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Cancer Advances 2024年第17期7卷 1-12页

作者： hui-juan cao Chen-Xi Wu Xiao-Le Xian Yong-Sen Jia Yue-Yue Yu Shu Zhao Ting-Ting Fu Traditional Chinese Medicine College North China University of Science and TechnologyTangshan 063210China.

Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like ***-mesenchymal transition contributes significantly to the metastasis,invasion,and development of treatment resistance in cancer *** have been many studies on suppression of tumor epithelial-mesenchymal transition by Chinese medicine in recent years,mainly based on Chinese herbal drug monomers and *** this review,we aim to describe the research progress on Chinese medicine in the t ransforming growth factor beta(T GF-β)sig naling pathway,we hope these will provide some guidance for further research on Chinese medicine targeting epithelial-mesenchymal transition.

关键词： epithelial-mesenchymal transition cancer Chinese medicine invasion metastasis

Interventions for preventing influenza: An overview of Cochrane systematic reviews and a Bayesian network meta-analysis

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Journal of Integrative Medicine 2021年第6期19卷 503-514页

作者： Yi Yuan Rui-ting Wang Jun Xia hui-juan cao Department of Tuina and Pain Management Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Nottingham Ningbo GRADE Centre The University of Nottingham NingboNingbo 315100Zhejiang ProvinceChina Division of Epidemiology and Public Health School of MedicineUniversity of NottinghamNottingham NG72RDUK Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Background:Influenza places a heavy public health burden in numerous countries every *** addition to vaccines,there are some interventions that are effective in preventing ***:This overview of systematic reviews(SRs)aimed to evaluate the efficacy and safety of interventions for influenza *** strategy:We searched the Cochrane Database of Systematic Reviews,2020,Issue 1 for relevant Cochrane SRs using the keywords‘‘common cold,"‘‘influenza,"and‘‘flu."Inclusion criteria:Cochrane SRs that investigated the prevention of influenza were *** included the general population without influenza or influenza-like symptoms,who were treated with preventative interventions and compared to individuals receiving no treatment or *** extraction and analysis:Two reviewers independently screened citations against pre-defined inclusion criteria and extracted *** methodological quality of these SRs was evaluated using the Assessing the Methodological Quality of Systematic Reviews-II(AMSTAR-II)*** primary outcome of our analysis was the incidence of influenza,and the secondary outcomes were the incidence of influenza-like illness and *** addition to the narrative summary of SR findings,we also pooled data from homogeneous trials among these SRs and produced evidence *** conducted a network meta-analysis to compare the effect across interventions and used the Cochrane approach to grading of recommendations,assessment,development,and evaluation(GRADE)to assess the quality of ***:Eleven Cochrane SRs were included,covering five medications,eleven vaccinations and four complementary *** these SRs,73%scored"high"quality on AMSTAR-II *** found that eight interventions,including amantadine,garlic,and six different vaccines,were beneficial for reducing the incidence of influenza compared to placebo,while oseltamivir,zanamivir,Ganmao capsule,Echinacea,and another three typ

关键词： Influenza Preventive measure Overview Network meta-analysis Evidence mapping Systematic review

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Prevalence of Vitamin A Deficiency in Children Aged 6 to 17 Years—Western and Central Rural Areas,China,2012–2021

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China CDC weekly 2024年第3期6卷 51-55页

作者： Peipei Xu juan Xu Wei cao Titi Yang Qian Gan Hongliang Wang Ruihe Luo hui Pan Qian Zhang National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Vitamin A deficiency(VAD)is a leading global nutritional concern,ranking among the top four major nutritional deficiencies *** prevalence of VAD is unevenly distributed across various regions,both within China and *** is added by this report?The report adds valuable insights into the vitamin A nutritional status of rural students aged 6–17 years who participated in the Nutrition Improvement Programme for Rural Compulsory Education Students(NIPRCES).Over the decade from 2012 to 2021,there was a modest improvement in vitamin A *** prevalence of VAD and sub-clinical VAD(SVAD)declined as the students *** the majority of the survey years,the incidence of VAD was higher among males and western regions compared to females and central regions,*** are the implications for public health practice?A comprehensive approach,incorporating dietary diversification,nutrition education,and food fortification,should be implemented to prevent VAD and SVAD especially in males,younger children and children in western areas.

关键词： vitamin Rural younger

Distributed Region Tracking and Perimeter Surveillance for Second-Order Multi-Agent Systems in Star-Shaped Sets

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Journal of Systems Science & Complexity 2024年第5期37卷 1995-2020页

作者： SHANG juan MO Lipo MI Rongxin cao Xianbing School of Mathematics and Statistics Beijing Technology and Business University The Department of Foundation Shijiazhuang Institute of Railway Technology School of Computer and Artificial Intelligence Beijing Technology and Business University Research Centre for Agri-Product Quality Traceability Beijing Technology and Business University Coordination Center of China National Computer Network Emergency Response Technical Team

This paper investigates region tracking and perimeter surveillance of second-order multi-agent systems, where all agents move within a star-shaped set. First, by coordination transformations,the region tracking problem is converted from the star-shaped sets to a circular region. The authors employ communication and collaboration to complete region tracking and perimeter surveillance tasks,and then revert back to the star-shaped set by using inverse transformations. Second, the authors propose a distributed control strategy based on attractive and interaction potential functions, under which all agents can quickly track a given circular region and move around the perimeter. Finally,the authors validate the effectiveness and performance advantages of the proposed method through simulation experiments.

关键词： Distributed control multi-agent systems star-shaped sets target tracking

Comparison of nonlinear modeling methods for the composite rubber clamp

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 763-778页

作者： Yiming cao hui MA Xumin GUO Bingfeng ZHAO hui LI Xin WANG Bing WANG School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Key Laboratory of Vibration and Control of Aero-Propulsion Systems of Ministry of Education of China Northeastern UniversityShenyang 110819China AVIC Shenyang Engine Design Institute Shenyang 110013China Dalian Mengyu Machinery Co. Ltd.Dalian 116317Liaoning ProvinceChina

The cubic stiffness force model(CSFM)and Bouc-Wen model(BWM)are introduced and compared *** unknown coefficients of the nonlinear models are identified by the genetic algorithm combined with *** fitting the identified nonlinear coefficients under different excitation amplitudes,the nonlinear vibration responses of the system are *** results show that the accuracy of the BWM is higher than that of the CSFM,especially in the non-resonant ***,the optimization time of the BWM is longer than that of the CSFM.

关键词： pipeline system nonlinear clamp model composite rubber clamp amplitude-dependent characteristic vibration response experiment

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Rapid synthesis of oxygen-defected molybdenum oxides quantum dots as efficient nanozymes for healing diabetic ulcers

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Nano Research 2024年第7期17卷 6376-6385页

作者： Fangjun cao hui Feng Jiaxin Yao Xiang Hou Tiezhi Jin Junfeng hui Shaanxi Key Laboratory of Qinling Ecological Security Shaanxi Institute of ZoologyXi’an 710072China Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing Ministry of EducationSchool of Chemical EngineeringNorthwest UniversityXi'an 710069China Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi'an 710069China

The continuous inflammatory response in diabetic skin wounds leads to excessive production of reactive oxygen species,which cause a vicious circle of long-term *** the therapeutic research of metal nanoenzymes for healing diabetic ulcers,it still faces the challenges in poor nanoenzymes activity and low-efficient therapeutic ***,ultrasmall oxygen-deficient MoO_(3−X)quantum dots were fabricated and employed as nanoenzymes for healing fiabetic *** PEGylation,PEGylated MoO_(3−X)quantum dots(MoO_(3−X)/PEG)with oxygen vacancies exhibits excellent photothermal,peroxidase/catalase-like *** addition,these MoO_(3−X)/PEG showed superior properties in scavenging H_(2)O_(2)and effectively inhibiting the scavenging of reactive oxygen *** importantly,such an oxygen-defected MoO_(3−X)/PEG had obvious antibacterial and skin repairing effects on alleviating hypoxia and excessive oxidative stress even in a mouse model of diabetic ulcers,inhibiting proinflammatory cytokines and significantly accelerating the healing of infected wounds,which shows great application potential for promoting wound *** work highlights that the developed oxygen defected molybdenum oxide compounds capable of peroxidaselike and catalase-like activities show great application potential for healing diabetes wound.

关键词： oxygen-defected molybdenum-based nanoenzymes antioxidant anti-inflammatory diabetes ulcer wounds

Investigation of the cell composition and gene expression in the delayed-type hypersensitivity tuberculin skin test

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Military Medical Research 2024年第1期11卷 148-151页

作者： hui-juan Duan Hong-Qian Chu Ting-Ming cao Guang-Ming Dai Na Tian Gang Sheng Zhao-Gang Sun Beijing Key Laboratory in Drug Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijing 101149China

Dear Editor,The tuberculin skin test(TST)reagents have continuously improved,with the ESAT6-CFP10(EC)test having recently been introduced,but are seldom based on the direction of the delayed-type hypersensitivity(DTH)*** studies only partially showed the infiltration and activation of immune cells and the production of cytokines of the skin induration[1,2],and lack the detailed measurements of cell proportions and gene expression in the DTH ***,in this study,we revealed the comprehensive characteristics of DTH by single-cell RNA sequencing(scRNA-seq)in the guinea pig tuberculosis(TB)model[Experimental Animal Welfare Ethics Committee,Beijing Tuberculosis and Thoracic Tumor Research Institute(2021-064)].

关键词： Tuberculin skin test Delayed-type hypersensitivity Single-cell RNA sequencing

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Enzymatic C1 reduction using hydrogen in cofactor regeneration

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 33-40页

作者： Ruishuang Sun Chenqi cao Qingyun Wang hui cao Ulrich Schwaneberg Yu Ji Luo Liu Haijun Xu Beijing Bioprocess Key Laboratory Beijing University of Chemical TechnologyBeijing 100029China Institute of Biotechnology Rheinisch-Westfälische Technische Hochschale(RWTH)AachenAachen 52074Germany

Carbon dioxide fixation presents a potential solution for mitigating the greenhouse gas *** carbon dioxide fixation,C1 compound reduction requires a high energy *** calculations suggest that the energy source for cofactor regeneration plays a vital role in the effective enzymatic C1 *** utilizes renewable hydrogen to achieve the regeneration and supply cofactor nicotinamide adenine dinucleotide(NADH),providing a driving force for the reduction reaction to reduce the thermodynamic barrier of the reaction cascade,and making the forward reduction pathway thermodynamically *** on the regeneration of cofactor NADH by hydrogenase,and coupled with formaldehyde dehydrogenase and formolase,a favorable thermodynamic mode of the C1 reduction pathway for reducing formate to dihydroxyacetone(DHA)was designed and *** resulted in accumulation of 373.19μmol·L^(-1) DHA after 2 h,and conversion reaching 7.47%.These results indicate that enzymatic utilization of hydrogen as the electron donor to regenerate NADH is of great significance to the sustainable and green development of bio-manufacturing because of its high economic efficiency,no by-products,and environment-friendly ***,formolase efficiently and selectively fixed the intermediate formaldehyde(FALD)to DHA,thermodynamically pulled formate to efficiently reduce to DHA,and finally stored the low-grade renewable energy into chemical energy with high energy density.

关键词： [NiFe]-hydrogenase SH formolase NADH regeneration C1 compound reduction thermodynamic calculation

A prompt-based approach to adversarial example generation and robustness enhancement

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Frontiers of Computer Science 2024年第4期18卷 85-96页

作者： Yuting YANG Pei HUANG juan cao Jintao LI Yun LIN Feifei MA Key Lab of Intelligent Information Processing of Chinese Academy of Sciences(CAS) Institute of Computing TechnologyCASBeijing 100190China School of Computer Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Computer Science Stanford UniversityCA 94305USA School of Computing National University of SingaporeSingapore 119077Singapore Laboratory of Parallel Software and Computational Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China

Recent years have seen the wide application of natural language processing(NLP)models in crucial areas such as finance,medical treatment,and news media,raising concerns about the model robustness and *** find that prompt paradigm can probe special robust defects of pre-trained language *** prompt texts are first constructed for inputs and a pre-trained language model can generate adversarial examples for victim models via *** results show that prompt paradigm can efficiently generate more diverse adversarial examples besides synonym ***,we propose a novel robust training approach based on prompt paradigm which incorporates prompt texts as the alternatives to adversarial examples and enhances robustness under a lightweight minimax-style optimization *** on three real-world tasks and two deep neural models show that our approach can significantly improve the robustness of models to resist adversarial attacks.

关键词： robustness adversarial example prompt learning pre-trained language model

Effects of penehyclidine hydrochloride on rat intestinal barrier function during cardiopulmonary bypass

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World Journal of Gastroenterology 2011年第16期17卷 2137-2142页

作者： Ying-Jie Sun hui-juan cao Qiang Jin Yu-Gang Diao Tie-Zheng Zhang Department of Anesthesiology General Hospital ofShenyang Commend Shenyang 110840 Liaoning Province China

AIM:To test the ability of penehyclidine hydrochloride (PHC) to attenuate intestinal injury in a rat cardiopulmonary bypass (CPB) ***:Male Sprague-Dawley rats were randomly divided into six groups (eight each):sham-operated control;sham-operated low-dose PHC control (0.6 mg/kg);sham-operated high-dose PHC control (2.0 mg/kg);CPB vehicle control;CPB low-dose PHC (0.6 mg/kg);and CPB high-dose PHC (2.0 mg/kg).Blood samples were collected from the femoral artery 2 h after CPB for determination of plasma diamine oxidase (DAO),D-lactate and endotoxin ***,liver,mesenteric lymph nodes and lung were removed for biochemical *** tissue ultrastructure was examined by electron ***:In the sham-operated groups,high-and low-dose-PHC had no significant impact on the levels of DAO,D-lactate and endotoxin,or the incidence of intestinal bacterial translocation (BT).Serum levels of DAO,D-lactate,endotoxin and the incidence of intestinal BT were significantly increased in the surgical groups,compared with the sham-operated groups (0.543 ± 0.061,5.697 ± 0.272,14.75 ± 2.46,and 0/40 vs 1.038 ± 0.252,9.377 ± 0.769,60.37 ± 5.63,and 30/40,respectively,all P < 0.05).PHC alleviated the biochemical and histopathological changes in a dosedependent *** levels of DAO,D-lactate,and endotoxin and the incidence of intestinal BT in the high-dose PHC group were significantly lower than in the low-dose PHC group (0.637 ± 0.064,6.972 ± 0.349,29.64 ± 5.49,and 14/40 vs 0.998 ± 0.062,7.835 ± 0.330,38.56 ± 4.28,and 6/40,respectively,all P < 0.05).CONCLUSION:PHC protects the structure and function of the intestinal mucosa from injury after CPB in rats.

关键词： Penehyclidine hydrochloride Intestinal mucosa injury Cardiopulmonary bypass