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Isolation and analysis of a TIR-specific promoter from poplar

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Forestry Studies in China 2007年第2期9卷 95-106页

作者： Zheng hui-quan lin shan-zhi Zhang Qian Zhang Zhen-zhen Zhang Zhi-yi Lei Yang Hou Lu Key Laboratory for Genetics and Breeding in Forest Trees and Ornamental Plants Ministry of Education Beijing Forestry UniversityBeijing 100083 P. R. China

A 5＇ flanking region of the well-conserved Toll/interleukin-1 receptor domain （TIR）-encoding sequence was isolated from the genomic DNA ofMelampsora magnusiana Wagner resistant clones of hybrid triploid poplars [（Populus tomentosa × P. bolleana） × P. tomentosa]. Sequencing results and alignment analysis show that the obtained TIR-specific promoter （named as PtTIRp01） was 1,732 bp in length; moreover 3＇ region of the PtTIRp01 contains a responds to the 5＇ composition of TIR-NBS type gene PtDRG02, of 747 bp long 5＇ region of TIR-NBS type gene PtDRG02 and its 398 bp complete TIR-encoding sequence, which significantly corindicating that the obtained TIR-specific promoter region consists upstream region of promoter （985 bp）. It was found that the 5＇ region of TIR-NBS type gene PtDRG02 was characterized in the downstream region of the transcriptional start, named as 5＇-untranslated region （5＇ UTR）, consisting of one 93 bp 5＇-untranslation exon, one 213 bp intron and one 441 bp TIR-encoding open reading frame （ORF）. In addition, several putative cis-acting motifs were present in the obtained TIR-specific promoter of PtDRG02, including one TATA box, one GC-rich, one AT-rich, one P-box, one 3-AF1 binding site, two CAAT boxes, two GT-1 motifs, three typical W-boxes, four I-boxes, and one multi-cis-acting fragment （MCF）. The latter contains five types of regulatory elements （E4, G-box, ABRE motif, box 1 and HVA 1 s）, most of which were homologous to the cis-acting regulatory elements involved in the activation of defense genes in plants. Thus, it can be suggested that TIR-specific promoter might be a pathogen-inducible promoter and be necessary for the inducible expression of defense-related genes. Key words Toll/interleukin- 1 receptor domain, promoter, Cis-acting element, poplar

关键词： Toll/interleukin- 1 receptor domain promoter Cis-acting element poplar

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基于多尺度特征增强的合成孔径光学图像复原

物理学报 2024年第6期73卷 209-221页

作者：张银胜童俊毅陈戈单梦姣王硕洋单慧琳无锡学院江苏省集成电路可靠性技术及检测系统工程研究中心无锡214105 南京信息工程大学电子信息工程学院南京210044

受物理孔径大小和光线散射等影响,合成孔径光学系统成像因通光面积不足和相位失真而出现降质模糊.传统合成孔径光学系统成像复原算法对噪声敏感,过于依赖退化模型,自适应性差.对此提出一种基于生成对抗网络的光学图像复原方法,采用U-Ne... 详细信息

受物理孔径大小和光线散射等影响,合成孔径光学系统成像因通光面积不足和相位失真而出现降质模糊.传统合成孔径光学系统成像复原算法对噪声敏感,过于依赖退化模型,自适应性差.对此提出一种基于生成对抗网络的光学图像复原方法,采用U-Net结构获取图像多级尺度特征,利用基于自注意力的混合域注意力提高网络在空间、通道上的特征提取能力,构造多尺度特征融合模块和特征增强模块,融合不同尺度特征间的信息,优化了编解码层的信息交互方式,增强了整体网络对原始图像真实结构的关注力,避免在复原过程中被振铃现象产生的伪影干扰.实验结果表明,与其他现有方法相比,该方法在峰值信噪比、结构相似性和感知相似度评估指标上分别提高了1.51%,4.42%和5.22%,有效解决合成孔径光学系统成像结果模糊退化的问题.

关键词：图像处理合成孔径多尺度特征融合

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao hui-lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

基于PSO的高线性四次分谐波下变频混频器设计

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仪表技术与传感器 2012年第12期 109-112页

作者：张银胜单慧琳周杰南京信息工程大学江苏南京210044

在介绍分谐波混频器的原理基础上,提出一种以粒子群算法作为全局搜索算法,以性能参数作为评估的混频器电路优化方法,利用ADS软件设计出一种本振为23 GHz,射频为92～94 GHz下的变频器电路,应用CST软件优化脊波导微带过渡结构,实现了W波... 详细信息

在介绍分谐波混频器的原理基础上,提出一种以粒子群算法作为全局搜索算法,以性能参数作为评估的混频器电路优化方法,利用ADS软件设计出一种本振为23 GHz,射频为92～94 GHz下的变频器电路,应用CST软件优化脊波导微带过渡结构,实现了W波段的信号到混频器射频端的引导。优化算法可以快速得到优化结果,仿真结果表明该下变频器的变频差损小于15dB,1dB压缩点较高,具有良好的线性度。

关键词：分谐波混频器下变频器粒子群算法脊波导微带过渡

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基于CPLD的温度采集系统的设计

微计算机信息 2008年第35期24卷 210-211,220页

作者：单慧琳陈钟荣张银胜南京信息工程大学电子与信息工程学院江苏210044 南京信息工程大学

本文介绍了一种基于CPLD的温度采集系统的设计方法,设计分为温度采集和LED显示两个功能模块。与常用温度采集系统相比,本设计采用高精度数字温度传感器MAX6627与CPLD控制芯片EPM3128ATC144,系统具有较高的准确性、通用性和灵活性,功能... 详细信息

本文介绍了一种基于CPLD的温度采集系统的设计方法,设计分为温度采集和LED显示两个功能模块。与常用温度采集系统相比,本设计采用高精度数字温度传感器MAX6627与CPLD控制芯片EPM3128ATC144,系统具有较高的准确性、通用性和灵活性,功能扩展后可通过高速数据传输接口实现与PC机的通信,对采集数据进行综合分析与处理。

关键词： CPLD MAX6627 LED

海洋放线菌Kocuria sp.次级代谢产物的研究

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中国海洋药物 2017年第3期36卷 11-17页

作者：姚蓉马明付晖单伟光林文翰浙江工业大学药学院浙江杭州310014 北京大学天然药物及仿生药物国家重点实验室北京100191

目的研究海洋放线菌Kocuria sp.的次级代谢产物。方法菌株摇瓶发酵,采用现代色谱学方法(硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备HPLC),对发酵产物进行分离,利用现代波谱学技术对化合物进行结构鉴定。结果从海洋放线菌Kocuria sp... 详细信息

目的研究海洋放线菌Kocuria sp.的次级代谢产物。方法菌株摇瓶发酵,采用现代色谱学方法(硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备HPLC),对发酵产物进行分离,利用现代波谱学技术对化合物进行结构鉴定。结果从海洋放线菌Kocuria sp.发酵液的乙酸乙酯萃取部分分离得到16个单体化合物。结论海洋放线菌Kocuriasp.可产生结构丰富多样的环肽类化合物,所有化合物均首次从Kocuria属放线菌中分离得到。

关键词：海洋放线菌 Kocuria属次级代谢产物环肽

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移动IP在校园网的应用设计

科学技术与工程 2007年第13期7卷 3167-3171页

作者：单慧琳张银胜南京信息工程大学电子与信息工程学院南京210044

分析了移动IP的基本原理,从实际应用的角度详细阐述了移动IP在校园网中的设计与实现过程,重点对网络架构设计、技术选择、上联方式设计等进行了分析设计。

关键词：移动IP 校园网网络架构设计上联方式设计

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min lin Mai Xiang Wen-hui Wei Shu-hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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