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Symptom experience and symptom burden of patients following first-ever stroke within 1 year： a cross-sectional study

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Neural Regeneration Research 2018年第11期13卷 1907-1912页

作者： Dan Shi Zheng Li Jian yang Bang-Zhong Liu hui xia School of Nursing Fudan University Shanghai China Xuhui District Center Hospital of Shanghai Shanghai China Zhongshan Hospital Affiliated to Fudan University Shanghai China

Symptoms that are multidimensional and concurrent should be assessed from different dimensions and managed together. Few studies have evaluated concurrent and multidimensional symptoms in patients with stroke. Most studies of stroke focused on dysfunctions and complications. We hypothesize that patients with stroke have a heavy symptom burden within 1 year. This study aimed to describe multidimensional and concurrent symptoms within 1 year after stroke. This study recruited 230 patients with stroke from the Rehabilitation Department of Xuhui District Center Hospital of Shanghai and the Shanghai Sunshine Rehabilitation Center in China from March to September 2017. The patients＇ multidimensional symptom experience and symptom burden were analyzed using a self-made structured questionnaire and the influential factors for symptom burden were identified. The mean number of symptoms in patients with stroke was 11.7 ± 3.5. More than two thirds of the participants suffered from at least 10 co-occurring symptoms. Unilateral limb weakness had the highest prevalence and frequency. Participation restriction had the highest symptom dimensions of severity and distress. Lack of self-care ability（severity）, memory deterioration（frequency）, imbalance of body（distress）, moodiness（distress）, being unable to move limbs at will（distress）, shoulder pain（distress）, and slower response（frequency） were independent factors of the total symptom burden score. These findings can provide essential information for efficient symptom management of patients with stroke.

关键词： nerve regeneration stroke burden multidimensional unilateral limb weakness participation restriction symptom management concurrent symptoms neural regeneration

A Robust Control Strategy to Improve Transient Stability for AC-DC Interconnected Power System with Wind Farms

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CSEE Journal of Power and Energy Systems 2019年第2期5卷 259-265页

作者： Qian hui Jinlu yang xia yang Zhe Chen Yan Li Yun Teng School of Electrical Engineering Shenyang University of TechnologyShenyang 110870China Department of Energy Technology Aalborg UniversityAalborg 9220Denmark State Grid East Inner Mongolia Electric Power Supply Co.LtdHohhot 010020China

In view of the variable parameters that affect the transient stability of electromagnetic torque and mechanical torque balance in AC-DC system,and the uncertainty of wind power in large-scale interconnection of wind *** paper proposes a linear parameter varying(LPV)robust feedback control method for transient stability of interconnected *** proposed LPV robust feedback control method uses the DC channel power control and the mechanical power in the interconnected system as the control target to improve the transient stability of the interconnected system with wind farm ***,aiming at the strong nonlinear characteristics of the interconnected system,the power balance and the wind power output uncertainty in the transient process,the transient process is designed as a linear model of variable ***,the H∞robust output feedback controller is designed according to the LPV *** transient stability control strategy topology and transfer function of the interconnected system are ***,the proposed scheme is verified by an interconnected system formed by four equal-value grids through AC and DC lines in a digital simulation *** results show that the LPV robust feedback control model proposed in this paper has better response characteristics and transient stability control effects for interconnected systems with wind power weak sendingend system.

关键词： AC/DC transmission interconnected power systems linear parameter varying robust control sending-end system transient stability wind power generation

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

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World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-Wei Fu Yue-Jing Li Ran Yu Rui-Qing Guo Li-xia Gao Sheng-xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Vapor-Phase Transport Synthesis of MnSAPO-34 and Its Catalytic Properties

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China Petroleum Processing & Petrochemical Technology 2012年第3期14卷 68-74页

作者： Shao hui Chen xia Wang Binbin Zhong Jing yang Chao School of Petrochemical Engineering Changzhou University Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of Sciences

MnSAPO-34 molecular sieves were synthesized by vapor-phase transport （VPT） method using triethylamine （Et3N） as a structure directing agent （SDA）, and were characterized by XRD, BET, SEM, UV-Vis, FT-IR, and TG analy- ses. The influence of the zeolite crystallization conditions and the dry-gel composition were investigated. The results showed that the synthesis conditions had an effect on the crystalline phase. Pure MnSAPO-34 had been obtained when it was crystallized at 140 C for 18 hours. The ratio of MnO/A1203 in the starting gel ranging from 0.1 to 0.2 resulted in pure MnSAPO-34 with a CHA topology. Beyond this scope, MnSAPO-5 with an AFI topology structure was obtained as an impurity substance. UV-Vis spectroscopy and FT-IR spectroscopy study indicated that manganese was incorporated into the framework of the molecular sieve. The catalytic performance of MnSAPO-34 molecular sieve was tested by ketalization reaction of l, 2-propanediol with cyclohexanone. High yield of cyclohexanone-1, 2-propanediol ketal was obtained.

关键词： MnSAPO-34 vapor-phase transport (VPT) ketalization

Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu Yifei yang Yike Jing Zhen Zeng Xuesong Yi Wei Sun Fei yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

Prenatal prednisone exposure disturbs fetal kidney development and its characteristics

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Journal of Environmental Sciences 2024年第11期145卷 75-87页

作者： Zhiping xia Songdi Wang Wen Wang Yutang Liu Tianshu yang hui Wang Ying Ao Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Prednisone is a synthetic glucocorticoid that is commonly used in both human and veterinary ***,it is also recognized as an emerging environmental *** be exposed to prednisone actively or passively throughmultiple pathways and cause developmental toxicity to the ***,the impact of prenatal prednisone exposure(PPE)on fetal kidney development remains *** this study,pregnant mice were administered prednisone intragastrically during full-term pregnancy with different doses(0.25,0.5,or 1 mg/(kg·day)),or at the dose of 1 mg/(kg·day)in different gestational days(GD)(GD0-9,GD10-18,or GD0-18).The pregnant mice were euthanized on *** staining revealed fetal kidney dysplasia,with an enlarged glomerular Bowman’s capsule space and a reduced capillary network in the PPE *** expression of the podocyte and the mesangial cell marker genes was significantly reduced in the PPE ***,overall gene expression in renal tubules and collecting ducts were markedly *** of the above effects were more pronounced in high-dose,full-term pregnancy,and female *** on the mechanism of the female fetal kidney have revealed that PPE reduced the expression of Six2,increased the expression of Hnf1β,Hnf4α,and Wnt9b,and inhibited the expression of glial cell line-derived neurotrophic factor(GDNF)and Notch signaling *** conclusion,this study demonstrated that there is a sex difference in the developmental toxicity of PPE to the fetal kidney,and the time effect is manifested as full-term pregnancy>early pregnancy>mid-late pregnancy.

关键词： Prenatal prednisone exposure Kidney developmental toxicity Glomerulus Toxicity characteristics

Characterization and comparison of two C-type lectins with novel key motifs from mud crab Scylla paramamosain

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Journal of Oceanology and Limnology 2022年第4期40卷 1628-1639页

作者： Boxin ZENG Taiwei DONG Yanting xia Shun yang Mengmeng HUANG hui FEI College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine Zhejiang Sci-Tech UniversityHangzhou 310018China

As an important pattern recognition receptor(PRR)in the innate immune system,C-type lectin plays an important role in the innate immune process of *** C-type lectins Sp CTL-C and Sp CTL-D were characterized from mud crab(Scylla paramamosain).The predicted Sp CTL-C and Sp CTL-D proteins both contain a single carbohydrate-recognition domain(CRD)with key motif Gln-Pro-Ala(QPA)and Met-Pro-Ala(MPA),*** CTL-C and Sp CTL-D transcripts distributed in all examined tissues,and the expression level was the highest in *** PRR,the purifi ed recombinant proteins r Sp CTL-C and r Sp CTL-D have high affi nity for three kinds of pathogen-associated molecular patterns(PAMPs):β-glucan,lipopolysaccharide,and ***,r Sp CTL-D can bind to all nine microorganisms tested,while r Sp CTL-C can bind to seven microorganisms except for Staphylococcus aureus and Micrococcus *** r Sp CTL-C and r Sp CTL-D showed agglutination activity towards fungi Pichia pastoris and Saccharomyces ***,r Sp CTL-C and r Sp CTL-D exhibited diff erent antimicrobial activities:r Sp CTL-D has a certain inhibitory eff ect on the growth of Vibrio fl uvialis and ***,while r Sp CTL-C has no obvious inhibitory *** results show that r Sp CTL-C and r Sp CTL-D had better phagocytosis-promoting eff ect on *** than the negative ***,both r Sp CTL-C and r Sp CTL-D had certain encapsulation-promoting ***,two C-type lectins with novel key motifs make an important impact as PRR in immune response towards *** the same time,they play diff erent functions in the innate immunity of mud crab ***.

关键词： Scylla paramamosain immune response innate immunity C-type lectin

Revealing the correlation between structural evolution and long-term cyclability of the LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)/artificial graphite pouch cells at various rates

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Particuology 2023年第10期81卷 162-173页

作者： Xu-Feng Zang Shengchen yang Ying Zou Yingying Zhang Tao Huang hui-Ling xia School of Science Huzhou UniversityHuzhou313000China Department of Engineering Technology Huzhou CollegeHuzhou313000China Laboratory Management Department Huzhou UniversityHuzhou313000China

In recent years,researches on improving high-voltage performance of lithium-ion batteries incorporating LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)and artificial graphite(AG)have been widely ***,limited attentions have been paid to understand the effects and influence mechanisms of charge and discharge rates and charge limit currents on cyclability of NCM523/AG ***,a∼1.9 Ah NCM523/AG pouch cell is employed,whose electrochemical and structural evolutions after 800 cycles at various rates are comprehensively *** find that cycling performances are strongly influenced by charge rate,followed by limit current and discharge *** cell charged at a high rate and cell charged until reaching a low limit current both exhibit low capacity retentions compared to the cell discharged at a high *** failure reasons are analyzed by advanced *** reveal that NCM523 cathodes of the cells deteriorated early experience severe transition metal dissolution,lattice distortion,and partial phase ***,the deposited transition metals on AG anodes catalyze the electrolyte consumption,lithium plating and active area ***,these side reactions notably increase cell impedance and electrochemical ***,these findings clearly outline the challenges and optimization direction for high-rate NCM523/AG cells.

关键词： Lithium-ion batteries Artificial graphite LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) Cycle life Charge-dischargerate Failure mechanism