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Era of diagnostic and interventional ultrasound

World Journal of Radiology 2011年第5期3卷 141-146页

作者： hui-xiong xu,department of medical ultrasound,{2. tenth people’s Hospital and the tenth people’s Hospital of tongji university,shanghai 2.0072.china hui-xiong xu Department of Medical Ultrasound Shanghai Tenth People's Hospital and the Tenth People's Hospital of Tongji University Shanghai 200072 China.

It is an era of diagnostic and interventional ultrasound (Us).Various new techniques such as three-dimensional Us(3D Us),interventional Us,and contrastenhanced Us(CEUs)have been introduced into clinical *** and his colleagues have taken advantage of these techniques and carried out a series of relevant *** use of 3D Us in the liver,gallbladder,liver tumor volumetry,guidance for ablation,and 3D CEUs has widened the application of 3D Us in the *** found that prognosis in patients with hepatocellular carcinoma(HCC)after thermal ablation with curative intent was determined by treatment response to ablation,pretreatment serum AFP,and liver function *** response to treatment was the most predictive factor for long-term *** compared the use of percutaneous microwave ablation and radiofrequency ablation for the treatment of HCC and found that both are effective methods in treating *** local tumor control,complications related to treatment, and long-term survival were equivalent for the two *** first compared the enhancement patterns of HCC and intrahepatic cholangiocarcinoma(ICC)and proposed the diagnostic clues for ICC,liver angiomyolipoma(AML),gallbladder cancer,renal carcinoma,and renal AML,which have greatly enhanced the role ofCEUs in the *** also evaluated the diagnostic performance of CEUs in characterizing complex cystic focal liver lesions and the agreement between two investigators with different experience levels;and found that CEUs is especially useful for the young *** assessed the effect of anti-angiogenic gene therapy for HCC treated by microbubble-enhanced Us exposure and concluded that gene therapy mediated by Us exposure enhanced by a microbubble contrast agent may become a new treatment option for HCC.

关键词： Ablation Cancer Contrast-enhanced ultrasound Interventional ultrasound Liver Three-dimensional ultrasound

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CABYR RNAi plasmid construction and NF-κB signal transduction pathway

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World Journal of Gastroenterology 2010年第39期16卷 4980-4985页

作者： Lin-Xiang shi,Yao-Ming He,Lin Fang,Hong-Bo Meng,Li-Jun Zheng,department of General surgery,shanghai {2. people’s Hospital,tongji university,shanghai 2.0072.china department of General surgery Shanghai Tenth People's Hospital Tongji University Shanghai 200072 China. ajijinwei@***

AIM:To construct the CABYR RNAi plasmid and study its relation with the nuclear factor(NF)-κB signal transduction ***:Human CABYR mRNA sequence was obtained from *** structure of cDNA sequence for the short hairpin RNA was BbsⅠ+sense+loop+ antisense+transcription terminator+KpnⅠ+Bam HⅠ.A CABYR silencing plasmid was constructed and transfected into the human embryo cell line *** real-time polymerase chain reaction was used to analyze CABYR and NF-κB gene ***:The CABYR and NF-κB expressions were detected in 2.3T *** oligonucleotide(5'-GCT-CAGATGTTAGGTAAAG-3')efficiently silenced the expression of *** expression of NF-κB was not significantly affected by silencing CABYR(P=0.743).CONCLUsION:CABYR can be found in the human embryo cell line *** 2.can efficiently silence its target,CABYR,indicating that CABYR is not related with the NF-κB signal transduction pathway.

关键词： CABYR Plasmid Nuclear factor-κB signal transduction RNAi Cabyrmid 2

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Experience with pulmonary vein isolation in patients with paroxysmal atrial fibrillation by using a circular cryoablation catheter

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上海医学 2007年第S1期30卷 107-108页

作者： xu Yawei, TANG Kai, ZHOU Ke, YU xuejing, CHEN Yanqing {2. of Cardiology, shanghai tenth people’ s Hospital, tongji university, shanghai 2.0072, china

Objective This study was to report our early experience with electrical isolation of pulmonary vein (PV) in paroxysmal atrial fibrillation (AF) by using a circular cryoablation catheter. Methods After electroanatomic model of LA/PVs was established by Carto, cryoablation was performed in each PV. If complete isolation of PVs could not be achieved, then additional radiofrequency ablations would be applied to ablate the conduction gaps. Results Cryoablation was performed in totally 58 PVs in 14 cases with paroxysmal AF. Thirty-one PVs (53.4%) were successfully isolated with the single use of the circular cryoablation catheter after 2.to 5 (3.2.1.5) cryoablation, while 2.to 4 additional radiofrequency ablations needed to be applied at gaps on the circular cryoablation lines to achieve completely isolation in 2. PVs (46.6%). After a follow up of 18±7 months, 11 patients (78.6%) remained AF free. selective pulmonary venography immediately and repeat magnetic resonance imaging (MRI) scan at 3 months post procedure showed there was no PV stenosis. Conclusion The circular cryoablation catheter can be safely used in the isolation of PVs in paroxysmal AF, But the efficacy of this technique needs to be further improved.

关键词： fibrillation paroxysmal isolation safely circular radiofrequency stenosis conduction immediately tot

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The susceptibility of ventricular arrhythmia to aconitine in conscious Lyon hypertensive rats

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Acta Pharmacologica sinica 2007年第2期28卷 211-215页

作者： Min LI~(2.3) Jin WANG~2.He-hui XIE~2.Fu-ming sHEN~2.Ding-feng sU~(2.4)2.department of Pharmacology,second Military.{2. university,shanghai 2.0433,china 3 department of Pediatrics,shanghai tenth people's Hospital,tongji university,{12. departmentofPharmacology SecondMilitaryMedicalUniversityShanghai200433China departmentofPediatrics ShanghaiTenthPeople'sHospitalTongjiUniversityShanghai200072China

Aim:The present work was designed to investigate the relationship betweenhemodynamic parameters and the susceptibility of ventricular arrhythmia toaconitine in conscious Lyon hypertensive rats(LH).Methods:Male LH and Lyonlow blood pressure rats(LL)were *** the determination of baroreflexsensitivity(BRs),ventricular arrhythmia was induced by aconitine infusion inconscious *** pressure(BP)was recorded during the period of ***:Compared with the LL rats,the LH rats possessed significantly higherBP,blood pressure variability and lower *** threshold of aconitine requiredfor ventricular fibrillation and cardiac arrest in the LH rats were significantly lowerthan those in the LL *** was found that all the hemodynamic parametersstudied were not correlated with the threshold of aconitine required for arrhythmia,with the exception of BRs,which was positively related to the threshold ofaconitine required for ventricular premature ***:The LH rats pos-sessed greater susceptibility to aconitine-induced ventricular arrhythmias whencompared to the LL *** greater susceptibility could not be attributed to anyone of the hemodynamic parameters alone studied in the LH *** is proposedthat various hypertension-associated abnormalities,including the abnormalhemodynamics,may co-contribute to this vulnerability to ventricular arrhythmias.

关键词： arrhythmia aconitine baroreflex sensitivity hypertension Lyon hypertensive rats

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Cycladophora davisiana(Radiolarian)in the Bering sea during the late Quaternary:A stratigraphic tool and proxy of the glacial subarctic Pacific Intermediate Water

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science china Earth sciences 2005年第10期48卷 1698-1707页

作者： WANG Rujian1 & CHEN Ronghua2.1. state Key Laboratory of Marine Geology, tongji university, {2. 2.0092. china 2. The Key Laboratory of submarine Geoscience, state Oceanic Administration, Hangzhou 310012. china state Key Laboratory of Marine Geology tongji university {2. china The Key Laboratory of submarine Geoscience state Oceanic Administration Hangzhou china

Cycladophora davisiana (Radiolarian) contents are counted in two cores of the Ber-ing sea and correlated well with the oxygen isotopic records of ice in the deep core obtained by the Greenland Ice sheet Project II (GIsP 2. and deep-sea sediments (sPECMAP) of the world oceans. Millennial scale climatic events, for example, Younge Dryas and B?lling/Aller?d events, Heinrich1 and Dansgaard-Oeschger1events, recorded by C. davisiana percents are distin-guished from Core B4-2. C. davisiana events b, c1, c2. d, e1 and e2. respectively, corresponding to oxygen isotopic 2.0, 3.1, 3.3, 4.0, 5.1 and 5.3, are identified from Core B2.9. High resolution re-cords of C. davisian are tuned to the oxygen isotopic records in GIsP 2.and sPECMAP and the depth-age frameworks are established in the two cores, supplying a stratigraphic base for future paleoceanographic and paleoclimatic studies. High C. davisiana during the glacial periods in the two cores indicate that they can serve as a proxy of the glacial subarctic Pacific Intermediate Water, which verifies the glacial subarctic Pacific Intermediate Water brought from the Bering sea.

关键词： Cycladophora davisiana, stratigraphic tool, YD and B/A events, Heinrich 1 and D/O1 events, proxy of glacial subarctic Pacific Intermediate Water, late Quaternary, Bering sea.

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Influence of norcantharidin on proliferation,proliferation-related gene proteins prolifera-ting cell nuclear antigen and Ki-67 of human gallbladder carcinoma GBC-sD cells

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 603-607页

作者： Yue-Zu Fan, Jin-Ye Fu, Ze-Ming Zhao and Cun-Qiu Chen shanghai, china {2. of surgery, tongji Hospital of tongji U- mversity, shanghai 2.0065, china {2. of surgery, Pudong people’ s Hospital, shanghai 2.12.0 , Chi- na department of surgery Tongji Hospital of Tongji University 389 Xincun Road Shanghai 200065 China. fanyuezu_shtj@***

BACKGROUND: Gallbladder carcinoma is a highly lethal and aggressive disease with early metastasis, strong invasion and poor prognosis. Most patients with this disease are at the advanced and un-resectable stage and should be consi- dered for palliative treatment such as chemotherapy and ra- diotherapy. Unfortunately, reports of chemotherapy and radiotherapy for gallbladder carcinoma are disappointing. We investigated the influence of norcantharidin (NCTD) on proliferation, proliferation-related gene proteins PCNA and Ki-67 of human gallbladder carcinoma GBC-sD cells in vitro. METHODs: GBC-sD cell lines of human gallbladder carci- noma were cultured by the cell culture technique. The ex- periment was divided into NCTD group and control group. The tetrazolium-based colorimetric assay was used to evaluate cell growth. The streptavidin-biotin complex method was used to determine the expressions of prolifera- tion-related gene proteins PCNA and Ki-67 of human gall- bladder carcinoma GBC-sD cells. REsULTs: NCTD inhibited the growth and proliferation of GBC-sD cells from 10 mg/L or after 6 hours in a dose- and time-dependent manner, with the IC50 value of 56.18 μg/ ml at 48 hours. After treatment with NCTD, the expression of PCNA (0.932.±0.031 vs. 0.318 ±0.02., P2.vs. 0.2.7 ±0.018, Ps were decreased significantly. CONCLUsION: NCTD inhibits the proliferation of human gallbladder carcinoma GBC-sD cells in vitro and the expres- sion of their proliferation-related gene proteins PCNA and Ki-67.

关键词： gallbladder neoplasm norcantharidin cell culture immunohistochemistry cell proliferation proliferating cell nuclear antigen, Ki-67

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Metaanalysis of the Resolution rate of Type 2.diabetes mellitus in patients undergoing Roux-en-Y gastric bypass surgery

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外科研究与新技术 2011年第2期 140-147页

作者：拉杰斯葛海燕 tongji university school of Medicine department of Gastro-Intestinal surgery Shanghai Tenth People's Hospital

Background One of the major comorbidities in obese and morbidly obese patients is Type 2.diabetes (T2.M) with approximately 2.% of them suffering from this disease. The objective of this review was to determine the impact of Roux-en-Y gastric bypass (RYGB) surgery on the resolution rate of T2.M in obese diabetic *** A systematic review was made into the literature using MEDLINE database to search for relevant studies reporting the resolution or improvement of T2.M post RYGB. Data from the case series and systematic review were collected for different age groups and different degrees of obesity (obese,morbidly obese,super obese) and metaanalysed. The various other aspects of the surgery regarding the complications,mortality rate,cost analysis,improvement in quality of life were also reviewed. Results Data from 56 relevant studies were retrieved containing a total of 102.9 patients. Metaanalysis of the data from case series and other systematic reviews showed that RYGB is an effective method for obtaining weight reduction in obese,morbidly obese patients and in elderly obese patients. The mean age of patients was 42.8 years,mean baseline BMI was 47.4 kg/*** mean percentage excess weight loss (%EWL) was 65.3% and mean change in BMI was 17.1 kg/*** mean resolution rate of diabetes was 76.4 % while the mean improved/resolved rate of T2.M was 87.4%. Conclusion RYGB is a highly effective method for patients of various degrees of obesity and different age groups for treatment of obesity and T2.M. It also appears to be an interesting option economically due to savings from diabetic medications which outweigh the costs of the surgery and follow-up coupled with increased quality of life.

关键词： obese bypass Meta obesity reporting suffering mortality economically regarding option

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A novel model-free approach for reconstruction of time-delayed gene regulatory networks

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中国科学：生命科学英文版 2006年第2期49卷 190-200页

作者： JIANG Wei1,2. LI Xia1,2.3,4, GUO Zheng1,2.3, LI Chuanxing1, WANG Lihong1 & RAO shaoqi1,5 1. department of Bioinformatics, Harbin medical {2., Harbin 150086, china 2. department of Computer science, Harbin Institute of Technology, Harbin 150080, china 3. school of Life science and Technology, tongji {2., shanghai 2.0092. china 4. Biomedical Engineering Institute, Capital {2. of medical sciences, Beijing 100054, china 5. departments of Cardiovascular Medicine and Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, UsA department of Bioinformatics Harbin Medical University Harbin 150086 China department of Computer science Harbin Institute of Technology Harbin 150080 China school of Life science Technology Tongji University Shanghai 200092 China Biomedical Engineering Institute Capital University of Medical Sciences Beijing 100054 China departments of Cardiovascular Medicine Molecular Cardiology Cleveland Clinic Foundation Cleveland Ohio 44195 USA

Reconstruction of genetic networks is one of the key scientific challenges in functional genomics. This paper describes a novel approach for addressing the regulatory dependencies be-tween genes whose activities can be delayed by multiple units of time. The aim of the proposed ap-proach termed TdGRN (time-delayed gene regulatory networking) is to reversely engineer the dy-namic mechanisms of gene regulations, which is realized by identifying the time-delayed gene regu-lations through supervised decision-tree analysis of the newly designed time-delayed gene expres-sion matrix, derived from the original time-series microarray data. A permutation technique is used to determine the statistical classification threshold of a tree, from which a gene regulatory rule(s) is ex-tracted. The proposed TdGRN is a model-free approach that attempts to learn the underlying regula-tory rules without relying on any model assumptions. Compared with model-based approaches, it has several significant advantages: it requires neither any arbitrary threshold for discretization of gene transcriptional values nor the definition of the number of regulators (k). We have applied this novel method to the publicly available data for budding yeast cell cycling. The numerical results demonstrate that most of the identified time-delayed gene regulations have current biological knowledge supports.

关键词： gene regulatory networks, time delayed, decision tree.

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The effect of folic acid on the development of stomach and other gastrointestinal cancers

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Chinese medical Journal 2003年第1期116卷 15-19页

作者：朱舜时施尧胡运彪李蓉蓉汪敏周怡和金冠球谢宇野shanghai Navy Hospital shanghai 2.0081 {2. 邬桂泉夏德凰shanghai Putuo people's Hospital 钱珍华宋海连shanghai Traditional and Western medical Integrated Hospital 屠伯强张丽冬萧树东 department of Gastroenterology The Renji Hospital and shanghai Institute of Digestive Disease shanghai First people's Hospital shanghai Navy Hospital shanghai Post and Telecommunication Hospital tongji university Railway Hospital shanghai Traditional and Western medical Integrated Hospital Human Nutrition Research Center on Aging

OBJECTIVE: To evaluate the roles of folic acid and beta-carotene in the chemoprevention of gastric and other gastrointestinal (GI) cancers. METHODs: In a randomized, double-blind, placebo-controlled trial, a total of 2.6 patients with atrophic gastritis were randomly assigned to one of the four groups: (1) folate (FA, 2. mg per day plus vitamin B(12. 1 mg, intramuscularly, per month for one year, then 2. mg two times a week plus 1 mg per three months for the next year); (2. natural beta-carotene (N-betaC, 30 mg per day for first year, then 30 mg two times a week for the next); (3) synthetic beta-carotene (s-betaC, administered as in N-betaC); and (4) placebo. Follow-ups continued from 1994 to 2.01. REsULTs: A total of 7 new cases of gastrointestinal cancers were diagnosed with 3 stomach, 1 colon and 1 esophageal cancers occurring in the placebo group; 1 stomach cancer in both of the N-betaC and s-betaC groups, and no cancer occurring in FA group. In terms of GI cancers, there was a significant reduction in the FA group, compared with the placebo group (P = 0.04). A similar trend was observed in both N-betaC and s-betaC groups (P = 0.07 - 0.08). Taken together, the three intervention groups displayed a highly significant decrease in occurrence (P = 0.004, vs placebo), and a lower risk for GI cancers (OR = 0.12. 95% confidence interval, 0.03 - 0.51). For development of gastric cancer, any one of the three active-treated groups did not reach statistically significant reduction. The FA group showed obvious improvement of the gastric mucosal lesions with more patients displaying lesions reversed or stable atrophy and inflammation (P = 0.04), reversed intestinal metaplasia (P = 0.06) at the end of follow-up, and reversed displasia (P = 0.017) at 12.months. Two cases of false jaundice were found in beta-carotene groups with no influence on administration, and no side-effects were reported in FA group. CONCLUsIONs: This trial revealed the interventional effect of folic acid

关键词： Adult Aged Anticarcinogenic Agents Double-Blind Method Female Folic Acid Gastric Mucosa Gastrointestinal Neoplasms Humans Male Middle Aged Patient Compliance Research support, Non-U.s. Gov't stomach Neoplasms beta Carotene

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大跨桥梁考虑地形及多点激励的地震响应分析

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同济大学学报（自然科学版） 2003年第6期31卷 641-646页

作者：刘洪兵范立础同济大学桥梁工程系解放军理工大学工程兵学院江苏南京210007

提出了可以离线计算的三维相关系数谱的概念 ,导出基于三维相关系数谱的多点激励反应谱方法 ,并用此方法对地震波在局部场地下的地形效应以及大跨度桥梁在多点激励作用下的地震响应进行了分析。

关键词：地形效应多点激励相关系数谱反应谱法

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