检索结果-南通市图书馆

Fine Particulate Matter-Induced Exacerbation of Allergic Asthma via Activation of T-cell Immunoglobulin and Mucin Domain 1

引用

Chinese Medical Journal 2018年第20期131卷 2461-2473页

作者： Yun-Xia Zhao hui-ran zhang Xiu-Na Yang Yu-Hao zhang Shan Feng Feng-Xue Yu Xi-Xin Yan Department of Respiratory and Critical Care Medicine The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Respiratory Medicine The Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China Department of Respiratory Medicine The Third Hospital of Shijiazhuang Shijiazhuang Hebei 050000 China Department of Emergency Jinzhou General Hospital Hebei 052260 China Department of Internal Medicine The Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China Department of Central Laboratory The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China

Background： Fine particulate matter （PM2.5） exacerbates airway inflammation and hyperreactivity in patients with asthma, but the mechanism remains unclear. The aim of this study was to observe the effects of prolonged exposure to high concentrations of PM2.5 on the pathology and airway hyperresponsiveness （AHR） of BALB/c mice undergoing sensitization and challenge with ovalbumin （OVA） and to observe the effects of apoptosis and T-cell immunoglobulin and mucin domain 1 （TIM-1） in this process. Methods： Forty female BALB/c mice were divided into four groups： control group, OVA group, OVA/PM group, and PM group （n - 10 in each group）. Mice in the control group were exposed to filtered clean air. Mice in the OVA group were sensitized and challenged with OVA. Mice in the OVA/PM group were sensitized and challenged as in the OVA group and then exposed to PM2.5 for 4 h per day and 5 days per week for a total of 8 weeks using a nose-only ＂PM2.5 online enrichment system＂ in The Second Hospital of Hebei Medical University. Mice in the PM group were exposed to the PM2.5 online enrichment system only. AHR was detected. Bronchoalveolar lavage fluid （BALF） was collected for cell classification. The levels of interleukin-4 （IL-4）, IL-5, and IL-33 in BALF were measured using enzyme-linked immunosorbent assay. Changes in histological structures were examined by light microscopy, and changes in ultramicrostructures were detected by electron microscopy. Apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling （TUNEL） assay in the lung tissues. Western blotting and immunohistochemistry were utilized to analyze the expression of Bcl-2, Bax, and TIM-1 in the lungs. Results： The results showed that AHR in the OVA/PM group was significantly more severe than that in the OVA and PM groups （P 〈 0.05）. AHR in the PM group was also considerably more severe than that in the control group （P 〈 0.05）. The BALF of OVA/PM group （28.00± 6.08 vs. 12.33 ±4.51, t

关键词： Apoptosis Asthma Fine Particulate Matter T-cell Immunoglobulin and Mucin Domain 1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

软件过程的OPEN描述与面向过程的CASE环境

引用

计算机科学 1994年第1期21卷 71-74页

作者：王晖张然复旦大学计算机科学系上海200433

1.引言软件是一种无形的逻辑产品,是软件开发人员的创造性思维的产物。尽管我们已有了一些软件质量的度量方法,但在软件开发过程结束以前,我们还无法对其质量作出精确可靠的预测。到目前为止,我们只能说:“合适的开发方法和良好的组织... 详细信息

1.引言软件是一种无形的逻辑产品,是软件开发人员的创造性思维的产物。尽管我们已有了一些软件质量的度量方法,但在软件开发过程结束以前,我们还无法对其质量作出精确可靠的预测。到目前为止,我们只能说:“合适的开发方法和良好的组织管理是成功的一半。”

关键词：软件开发软件过程 CASE OPEN描述

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevalence of Chronic Kidney Disease-Mineral Bone Disorder in Hemodialysis Patients in Hebei,China

引用

Chinese Medical Journal 2018年第22期131卷 2749-2751页

作者： Jing-Jing Jin Sheng-Lei zhang Jin-Sheng Xu Li-Wen Cui hui-ran zhang Ya-Ling Bai Department of Nephrology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050011China

To the Editor:Chronic kidney disease-mineral bone disorder (CKD-MBD)has been found universally in hemodialysis (HD) *** increases the risk of cardiovascular morbidity and mortality,particularly vascular calcification.[1]Consequently, it is crucial to effectively control the biochemical indicators' abnormalities of ***,al guidelines have provided measures for CKD-MBD,but relevant research from developing countries is limited,especially in China.[2]

关键词： Prevalence Hemodialysis Patients

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents

Membrane microdomain determines the specificity of receptor-...

引用

中国神经科学学会第十届全国学术会议

作者： hui-ran zhang Ya-Ni LIU Jia-Xi XU Fan zhang hui-Ling LIANG Xiao-Na DU Hai-Lin zhang The Key Laboratory of Neural and Vascular Biology Ministry of Education

Objective Kv7/M current is one of the major mechanisms controlling the neuronal *** of Kv7/M can be modulated by activation of G protein coupled receptors(GPCR) with distinct signaling mechanisms,represented by M type acetylcholine receptor(M) and type II bradykinin receptor(B).Membrane microdomain has been implicated in the specificity of various cell *** study is intended to understand the role of lipid raft in the specificity of Kv7/M current modulation by activation of *** Amphotericin B perforated patch clamp was performed to record Kv7/M *** raft was isolated through sucrose density gradient centrifugation and Triton X-100 solubilization,and it was identified by the localization of its marker *** Carise was measured with laser scanning confocal ***-immunoprecipitation was done to observe the interaction of IPR with BR before and after MpCD ***(1) Methyl-p-cyclodextrin(MpCD),which has often been used to disrupt the integrity of the lipid raft,significantly reduced the bradykinin receptors(B2R)-induced but not muscarinic receptors(MR)-induced inhibition of Kv7/M current.(2) BR and related signaling molecules,but not MR were found in the cavoelin-containing raft fractions in rat superior cervical ganglion(SCG).Furthermore,activation of BR translocated more BR into the hpid raft,which was not observed for activation of MR.(3) BR-induced intracellular Ca rising was also greatly reduced after MpCD treatment.(4) BR but not MR was found to interact with IP *** Lipid rafts play a crucial role in bradykinin mediated inhibition of M currents in SCG neurons.

关键词： lipid raft receptor Kv7/M current modulation specificity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

冬枣采后生理及保鲜技术研究进展

引用

保鲜与加工 2017年第1期17卷 134-138页

作者：张惠然张军南京信息工程大学语言文化学院江苏南京210044

冬枣采后贮藏期间各项生理指标变化较大,应采取保鲜措施减缓生理变化,延缓衰老。本文从呼吸作用、内含物变化、乙烯释放、酶的作用几方面概述了冬枣的采后生理特性,并从物理保鲜、化学保鲜、生物保鲜3个方面综述了国内外冬枣保鲜技术研... 详细信息

冬枣采后贮藏期间各项生理指标变化较大,应采取保鲜措施减缓生理变化,延缓衰老。本文从呼吸作用、内含物变化、乙烯释放、酶的作用几方面概述了冬枣的采后生理特性,并从物理保鲜、化学保鲜、生物保鲜3个方面综述了国内外冬枣保鲜技术研究进展,指出各类保鲜技术的保鲜机理及优缺点等,展望了冬枣保鲜的研究方向,以期为我国冬枣产业的发展提供理论指导。

关键词：冬枣采后生理保鲜技术研究进展展望

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

引用

Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan zhang Xingyu Zhou Qian Wang Changyu Liu Yangyang Liu hui Wang Xiaojie Liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Endogenous/exogenous dual stimulation“ROS engineering”amplification combined with autophagy-augmented for efficient ferroptosis therapy

引用

Nano Research 2025年第1期18卷 597-606页

作者： Pengye Du Pengpeng Lei Yuan Liang ran An Yi Wei Shuyu Liu Jianhao Zheng Hongjie zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry Tsinghua UniversityBeijing 100084China

“Reactive oxygen species(ROS)engineering”is one of the most promising anti-tumor treatments developed in recent *** explosion of ROS will cause oxidative stress,thereby inducing tumor cell ***,ROS accumulation in tumor cells is eliminated by endogenous cellular self-regulation *** this work,a kind of endogenous/exogenous dual stimulation nanoagent noted as UMZC is *** reaction occurs between NH_(2)-MIL-88B(Fe)contained in UMZC and the overexpression of endogenous H_(2)O_(2)to generate ROS,amplified by endogenous H_(2)S of colon tumor *** addition,NH_(2)-MIL-88B(Fe)also functions to deplete glutathione(GSH)for stopping it from consuming *** nanoparticles at the core of UMZC convert near-infrared into visible light,which excites zinc phthalocyanine to initiate the photochemical reaction that generates more ROS,thus alleviating the lack of tissue penetration depth for visible *** agonist chitosan oligosaccharides induce enhancement of cellular autophagy for disrupting cellular metabolic stress and the resistance to oxidative stress of tumor cells,allowing“ROS engineering”to fully exert anti-tumor *** of ROS generation,GSH depletion,and induced cellular autophagy caused by nanoagents have promoting effects on the occurrence of ***,the nanoagents show the ability to effectively treat colon tumors.

关键词： reactive oxygen species(ROS)engineering upconversion nanoparticles cellular autophagy ferroptosis tumor therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

引用

Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan ran Zihan Li Tianyuan Zhao Fangfang zhang Juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unraveling brain aging through the lens of oral microbiota

引用

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi zhang Jing Qu Guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种探索高熵合金相形成的端到端机器学习框架

引用

Transactions of Nonferrous Metals Society of China 2023年第7期33卷 2110-2120页

作者：张惠然胡瑞刘茜李盛洲张光捷钱权丁广太戴东波上海大学计算机工程与科学学院上海200444 上海大学材料基因研究院上海200444 之江实验室杭州311100 Department of Computer Science University of TsukubaTsukubaIbaraki 305-8573Japan

探索高熵合金(HEAs)的相形成规则对于新型合金的设计具有明确的指导意义。提出一种端到端的框架用来从特征池和模型池中分别选择特征子集和机器学习(ML)模型。在该框架中,模型池中的模型基于其获得的特征重要性来选择适合自身的特征子集... 详细信息

探索高熵合金(HEAs)的相形成规则对于新型合金的设计具有明确的指导意义。提出一种端到端的框架用来从特征池和模型池中分别选择特征子集和机器学习(ML)模型。在该框架中,模型池中的模型基于其获得的特征重要性来选择适合自身的特征子集;通过评估每个模型和其对应的特征子集的拟合结果,用于建立目标任务的预测模型;最终,获得影响HEAs相形成的重要因素。研究结果显示,建立的相预测模型可将430种HEAs分成5种相,测试准确度达到87.8%,并且通过分析模型发现,当原子尺寸差异大于8.295%时,HEAs的单相固溶体的形成受到抑制。

关键词：特征选择高熵合金机器学习相预测 Hume-Rothery规则

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：