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Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1146-1166页

作者： Qiong Li Lin-Yi Huang hui-ping xue Department of Gastroenterology and Hepatology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors in the *** in recent years tremendous progress has been made in its early detection,the postoperative overall survival(OS)of GC patients remains extremely low.A number of studies have shown that age,to varying degrees,affects the prognosis of patients with ***,this study retrospectively analyzed the clinical and pathologic data of patients with GC to explore the differences in the clinical characteristics and prognostic factors in different age *** To explore the difference in clinicopathological characteristics and prognostic factors in GC patients in different age *** In this retrospective study,we analyzed 1037 GC patients admitted to Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from May 2010 to January *** patients were divided into two groups based on age:Younger group(less than 70 years old)and older group(no less than 70 years old).In the younger group,we subdivided the patients in two subgroups by a cutoff value of 45 *** clinical features and prognostic factors were analyzed in both ***,we retrieved studies that evaluated the predictive role of neutrophil-lymphocyte ratio(NLR)by searching two medical databases,PubMed and EMBASE,to conduct a ***-effects model was used to pool the *** In the retrospective study,the mean OS time of the younger group(64.7 mo)was significantly longer than that of the older group(48.1 mo)(P<0.001).Among patients under 70 years of age,hospitalization time,tumor–node–metastasis(TNM)stage,vascular invasion,and preoperative low pre-albumin were independently associated with OS(P<0.005).In patients aged 70 years and above,TNM stage,esophageal invasion,histological type,and preoperative NLR were independent factors for OS(P<0.05).The OS of these older patients was also significantly shorter(P<0.05).In the meta-analysis,19 retrieved studies inc

关键词： Gastric cancer Neutrophil-lymphocyte ratio Age Prognosis Overall survival Meta-analysis

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Application of psychological intervention in intensive care unit nursing for patients with severe acute pancreatitis

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World Journal of Psychiatry 2024年第6期14卷 913-919页

作者： Chun-Xia Huang Xiao-Yan Xu Dong-Mei Gu hui-ping xue Department of Outpatient The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Emergency Intensive Care Unit The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Nursing The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Severe acute pancreatitis(SAP)is a familiar critical disease in the intensive care unit(ICU)*** staff are important spiritual pillars during the treatment of patients,and in addition to routine nursing,more attention needs be paid to the patient’s psychological *** To investigate the effects of psychological intervention in ICU patients with *** One hundred ICU patients with SAP were hospitalized in the authors’hospital between 2020 and 2023 were selected,and divided into observation and control groups per the hospitalization *** control and observation groups received routine nursing and psychological interventions,*** groups are being compared,using the Self-rating Anxiety Scale(SAS),Self-Determination Scale(SDS),Acute Physiology and Chronic Health Evaluation(APACHE)Ⅱ,and 36-item Short Form Health Survey(SF-36)scores;nursing satisfaction of patients;ICU care duration;length of stay;hospitalization expenses;and the incidence of *** After nursing,the SDS,SAS,and APACHEⅡ scores in the experimental group were significantly lower than in the control group(P<0.05).The SF-36 scores in the observation group were significantly higher than those in the control group(P<0.05).The nursing satisfaction of patients in the experimental group was 94.5%,considerably higher than that of 75.6% in the control group(P<0.05).The ICU care duration,length of stay,and hospitalization expenses in the observation group were significantly lower than those in the control group,and the incidence of complications was lower(P<0.05).CONCLUSION For patients with SAP,the implementation of standardized psychological intervention measures can effectively alleviate adverse psychological conditions.

关键词： Severe acute pancreatitis Intensive care unit nursing Psychological intervention Changes of psychological status Short Form Health Survey

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Effects of ultrasound monitoring of gastric residual volume on feeding complications,caloric intake and prognosis of patients with severe mechanical ventilation

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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1719-1727页

作者： Xiao-Yan Xu hui-ping xue Ming-Jun Yuan You-Rong Jin Chun-Xia Huang Department of Emergency Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina 不详 Department of Emergency Outpatient Nantong University Affiliated HospitalNantong 226001Jiangsu ProvinceChina

BACKGROUND Monitoring of gastric residual is an important approach for assessing gastric emptying in patients with mechanical *** monitoring gastric contents,the enteral nutrition scheme can be adjusted in time to ensure feeding *** To investigate the effects of ultrasound monitoring on the incidence of feeding complications,daily caloric intake and prognosis of patients with severe mechanical *** analyze the clinical significance of ultrasound monitoring of gastric residual volume(GRV)up to 250 mL to provide a theoretical basis for clinical *** Patients admitted to the department of emergency medicine of the Affiliated Hospital of Nantong University from January 2018 to June 2022 who received invasive mechanical ventilation and continuous enteral nutrition support within 24-48 h after admission were enrolled in this *** records for patients within 7 d of hospitalization were retrospectively analyzed to compare the incidence of feeding complications,daily caloric intake and clinical prognosis between patients with gastric residual≥250 mL and<250 mL,as monitored by ultrasound on the third *** A total of 513 patients were enrolled in this *** of abdominal distension,diarrhea,and vomiting in the<250 mL and≥250 mL groups were:18.4%vs 21.0%,23.9%vs 32.3%and 4.0%vs 6.5%,respectively;mortality rates were 20.8%vs 22.65%;mechanical ventilation durations were 18.30 d vs 17.56 d while lengths of stay in the intensive care units(ICU)were 19.87 d vs 19.19±5.19 *** in the above factors between groups were not *** residual≥250 mL was not an independent risk factor for death and prolonged ICU ***,target feeding time of patients in the≥250 mL group was longer than that of patients in the≥250 mL group,and caloric intake(22.0,23.6,24.8,25.3 kcal/kg/d)for patients in the≥250 mL group from the 4^(th) day to the 7^(th) day of hospitalization was lower than that of patients in the≥2

关键词： Gastric residual monitoring Mechanical ventilation Vomit Caloric intake Prognosis

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Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis

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World Journal of Gastroenterology 2008年第28期14卷 4558-4561页

作者： Li-hui Deng ping xue Qing Xia Xiao-Nan Yang Mei-Hua Wan Department of Integrated Traditional Chinese and Western Medicine West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM： To investigate the effect of admission hypertriglyceridemia （HTG） on the episodes of severe acute pancreatitis （SAP）. METHODS： One hundred and seventy-six patients with SAP were divided into HTG group （n = 45） and control group （n = 131） according to admission triglyceride （TG） ≥ 5.65 mmol/L and 〈 5.65 retool/L, respectively. Demographics, etiology, underlying diseases, biochemical parameters, Ranson＇ s score, acute physiology and chronic heath evaluation Ⅱ （APACHE Ⅱ） score, Balthazar＇s computed tomography （CT） score, complications and mortality were compared. Correlation between admission TG and 24-h APACHE Ⅱ score was analyzed. RESULTS： SAP patients with HTG were younger （40.8 ± 9.3 years vs 52.6 ± 13.4 years, P 〈 0.05） with higher etiology rate of overeating, high-fat diet （40.0% vs 14.5%, P 〈 0.05） and alcohol abuse （46.7% vs 23.7%, P 〈 0.01）, incidence rate of hypocalcemia （86.7% vs 63.4%, P 〈 0.01） and hypoalbuminemia （84.4% vs 60.3%, P 〈 0.01）, 24-h APACHE Ⅱ score （13.6 ± 5.7 vs 10.7 ± 4.6, P 〈 0.01） and admission serum glucose （17.7 ± 7.7 vs 13.4 ± 6.1, P 〈 0.01）, complication rate of renal failure （51.1% vs 16.8%, P 〈 0.01）, shock （37.9% vs 14.5%, P 〈 0.01） and infection （37.4% vs 18.3%, P 〈 0.01） and mortality （13.1% vs 9.1%, P 〈 0.01）. Logistic regression analysis showed a positive correlation between admission TG and 24-h APACHE Ⅱ score （r = 0.509, P = 0.004）.CONCLUSION： The clinical features of SAP patients with HTG are largely consistent with previous studies, HTG aggravates the episodes of SAP.

关键词： Clinical study Hypertriglyceridemia Severe acute pancreatitis Clinical features Outcome

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： hui Zhu Li Mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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实然与应然——法律伦理之可能

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现代法学 2004年第5期26卷 40-46页

作者：李光辉文学平西南政法大学重庆400031

法律伦理及法律伦理学是否可能取决于从法律伦理行为事实能否推导出法律伦理行为应该。然而,单纯从行为事实是推不出行为应该的,只有通过法律目的判断以及法律伦理行为事实和法律目的之关系判断才能从法律伦理行为事实如何推导出法律伦... 详细信息

法律伦理及法律伦理学是否可能取决于从法律伦理行为事实能否推导出法律伦理行为应该。然而,单纯从行为事实是推不出行为应该的,只有通过法律目的判断以及法律伦理行为事实和法律目的之关系判断才能从法律伦理行为事实如何推导出法律伦理行为应该如何。法律伦理行为之应该经由人们的实践活动可以变为现实,其具体保障在于法律伦理良心、法律伦理名誉及底线法律伦理的法律化。

关键词：法律伦理法律制度伦理原则法律价值

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稀土对半固态铝合金组织的影响

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中国稀土学报 2005年第S2期23卷 104-106页

作者：李辉李萍薛克敏合肥工业大学材料科学与工程学院安徽合肥230009

采用稀土处理ZL104铝合金,研究了稀土对铝合金半固态重熔加热过程中组织变化的影响。结果发现:稀土显著细化了半固态铝合金的球形晶粒组织,并提高了球形晶粒的圆整度和均匀性。而且,稀土明显降低了初生树枝晶的球化速度和球形晶粒的长... 详细信息

采用稀土处理ZL104铝合金,研究了稀土对铝合金半固态重熔加热过程中组织变化的影响。结果发现:稀土显著细化了半固态铝合金的球形晶粒组织,并提高了球形晶粒的圆整度和均匀性。而且,稀土明显降低了初生树枝晶的球化速度和球形晶粒的长大速度,大大地延长了球形晶粒粗化的时间。并且,进一步分析了稀土细化机制。

关键词：铝合金半固态球形晶粒细化稀土

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基于System Generator的简化粒子滤波算法设计及硬件实现

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电光与控制 2018年第5期25卷 100-105页

作者：王佳辉王义平薛雅丽南京航空航天大学南京210016

针对粒子滤波计算量大、硬件实现困难的问题,提出了一种用于纯方位跟踪的简化粒子滤波算法,并通过Xilinx System Generator在FPGA上实现。首先,对通用粒子滤波算法进行适当简化,使其减少计算量并且易于硬件实现;其次,采用模块化设计,利... 详细信息

针对粒子滤波计算量大、硬件实现困难的问题,提出了一种用于纯方位跟踪的简化粒子滤波算法,并通过Xilinx System Generator在FPGA上实现。首先,对通用粒子滤波算法进行适当简化,使其减少计算量并且易于硬件实现;其次,采用模块化设计,利用状态机综合并实现各个模块的时序控制;最后,转换为硬件语言,完成硬件仿真。仿真结果表明,所设计的简化粒子滤波算法各个模块工作正常,且具有较好的跟踪精度及运行速度,可用于非线性、非高斯系统的粒子滤波实现,对于粒子滤波的硬件实现方面具有一定的参考价值。

关键词：纯方位跟踪粒子滤波 FPGA System Generator 硬件实现

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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