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Choriocarcinoma misdiagnosed as cerebral hemangioma:A case report

World Journal of Clinical Cases 2021年第30期9卷 9174-9181页

作者： hui-qiong huang Feng-Ming Gong Ru-Tie Yin Xiao-Juan Lin Gynecological Oncology of Biotherapy Laboratory Department of Gynecology and ObstetricsKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Choriocarcinoma is a subtype of gestational trophoblastic disease,gestational trophoblastic *** with brain metastasis are rare and information on the optimal treatment and patient outcome is *** order to improve the prognosis of this disease,accurate and timely treatments are very important for the patient of brain metastasis by *** SUMMARY A 17-year-old unmarried girl was misdiagnosed with a cerebral hemangioma with intracranial hemorrhage in a local hospital after presentation with severe head *** underwent craniotomy three times for *** pathological results of posterior intracranial hematoma showed choriocarcinoma,and the patient was diagnosed as choriocarcinoma(21 points in stage IV).After uterine artery embolization,etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine chemotherapy for 7 cycles,and whole brain radiotherapy,the patient achieved *** has been followed for 2 years with no signs of tumor *** For female patients of childbearing age with an intracranial hematoma,the possibility of brain metastasis by choriocarcinoma should be *** is necessary to obtain a detailed history,including menstruation,beginning age of first sex,contraception,*** level ofβ-human chorionic gonadotropin should be tested at the beginning,and a stratified treatment should be administered according to the International Federation of Gynecology and Obstetrics staging and World Health Organization prognostic scoring systems.

关键词： Brain metastasis Choriocarcinoma Uterine artery embolization Chemotherapy Whole brain radiotherapy Craniotomy Case report

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A general stabilizing strategy based on vitamin C for n-type organic semiconductors

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Science China Materials 2025年第01期 303-304页

作者： hui huang College of Materials Science and Opto-Electronic Technology Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Organic semiconductors (OSCs), as an emerging next-generation semiconductor material, hold promising prospects in fields such as flexible displays, electronic skins, smart healthcare,and the Internet of Things, due to their excellent flexibility,solution processability, and tunable band structures [1,2]. These molecules are often classified into n-type and p-type, depending on whether the prevalent charge carriers are electrons or holes[3].

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小剂量Gn启动在超长方案患者行IVF/ICSI-ET助孕治疗中的应用

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生殖与避孕 2016年第12期36卷 976-980页

作者：田莉峰伍琼芳唐亮黄志辉苏琼李游许定飞江西省妇幼保健院生殖中心南昌330006

目的：探讨正常卵巢反应不孕患者行体外受精／卵胞质内单精子显微注射．胚胎移植（invitro fertilization／intracytoplasmic sperm injection and embryo transfer，IVF／ICSI-ET）助孕治疗中早卵泡期超长方案时采用小剂量促性腺激素（... 详细信息

目的：探讨正常卵巢反应不孕患者行体外受精／卵胞质内单精子显微注射．胚胎移植（invitro fertilization／intracytoplasmic sperm injection and embryo transfer，IVF／ICSI-ET）助孕治疗中早卵泡期超长方案时采用小剂量促性腺激素（gonadotropin，Gn）启动对临床结局的影响。方法：回顾性分析行早卵泡期超长方案患者1393例，其中小剂量Gn启动组（A组，Gn75-149u）858例，正常剂量Gn启动组饵组，Gn150-225U）535例。分析不同Gn启动剂量患者的临床结局。结果：A组Gn使用时间长，Gn使用总量低，获卵数少，hCG注射日E2水平低、LH水平高，双原核（2PN）受精率、优质胚胎率、种植率、临床妊娠率均高于B组，差异有统计学意义（P〈0．05）。早期流产率、全部胚胎冷冻率及中重度卵巢过度刺激综合征（ovarian hyperstimulation syndrome，OHSS）发生率组间无明显统计学差异（P〉0．05）。结论：在早卵泡期超长方案中使用小剂量Gn启动超促排卵可获得更佳的临床结局，值得推广。

关键词：小剂量Gn启动早卵泡期超长方案体外受精/卵胞质内单精子显微注射.胚胎移植 (IVF/ICSI—ET) 临床妊娠率

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： hui Zhu Li Mu Xi Xu Tianyi huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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血清人附睾蛋白联合糖链抗原-125检测在卵巢癌诊断中作用的系统评价

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中华妇幼临床医学杂志（电子版） 2012年第3期8卷 245-248页

作者：黄慧琼唐静彭鸿灵赵霞四川大学华西第二医院妇产科成都610041

目的系统评价血清人附睾蛋白(HE4)联合糖链抗原-125(CA125)测定对卵巢癌的诊断价值及临床应用前景。方法计算机检索Cochrane图书馆、Medline、Pubmed、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库[维普(VIP)]等数据库,检索年... 详细信息

目的系统评价血清人附睾蛋白(HE4)联合糖链抗原-125(CA125)测定对卵巢癌的诊断价值及临床应用前景。方法计算机检索Cochrane图书馆、Medline、Pubmed、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库[维普(VIP)]等数据库,检索年限均从建库至2012年2月,收集有关血清HE4联合CA125检测诊断卵巢癌的诊断试验,手工检索相关会议论文集、学位论文汇编等。根据Cochrane系统评价方法筛选研究并提取数据,采用Meta-DiSc1.4软件进行Meta分析(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准)。结果 12篇文献符合纳入标准纳入本系统评价,其中卵巢癌病例组为848例,正常或非卵巢癌病例对照组为1468例。各研究之间存在异质性,按照随机效应模型计算,CA125单独检测及CA125联合HE4检测,对卵巢癌诊断的汇总灵敏度、阴性似然比、诊断比值比(DOR),受试者工作特征曲线下面积SROCAUC及Cochrane-Q指数分别为:81%(95%CI:0.79～0.84)与93%(95%CI:0.92～0.95);0.26(95%CI:0.22～0.32)与0.10(95%CI:0.07～0.14);14.02(95%CI:8.50～23.11)与56.46(95%CI:34.86～91.47)及0.8697与0.9544;0.80200与0.89605。结论 HE4作为诊断卵巢癌的新型肿瘤标志物与CA125联合检测,可提高卵巢癌的诊断准确率。

关键词：人附睾蛋白联合糖链抗原-125 卵巢癌诊断 Meta分析

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Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1146-1166页

作者： qiong Li Lin-Yi huang hui-Ping Xue Department of Gastroenterology and Hepatology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors in the *** in recent years tremendous progress has been made in its early detection,the postoperative overall survival(OS)of GC patients remains extremely low.A number of studies have shown that age,to varying degrees,affects the prognosis of patients with ***,this study retrospectively analyzed the clinical and pathologic data of patients with GC to explore the differences in the clinical characteristics and prognostic factors in different age *** To explore the difference in clinicopathological characteristics and prognostic factors in GC patients in different age *** In this retrospective study,we analyzed 1037 GC patients admitted to Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from May 2010 to January *** patients were divided into two groups based on age:Younger group(less than 70 years old)and older group(no less than 70 years old).In the younger group,we subdivided the patients in two subgroups by a cutoff value of 45 *** clinical features and prognostic factors were analyzed in both ***,we retrieved studies that evaluated the predictive role of neutrophil-lymphocyte ratio(NLR)by searching two medical databases,PubMed and EMBASE,to conduct a ***-effects model was used to pool the *** In the retrospective study,the mean OS time of the younger group(64.7 mo)was significantly longer than that of the older group(48.1 mo)(P<0.001).Among patients under 70 years of age,hospitalization time,tumor–node–metastasis(TNM)stage,vascular invasion,and preoperative low pre-albumin were independently associated with OS(P<0.005).In patients aged 70 years and above,TNM stage,esophageal invasion,histological type,and preoperative NLR were independent factors for OS(P<0.05).The OS of these older patients was also significantly shorter(P<0.05).In the meta-analysis,19 retrieved studies inc

关键词： Gastric cancer Neutrophil-lymphocyte ratio Age Prognosis Overall survival Meta-analysis

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-hui Jiang hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Integral inference method for da/dN-ΔK and P-da/dN-ΔK curves

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航空动力学报 2011年第6期26卷 1251-1256页

作者： FU hui-min WU qiong Research Center of Small Sample Technology Beijing University o~ Aeronautics and Astronautics Beijing 100191 China

The integral inference method for fatigue crack growth(FCG) curve was established based on the two-variance regression *** estimates of da/dN-ΔK curve and P-da/dN-ΔK curve with high confidence level and high survival probability were also *** data scatter with stress intensity factor ranges in reality,which limits the group test method's *** presented method analyzes FCG curve as an integration,thus it can exploit the lengthwise information among the FCG rates corresponding to different stress intensity factor ***,compared with group test method,the presented method can not only save specimens,but also have higher precision in the evaluations of da/dN-ΔK and P-da/dN-ΔK curves.

关键词： aero-engine fatigue crack growth(FCG) crack growth rate integral estimate reliability

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中国新诊断癫痫儿童首选丙戊酸钠或左乙拉西坦治疗方案的成本效果分析

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中华实用儿科临床杂志 2013年第1期28卷 42-47页

作者：高静云王颖慧杨莉臧莉莉黄琼辉赵海娟王云秀王丽姜玉武吴晔北京大学第一医院儿科 100034 北京大学公共卫生学院

目的对中国新诊断癫痫患儿首选丙戊酸钠（VPA）或左乙拉西坦（LEV）治疗方案进行成本效果分析，从药物经济学角度为抗癫痫药的个体化选择提供依据。方法利用决策树模型模拟新诊断的癫痫患儿VPA一线治疗或LEV一线治疗后的不同结局，总观... 详细信息

目的对中国新诊断癫痫患儿首选丙戊酸钠（VPA）或左乙拉西坦（LEV）治疗方案进行成本效果分析，从药物经济学角度为抗癫痫药的个体化选择提供依据。方法利用决策树模型模拟新诊断的癫痫患儿VPA一线治疗或LEV一线治疗后的不同结局，总观察时间为6个月。LEV或VPA单药治疗3个月进行第1次疗效评估，根据评估结果调整药物（继续用原药、添加或换用VPA或LEV），再治疗3个月进行第2次疗效评估。分别获得VPA一线治疗或LEV一线治疗患儿6个月的治疗成本以及治疗效果，在决策树模型中进行成本效果分析。用增量成本效果比来反映2种治疗方案的效果和成本的综合比较，即一种治疗方案较另一种治疗方案多增加1例无发作病例所需要多支出的成本。结果对于中位数体质量的中国儿童，LEV一线治疗较VPA一线治疗每新增1例无发作病例，6个月需多支出4981．858元。如果6个月的意愿支付成本在4000元以上，则LEV一线治疗方案成本效果更好的可能性大。6个月的支付成本为25000元时，LEV一线治疗方案具有更好成本效果的概率为90％。结论低意愿支付成本的情况下，VPA一线治疗的成本效果更佳，高意愿支付成本的情况下，LEV一线治疗的成本效果更佳。在其他因素综合考虑的情况下，药物经济学因素应作为个体化药物选择的考虑指标之一。

关键词：癫痫成本效果分析丙戊酸钠左乙拉西坦儿童

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du hui huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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