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Performance of Hybrids between Weedy Rice and Insect-resistant Transgenic Rice under Field Experiments: Implication for Environmental Biosafety Assessment

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Journal of Integrative Plant Biology 2009年第12期51卷 1138-1148页

作者： Qian-Jin Cao hui xia xiao yang Bao-Rong Lu Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science Fudan University Shanghai 200433 China

Transgene escape from genetically modified （GM） rice into weedy rice via gene flow may cause undesired environmental consequences. Estimating the field performance of crop-weed hybrids will facilitate our understanding of potential introgression of crop genes （including transgenes） into weedy rice populations, allowing for effective biosafety assessment. Comparative studies of three weedy rice strains and their hybrids with two GM rice lines containing different insect- resistance transgenes （CpTI or Bt/CpTI） indicated an enhanced relative performance of the crop-weed hybrids, with taller plants, more tillers, panicles, and spikelets per plant, as well as higher 1000-seed weight, compared with the weedy rice parents, although the hybrids produced less filled seeds per plant than their weedy parents. Seeds from the F1 hybrids had higher germination rates and produced more seedlings than the weedy parents, which correlated positively with 1000-seed weight. The crop-weed hybrids demonstrated a generally enhanced relative performance than their weedy rice parents in our field experiments. These findings indicate that transgenes from GM rice can persist to and introgress into weedy rice populations through recurrent crop-to-weed gene flow with the aid of slightly increased relative fitness in F1 hybrids.

关键词： biosafety ecological consequences fitness GM rice insect-resistance transgene Oryza sativa f. spontanea.

Endometrial squamous cell carcinoma originating from the cervix: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8782-8787页

作者： Xin-Yu Shu Zhang Dai Shuang Zhang hui-xia yang hui Bi Department of Gynecology and Obstetrics Peking University First HospitalBeijing 100034China Department of Pathology Peking University First HospitalBeijing 100034China

BACKGROUND Cervical squamous cell carcinoma(SCC)is the most common type of cervical carcinoma and is generally derived from a precancerous stage called cervical high-grade squamous intraepithelial lesion(HSIL).Usually,the cancer metastasizes through lymphatic or hematogenous dissemination,but rarely spreads upward into the ***,we report a case of cervical HSIL extending into the endometrium and finally progressing to SCC in the uterine *** SUMMARY A 57-year-old postmenopausal woman visited our department and requested a routine cervical *** years ago,she had undergone a cervical loop electrosurgical excision procedure because of HSIL found during the gynecological examination,and she had not been checked again *** time,a relapse of the cervical HSIL was diagnosed along with uterine pyometra and endometrial *** 2 wk of antibiotic treatment,a laparoscopic hysterectomy was performed,and the final pathological examination revealed that the cervical HSIL had spread directly upward into the uterine cavity,gradually developing into cervical SCC in the *** Cervical HSIL/SCC can directly spread upward into the uterus with the most common symptoms of pyometra and cervical *** attention should be given to the early detection and prevention of this disease.

关键词： Endometrial squamous cell carcinoma Superficial spreading Cervical carcinoma Pyometra Cervical stenosis Case report

Four-year-old anti-N-methyl-D-aspartate receptor encephalitis patient with ovarian teratoma: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5319-5324页

作者： Cong-Ying Xue hui Dong hui-xia yang Yu-Wu Jiang Ling Yin Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Pediatrics Peking University First HospitalBeijing 100034China

BACKGROUND A population-based comparative study in United States shows that the prevalence and incidence of autoimmune encephalitis are comparable to those of infectious encephalitis and its detection is increasing over *** patients are complicated with ovarian *** younger the patient is,the less likely a tumor will be *** SUMMARY This case report describes the successful treatment of anti-N-methyl-D-aspartatereceptor(NMDAR)encephalitis by early laparoscopic ovarian cystectomy and immunotherapy in a 4-year-old female *** to the best of our knowledge,this detailed case report describes the youngest patient to date with anti-NMDAR encephalitis who underwent laparoscopic ovarian *** Although the younger the patient is,the less likely a tumor will be detected,we still emphasize that all patients with suspected or confirmed anti-NMDAR encephalitis should be screened for ovarian tumors if *** initiation of immunotherapy and tumor removal are crucial for good outcomes.

关键词： Anti-N-methyl-D-aspartate receptor encephalitis Childhood Laparoscopic surgery Ovarian teratoma Case report

Myomatous erythrocytosis syndrome:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3206-3212页

作者： Xin-Yu Shu Na Chen Bi-Yun Chen hui-xia yang hui Bi Department of Obstetrics and Gynaecology Peking University First HospitalBeijing 100034China Department of Obstetrics and Gynaecology The Hospital of Cang TownCangzhou 223900Hebei ProvinceChina

BACKGROUND Uterine myoma is the most common benign tumor among women and is often accompanied by ***,we report the case of a patient with a very large leiomyoma but with a hemoglobin level as high as 197 g/*** undergoing hysterectomy,all her hematological parameters returned to *** staining of her myoma for erythropoietin showed strong positivity,which suggested that erythropoietin may be the cause of her erythrocytosis.A multidisciplinary team played a significant role in treating the *** SUMMARY A 47-year-old woman visited our department complaining that her abdomen had been continuously growing for the past 2 *** careful examinations,she was suspected of having a very large *** was also diagnosed with erythrocytosis because her RBC count was 6.49×10^(12)/L,hemoglobin was 197 g/*** a multidisciplinary team consultation,bilateral ureteral stents were placed,and 800 m L blood was removed by *** patient then underwent hysterectomy and bilateral *** recovered well from the operation,and her hemoglobin level decreased sharply following the ***-molecular-weight heparin was administered daily to prevent postoperative *** was discharged from the hospital on the fourth postoperative *** months later,all her hematological parameters returned to *** analysis of the myoma revealed that it was a benign leiomyoma,with partial hyalinization,and strong positivity for erythropoietin in immunohistochemical staining suggested that erythropoietin may be responsible for the *** Erythropoietin ectopically produced from the myoma was responsible for the erythrocytosis in this patient.A multidisciplinary team is strongly recommended.

关键词： Myomatous erythrocytosis syndrome Erythrocytosis Uterine myoma Erythropoietin Multiple disciplinary team Case report

Case Report:Liquid-based cytology aids in primary fallopian tube cancer diagnosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 635-638页

作者： Zhuo REN Yun-ping ZHANG hui-xia yang Li-rong ZHU Department of Obstetrics and Gynecology Haidian District Maternal and Child Healtheare Hospital Beijing 100080 China Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China

Primary fallopian tube carcinoma(PFTC) is a rare malignant carcinoma among all genital tract *** occurs most commonly in postmenopausal women and is similar to ovarian malignancy historically and *** of its insidious onset and silent course,the diagnosis is made usually ***-based cytology(LBC) is a type of method for cervical cancer screening,but sometimes it may aid in making PFTC *** report a 47-year-old woman with PFTC,whose diagnosis was made with the aid of LBC.

关键词： Primary fallopian tube carcinoma (PFTC) Liquid-based cytology (LBC) Diagnosis

Successful pregnancy after protective hemodialysis for chronic kidney disease: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4521-4526页

作者： Meng-Lu Wang Ying-Dong He hui-xia yang Qian Chen Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China

BACKGROUND Chronic kidney disease(CKD)affects almost 3%of females of child-bearing age,who have a high risk of adverse maternal and fetal ***,high renal burden as a result of pregnancy may lead to deterioration of renal *** increasing number of women with CKD stages 3 to 5 have a strong desire to conceive,and both obstetricians and nephrologists are faced with enormous challenges in terms of their treatment and *** SUMMARY The case of a 35-year-old pregnant woman with a 10-year history of mild mesangial proliferative glomerulonephritis is described *** progressed from stage 3 to stage 5 rapidly during pregnancy,and protective hemodialysis was started at 28 wk of *** to preeclampsia at 34 wk of gestation,cesarean section was performed and a healthy baby was *** was discontinued at 4 wk *** 1 year of follow-up,her renal function was stable,and her baby exhibited good growth and *** Protective hemodialysis during pregnancy can prolong gestational age and improve maternal and fetal outcomes in women with advanced CKD.

关键词： Pregnancy Obstetrics Chronic kidney disease Hemodialysis Nephrology Case report

Interpretation of Chinese expert consensus on diagnosis and management of amniotic fluid embolism

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Chinese Medical Journal 2020年第14期133卷 1719-1721页

作者： Ye Feng hui-xia yang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus Peking University First HospitalBeijing 100034China

Amniotic fluid embolism(AFE)is a rare but potentially lethal condition characterized by an abrupt onset,unpredictability,and high fatality *** Society forMaternal-FetalMedicine(SMFM)published clinical guideline No.9“Amniotic fluid embolism:diagnosis and management”in 2016.[1]Based on this guideline and other relevant studies,the Obstetrics Group of the Chinese Society of Obstetrics and Gynecology,Chinese Medical Association,developed a consensus on the diagnosis and treatment of AFE in December 2018,aiming to standardize its diagnosis and management,and to improve maternal and perinatal outcomes.

关键词： diagnosis fluid embolism

Diabetes Management beyond Pregnancy

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Chinese Medical Journal 2017年第9期130卷 1009-1011页

作者： Geng Song Chen Wang hui-xia yang Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China

Hyperglycemia in pregnancy is one of the most common pregnancy disorders, including gestational diabetes mellitus （GDM） and diabetes in pregnancy （DIP）. Either preexisting diabetes （Type I or Type II） which antedates pregnancy or is first detected during pregnancy, it is associated with adverse outcomes both in mother and child, not only for the short-term consequences but also for the long-term consequences. During the past few decades, some progress has been achieved in the management in hyperglycemia in pregnancy, and severe complications of mothers and offspring were significantly reduced.

关键词： Diagnosis Gestational Diabetes Mellitus Prevention Treatment

Clinical diagnosis and treatment of “atypical” HELLP syndrome

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Gynecology and Obstetrics Clinical Medicine 2022年第3期2卷 105-108页

作者： Ying-dong He hui-xia yang Department of Obstetrics and Gynecology Peking University First HospitalBeijingPR China

HELLP syndrome is regarded as one of the most serious manifestations of preeclampsia,but approximately 15%of patients with HELLP syndrome have no clinical manifestations of preeclampsia;furthermore,although most cases of HELLP syndrome occur after 34 weeks,some cases occur at a much earlier gestational stage,even before 20 weeks of gestation,the underlying pathogenesis of“atypical”HELLP syndrome with very early onset or the basis of non-preeclampsia manifestations should be more actively *** should carefully identify the potential etiology of“atypical”HELLP syndrome in order to provide a reasonable treatment and improve maternal and fetal prognosis.

关键词： HELLP syndrome Atypical