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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Changes in vegetation and soil properties during recovery of a subtropical forest in South China

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Journal of Mountain Science 2018年第1期15卷 46-58页

作者： huang fang-fang ZHANG Wei-qiang GAN Xian-hua huang Yu-hui GUO Yue-dong WEN Xiao-ying Guangdong Provincial Key Laboratory of Silviculture Protection and Utilization Guangdong Academy of Forestry

Secondary forests account for a large amount of subtropical forest due to persistent anthropogenic disturbance in *** interaction between vegetation and soil during recovery process is rather complex and dependent on forest *** how vegetation and soil properties changes and how their relationship develops in secondary forests is key to effective forest restoration and *** we explored the patterns of vegetation and soil properties as well as their correlations during forest recovery process in a subtropical forest in south *** of three forest types,i.e.,broadleaf-conifermixedforest,broadleaved forest and old growth stand,were established to represent the recovery *** results showed that diversity patterns in the tree,shrub and herb layers were different:in the tree layer the species diversity peaked at the intermediate stage,while in the understory layers it decreased *** of the soil factors showed an increasing trend,and different effects of soil factors were found for the three layers as well as for the two spatial ***,our results suggested that vegetation and soil might be interdependent during the recovery *** studies are needed on exploring how vegetation interplays with soil at different scales and how nutrient limitations affects the vegetation development in a chronosequence.

关键词： Forest recovery Vegetation change Soil property Subtropical Succession

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Climate change has more adverse impacts on the higher mountain communities than the lower ones: people’s perception from the northern Himalayas

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Journal of Mountain Science 2019年第11期16卷 2625-2639页

作者： huang Xiao-hui ZHOU Yao-zhi fang Jiang-ping HOU Lei Tibet Agriculture&Animal Husbandry University Linzhi 8600China Research Institute of Tibet Plateau Ecology Tibet Agriculture&Animal Husbandry UniversityLinzhi 8600China United Key Laboratories of Ecological Security Tibet Autonomous RegionLinzhi 8600China Resources&Environment College Tibet Agriculture&Animal Husbandry UniversityLinzhi 8600China

The Himalayas are assumed to experience rapid climate change,with serious environmental,social and economic consequences for people living in and around the mountain ***,the extent of climate change and its impact on the region are underexplored,especially on northern slope of the *** on local knowledge,we report perceived changes in climate and consequences of such changes for natural andsocial *** respondents in this study were distributed at a continuous elevation gradient of 3570-4646 m above sea level in the northern ***,it is possible to analyze the process of the shift of bioclimate zones under climate change and the differences in climate change effects cross *** those in the pastoral area(Zhegu town)with an altitude of 4600 m,91.2%(n=114)of the respondents believe that the climate is obviously changing;the ratio of reporting rainfall decreasing is 77.2%(n=114);those who perceive delayed rainy season,and increased climate change-related natural disasters account for 38.9%(n=113),72.8%(n=103),respectively;more than two thirds(70.3%)(n=111)view drought as the biggest challenge to address climate change,and more than half(59.3%)(n=113)of the respondents believe that the impact of climate change is mainly *** these data rank first among the four survey areas(Zhegu town/pastoral region,Nedong County/crop growing regions,Zhanang County/crop growing region and Nagarze County/farming-pastoral region).Due to climate warming,Labidura riparia spreads to a higher altitude in the basins in Nedong County(Shannan City,Tibet)and Zhanang County(Shannan City,Tibet)at the rate of 31.1±6.4 m/a and 46.7±8.8 m/a,respectively in *** of the respondents view the natural variability as the main cause of climate changes,only 10.7%-29.0%among them view human activities as the main *** challenges for local people to address climate change include droughts and economic *** local perceptions conf

关键词： Northern Himalayan Climate change Perception Elevation gradient Tibet

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田湾核电站水泥基灌浆料试验与应用

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中国核电 2009年第3期2卷 224-229页

作者：钱伏华王开华方辉煌朱国栋中国核工业华兴建设有限公司江苏仪征211900 中国核工业建设集团公司北京100037

对灌浆料的成分、试验方法及施工养护工艺等方面的试验结果进行深入分析研究,并结合田湾核电站的设备基础灌浆的应用情况,对核电现场的几种灌浆料产生质量缺陷的原因进行分析,以选择适合于核电工程需要的高质量灌浆料以及适应施工条件... 详细信息

对灌浆料的成分、试验方法及施工养护工艺等方面的试验结果进行深入分析研究,并结合田湾核电站的设备基础灌浆的应用情况,对核电现场的几种灌浆料产生质量缺陷的原因进行分析,以选择适合于核电工程需要的高质量灌浆料以及适应施工条件的施工养护工艺。

关键词：核电站设备基础灌浆模拟实验

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MC-ICP-MS 测定岩石标准物质的钒同位素组成

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岩矿测试 2025年第1期44卷 63-74页

作者：徐丽怡于慧敏丁昕黄方中国科学技术大学地球和空间科学学院岩石圈演化与环境演变全国重点实验室安徽合肥230026 中国科学院比较行星学卓越创新中心中国科学技术大学安徽合肥230026

随着分析方法的发展和分析精度的提升,钒同位素已经越来越多地被用于各种地质过程研究。为了确保钒同位素分析测试过程中,可以有效地监控数据的准确度和精度,方便国际各实验室之间的数据对比,同时考虑到早期国际上常用美国地质调查局(US... 详细信息

随着分析方法的发展和分析精度的提升,钒同位素已经越来越多地被用于各种地质过程研究。为了确保钒同位素分析测试过程中,可以有效地监控数据的准确度和精度,方便国际各实验室之间的数据对比,同时考虑到早期国际上常用美国地质调查局(USGS)的标准物质面临着库存不足等问题,本文采用多接收电感耦合等离子体质谱仪(MC-ICP-MS)测定了一系列国际地质标准物质和国家地质标准物质的钒同位素组成,δ51V值的测试精度优于0.08‰。本文选取的标准物质主要来自日本地质调查局(GSJ)和中国地质科学院地球物理地球化学勘查研究所(IGGE),包括一个安山岩(JA-1),三个玄武岩(JB-3、JB-1b和GBW07105),一个辉长岩(JGb-1),一个辉绿岩(GBW07123)以及一个土壤(GBW07454),钒含量范围为77~635μg/g,涵盖了目前大部分火成岩和部分土壤等天然样品含量的范围。这些标准物质除了土壤GBW07454,其他标准物质的钒同位素组成未曾被报道。经测量表明,辉长岩标准物质JGb-1具有最高δ51V值,为−1.05‰±0.08‰,安山岩标准物质JA-1具有最低δ51V值,为−0.34‰±0.06‰,其余标准物质的δ51V值变化范围为−0.72‰~−0.81‰,均落在MORB范围内。本文对这些标准物质钒同位素组成的报道,丰富了钒同位素研究的标准物质数据库,有助于未来在更多领域开展钒同位素研究。

关键词：钒同位素火成岩 MC-ICP-MS 标准物质高精度分析方法

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基于轻量化卷积神经网络的桥梁斜拉索PE护套损伤识别方法

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土木与环境工程学报（中英文） 2025年第1期47卷 167-178页

作者：刘啸宇黄永徐峰李惠上海交通大学船舶海洋与建筑工程学院上海200240 哈尔滨工业大学土木工程学院哈尔滨150090

深度神经网络和计算机视觉技术近年来在结构健康监测中发挥了越来越重要的作用。利用无人机航拍采集的桥梁斜拉索损伤图像数据,研究基于深度学习技术的斜拉索PE护套损伤识别方法。为实现在较低运算能力设备上对大跨度桥梁斜拉索表面局... 详细信息

深度神经网络和计算机视觉技术近年来在结构健康监测中发挥了越来越重要的作用。利用无人机航拍采集的桥梁斜拉索损伤图像数据,研究基于深度学习技术的斜拉索PE护套损伤识别方法。为实现在较低运算能力设备上对大跨度桥梁斜拉索表面局部损伤的智能快速识别,解决传统深度卷积神经网络的运算效率相对较低、模型参数规模较大的问题,提出轻量化处理的区域推荐型卷积神经网络模型。介绍区域推荐网络与其轻量化改进方法的理论基础,分析轻量化模型处理的必要性,其能在保证识别精度的前提下降低模型训练与预测的设备性能需求,达到节约计算资源与时间的目的;通过数据增广等多手段解决损伤样本数据量不足的问题,设置对比试验,统计分析结果,验证了轻量化神经网络模型的优越性。结果表明,轻量化网络在牺牲少量识别准确度的前提下,能够在较大程度上实现对模型复杂度与计算量的改进,在工程应用中能有效拓展神经网络的实用性。

关键词：桥梁斜拉索智能损伤识别轻量化神经网络计算机视觉深度学习

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Internet of Lamps for Future Ubiquitous Communications:Integrated Sensing,Hybrid Interconnection,and Intelligent Illumination

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China Communications 2022年第3期19卷 132-144页

作者： Fubin Wang Xuan huang fang Yang hui Yang Jun Wang Jian Song Department of Electronic Engineering Tsinghua National Laboratory of Information Science and TechnologyTsinghua UniversityBeijing 100084China Key Laboratory of Digital TV System of Guangdong Province and Shenzhen City Research Institute of Tsinghua University in ShenzhenShenzhen 518057China

The ubiquitous deployment and restricted consumption are the requirements restricting the development of Internet of ***,a promising technology named Internet of Lamps(Io L)is discussed in this paper to address these *** with other communication networks,the remarkable advantage of Io L is that it can make full use of the existing lighting networks with sufficient power *** lamps can be connected to the Internet through wired power line communication and/or wireless communication,while the integration of integrated sensing,hybrid interconnection,and intelligent illumination is *** this paper,the Io L is discussed from three aspects including sensing layer,network layer,and application layer,realizing the comprehensive upgrade based on the conventional communication and illumination ***,several novel technologies of Io L are discussed based on the requirements of sensing,communication,and control,which have put forward practical solutions to the issues faced by Io ***,the challenges and opportunities for Io L are highlighted from various parts of the system structure,so as to provide future insights and potential trends for researchers in this field.

关键词： Internet of Lamps(IoL) integrated sensing hybrid interconnection intelligent illumination

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Inflation and Singularity of a Bianchi Type-VII0 Universe with a Dirac Field in the Einstein–Cartan Theory

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Chinese Physics Letters 2011年第8期28卷 360-363页

作者： huang Zeng-Guang fang Wei LU hui-Qing School of Science Huaihai Institute of TechnologyLianyungang 222005 Department of Physics Shanghai Normal UniversityShanghai 200234 The Shanghai Key Lab of Astrophysics Shanghai 200234 Department of Physics Shanghai UniversityShanghai 200444

We discuss Bianchi type-VII0 cosmology with a Dirac field in the Einstein–Cartan(E−C)theory and obtain the equations of the Dirac and gravitational fields in the E-C theory.A Bianchi type-VII0 inflationary solution i... 详细信息

关键词： theory Cartan Dirac

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Inflation and Singularity in Einstein-Cartan Theory

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Chinese Physics Letters 2011年第2期28卷 254-257页

作者： huang Zeng-Guang fang Wei LU hui-Qing School of Science Huaihai Institute of TechnologyLianyungang 222005 Department of Physics Shanghai Normal UniversityShanghai 200234 Department of Physics Shanghai UniversityShanghai 200444 The Shanghai Key Lab of Astrophysics Shanghai Normal UniversityShanghai 200234

Within the framework of Einstein-Cartan theory,we obtain a general condition leading to singularity and inflation for all Bianchi cosmological *** the spin energy is smaller than anisotropic energy density(i.e.S^(2)σ^(2)-pv/^(2)(pv is vacuum energy density),the Universe can undergo an inflation *** of Bianchi type-IX,I and V cosmological models are discussed.

关键词： phase Einstein singularity

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Impact of physical representations in CALMET on the simulated wind field over land during Super Typhoon Meranti(2016)

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Frontiers of Earth Science 2019年第4期13卷 744-757页

作者： Sui huang Shengming TANG hui YU Wenbo XUE Pingzhi fang Peiyan CHEN Chinese Academy of Meteorological Sciences Beijing 100081China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Key Laboratory of Numerical Modeling for Tropical Cyclones China Meteorological Administration Shanghai 200030China The Joint Laboratory for Typhoon Forecasting Technique Applications between Shanghai Typhoon Institute and Wenzhou Meteorological Bureau Wenzhou 325000China

A WRF(Weather Research and Forecasting Model)/CALMET(California Meteorological Model)coupled system is used to investigate the impact of physical representations in CALMET on simulations of the near-surface wind field of Super Typhoon Meranti(2016).The coupled system is configured with a horizontal grid spacing of 3 km in WRF and 500 m in CALMET,*** model performance of the coupled WRF/CALMET system is evaluated by comparing the results of simulations with observational data from 981 automatic surface stations in Fujian *** root mean square error(RMSE)of the wind speed at 10 m in all CALMET simulations is significantly less than the WRF simulation by 20%^30%,suggesting that the coupled WRF/CALMET system is capable of representing more realistic simulated wind speed than the mesoscale model *** impacts of three physical representations including blocking effects,kinematic effects of terrain and slope flows in CALMET are examined in a specified local region called Shishe *** results show that before the typhoon landfall in Xiamen,a net downslope flow that is tangent to the terrain is generated in the west of Shishe Mountain due to blocking effects with magnitude exceeding 10 m/***,the blocking effects seem to take no effect in the strong wind area after typhoon *** being affected by the typhoon strong wind or not,the slope flows move downslope at night and upslope in the daytime due to the diurnal variability of the local heat flux with magnitude smaller than 3 m/*** kinematic effects of terrain,which are speculated to play a significant role in the typhoon strong wind area,can only be applied to atmospheric flows in stable conditions when the wind field is quasinondivergent.

关键词： physical representations CALMET wind field Super Typhoon Meranti

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