the liver. The scRNA-seq performed on the livers of the TCS-treated and control groups profiled the gene expressions of > 76,000 cells belonging to 13 major cell types. Among these types, hepatocytes and hepatic stellate cells(HSCs)were significantly increased in TCS-

关键词： Triclosan Single cell RNA sequencing Liver fibrogenesis Hepatic stellate cell

Spray pyrolysis-derived W-doped MoSe_2/rGO paper-like microspheres:optimization of microstructure and mesostructure for enhanced lithium storage

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Rare Metals 2024年第7期43卷 3019-3031页

作者： Wei Wang jun-Yu chen Jie Ouyang Hong Yin Ao-Jie Li Liang chen jun-Lin Huang Yu-Can Zhu Gang-Yong Li Zhao-hui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and TechnologyYueyang 414006China School of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang414006China Hunan Province Key Laboratory of Materials Surface&Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and TechnologyChangsha 410004China International Iberian Nanotechnology Laboratory(INL) AvMestre Jose Veiga4715-330 BragaPortuga

Two-dimensional MoSe_2 is a promising candidate for lithium-ion battery ***,its conductivity and lithium storage volumetric effect still need to be *** this work,W-doped MoSe_2/rGO paper-like microspheres are successfully prepared through ultrasonic spray pyrolysis,achieving optimization at both the microstructure and mesostructure to enhance the lithium storage performance of the ***,by utilizing the similar two-dimensional structure between MoSe_2 and rGO,self-assembly is achieved through spray pyrolysis,resulting in a well-defined van der Waals heterostructure at the interface on the microscale,enhancing the electron and ion transfer capability of the ***,the mesoscale paper-like microsphere morphology provides additional volume expansion buffering ***,W-doping not only increases the interlayer spacing of MoSe_2(0.73 nm),thereby reducing the diffusion resistance of Li+,but also allow for the modulation of the energy band structure of the *** functional theory(DFT)calculations confirm that W-doped MoSe_2/rGO exhibits the narrowest bandgap(0.892 eV).Therefore,the composite demonstrates excellent lithium storage performance,maintaining a specific capacity of 732.9 mAh·g^(-1)after 300 cycles at a current density of 1 A·g^(-1).

关键词： Molybdenum selenide Heterostructure Microspheres Li-ion batteries Kinetics

Hierarchical V_(3)S_(4)/C nanofibers with fast kinetics for superior alkali metal batteries

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Rare Metals 2024年第4期43卷 1836-1844页

作者： Li chen Zhi-Xin Rao Zhi chen Zhao-hui Wu Shuai Yang Zhi-jun Feng hui-Yong Yang Fan-Yan Zeng Xi-Bao Li Jin-Yang Hu jun-Tong Huang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang330063China School of Aeronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang330063China

Owing to the numerous benefits,including low cost and great theoretical capacity,V3S4 has been a research hotspot for Li^(+)/Na^(+)/K^(+) ***,the V_(3)S_(4) electrode with long cycling stability and high specific capacities continues to pose significant *** this work,vacuum vulcanization is combined with electrospinning to synthesize V_(3)S_(4)/C composite nanofibers(V_(3)S_(4)@CNF).

关键词： composite fibers kinetics

The mechanism and relevant mediators associated with neuronal apoptosis and potential therapeutic targets in subarachnoid hemorrhage

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Neural Regeneration Research 2023年第2期18卷 244-252页

作者： Qi Tian Sheng Liu Shou-Meng Han Wei Zhang Xian-Yao Qin jun-hui chen cheng-Li Liu Yu-Jia Guo Ming-Chang Li Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Subarachnoid hemorrhage(SAH)is a dominant cause of death and disability wo rldwide.A sharp increase in intracranial pressure after SAH leads to a reduction in cerebral perfusion and insufficient blood supply for neuro ns,which subsequently promotes a series of pathophysiological responses leading to neuronal *** previous experimental studies have reported that excitotoxicity,mitochondrial death pathways,the release of free radicals,protein misfolding,apoptosis,nec rosis,autophagy,and inflammation are involved solely or in combination in this *** them,irreversible neuronal apoptosis plays a key role in both short-and long-term prognoses after *** apoptosis occurs through multiple pathways including extrinsic,mitochondrial,endoplasmic reticulum,p53 and oxidative ***,a large number of blood contents enter the subarachnoid space after SAH,and the secondary metabolites,including oxygenated hemoglo bin and heme,further aggravate the destruction of the blood-brain barrier and vasogenic and cytotoxic brain edema,causing early brain injury and delayed cerebral ischemia,and ultimately increasing neuronal *** there is no clear and effective therapeutic strategy for SAH thus far,but by understanding apoptosis,we might excavate new ideas and approaches,as targeting the upstream and downstream molecules of apoptosis-related pathways shows promise in the treatment of *** this review,we summarize the existing evidence on molecules and related drugs or molecules involved in the apoptotic pathway after SAH,which provides a possible target or new strategy for the treatment of SAH.

关键词： blood-brain barrier mechanism mediators neuronal apoptosis pathways subarachnoid hemorrhage targets treatment

Recent advancements in hydrometallurgical recycling technologies of spent lithium-ion battery cathode materials

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Rare Metals 2024年第3期43卷 879-899页

作者： Juan Wu Li Xiao Li Shen Jian-jun Ran hui Zhong Yi-Rong Zhu Han chen College of Materials and Advanced Manufacturing Hunan University of TechnologyZhuzhou412007China School of Resources Processing and Bioengineering Central South UniversityChangsha410083China Guangdong JiaNa Energy Technology Company Qingyuan513000China

The rapidly increasing production of lithium-ion batteries(LIBs)and their limited service time increases the number of spent LIBs,eventually causing serious environmental issues and resource *** the perspectives of clean production and the development of the LIB industry,the effective recovery and recycling of spent LIBs require urgent *** study provides an overview of the current hydrometallurgical processes employed in the recycling of spent cathode materials,focusing on the leaching of valuable metals and their *** particular,this research reviews the various leaching systems(inorganic acid,organic acid,and ammonia)and the separation of valuable metals,and then,recommendations for subsequent study are offered in an attempt to contribute to the development of highly efficient methods for recycling spent cathode *** addition,a range of existing technologies,such as solvent extraction,chemical precipitation,electrochemical deposition,and regeneration,for the postprocessing of leaching solutions are ***,the promising technologies,existing challenges and suggestions with respect to the development of effective and environmentally friendly recycling methods for handling spent cathode materials are identified.

关键词： Spent lithium-ion batteries(LIBs) Cathode material Hydrometallurgy Leaching Recycling

An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation

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CCS Chemistry 2022年第1期4卷 304-317页

作者： Jingjing Xie Guangya Zhu Ming Gao Jie Xi Ge chen Xinxin Ma Yu Yan Zhiyuan Wang Ze-jun Xu hui-jun chen Hong-Dong Hao Yaoyang Zhang Zhu-jun Yao Jidong Zhu Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201203 University of the Chinese Academy of Sciences Beijing 100049 State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210023 School of Life Sciences Westlake UniversityHangzhou 310012 Department of Translational Research in Psychiatry Max Planck Institute of PsychiatryMunich 80804 State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032 Center for Excellence in Molecular Synthesis Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032

Artemisinin and its derivatives,commonly known as antimalarial drugs,have gradually come to be regarded as potential antitumor agents,although their cytotoxic efficacy and mechanisms of action remain to be ***,we report that an artemisinin analog,ART1,can potently induce ferroptosis in a subset of cancer cell ***–activity relationship(SAR)analysis reveals that both the endoperoxide moiety and the artemisinin skeleton are required for the antitumor activity of *** with ART1-based small-molecule tools,chemical proteomic analysis identified the HSD17B4 protein as a direct target of ***17B4 resides in peroxisomes and is an essential enzyme in the catabolism of very-long-chain fatty *** results demonstrate that ART1 initiates ferroptosis through selective oxidation of the fatty acids in peroxisomes by hijacking the HSD17B4 protein without disturbing its enzymatic function,providing a promising mechanism to develop therapeutics for cancer treatment.

关键词： artemisinin derivative antitumor ferroptosis HSD17B4 selectivity mesenchymal

Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology

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Neuroscience Bulletin 2024年第6期40卷 840-844页

作者： Jia-hui chen Ai-hui Tang Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research Center and Biomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei230027China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei230088China

Excitatory synapses serve as the primary sites for information transmission between neurons in the *** work over the past decades has identified and revealed multiple compositions and functions of the synaptic proteome in the postsynaptic density(PSD),including receptors,scaffold proteins,and signaling molecules,which work together to ensure stable and effective synaptic transmission.

关键词： Receptor scale Glutamate