检索结果-南通市图书馆

Efficacy of postoperative adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma patients with microvascular invasion

引用

World Journal of Gastroenterology 2017年第41期23卷 7415-7424页

作者： Jia-Zhou Ye Jun-Ze Chen zi-hui li Tao Bai Jie Chen Shao-liang Zhu Le-Qun li Fei-Xiang Wu Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor Ministry of Education Department of General Surgery The Ninth Affiliated Hospital of Guangxi Medical University

AIM To investigate the efficacy and safety of postoperative adjuvant transcatheter arterial chemoembolization(PA-TACE) in preventing tumor recurrence and improving survival in Barcelona Clinic liver Cancer(BCLC) early(A) and intermediate(B) stage hepatocellular carcinoma(HCC) patients with microvascular invasion(MVI).METHODS A total of 519 BCLC A or B HCC patients treated by liver resection alone or followed by PA-TACE between January 2012 and December 2015 were studied retrospectively. Univariate and multivariate analyses were performed to investigate the risk factors for recurrence-free survival(RFS) and overall survival(OS). Multiple logistic regression was used to identify the clinicopathological characteristics associated with MVI. The rates of RFS and OS were compared among patients with or without MVI treated with liver resection alone or followed by PA-TACE. RESULTS Univariate and multivariate analyses demonstrated that serum AFP level > 400 ng/m L, tumor size > 5 cm, tumor capsule invasion, MVI, and major hepatectomy were risk factors for poor OS. Tumor capsule invasion, MVI, tumor size > 5 cm, HBV-DNA copies > 1 x 104 IU/m L, and multinodularity were risk factors for poor RFS. Multiple logistic regression identified serum AFP level > 400 ng/m L, tumor size > 5 cm, and tumor capsule invasion as independent predictors of MVI. Both OS and DFS were significantly improved in patients with MVI who received PA-TACE as compared to those who underwent liver resection alone. Patients without MVI did not show a significant difference in OS and RFS between those treated by liver resection alone or followed by *** PA-TACE is a safe adjuvant intervention and can efficiently prevent tumor recurrence and improve the survival of BCLC early-and intermediate-stage HCC patients with MVI.

关键词： Hepatocellular carcinoma Microvascular invasion Postoperative adjuvant transcatheter arterial chemoembolization Recurrence-free survival Overall survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Portable fluorogenic probe for monitoring of volatile amine vapour and food spoilage

引用

Chinese Chemical Letters 2024年第3期35卷 257-261页

作者： Jian-Hao Zhao Wen-Xing Xu Bin li Wei Xu Wu-Kun Zhang Ming-Shuai Yuan hui-zi li Qing-Guo He Xiang Ma Jian-Gong Cheng Yan-Yan Fu State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of the Chinese Academy of SciencesBeijing 100039China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

There are urgent needs of volatile amine gas sensors with high-performance in food quality control,disease monitoring and environmental ***-film fluorescent probe is suitable for amine vapour sensing due to its high sensitivity,high selectivity,and no polluting ***,a novel fluorescent probe based on indacenodithiophene structure withπconjugated system was designed and *** experimental results show that the films prepared by this material exhibit rapid and distinct fluorescence quenching after being exposed to saturated vapours of primary amine,secondary amine and tertiary amine represented by n-propylamine,diethylamine and trimethylamine,*** quenching of fluorescence is 84%,87%and 96%,respectively,within 10 *** detection mechanism of probe for primary amine is based on specific chemical reaction,while the detection mechanism for secondary amine and tertiary amine is intramolecular charge *** experiments show that the detection limit of the fluorescent probe for trimethylamine,an important marker of food spoilage,could reach 4.610 ***-site detection based on spoilage of small yellow croaker suggests the material possesses the potential for food freshness *** simple fluorogenic probe is an original approach to simplify real-time visual monitoring of volatile amine vapour.

关键词： Fluorescent probe Volatile amine Gas sensing Trimethylamine Food spoilage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

引用

Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multivariate synergy for heightening ionic HOF robustness and proton conductivity

引用

Science China Chemistry 2025年

作者： Xiang-Tian Bai li-hui Cao Xu-Yong Chen Jia-Yu Wang zi-Ye Zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于能量法的尾矿土动孔压模型研究

引用

岩土工程学报 2016年第11期38卷 2051-2058页

作者：刘叔灼李慧子单毅李康巴凌真华南理工大学土木与交通学院广东广州510641 华南理工大学亚热带建筑科学国家重点实验室广东广州510641 广东省重工建筑设计院有限公司广东广州510040

通过应力控制式动三轴不排水循环剪切试验,对饱和尾矿土在循环应力比、轴–径向固结应力比等因素下孔隙水压力与累积能量耗散关系进行研究。研究结果表明孔隙水压力增长与塑性应变累积能量耗散和土体黏滞累积能量耗散密切相关。当循环... 详细信息

通过应力控制式动三轴不排水循环剪切试验,对饱和尾矿土在循环应力比、轴–径向固结应力比等因素下孔隙水压力与累积能量耗散关系进行研究。研究结果表明孔隙水压力增长与塑性应变累积能量耗散和土体黏滞累积能量耗散密切相关。当循环应力比cR介于0.205～0.238、轴–径向固结应力比cK介于1.0～1.3时,孔隙水压力–能量之间存在临界状态。通过非线性回归分析初步建立了循环应力比和轴–径向固结应力比条件下饱和尾矿土的孔隙水压力能量模型,从变化机理上阐述孔隙水压力的变化规律并消除了周次的不确定性对于孔隙水压力模型的影响,对预测循环荷载作用下饱和土的孔隙水压力具有借鉴意义。

关键词：孔隙水压力能量模型饱和尾矿土循环应力比固结应力比

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PREDICTING SUBCHLOROPLAST LOCATIONS OF PROTEINS BASED ON THE GENERAL FORM OF CHOU＇S PSEUDO AMINO ACID COMPOSITION： APPROACHED FROM OPTIMAL TRIPEPTIDE COMPOSITION

引用

International Journal of Biomathematics 2013年第2期6卷 47-60页

作者： HAO liN CHEN DING LU-FENG YUAN WEI CHEN hui DING zi-QIANG li FENG-BIAO GUO JIAN HUANG NI-NI RAO Key Laboratory for Neurolnformation of Ministry of EducationCenter of Bioinformatics School of Life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 P. R. China

Chloroplasts are organelles found in plant cells that conduct photosynthesis. The subchloroplast locations of proteins are correlated with their functions. With the availability of a great number of protein data, it is highly desired to develop a com- putational method to predict the subchloroplast locations of chloroplast proteins. In this study, we proposed a novel method to predict subchloroplast locations of proteins using tripeptide compositions. It first used the binomial distribution to optimize the feature sets. Then the support vector machine was selected to perform the prediction of subchloroplast locations of proteins. The proposed method was tested on a reliable and rigorous dataset including 259 chloroplast proteins with sequence identity ≤ 25%. In the jack-knife cross-validation, 92.21% envelope proteins, 93.20% thylakoid mem- brane, 52.63% thylakoid lumen and 85.00% stroma can be correctly identified. The overall accuracy achieves 88.03% which is higher than that of other models. Based on this method, a predictor called ChloPred has been built and can be freely available from http：//***/people/hlin/tools/ChloPred/. The predictor will provide important information for theoretical and experimental research of chloroplast proteins.

关键词： Subchloroplast localization tripeptide binomial distribution support vectormachine.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

引用

Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai hui Ma Yue Zhang Jinfeng li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vector meson's spin alignments in high energy reactions

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-hui Chen Zuo-Tang liang Yu-Gang Ma Xin-li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

湿病与水通道蛋白的相关性研究进展

引用

中西医结合学报 2011年第1期9卷 5-10页

作者：李姿慧王键蔡荣林北京中医药大学基础医学院北京100029 安徽中医学院中医临床学院安徽合肥230038 安徽中医学院针灸经络研究所安徽合肥230038

湿邪为病广泛存在于人体多个脏腑疾病中,中医学历来对湿邪致病极为重视。近年来研究发现,湿病与水通道蛋白有着密切的相关性。本文就近几年水通道蛋白与湿病的相关性研究进展进行分析探讨。现已发现,水通道蛋白与人体泌尿、消化、呼吸... 详细信息

湿邪为病广泛存在于人体多个脏腑疾病中,中医学历来对湿邪致病极为重视。近年来研究发现,湿病与水通道蛋白有着密切的相关性。本文就近几年水通道蛋白与湿病的相关性研究进展进行分析探讨。现已发现,水通道蛋白与人体泌尿、消化、呼吸及中枢神经系统的功能密切相关。水通道蛋白的正常表达可能是运化水湿、津液输布的分子生物学基础,而水通道蛋白的表达失常可能是湿病形成的重要原因之一。研究湿病与水通道蛋白的关系对于了解湿病的发生机制以及指导湿病的治疗具有十分重要的意义。

关键词：湿痫水通道蛋白相关性综述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

淫羊藿次苷Ⅰ与其原型药物淫羊藿苷对rBMSCs成骨性分化的影响比较

引用

中国骨质疏松杂志 2017年第8期23卷 1011-1016页

作者：訾慧孙丽蒋宁林庶茹郑洪新辽宁中医药大学中医脏象理论及应用教育部重点实验室辽宁沈阳110847

目的观察淫羊藿次苷Ⅰ(IcarisideⅠ)与其原型药物淫羊藿苷(Icariin,ICA)对大鼠骨髓间充质干细胞(rat bone marrow stromal cells,r BMSCs)成骨分化过程中碱性磷酸酶(ALP)、骨钙素(BGP)蛋白表达量及ALP、BGP、Osterix和Runx-2 mRNA表达的影响。方法贴壁筛选法体外培养r BMSCs,以1×10-5mol/L的ICA和IcarisideⅠ对r BMSCs的成骨性分化进行药物干预。EliSA法检测ICA组、IcarisideⅠ组和空白对照组及转化液组之间ALP活性、BGP分泌量;RT Real-Time PCR法检测ALP、BGP、Osterix和Runx-2 mRNA基因表达。结果与空白对照组相比,IcarisideⅠ与其原型药物ICA均可显著增强r BMSCs的ALP活性,促进BGP的分泌,提高ALP、BGP、Osterix和Runx-2的mRNA水平(P<0.01)。IcarisideⅠ与ICA组比较,其ALP、BGP蛋白表达量及基因表达明显高于ICA组(P<0.01),Osterix和Runx-2的基因表达两组无显著性差异。结论 IcarisideⅠ也能促进r BMSCs成骨性分化,并且其活性高于原型药物ICA,也是淫羊藿发挥抗骨质疏松活性的主要成分。(2)提示补肾中药淫羊藿其补肾壮骨作用与促进ALP、BGP蛋白分泌量,上调ALP、BGP、Osterix和Runx-2的mRNA水平有关。

关键词：中医中药:淫羊藿次苷Ⅰ 淫羊藿苷成骨性分化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：