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Chinese Medical Journal 2020年第12期133卷 1479-1480页

作者： hui-xia gao Ya-Nan Li Zun-Gui Xu Yu-Ling Wang Hai-Bin Wang Jin-Feng Cao De-Qin Yuan Li Li Yi Xu Zhi Zhang Ying Huang Jian-Hua Lu Yu-Zhen Liu Er-Hei Dai Department of Laboratory Medicine Fifth Hospital of ShijiazhuangHebei Medical UniversityShijiazhuangHebei 050021China Department of Laboratory Medicine Hospital of XiongxianXiong’an New AreaHebei 071800China Department of Tuberculosis Fifth Hospital of ShijiazhuangHebei Medical UniversityShijiazhuangHebei 050021China Intensive Care Unit Fifth Hospital of ShijiazhuangHebei Medical UniversityShijiazhuangHebei 050021China

To the Editor:The epidemic caused by 2019 novel coronavirus(2019-nCoV)has drawn public attention.[1]Huge infected population and enormous economic loss make it the urgent public health event to deal with.Confirmatory test targeting virus RNA was established at the early stage of outbreak and then used for 2019-nCoV infection diagnosis.[2]However,high risk of laboratory infection,high-qualified personnel,and strict operation condition hampered its application into primary hospitals and community clinics.[3]In this study,the serum immunoglobulin(Ig)M and IgG antibodies were detected in 2019-nCoV confirmed cases of different stages.Furthermore,three different immunological assays,chemiluminescent immunoassay(CLIA),gold immunochromatographic assay(GICA),and enzyme-linked immunosorbent assay(ELISA)were used for IgM and IgG detection.

关键词： infected antibodies immunoglobulin

Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3108-3118页

作者： xiang-Na Zhao Yue You xiao-Ming Cui hui-xia gao Guo-Lin Wang Sheng-Bo Zhang Lin Yao Li-Jun Duan Ka-Li Zhu Yu-Ling Wang Li Li Jian-Hua Lu Hai-Bin Wang Jing-Fang Fan Huan-Wei Zheng Er-Hei Dai Lu-Yi Tian Mai-Juan Ma Center for Disease Control and Prevention of Chinese People's Liberation Army BeijingChina The Walter and Eliza Hall Institute of Medical Research ParkvilleVicAustralia Department of Medical Biology The University of MelbourneParkvilleVicAustralia State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina The Fifth Hospital of Shijiazhuang Hebei Medical UniversityShijiazhuangChina

While some individuals infected by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)present mild-to-severe disease,many SARS-CoV-2-infected individuals are asymptomatic.We sought to identify the distinction of immune response between asymptomatic and moderate patients.We performed single-cell transcriptome and T-cell/B-cell receptor(TCR/BCR)sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic,moderate,and severe patients with healthy controls.Asymptomatic patients displayed increased CD56^(bri)CD16^(-) natural killer(NK)cells and upregulation of interferon-gamma in effector CD4^(+) and CD8^(+) T cells and NK cells.They showed more robust TCR clonal expansion,especially in effector CD4^(+) T cells,but lack strong BCR clonal expansion compared to moderate patients.Moreover,asymptomatic patients have lower interferon-stimulated genes(ISGs)expression in general but large interpatient variability,whereas moderate patients showed various magnitude and temporal dynamics of the ISGs expression across multiple cell populations but lower than a patient with severe disease.Our data provide evidenee of different immune signatures to SARS-CoV-2 in asymptomatic infections.

关键词： patients asymptomatic interferon

High efficiency removal of NO using waste calcium carbide slag by facile KOH modification

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Journal of Environmental Sciences 2024年第5期139卷 182-192页

作者： Fang Wang hui Li Jiyun gao Na Geng Enzhu Jiang Futing xia Mingwu xiang Lijuan Jia Ping Ning School of Chemistry and Environment Yunnan Minzu UniversityKunming 650504China Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China

Waste calcium carbide slags(CS),which are widely applied to desulfurisation,are not typically used in denitration.Herein,to well achieve waste control by waste,a facile and highefficiency denitration strategy is developed using KOH to modify the calcium carbide slags(KCS).Various KCS samples were investigated using a series of physical and chemical characterisations.The performance test results showed that the KOH concentration and reaction temperature are the main factors affecting the denitration efficiency of KCS,and CS modified with 1.5 mol/L KOH(KCS-1.5)can achieve 100% denitration efficiency at 300℃.Such excellent removal efficiency is due to the catalytic oxidation of the oxygen-containing functional groups derived from the KCS.Further studies showed that KOH treatment significantly increased the concentration of oxygen vacancies,nitro compounds,and basic sites of CS.This study provides a novel strategy for the resource utilisation of waste CS in the future.

关键词： Waste Carbide slag KOH Effective denitration

Rosemary extract improves egg quality by altering gut barrier function,intestinal microbiota and oviductal gene expressions in late-phase laying hens

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Journal of Animal Science and Biotechnology 2024年第1期15卷 295-312页

作者： Lianhua Zhang Junwei Ge Fei gao Min Yang hui Li Fei xia Hongtong Bai xiangshu Piao Zhiying Sun Lei Shi Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Rosemary extract(RE)has been reported to exert antioxidant property.However,the application of RE in late-phase laying hens on egg quality,intestinal barrier and microbiota,and oviductal function has not been systematically studied.This study was investigated to detect the potential effects of RE on performance,egg quality,serum parameters,intestinal heath,cecal microbiota and metabolism,and oviductal gene expressions in late-phase laying hens.A total of 21065-week-old“Jing Tint 6”laying hens were randomly allocated into five treatments with six replicates and seven birds per replicate and fed basal diet(CON)or basal diet supplemented with chlortetracycline at 50 mg/kg(CTC)or RE at 50 mg/kg(RE50),100 mg/kg(RE100),and 200 mg/kg(RE200).Results Our results showed that RE200 improved(P<0.05)Haugh unit and n-6/n-3 of egg yolk,serum superoxide dismutase(SOD)compared with CON.No significant differences were observed for Haugh unit and n-6/n-3 of egg yolk among CTC,RE50,RE100 and RE200 groups.Compared with CTC and RE50 groups,RE200 increased serum SOD activity on d 28 and 56.Compared with CON,RE supplementation decreased(P<0.05)total cholesterol(TC)level.CTC,RE100 and RE200 decreased(P<0.05)serum interleukin-6(IL-6)content compared with CON.CTC and RE200 increased jejunal m RNA expression of ZO-1 and Occludin compared with CON.The biomarkers of cecal microbiota and metabolite induced by RE 200,including Firmicutes,Eisenbergiella,Paraprevotella,Papillibacter,and butyrate,were closely associated with Haugh unit,n-6/n-3,SOD,IL-6,and TC.PICRUSt2 analysis indicated that RE altered carbohydrate and amino acid metabolism of cecal microbiota and increased butyrate synthesizing enzymes,including 3-oxoacid Co A-transferase and butyrate-acetoacetate Co A-transferase.Moreover,transcriptomic analysis revealed that RE200 improved gene expressions and functional pathways related to immunity and albumen formation in the oviductal magnum.Conclusions Dietary supplementation with 200 mg/kg RE could increase egg quality of late-p

关键词： Intestinal health Laying hens Microbiota Oviductal function Phytochemicals Production

DNA Damage-driven Inflammatory Cytokines:Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

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Current Medical Science 2024年第2期44卷 261-272页

作者： Meng-jie WANG Yu xia Qing-lei gao Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Cancer Invasion and Metastasis(Ministry of Education) Hubei Key Laboratory of Tumor Invasion and MetastasisTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

DNA damage occurs across tumorigenesis and tumor development.Tumor intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment(TIME)and dominate tumor progression.Accumulating evidence documents that multiple signaling pathways,including cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein(ATM/ATR),are activated downstream of DNA damage and they are associated with the secretion of diverse cytokines.These cytokines possess multifaced functions in the anti-tumor immune response.Thus,it is necessary to deeply interpret the complex TIME reshaped by damaged DNA and tumor-derived cytokines,critical for the development of effective tumor therapies.This manuscript comprehensively reviews the relationship between the DNA damage response and related cytokines in tumors and depicts the dual immunoregulatory roles of these cytokines.We also summarize clinical trials targeting signaling pathways and cytokines associated with DNA damage and provide future perspectives on emerging technologies.

关键词： DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

LSM6 promotes cell proliferation and migration regulated by HMGB1 in laryngeal squamous cell carcinoma

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Engineered Regeneration

Engineered Regeneration 2024年第2期5卷 247-254页

作者： Dengbin Ma Jiayi Li hui Li Yao Tang xia gao Hong Chen xiaoyun Qian xiaohui Shen Department of Otolaryngology Head and Neck Surgery Research Institute of OtolaryngologyNanjing Drum Tower HospitalJiangsu Provincial Key Medical DisciplineAffiliated Hospital of medical SchoolNanjing UniversityNanjing210008China Department of Otorhinolaryngology Minda Hospital of Hubei Minzu UniversityEnshi445000China Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University 321 Zhongshan RoadNanjing210008China

Elevated levels of high mobility group protein B1(HMGB1)play a significant role in the pathogenesis of many diseases,but is particularly important for the formation of malignant tumors.Nonetheless,the function of HMGB1 and the underlying mechanism of laryngeal squamous cell carcinoma(LSCC)remain incompletely understood,causing uncertainty.Here we found immunohistochemistry from 97 LSCC tissues showed HMGB1 was upreg-ulated,which was associated with poor differentiation.HMGB1 knockdown could significantly inhibit wound closure and colony formation.The full-genome gene expression microarray was performed to investigate the mechanism.After knockdown of HMGB1 by siRNA,among the expressed differential genes,10 genes were ran-domly selected for validation.Then,shRNA lentivirus targeting these genes were constructed to explore their role in LSCC by cell proliferation assay.LSM6 downregulation was dramatically promoted by HMGB1 knockdown,resulting in higher expression in LSCC tissues.Furthermore,downregulation of LSM6 could significantly suppress cell proliferation,migration and colony formation.This study indicated that HMGB1 promoted LSCC cell malig-nant phenotypes through regulation of LSM6.We anticipate that HMGB1-LSM6 could be a putative therapeutic target for LSCC.

关键词： HMGB1 LSM6 Laryngeal squamous cell carcinoma Cell proliferation Migration

On hypersurfaces of H2×H2

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Science China Mathematics 2024年第2期67卷 339-366页

作者： Dong gao hui Ma Zeke Yao School of Science Beijing University of Civil Engineering and Architecture Department of Mathematical Sciences Tsinghua University

In this paper, we study hypersurfaces of H2× H2. We first classify the hypersurfaces with constant principal curvatures and constant product angle functions. Then we classify homogeneous hypersurfaces and isoparametric hypersurfaces, respectively. Finally, we classify the hypersurfaces with at most two distinct constant principal curvatures, as well as those with three distinct constant principal curvatures under some additional conditions.

关键词： constant principal curvature homogeneous hypersurface isoparametric hypersurface 53C42 53B25 53C40

A NEW GLOBAL OPTIMIZATION ALGORITHM FOR MIXED-INTEGER QUADRATICALLY CONSTRAINED QUADRATIC FRACTIONAL PROGRAMMING PROBLEM

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Journal of Computational Mathematics 2024年第3期42卷 784-813页

作者： Bo Zhang Yuelin gao xia Liu xiaoli Huang School of Civil and Hydraulic Engineering School of Mathematics and StatisticsNingxia UniversityYinchuan 750021China School of Mathematics and Information Science North Minzu UniversityYinchuan 750021China Ningxia Province Key Laboratory of Intelligent Information and Data Processing Yinchuan 750021China School of Mathematics and Statistics Ningxia UniversityYinchuan 750021China

The mixed-integer quadratically constrained quadratic fractional programming(MIQCQFP)problem often appears in various fields such as engineering practice,management science and network communication.However,most of the solutions to such problems are often designed for their unique circumstances.This paper puts forward a new global optimization algorithm for solving the problem MIQCQFP.We first convert the MIQCQFP into an equivalent generalized bilinear fractional programming(EIGBFP)problem with integer variables.Secondly,we linearly underestimate and linearly overestimate the quadratic functions in the numerator and the denominator respectively,and then give a linear fractional relaxation technique for EIGBFP on the basis of non-negative numerator.After that,combining rectangular adjustment-segmentation technique and midpointsampling strategy with the branch-and-bound procedure,an efficient algorithm for solving MIQCQFP globally is proposed.Finally,a series of test problems are given to illustrate the effectiveness,feasibility and other performance of this algorithm.

关键词： Global optimization Branch and bound Quadratic fractional programming Mixed integer programming

Weyl Type Theorem for Bounded Linear Operator and Its Functional Calculus

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Acta Mathematica Sinica,English Series 2024年第2期40卷 528-536页

作者： gao hui Zi FENG Peng Tong LI School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

Let H be a complex infinite dimensional Hilbert space and B(H)be the algebra of all bounded linear operators on H.In this paper,we mainly study the operators that satisfy both a-Weyl's theorem and property(R).Also,the operators whose functional calculus satisfies the two properties are also explored.We give the features for the operator or its functional calculus for which both a-Weyl's theorem and property(R)hold.

关键词： a-Weyl's theorem property(R) functional calculus

Distributed Source-Load-Storage Cooperative Low-Carbon Scheduling Strategy Considering Vehicle-to-Grid Aggregators

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 440-453页

作者： xiao Xu Ziwen Qiu Teng Zhang hui gao School of Automation Nanjing University of Posts and TelecommunicationsNanjing210023China

The vehicle-to-grid(V2G)technology enables the bidirectional power flow between electric vehicle(EV)batteries and the power grid,making EV-based mobile energy storage an appealing supplement to stationary energy storage systems.However,the stochastic and volatile charging behaviors pose a challenge for EV fleets to engage directly in multi-agent cooperation.To unlock the scheduling potential of EVs,this paper proposes a source-load-storage cooperative low-carbon scheduling strategy considering V2G aggregators.The uncertainty of EV charging patterns is managed through a rolling-horizon control framework,where the scheduling and control horizons are adaptively adjusted according to the availability periods of EVs.Moreover,a Minkowski-sum based aggregation method is employed to evaluate the scheduling potential of aggregated EV fleets within a given scheduling horizon.This method effectively reduces the variable dimension while preserving the charging and discharging constraints of individual EVs.Subsequently,a Nash bargaining based cooperative scheduling model involving a distribution system operator(DSO),an EV aggregator(EVA),and a load aggregator(LA)is established to maximize the social welfare and improve the low-carbon performance of the system.This model is solved by the alternating direction method of multipliers(ADMM)algorithm in a distributed manner,with privacy of participants fully preserved.The proposed strategy is proven to achieve the objective of low-carbon economic operation.

关键词： Electric vehicle(EV) low-carbon scheduling mobile storage system Nash bargaining power flexibility alternating direction method of multipliers(ADMM).