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Acetyl-11-keto-β-boswellic acid extracted from Boswellia serrata promotes Schwann cell proliferation and sciatic nerve function recovery

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Neural Regeneration Research 2018年第3期13卷 484-491页

作者： xiao-wen jiang bin-qing zhang lu qiao lin liu xue-wei wang wen-hui yu Department of Veterinary Medicine Northeast Agricultural University Harbin Helongjiang Province China

Frankincense can promote blood circulation. Acetyl-11-keto-β-boswellic acid （AKBA） is a small molecule with anti-inflammatory properties that is derived from Boswellia serrata. Here, we hypothesized that it may promote regeneration of injured sciatic nerve. To address this hypothesis, we established a rat model of sciatic nerve injury using a nerve clamping method. Rats were administered AKBA once every 2 days at doses of 1.5, 3, and 6 mg/kg by intraperitoneal injection for 30 days from the 1st day after injury. Sciatic nerve function was evaluated using the sciatic functional index. Degree of muscle atrophy was measured using the triceps surae muscle Cuadros *** changes were observed by hematoxylin-eosin staining. Western blot analysis was used to detect expression of phospho-extracellular signal-regulated kinase 1 and 2 （p-ERK1/2） in injured nerve. S100 immunoreactivity in injured nerve was detected by immunohistochemistry. In vivo experiments showed that 3 and 6 mg/kg AKBA significantly increased sciatic nerve index, Cuadros index of triceps muscle, p-ERK1/2 expression, and S100 immunoreactivity in injured sciatic nerve of sciatic nerve injury model rats. Furthermore,for in vitro experiments, Schwann cells were treated with AKBA at 0–20 μg/mL. Proliferation of Schwann cells was detected by Cell Counting Kit-8 colorimetry assay. The results showed that 2 μg/mL AKBA is the optimal therapeutic concentration. In addition, ERK phosphorylation levels increased following 2 μg/mL AKBA treatment. In the presence of the ERK1/2 inhibitor, PD98059 （2.5 μL/mL）, the AKBA-induced increase in p-ERK1/2 protein expression was partially abrogated. In conclusion, our study shows that AKBA promotes peripheral nerve regeneration with ERK protein phosphorylation playing a key role in this process.

关键词： nerve regeneration acetyl-11-keto-β-boswellic acid peripheral nerve injury repair sciatic nerve crush injury Schwann cells cell proliferation ERK signaling pathway PD98059 neural regeneration

Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: molecular mechanism

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Neural Regeneration Research 2022年第12期17卷 2778-2784页

作者： Yao Wang Zong-Liang Xiong Xiang-Lin Ma Chong Zhou Mo-Han Huo Xiao-wen Jiang wen-hui yu Department of Veterinary Medicine Northeast Agricultural UniversityHarbinHeilongjiang ProvinceChina College of Life Sciences Northeast Agricultural UniversityHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Education Department for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbinHeilongjiang ProvinceChina Institute of Chinese Veterinary Medicine Northeast Agricultural UniversityHarbinHeilongjiang ProvinceChina

Previous studies showed that acetyl-11-keto-beta-boswellic acid(AKBA),the active ingredient in the natural Chinese medicine Boswellia,can stimulate sciatic nerve injury repair via promoting Schwann cell ***,the underlying molecular mechanism remains poorly *** this study,we performed genomic sequencing in a rat model of sciatic nerve crush injury after gastric AKBA administration for 30 *** found that the phagosome pathway was related to AKBA treatment,and brain-derived neurotrophic factor expression in the neurotrophic factor signaling pathway was also highly *** further investigated gene and protein expression changes in the phagosome pathway and neurotrophic factor signaling *** expression in the phagosome pathway was markedly decreased,and brain-derived neurotrophic factor,nerve growth factor,and nerve growth factor receptor expression levels in the neurotrophic factor signaling pathway were greatly ***,expression levels of the inflammatory factors CD68,interleukin-1β,pro-interleukin-1β,and tumor necrosis factor-αwere also *** basic protein-andβ3-tubulin-positive expression as well as the axon diameter-to-total nerve diameter ratio in the injured sciatic nerve were also *** findings suggest that,at the molecular level,AKBA can increase neurotrophic factor expression through inhibiting myeloperoxidase expression and reducing inflammatory reactions,which could promote myelin sheath and axon regeneration in the injured sciatic nerve.

关键词： AKBA axon genomics inflammatory injury and repair myelin sheath myeloperoxidase neurotrophic factor peripheral nerve phagosome pathway regeneration Sprague-Dawley rat

Tunable structural coloration of ultrathin zirconia nanotubes film

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Rare Metals 2023年第10期42卷 3304-3310页

作者： Xi-Di Sun hui-wen yu Cheng-Yan Zhao Jing Zhang Yi Shi Li-Jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing210093China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China

Zirconium(Zr) is a rare metal widely used in aero space and military ***,its single color does not meet the requirements of camouflage and ***,a series of ultrathin structural colorations of Zr by coating it with a on... 详细信息

关键词： structural film coating

Identification of a delayed leaf greening gene from a mutation of pummelo

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Science China(Life Sciences) 2021年第7期64卷 1165-1173页

作者： hui-wen yu Zhi-Hao Lu Xia Wang Dan Liu Jia-Xian He Xiao-Lin Jiang Ling-Jun Ke wen-Wu Guo Xiu-Xin Deng Qiang Xu Key Laboratory of Horticultural Plant Biology(Ministry of Education) Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Landscape Plants with Fujian and Taiwan Characteristics ofFujian Colleges and Universities Minnan Normal UniversityZhangzhou 363000China

Delayed greening of young leaves is an unusual phenomenon of plants in *** are mostly evergreen tree ***,a natural mutant of“Guanxi”pummelo(Citrus maxima),which shows yellow leaves at the young stage,was characterized to identify the genes underlying the trait of delayed leaf greening in plants.A segregating population with this mutant as the seed parent and a normal genotype as the pollen parent was *** DNA pools respectively from the leaves of segregating seedlings with extreme phenotypes of normal leaf greening and delayed leaf greening were collected for *** segregant analysis(BSA)and In Del marker analysis demonstrated that the delayed leaf greening trait is governed by a 0.3 Mb candidate region on chromosome *** expression analysis further identified a key candidate gene(Citrus Delayed Greening gene 1,CDG1)in the 0.3 Mb region,which showed significantly differential expression between the genotypes with delayed and normal leaf greening *** was a 67 bp In Del region difference in the CDG1 promoter and the In Del region contains a TATA-box *** laser-scanning microscopy revealed that the CDG1-GFP fusion protein signals were co-localized with the chloroplast signals in the *** of CDG1 in tobacco and Arabidopsis led to the phenotype of delayed leaf *** results suggest that the CDG1 gene is involved in controlling the delayed leaf greening phenotype with important functions in chloroplast development.

关键词： citrus pummelo delayed leaf greening chlorophyll

Simulations and software development for the Hard X-ray Imager onboard ASO-S

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Research in Astronomy and Astrophysics 2019年第11期19卷 93-102页

作者： Yang Su Wei Liu You-Ping Li Zhe Zhang Gordon JHurford Wei Chen yu Huang Zhen-Tong Li Xian-Kai Jiang Hao-Xiang Wang Fan-Xiao-yu Xia Chang-Xue Chen wen-hui yu Fu yu Jian Wu Wei-Qun Gan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China University of Applied Sciences and Arts Northwestern Switzerland Bahnhofstrasse 65210WindischSwitzerland Space Science Laboratory University of California7 Gauss Way94720 BerkeleyUSA School of Space Science and Physics Shandong UniversityWeihai 264209China

China’s first solar mission,the Advanced Space-based Solar Observatory(ASO-S),is now changing from Phase B to Phase *** main scientific objectives are summarized as’1M2B’,namely magnetic field and two types of bursts(solar flares and coronal mass ejections).Among the three scientific payloads,Hard X-ray Imager(HXI)observes images and spectra of X-ray bursts in solar *** this paper,we briefly report on the progresses made by the HXI science team(data and software team)during the design phase(till May 2019).These include simulations of HXI imaging,optimization of HXI grids,development of imaging algorithms,estimation of orbital background,as well as in-orbit calibration *** efforts provided guidance for the engineering,improved HXI’s imaging capability and reduced the cost of the instrument.

关键词： techniques X-ray imaging-techniques simulation Sun X-rays-Sun flares

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： hui-Feng Wang wen-Jie Shi yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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地道桥竖向自振频率研究

铁道学报 2001年第2期23卷 116-119页

作者：周智辉 wen yu-song 中南大学土木建筑学院，湖南长沙　410075 Civil Architectural Engineering College University of Southcentral ChinaChangsha 410075China

结合现场实测资料，提出了地道桥动力特性分析的有限元模型。运用有限元计算模型。计算了各种类型地道桥的竖向基频，并提出正常状态地道桥竖向基频的经验表达式，为估算正常状态地道桥基频提供一种参考方法。

关键词：地道桥基频有限元法竖向自振频率动力特性分析计算模型

Development of 600MPa Cold Rolled Dual Phase Steel for Automotive Application in BX Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 987-989页

作者： GAO Hong-gang,CHEN Li-hong,LIU Ming-hui,yu wen-tao,WANG Ya-fen (Technology Center of Benxi Iron and Steel (Group) Co,Ltd.Benxi 117000,Liaoning,China) Benxi Iron & Steel Grp Co Ltd Ctr Technol Benxi 117000 Liaoning Peoples R China

BX STEEL has developed 600MPa cold rolled dual phase in order to adapt to the market *** paper introduces the design of chemical composition,hot rolling,cold rolling and annealing process of experimental *** finished product property meets the technical standard,the microstructure is typical dual phase,F+M(14-16%).This product has been produced commercially in BX STEEL,and has been approved by end users.

关键词： automotive application dual phase microstructure

Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer

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Chinese Medical Journal 2008年第24期121卷 2534-2538页

作者： CAI Shi-rong WANG Zhao CHEN Chuang-qi WU wen-hui HE yu-long ZHAN wen-hua ZHANG Chang-hua CUI Ji WU hui Department of Gastrointestinal Surgery First Affiliated Hospital Sun Yat-sen University Gastric Cancer Center of Sun Yat-sen University Guangzhou Guangdong 510080 China

Background Accumulated evidences demonstrate that phosphatase of regeneration liver-3 （PRL-3） is associated with metastasis of multiple tumor types, and has been validated as a potential therapeutic target for metastasis. High expression of PRL-3 was implicated in lymph node metastasis of gastric cancer. In the present study, we investigated the role of silencing PRL-3 expression by microRNA （miRNA） interference in gastric cancer growth. Methods RNA interference, mediated by recombinant lentivirus expressing artificial PRL-3 miRNA, was employed to knockdown PRL-3 expression in human SGC7901 gastric cancer cells. MTT assay and tumor implantation experiment were conducted to determine the role of PRL-3 in the proliferation of SGC7901 cells and tumor growth. Results Transfection of recombinant lentivirus expressing artificial PRL-3 miRNA significantly suppressed the proliferation of SGC7901 cells in vitro. The implanted tumor size of the PRL-3 transfection group was （1.92±0.18） cm^3, significantly smaller compared with controls （P 〈0.001）. Conclusions Knockdown of PRL-3 significantly suppressed the proliferation of SGC7901 cells in vitro and tumor growth in vivo. PRL-3 plays a key role in the growth of gastric cancer. PRL-3 should be considered as a potential therapeutic target.

关键词： PRL-3 stomach neoplasms RNA interference