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A new isoquinoline derivative from the leaves of Magnolia sieboldii ***

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Chinese Chemical Letters 2010年第12期21卷 1446-1448页

作者： Di Wu Ru Ping Wang Shao Jiang Song Li Jun Wu hui yuan gao The Liaoning Provincial Public Security Office Shenyang 110032 China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China

Magnoline（1）,a new isoquinoline derivative,was isolated from the leaves of Magnolia sieboldii ***（Magnoliaceae）.Its structure was elucidated on the basis of spectral analysis including 1D,2D NMR and HR-TOF-MS.

关键词： Magnolia sieboldii K. Koch Isoquinoline Structural identification

A new alkaloid from Castanea mollissima Blume

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Chinese Chemical Letters 2008年第7期19卷 832-834页

作者： Dong Song Zhang hui yuan gao Xiao Mei Song Zhi Shu Tang Li Jun Wu School of Traditional Chinese Medicines Shenyang Pharmaceutical University Shenyang 110016 China School of Shanxi University of Chinese Medicines Xianyang 712046 China

A new alkaloid, named 6-（2＇,3＇-dihydroxy-4＇-hydroxymethyl-tetrahydro-furan-1＇-yl）cyclopentadiene[c]pyrrole-1,3-diol, was isolated from the seeds of Castanea mollissima Blume. The structure was elucidated based o... 详细信息

关键词： Castanea mollissima Blume Alkaloid 6-(2',3'-Dihydroxy-4'-hydroxylmethyl-tetrahydro-furan-1'-yl)cyclopentadiene[c]pyrrole-1,3-diol

The chemical constituents of the tissue culture cells of Daphne giraldii cullus

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Chinese Chemical Letters 2009年第11期20卷 1335-1338页

作者： Zhao Hua Wu Li Bo Wang hui yuan gao Jian Huang Bo Hang Sun Shu hui Li Li Jun Wu School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Department of Pharmacology Mudanjiang Medical College Mudanjiang 157001 China

Three compounds were isolated from the tissue culture cells of Daphne giraldii cullus, their structures were identified as daphneolone （1）, S-（＋）-1-（4-hydroxy-3-methoxyphenyl）-3-hydroxy-5-phenyl-l-pentanone （2）, S-（＋）-1-（4-methoxyphenyl）-3- hydroxy-5-phenyl-l-pentanone （3）, and among them, 2 was a new compound, 3 was a novel natural product.

关键词： Tissue culture cells Daphne giraldii cullus Chemical constituents Structural identification

A new compound with cytotoxic activities from the leaves of Panax ginseng C.A. Meyer

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Chinese Chemical Letters 2008年第7期19卷 837-840页

作者： Li Bo Wang Zhao Hua Wu hui yuan gao Jian Huang Bo Hang Sun Li Jun Wu School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Department of Pharmacology Mudanjiang Medical College Mudanjiang 157001 China

A new compound, 3,6,20（S）-trihydroxy- 12,23-epoxydammar-24-ene,6,20-di-O-β-D-glucopyranoside （1）, was isolated from the leaves of Panax ginseng C.A. Meyer, whose structural elucidation was carried out by means of spectral analysis （including IR, HR- FAB-MS and NMR）. This compound showed the moderate cytotoxic activities against U937 and HeLa cells by using the MTT method.

关键词： Panax ginseng 3,6,20(S)-Trihydroxy-12,23-epoxy-dammar-24-ene,6,20-Di-O-β-D-glucopyranoside Cytotoxic activity

New Cassane Diterpenoids from the Seed Kernels of Caesalpinia cucullata, Exhibit Anti-inflammatory Effect in vitro by Inhibiting iNOS Enzymatic Activity

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Chinese Journal of Chemistry 2021年第6期39卷 1625-1634页

作者： Miao Wang Yi-Ren Yang Yan Yin Kai-Ru Song Li-Ping Long Xian-Zhe Li Bei Zhou hui-yuan gao School of Traditional Chinese Moterio Medico Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education Shenyang Pharmoceuticol UniversityShenyangLiaoning 110016China

Inflammation is a complex biological response to *** cassane diterpenoids from Caesalpinia genus exhibit significant anti-inflammation *** new cassane diterpenoids(1-8)along with seven known ones(9-15)were obtained from the seed kernels of Caesalpinia cucullata *** is the first report on chemical investigation of the seed kernels of ***,and the cassane diterpenes were found in this plant for the first *** structures were elucidated based on the extensive spectroscopic analyses,and the absolute configurations were identified by ECD calculation and X-ray *** compounds were evaluated for their anti-inflammation activity by inhibiting NO production in LPS-induced RAW 264.7 *** 1-2 and 9-11 exhibited effective inhibitory activity with inhibition rate more than 50%.The iNOS enzyme activity and molecular docking experiments were performed to explore the preliminary ***,a potential anti-inflammatory mechanism revealed that the bioactive cassane inhibited overproduction of NO by targeting key residues in the iNOS active cavity to reduce iNOS enzymatic activation.

关键词： Caesalpinia cucullata Roxb. Cassane diterpenoids Structure elucidation Biological activity iNOS enzyme activity

Two new secoiridoid glucosides from Syringa velutina Kom

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Chinese Chemical Letters 2009年第6期20卷 702-705页

作者： Xue Song Feng Yang Qu Zhao Hua Wu Lei Xu Dong Song Zhang hui yuan gao Li Jun Wu School of Traditional Chinese Medicines Shenyang Pharmaceutical University Shenyang 110016 China School of Pharmaceutical Sciences China Medical University Shenyang 110001 China Pharmacy Department Mudanjiang Medical University Mudanjiang 157011 China

Chemical investigation of Syringa velutina Kom. led to the isolation of two new secoiridoid glucosides. Their structures were identified as 6＇-O-（6, 7-dihyrofoliamenthoyl）-8-epi-longisidic acid （syrveoside A, 1） and 6＇-O-menthiafoloyl-8-epi-ldngisidic acid （syrveoside B, 2） on the basis of chemical and physicochemical evidence.

关键词： Syringa velutina Kom. Secoiridoid glucosides Syrveoside A Syrveoside B

Contribution of the Alternative Respiratory Pathway to PSII Photoprotection in C3 and C4 Plants

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Molecular Plant 2017年第1期10卷 131-142页

作者： Zi-Shan Zhang Mei-Jun Liu Renate Scheibe Jennifer Selinski Li-Tao Zhang Cheng Yang Xiang-Long Meng hui-yuan gao State Key Laboratory of Crop Biology ColLege of Life Sciences College of Horticulture Science and Engineering Shandong Agricultural University Tai'an-271018 China Department of Plant Physiology FB5 University of Osnabrueck 49069 Osnabrueck Germany National and Local Joint Engineering Laboratory of Ecological Mariculture Institute of Oceanology Chinese Academy of Sciences 7 Nanhai Road Qingdao 266071 China Wheat Research Institute Henan Academy of Agricultural Sciences Zhengzhou Henan 450002 China These authors contributed equally te this article.

The mechanism by which the mitochondrial alternative oxidase （AOX） pathway contributes to photosystem II （PSII） photoprotection is in dispute. It was generally thought that the AOX pathway protects photosystems by dissipating excess reducing equivalents exported from chloroplasts through the malate/oxaloacetate （Mal/OAA） shuttle and thus preventing the over-reduction of chloroplasts. In this study, using the aoxla Arabidopsis mutant and nine other C3 and C4 plant species, we revealed an additional action model of the AOX pathway in PSII photoprotection. Although the AOX pathway contributes to PSII photoprotection in C3 leaves treated with high light, this contribution was observed to disappear when photorespiration was suppressed. Disruption or inhibition of the AOX pathway significantly decreased the photorespiration in C3 leaves. Moreover, the AOX pathway did not respond to high light and contributed little to PSII photoprotection in C4 leaves possessing a highly active Mal/OAA shuttle but with little photorespiration. These results demonstrate that the AOX pathway contributes to PSII photoprotection in C3 plants by maintaining photo- respiration to detoxify glycolate and via the indirect export of excess reducing equivalents from chloro-plasts by the MaI/OAA shuttle. This new action model explains why the AOX pathway does not contribute to PSII photoprotection in C4 plants.

关键词： alternative oxidase photoprotection photosystem II photorespiration C3 plant C4 plant

Role of tumor associated macrophages in relapse of primary gastrointestinal diffuse large B cell lymphoma and their clinical significance

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Journal of Hainan Medical University 2019年第5期25卷 26-30页

作者： Juan Meng yuan-hui gao Hai-Xia Xu Mei-Qing Wang Zheng-Yi Chen Department of Oncology Affiliated Haikou Hospital of Xiangya Medical CollegeCentral South UniversityHaikouHainan Province570208China Center Laboratory Affiliated Haikou Hospital of Xiangya Medical CollegeCentral South UniversityHaikouHainan Province570208China Department of Pathology Affiliated Haikou Hospital of Xiangya Medical CollegeCentral South UniversityHaikouHainan Province570208China Department of Gastroenterology Affiliated Haikou Hospital of Xiangya Medical CollegeCentral South UniversityHaikouHainan570208China

Objective:To investigate the correlation between the change in expression of the tumor associated macrophage (TAM) markers CD68 and CD206 and the clinicopathological ***: We retrospectively analyzed 28 PGI-DLBCL patients by immunohistochemical stainning. The surface expression of biomarkers CD68 and CD206 on TAMs in samples obtained at diagnosis was compared with that in specimens obtained at first relapse. Based on the change in expression levels of CD68 and CD206 from diagnosis to relapse, patients were categorized into three groups:'increased','stable' and'decreased'. Results: A significant difference was observed between the three groups with respect to CD68 and CD206 expressions (P=0.012) and there existed a consistency between the two (P=0.008). The three groups showed a negative correlation with age, sex, stage, B symptoms, diagnosis, ECOG performance status, and IPI scores, while a positive correlation was observed with the site of lesion of CD206 expression (P=0.032). The time to relapse (TTR) in the three groups of CD68 and CD206 was not significantly different (P=0.23,P=0.818).Conclusion: Our study suggests that increase in CD206 and decrease in CD68 expression at relapse indicates M1-TAM polarization into M2-TAM, which plays an important role in PGI-DLBCL relapse. Furthermore, M2-TAM polarization may be associated with the site of Primary gastric diffuse large B lymphoma.

关键词： PGI-DLBCL Time to Relapse (TTR) Polarized macrophage Immunohistochemistry Relapse

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2124合金淬火后的室温停留效应

中国有色金属学报 2017年第7期27卷 1344-1351页

作者：景慧博柏振海罗兵辉尹远高阳中南大学材料科学与工程学院长沙410083

为了探明2124合金的淬火后室温停留效应对合金力学性能的影响并找到应对措施,运用拉伸试验、硬度试验、电导率测试、DSC测试、XRD实验、EDS、TEM实验手段对2124合金淬火后室温停留不同时间的力学性能、相变过程及显微组织进行分析。结... 详细信息

为了探明2124合金的淬火后室温停留效应对合金力学性能的影响并找到应对措施,运用拉伸试验、硬度试验、电导率测试、DSC测试、XRD实验、EDS、TEM实验手段对2124合金淬火后室温停留不同时间的力学性能、相变过程及显微组织进行分析。结果表明:合金淬火后室温停留降低2124合金随后185℃人工时效的峰值强度,屈服强度最大降低60 MPa,伸长率略有升高,但低于1.5%;室温停留阶段合金内部析出物为GPB区,并且位错密度降低;室温停留24 h后185℃人工时效阶段主要强化相S相的析出激活能由淬火后直接时效的56.8k J/mol上升至72.7 k J/mol,室温停留阶段位错密度的降低抑制了S相的非均匀析出是导致S相析出激活能升高的原因之一;在淬火后对材料进行3%冷变形即可消除室温停留对2124合金强度、硬度带来的不利影响。

关键词： 2124合金力学性能淬火后室温停留 S相