检索结果-南通市图书馆

A new alkaloid from Lycoris aurea

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2009年第11期20卷 1319-1320页

作者： hui fang pi Peng Zhang Han Li Ruan Yong hui Zhang Han Dong Sun Ji Zhou Wu Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Hubei Key Laboratory of Natural Medicinal Chemistry and Resources Evaluation Wuhan 430030 China

A new alkaloid was isolated from the bulbs of Lycoris aurea （L＇Herit.） Herb. Its structure was established as 3-o-ethyltazettinol through chemical and spectroscopic studies including 2D NMR.

关键词： Lycoris aurea 3-o-Ethyltazettinol

Two New Ursane-type Triterpenoid Glycosides from Ilex Cornuta

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2018年第6期38卷 976-981页

作者： Hai-xia ZHAN Juan LI Han-li RUAN Peng ZHANG hui-fang pi School of Pharmacy Tongji Medical CollegeHuazhong University of Seience and TechnologyHubei Key Laboratory of Natural Medicinal Chemistry and Resource EvaluationWuhan 430030China Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Ilex cornuta (***)is a traditional Chinese medicine (TCM)that has been used in clinical practice for hundreds of *** order to provide more information about the chemical basis of its pharmacological effects,phytochemical investigation on the roots of L cornuta was conducted in this *** roots of the plant were firstly extracted with 95% EtOH,and then the crude was partitioned with petroleum ether,EtOAc and n-butyl *** chromatographies were employed to isolate the crude step by step and the crude was further purified by semipreparative high performance liquid chromatography (HPLC).As a result,two new triterpenoid saponins (1,2),together with 12 known compounds (3-14),were isolated from the roots of I. *** structures were determined based on nuclear magnetic resonance (NMR),mass spectrum (MS)technologies,chemical reactions as well as gas chromatography (GC).Compounds 4,6,8,11,12 and 13 were isolated from this genus for the first *** structures of compounds 1 and 2 were determined as 3β-O-α-D-xylopyranosyl-(1→3)-α-L-2-O-acetylarabinopyranosyl-(1→2)-β-D glucopyranosyl-23-hydroxyl-20α(H)-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester (1)and 3β-O-α-D-xylopyranosly-(1→3)-α-L-2-O-acetylarabinopyranosyl-(1→2)-β-D-glucopyranosyl-19α,23-dihydroxyl-20α(H)-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester(2).

关键词： Ilex cornuta aquifoliaceae triterpenoids

A new cycloartane triterpenoid from the leaves and stems of Fritillaria hupehensis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第4期18卷 418-420页

作者： hui fang pi Peng Zhang Tian Zhu Han Li Ruan Yong hui Zhang Han Dong Sun Ji Zhou Wu Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Kunming 650204 China

A new triterpenoid has been isolated from the leaves and stems of Fritillaria hupehensis Hsiao et K.C. Hsia. Its structure was established as （2329-9,19-cycloart-23-ene-3α,25-diol 1 through chemical and spectroscopi... 详细信息

关键词： Fritillaria hupehensis Cycloartane triterpenoids (23Z)-9,19-Cycloart-23-ene-3α,25-diol

Two new ent-kaurane diterpenoids from the aerial parts of Isodon excisoides

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2014年第1期25卷 131-133页

作者： Ke Jiao Huo-Yun Li Peng Zhang hui-fang pi Han-Li Ruan Ji-Zhou Wu Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Tongji School of Pharmaceutical SciencesHuazhong University of Science and Technology

Two new ent-kaurane diterpenoids, ent-7α,14β-dihydroxykaur-16-en-15-one-20-oic acid （1） and 1,7α,12β,14β-tetrahydroxy-1,10-seco-ent-kaur-10,16-dien-15-one （2）, together with six known ones （3-8）, were isolated from the EtOAc extract of the aerial parts of lsodon excisoides. Their structures were elucidated on the basis of 1D NMR and 2D NMR analyses as well as HR-ESI-MS experiments.

关键词： lsodon excisoides ent-Kaurane Diterpenoid

Anti-inflammatory Activity of Mollugin on DSS-induced Colitis in Mice

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2020年第5期40卷 910-916页

作者： Juan LI Jin-ling ZHANG Xue-peng GONG Meng XIAO Yuan-yuan SONG hui-fang pi Guang DU Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy The Central Hospital of XianningXianning 437100China School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

We aimed to explore the anti-infammatory bactivity of mollugin extracted from Rubia cordifolia L,a traditional Chinese medicine,on dextran sulfate sodium(DSS)-induced ulcerative colitis(UC)in *** C57BL/6 mice were divided into a control group(n=6),a model group(n=6),and three experimental groups(40,20,10 mg/kg of mollugin,n=6 each).DSS solution(3%)was given to mice in the model group and experimental groups from day 4 to day 10 to induce the mouse UC *** in the experimental groups were intragastrically administrated mollugin from day 1 to day *** were orally given distilled water in the control group for the whole experiment time and in the model group from day 1 to day *** changes in colon pathology were detected by hematoxylin and eosin(HE)***-1β(IL-1β)in the serum,and tumor necrosis factor-α(TNF-α)and interferon-γ(IFN)in the tissues were measured by enzyme linked immunosorbent *** levels of Toll-like receptor 4(TLR4)and myeloid differentiation factor 88 in the colon tissues were detected by *** showed that mollugin could significantly reduce weight loss and the disease activity index in the DSS-induced UC mouse *** examinations demonstrated that mollugin treatment effectively improved the histological damage(P<0.05).The overproduction of IL-Iβand TNF-α was remarkably inhibited by mollugin treatment at doses of 20 and 40 mg/kg(P<0.05).Additionally,the levels of TLR4 in colon tissues were significantly reduced in mollugin-treated groups compared with the DSS *** findings demonstrated that mollugin ameliorates DSS-induced UC by inhibiting the production of pro-inflammatory chemocytokines.

关键词： mollugin anti-inflammatory activity DSS-induced colitis

Synthesis and antitussive evaluation of verticinone-cholic acid salt,a novel and potential cough therapeutic agent

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第10期28卷 1591-1596页

作者： fang-zhou XU~(2,3),Chang CHEN~2,Yong-hui ZHANG~2,Han-li RUAN~2,hui-fang pi~2,Pong ZHANG~2,Ji-zhou WU~(2,4)~2 Faculty of Pharmaceutical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China~3 Department of Pharmacy,Peking University Shenzhen Hospital,Shenzhen 518036,China Faculty of Pharmaceutical Sciences Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Pharmacy Peking University Shenzhen Hospital Shenzhen China

Aim:To seek a novel and potent antitussive drug based on Shedan-Chuanbeipowder,a complex of traditional Chinese medicine preparation for cough ***:Verticinone-cholic acid (Ver-CA) salt,a novel,salifying derivative ofverticinone and cholic acid,both of which are the major bioactive components inShedan-Chuanbei powder,was *** then evaluated the antitussiveactivity and the acute toxicity of the ***:The new compound,with goodsolubility in water,has much more potent antitussive activity in comparison withthe same dose of single verticinone and single cholic *** administration 3mg/kg of Ver-CA could result in over 50% reduction of a citric acid-induced *** with naloxone (0.8 mg/kg,ip) can only partially antagonize its anti-tussive *** the other hand,glybenclamide (3 mg/kg,ip),an ATP-sensitiveK~+ channel blocker,can also significantly reduce the antitussive effect of Ver-CA.A further acute toxicity study showed that the LD50values of Ver-CA were 3 timesthat of ***:Based on the studies of pharmacology and acutetoxicity,the salt has a synergic and attenuated toxicity compared with singleverticinone and cholic ***,the present study also suggests that Ver-CA,a potential novel antitussive agent,may exert its antitussive effect via boththe peripheral (modulated by ATP-sensitive K~+ channels) and central mechanisms(modulated by the opioid receptor).

关键词： verticinone-cholic acid salt Shedan-Chuanbei powder,cholic acid verticinone antitussive effect ATP-sensitive K~+ channels

Two new ursane-type triterpenoid glycosides from Ilex cornuta

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Two new ursane-type triterpenoid glycosides from Ilex cornut...

New diterpenoids from Kinostemon ornatum

中国化学会第十二届全国天然有机化学学术会议

作者： Hai-Xia ZHAN Gui-Feng Liu Juan LI hui-fang pi School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Pharmacy Department of Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology

Ilex cornuta is a kind of plant used for traditional Chinese medicines(TCM) for hundreds of *** order to provide more information about the chemical basis of its pharmacological effects,phytochemical investigation on the roots of *** was Ionducted in this *** new triterpenoid saponins(1,2),together with 12 known compounds(3-14).were isolated from the roots of *** structures were determined based on NMR,MS technologies,chemical reactions as well as *** 4,6,8,11,12 and 13 were isolated from this genus for the first time .The structures of compounds 1 and 2 were determined as 3β-O-α-Dxylopyranosyl-(1→3)-α-L-2-O-acetylarabinopyranosyl-(1→2)-β-D-glucopyranosyl-23-hydroxyl-20α(H)-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester(1) and 3 P-O-α-D-xylopyranosly-(1→3)-α-L-2-O-acetylarabinopyranosyl-(1→2)-β-D-glucopyranosyl-19α,23-dihydroxyl-20α(H)-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester(2).

关键词： Ilex cornuta Aquifoliaceae Triterpenoids Structural elucidation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

New diterpenoids from Kinostemon ornatum

TWO NEW STEROIDAL ALKALOIDS FROM BULBS OF FRITILLARIA LICHUANENSIS

中国化学会第十届全国天然有机化学学术会议

作者： Gui-Feng Liu Wen-Yu Zhao Jie Zou hui-fang pi School of Pharmacy Tongji Medical College Huazhong University of Science and Technology Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Wuhan Institute of Dermatology and Venereology

The whole plan of Kinostemon ornatum(Hemsl)Kudo has been used as a folk medicine for the treatment of cancer,hepatitis in *** new compounds,kinostemon A(1),kinostemon B(2),15-methoxy-kinalborin A(3),2-carboxymethyl-5-methoxy-furan-3-carboxylic acid(4)and kinostemon C(5),together with 15 known compounds were isolated from this ***

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

TWO NEW STEROIDAL ALKALOIDS FROM BULBS OF FRITILLARIA LICHUA...