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Postoperative efficacy,safety,predictability,and visual quality of implantable collamer lens implantation versus small incision lenticule extraction in myopic eyes:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 442-452页

作者： Hong-Yu li zi Ye Zhao-hui li Medical School of Chinese PLA Beijing 100853China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To compare the postoperative efficacy,safety,predictability,and visual quality of implantable collamer lens(ICL)implantation versus small incision lenticule extraction(SMILE)in myopia ***:Pub Med,EMBASE,Web of Science,Cochrane library and several Chinese databases were searched at May 2021 to select relevant studies in comparison of clinical outcomes between ICL implantation and SMILE for *** primary outcomes were efficacy,safety,and *** the secondary outcomes were postoperative higher-order ocular aberrations(HOAs),modulation transfer function cutoff frequency(MTF),objective scatter index(OSI),contrast sensitivity and a quality of vision(Qo V)***:A total of 1036 eyes from 10 studies,of which 503 eyes underwent ICL implantation and 533 eyes underwent SMILE,were enrolled in this *** results revealed that ICL group had a better safety index and post-corrected distance visual acuity(CDVA)(P=0.007,line(P=0.007)than the SMILE *** significant differences were found in comparison of the other primary *** the longterm follow-up(>6mo),ICL group had a lower total HOA,coma,and spherical aberration than SMILE group(P=0.003,lity for correcting high ***,ICL group is relatively safer and also has better visual quality in comparison of SMILE group.

关键词： implantable collamer lens small incision lenticule extraction myopia refractive surgery Meta-analysis

Radix Scrophulariae Extracts Exert Effect on Hyperthyroidism via MST1/Hippo Signaling Pathway

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Chinese Journal of Integrative Medicine 2023年第11期29卷 998-1006页

作者： ZHANG Ning YE Tao LU Xu li zi-hui li ling Department of Pharmacy The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang(50001)China Department of Chinese Medicine Rehabilitation The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang(50001)China College of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang(550025)China College of life and Health Dalian UniversityDalianLiaoning Province(116622)China

Objective:To explore the mechanism of Radix Scrophulariae(RS)extracts in the treatment of hyperthyroidism rats by regulating proliferation,apoptosis,and autophagy of thyroid cell through the mammalian sterile 20-like kinase 1(MST1)/Hippo ***:Twenty-four rats were randomly divided into 4 groups according to a random number table:control,model group,RS,and RS+Hippo inhibitor(XMU-MP-1)groups(n=6 per group).Rats were gavaged with levothyroxine sodium tablet suspension(LST,8μg/kg)for 21 days except for the control ***,rats in the RS group were gavaged with RS extracts at the dose of 1,350 mg/kg,and rats in the RS+XMU-MP-1 group were gavaged with 1,350 mg/kg RS extracts and 1 mg/kg *** 15 days of administration,thyroid gland was taken for gross observation,and histopathological changes were observed by hematoxylin-eosin *** structure of Golgi secretory vesicles in thyroid tissues was observed by transmission electron *** expression of thyrotropin receptor(TSH-R)was observed by ***-deoxynucleoitidyl transferase mediated nick end labeling assay was used to detect cell apoptosis in thyroid ***-time quantity primer chain reaction and Western blot were used to detect the expressions of MST1,p-large tumor suppressor gene 1(LATS1),p-Yes1 associated transcriptional regulator(YAP),proliferating cell nuclear antigen(PCNA),G_(1)/S-specific cyclin-D1(Cyclin D1),B-cell lymphoma-2(Bcl-2),Caspase-3,microtubule-associated proeins light chain 3Ⅱ/Ⅰ(LC3-Ⅱ/Ⅰ),and recombinant human autophagy related 5(ATG5).Thyroxine(T4)level was detected by enzyme-linked immunosorbent ***:The thyroid volume of rats in the model group was significantly increased compared to the normal control group(Plicular epithelial cells,disorderly arrangement,and irregular morphology *** secretion of small vesicles by Golgi apparatus was reduced,and the exp

关键词： Radix inhibited Scr

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腹膜透析相关性腹膜炎的细菌谱及耐药性分析

华西医学 2017年第8期32卷 1221-1224页

作者：周雪丽秦敏任英李莉刁永书唐晓红钟慧李孜四川大学华西医院肾脏内科成都610041

目的分析腹膜透析相关性腹膜炎(peritoneal dialysis associated peritonitis,PDAP)病原菌分布及耐药性变化。方法回顾分析2014年1月—12月行持续非卧床腹膜透析并发生PDAP患者的临床资料,分析其发生PDAP的致病菌、耐药性、转归情况和... 详细信息

目的分析腹膜透析相关性腹膜炎(peritoneal dialysis associated peritonitis,PDAP)病原菌分布及耐药性变化。方法回顾分析2014年1月—12月行持续非卧床腹膜透析并发生PDAP患者的临床资料,分析其发生PDAP的致病菌、耐药性、转归情况和可能诱因。结果共有64例患者发生了72例次PDAP,病原菌培养阳性36株(50.0%),其中革兰阳性(Gram-positive,G+)菌24株(66.7%),革兰阴性(Gram-negative,G–)菌7株(19.4%),真菌5株(13.9%)。G+菌对万古霉素、利奈唑胺、利福平的耐药率均为0%,对左氧氟沙星、庆大霉素、头孢唑林耐药率分别为14.3%、26.3%、50.0%。G–杆菌对丁胺卡那霉素和亚胺培南耐药率均为0%,对庆大霉素和头孢他啶均为28.6%,对左氧氟沙星、氨苄青霉素耐药率分别为42.9%、100.0%。结论 PDAP病原菌及耐药性已发生很大变化,应根据各中心病原菌及耐药性特点选用抗菌药物,同时需努力提高透出液培养阳性率及PDAP的治愈率。

关键词：腹膜透析腹膜炎耐药性

新一代微测序基因芯片的设计及其耐药性检测效果的初步研究

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中国防痨杂志 2019年第6期41卷 609-615页

作者：孙照刚张洪静李自慧孙琦吕琳娜潘丽萍 Sandy Gilbert 张宗德许绍发 James Xia 首都医科大学附属北京胸科医院北京市结核病胸部肿瘤研究所 101149

目的设计和评价微测序基因芯片检测结核分枝杆菌(MTB)耐药性的价值。方法于北京结核病临床数据和样本资源库选取MTB实验室标准菌株(H37Rv)和109株MTB临床分离株,采用绝对浓度法进行表型药物敏感性试验(简称“表型药敏试验”)和基因测序... 详细信息

目的设计和评价微测序基因芯片检测结核分枝杆菌(MTB)耐药性的价值。方法于北京结核病临床数据和样本资源库选取MTB实验室标准菌株(H37Rv)和109株MTB临床分离株,采用绝对浓度法进行表型药物敏感性试验(简称“表型药敏试验”)和基因测序法检测MTB耐药相关基因突变(包括inhA、katG、rpsL、gyrA、rrs、eis、rpoB和embB基因)。以荧光标记探针为基本检测原理设计制备微测序基因芯片,检测109株MTB临床分离株耐药基因突变,分析微测序基因芯片的检测效能。结果通过表型药敏试验及基因测序检测,明确了109株MTB临床分离株耐药相关基因(inhA、katG、rpsL、gyrA、rrs、eis、rpoB和embB基因)突变位点及突变形式。微测序耐药检测基因芯片初期设计包含了katG、inhA、rpoB、gyrA、embB、rpsL、rrs和eis基因的目前已报道的所有突变位点的全部已知突变形式,共计220条探针,并确认出67条优秀探针。采用包含67条探针的微测序耐药检测基因芯片对109株MTB临床分离株进行检测。结果发现,与测序结果相比,除检测embB基因突变的2条探针外,其余65条探针检测碱基突变形式的符合率均超过95%,其中42条探针检测的符合率达到100.00%。以测序结果为参照标准,基因芯片检测对embB基因、gyrA基因、inhA基因、katG基因、rpoB基因、rpsL基因、eis基因和rrs基因突变检测的敏感度分别为64.21%(61/95)、80.00%(8/10)、95.83%(23/24)、98.55%(68/69)、92.63%(88/95)、93.85%(61/65)、75.00%(3/4)和94.44%(17/18);特异度分别为92.86%(13/14)、100.00%(99/99)、97.65%(83/85)、87.50%(35/40)、85.71%(12/14)、63.64%(28/44)、100.00%(105/105)和98.90%(90/91);Kappa值分别为0.29、0.88、0.92、0.88、0.68、0.60、0.85、0.93。结论本研究研发设计了一套包含67条探针微测序耐药基因检测芯片,经过初步验证后证明其检测MTB耐药相关基因突变的效能较好,对embB基因的耐药检测探针还需进一步优化,使之更好的满足临床需求。

关键词：分枝杆菌,结核结核,抗多种药物性微生物敏感性试验基因突变芯片分析技术技术评估,生物医学

Notes on linear Codes over Finite Commutative Chain Rings

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Acta Mathematicae Applicatae Sinica 2011年第1期27卷 141-148页

作者： zi-hui liu Department of Mathematics Beijing Institute of Technolggy Beijing 100081 China

The properties of the generator matrix are given for linear codes over finite commutative chain rings, and the so-called almost-MDS （AMDS） codes are studied.

关键词： AMDS codes weight hierarchies finite chain rings

云南省峨山县“十二五”规划期间结核病防治成本效益分析

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中国防痨杂志 2017年第3期39卷 318-321页

作者：代水琼普洪学赵子辉巴丽英李银云南省峨山彝族自治县疾病预防控制中心办公室 653200 云南省峨山彝族自治县疾病预防控制中心结核病防治科 653200

按照全国结核病防治规划（2001-2011年）终期评估实施方案与细则,分析峨山县“十二五”规划期间结核病防治经费的投入和产出情况,计算成本-效益比,为卫生资源的有效配置及合理使用提供科学依据.期间,各级对峨山县投入结核病防治经费共66... 详细信息

按照全国结核病防治规划（2001-2011年）终期评估实施方案与细则,分析峨山县“十二五”规划期间结核病防治经费的投入和产出情况,计算成本-效益比,为卫生资源的有效配置及合理使用提供科学依据.期间,各级对峨山县投入结核病防治经费共66.55万元,全县发现活动性肺结核患者248例,成功治疗涂阳和涂阴患者共240例,减少因结核病死亡61例,避免新感染989名,避免新发患者99名,节约医疗费用67 372.89元,挽回1558.6个伤残调整生命年（DALY）,挽回的社会总价值达4066.34万元.每挽回一个DALY损失,政府仅需投入426.99元;政府每投入1元结核病防治经费,可以产生61.20元的社会经济效益.结果表明,峨山县“十二五”规划期间结核病防治工作有效控制了传染源、减少了发病和死亡人数,挽回了大量社会劳动力,取得显著的经济效益和社会效益.

关键词：结核综合预防卫生经费支出费用效益分析

TCM network pharmacology:A new trend towards combining computational,experimental and clinical approaches

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Chinese Journal of Natural Medicines 2021年第1期19卷 1-11页

作者： WANG Xin WANG zi-Yi ZHENG Jia-hui li Shao Institute for TCM-X MOE Key Laboratory of Bioinformatics/Bioinformatics DivisionBNRISTDepartment of AutomationTsinghua UniversityBeijing 100084China

Traditional Chinese medicine(TCM)is a precious treasure of the Chinese nation and has unique advantages in the prevention and treatment of *** holistic view of TCM coincides with the new generation of medical research paradigm characterized by network and *** gave birth to a new method featuring holistic and systematic"network target",a core theory and method of network *** is also an important research object of network *** network pharmacology,which aims to understand the network-based biological basis of complex diseases,TCM syndromes and herb treatments,plays a critical role in the origin and development process of network *** review introduces new progresses of TCM network pharmacology in recent years,including predicting herb targets,understanding biological foundation of diseases and syndromes,network regulation mechanisms of herbal formulae,and identifying disease and syndrome biomarkers based on biological *** studies show a trend of combining computational,experimental and clinical approaches,which is a promising direction of TCM network pharmacology research in the *** that TCM network pharmacology is still a young research field,it is necessary to further standardize the research process and evaluation indicators to promote its healthy development.

关键词： Network pharmacology Traditional Chinese medicine Network target Computation Experiment Clinical approach

Chain Dynamics Heterogeneity in Plasticized Poly(vinyl butyral)(PVB) as Elucidated by Solid-State NMR

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Chinese Journal of Polymer Science 2024年第1期42卷 113-124,I0010页

作者： Jing Lv Xu Chen zi-Shuo Wu Ya-hui li Wei Chen National Synchrotron Radiation Laboratory Anhui Provincial Engineering Laboratory of Advanced Functional Polymer FilmCAS Key Laboratory of Soft Matter ChemistryUniversity of Scienceand Technology of ChinaHefei 230026China

The chain dynamics heterogeneity of the poly(vinyl butyral)(PVB) plasticized by triethylene glycol bis(2-ethylhexa noate)(TEG-EH) was investigated by various solid-state NMR *** plasticized PVB shows two domains in distinct molecular dynamics differences,namely,rigid and soft domains,where the latter is the plasticizer-rich *** time domain low field NMR was first used to investigate the dynamics heterogeneity of the plasticized PVB,and the results show the decreasing activated energy of components in the soft domain of plasticized PVB(E_a=20.2 kJ/mol) as compared with that of the pristine one(E_a=24.3 kJ/mol).Detailed dynamics heterogeneity was obtained by high-field NMR with site-specific *** quadrupole-echo ~2H-NMR was adopted to elucidate the dynamics heterogeneity of the vinyl alcohol(VA) units,where only the hydroxyl group of VA is *** ~1H-^(13)C WISE NMR spectra show that there is not much difference in the mobility of the VB unit in PVB with and without plasticizer,whereas the glass transition temperature differed by approximately 53℃.This is further supported by Torchia's T_1 relaxation *** origin of such an unusual phenomenon is attributed to the critical role of the remaining VA(~22%) in the soft domain,where the VA units locally aggregate through hydrogen ***,the existence of a mobility gradient in the VB unit has been ***,the mobility difference for VB with different stereo-geometry(meso or racemic conformation) is observed for the first *** indicates the importance of modulating the ratio of meso over racemic VB for controlling the macroscopic perfo rmance of PVB.

关键词： Poly(vinyl butyral) Dynamics heterogeneity Plasticizer Solid state NMR

分子筛催化异构化技术在增产MTBE中的应用

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天津化工 2017年第2期31卷 28-30,37页

作者：刘佳刚刘超谭荣辉李子豪中国石油乌鲁木齐石化公司新疆乌鲁木齐830019

乌鲁木齐石化公司40万t/a轻汽油醚化装置,通过增加12.6万t/a醚后碳四异构化单元,采用分子筛催化异构化技术,对醚后碳四进行异构化反应,达到增产MTBE目的,标定结果表明,醚后碳四转化率基本在30%以上,MTBE产量1.3t/h,大大提高了经济效益。

关键词：醚后碳四异构化 MTBE 催化分子筛