检索结果-南通市图书馆

Clinical and genetic study of spinocerebellar ataxia type 7 in East Asian population

Chinese Medical Journal 2010年第16期123卷 2274-2278页

作者： HAN Yan YU Long ZHENG hui-min GUAN yang-tai Department of Neurology Changhai Hospital Second Military Medical University Shanghai 200433 China

Background Spinocerebellar ataxia type 7 （SCA7） is known as an autosomal dominant cerebellar ataxia; patients with genetically confirmed diagnoses of SCA7 have increased rapidly in recent ***, SCA7 is a rare subtype of SCA, and most data available about SCA7 are those of white *** aim of the present study was to systematically review the prevalence and clinical and genetic aspects of SCA7 patients in East Asian *** A search for publications on SCA7 was performed by using the ＂PubMed＂ database with the published language limited in *** mainly focusing on the prevalence of SCA7 in patients with SCA and the clinical and genetic features of SCA7 patients were fully reviewed and *** The prevalence of SCA7 in SCA patients ranged from 0 to 7.7%, which was similar to those reported *** clinical manifestations were typically present at the 30＇s of its victims （median, 29 years; interquartile range （IQR）,19.5-36.5 years）, and the symptoms appeared 15 years （（15.17±4.22） years） earlier on average in the offspring than in the *** ataxia and visual impairment were both found in all patients of whom the clinical features were *** SCA7 alleles contained 40-100 CAG repeats, with a median of 47 repeats （IQR, 44.5-50.0）; and the offspring had 13 more repeats on average compared with their parents （12.62±19.03）.A strong negative correlation was found between CAG repeat size and the onset age of patients （r=-0.739, P=0.000）.In addition, no significant difference was found in CAG repeat sizes between patients with visual impairment as the initial symptom and those with gait disturbance as their initial symptom （P=0.476）.Conclusions The prevalence of SCA7 in SCA patients, the age at onset and CAG repeats of SCA7 patients in East Asia are consistent with those of white ***, larger population study is needed to assess the correlation between the CAG repeat size and initial symptoms of

关键词： spinocerebellar ataxia type 7 East Asia clinical features genetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Occurrence and Culture of Mycorrhizal Fungi Associated with Oaks in Dandong Region, Liaoning Province

引用

Pedosphere 2005年第2期15卷 232-237页

作者： WANGhui DAILi-min yangBao-Shan LANGQing-Long GUhui-Yan InstituteofAppliedEcology ChineseAcademyofSciencesShenyang110016（China）／／GraduateSchoolofChineseAcademyofSciencesBeijing100039（China） InstituteofAppliedEcology ChineseAcademyofSciencesShenyang110016（China） InstituteofLiaoningSericulturalScience Fengcneng118100（China） InstituteofAppliedEcology ChineseAcademyofSciencesShenyang110016（China）／／CollegeofForestryNortheastForestryUniversityHarbin150040（China）

With both field investigation and pure culture experiments, the occurrence and optimal essential growth of mycorrhizal fungi with oaks in Dandong Region of Liaoning Province, China were investigated from 1997-2002 A total of 36 species of mycorrhizal fungi associated with oaks were observed. The results showed that the occurrence of mycorrhizal fungi was related to tree species, tree ages, and months of the year, with at least 20 fungi species being associated with more than two oak species. The highest Sim…

关键词： mycorrhizal fungi rnycorrhizal relationship oak pure culture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一类三种群竞争合作系统的传播问题

引用

数学学报（中文版） 2023年第3期66卷 519-526页

作者：王飏杨慧敏黎雄山西大学数学科学学院太原030006 北京师范大学数学科学学院北京100875

本文主要研究一类三种群竞争合作系统的波前解存在性及最小波速的选择机制问题.通过构造合适的上下解并结合严格的分析过程,得到了系统存在波前解的一些充分条件.本文的结果改进了已有文献中的相关结果,特别地,在存在性结果的基础上,我... 详细信息

本文主要研究一类三种群竞争合作系统的波前解存在性及最小波速的选择机制问题.通过构造合适的上下解并结合严格的分析过程,得到了系统存在波前解的一些充分条件.本文的结果改进了已有文献中的相关结果,特别地,在存在性结果的基础上,我们进一步给出最小波速线性决定的一些充分条件.这些结果丰富了三种群竞争合作系统的相关研究.

关键词：竞争合作系统行波解最小波速

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Liver synthetic function in predicting the prognosis of pregnancy complicating fulminant hepatitis

引用

Chinese Medical Journal 2007年第24期120卷 2311-2313页

作者： LI Xiao-mao DENG Liu-zhi SHEN hui-min yang Yue-bo LI Meng-xiong CHEN Xiao-wei YIN Yu-zhu ZHOU Shui-sheng Department of Obstetrics and Gynecology Third Affiated Hospital of Sun Yat-sen University Guangzhou 510630 China

Pregnancy complicating fulminant hepatitis is characterized by rapid progress, complicated clinical symptoms, and association with blood coagulation dysfunction, hepatic encephalopathy, hepatorenal syndrome, toxic enteroparalysis and infection. Late pregnancy complicating fulminant hepatitis, which has a high fatality rate, is one of the maior causes of death of gravida and puerperant in China. Searching for exact objective indexes and correct judgement of the prognosis is extremely important to clinical work. The indexes of liver function mainly include （1） indexes for the damage of hepatic cells and its degree such as alanine transaminase （ALT）, etc; （2） indexes for the synthesis function of hepatic cells such as albumin （ALB）, total cholesterol （CHOL）, prothrombin time （PT）, prothrombin activity （PTA）, etc; （3） indexes for the function of liver excretion, metabolism and detoxication such as total bilirubin （TBIL）, total bile acid （TBA）, blood ammonia （NH3）, etc.

关键词： pregnancy fulminant hepatitis liver function prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Extramedullary plasmacytoma with the uvula as first affected site:A case report

引用

World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing yang hui Peng Sheng-Ke Tu min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adiponectin Inhibits Hepatocellular Carcinoma Through Redox Signalings

Adiponectin Inhibits Hepatocellular Carcinoma Through Redox ...

引用

第八届全国医学生物化学与分子生物学第五届全国临床应用生物化学与分子生物学2013华东六省一市生物化学与分子生物学联合学术研讨会

作者： Chen-Guang Zhang Ji-Fang Yuan Su-Qian Xing hui-min yang Shu-Dong Zhao Hong Zhang Department of Medical Genetics Capital Medical University Deparrment of Neurobiology Key Laboratory for Neurodegenerative Disease of the Mini stry of EducationCapital Medical University School of Basic Medical Sciences Capital Medical University

Adiponec tin inhibits Hepatocellular Carcinoma(HCC),but the underlying mechanism remains *** results indicate that oxidative stress might play an important role in this *** of HCC cells with adiponectin decreased the cell viability accompa nied by an increase of intracellular reactive oxygen species(ROS) *** of anti-oxidant proteins or pretreatment with reductant N-acetyl cysteine(NAC)in HCC cells could attenuate or even reverse the inhibitory effect of *** further explore d the role of ROS in adiponection-induced apoptosis HCC and found that the increase of the intracellular ROS level increased the phosphorylation level of C-Jun-amino-terminal kinase(JNK) and cyctochrom c release from the mitochondria,as well as decreased ratio of Bax/Bcl2,activation of caspase3 and increased level of polyADP-ribosepolymerase(PARP)*** findings added new insight into the mechanism of HCC and probably provided a new therapeutic target for HCC.

关键词： adiponectin ROS HCC apotosis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

基于低秩优化的CT图像目标检测方法

引用

计算机工程与设计 2018年第7期39卷 2080-2083页

作者：张敏辉杨剑成都师范学院计算机科学学院四川成都611130 电子科技大学成都学院计算机学院四川成都611130

针对传统的模式识别方法难以识别CT图像中不规则目标的问题,提出一种基于低秩优化的目标识别方法。利用病灶部位在影像中的稀疏性与多样性,将众多CT图像配准到标准图像中并连接为一个矩阵;利用矩阵中正常组织部分的低秩性和病灶组织部... 详细信息

针对传统的模式识别方法难以识别CT图像中不规则目标的问题,提出一种基于低秩优化的目标识别方法。利用病灶部位在影像中的稀疏性与多样性,将众多CT图像配准到标准图像中并连接为一个矩阵;利用矩阵中正常组织部分的低秩性和病灶组织部分的稀疏性,将矩阵分解为低秩成分和稀疏成分;通过低秩优化寻找矩阵中的低秩成分和稀疏成分,直接分离出病灶组织。实验结果表明,该方法相对于传统的分类和聚类算法可以极大减少误诊率,具有更快的运行效率,可更有效地运用于辅助诊断。

关键词：低秩优化 CT图像诊断目标检测图像处理模式识别

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In situ electrochemical synthesis of MOF-5 and its application in improving photocatalytic activity of BiOBr

引用

Transactions of Nonferrous Metals Society of China 2015年第12期25卷 3987-3994页

作者：杨慧敏刘宪宋秀丽杨太来梁镇海樊彩梅太原理工大学化学化工学院太原030024

Metal-organic frameworks（MOFs） are important functional materials. MOF-5（IL）（Zn4O（BDC）3（BDC=1,4-benzenedicarboxylate） was in situ synthesized by the electrochemical method using a tunable ionic liquid（IL）, 1-butyl-3-methylimidazolium chloride, as template. The crystallization of distinctly spherical MOF-5（IL） synthsized in ionic liquid by the electrochemical method is attributed to π-π stacking effect, ionic bond, and coordination bond. The analysis results show that the product MOF-5（IL） exhibits better crystallinity and higher thermal stability than MOF-5 generated using the solvothermal method. The cyclic voltammetry reveals that the electrosynthesis reaction is irreversible and controlled by the diffusion. The experiments on methylorange degradation show that the unique structure characteristics of MOF-5（IL） can enhance the photocatalytic ability of Bi OBr. Therefore, MOFs can replace noble metals to improve the photocatalytic properties of bismuth oxyhalide.

关键词： metal-organic framewok(MOF) ionic liquids template agent in situ electrochemical synthesis Bi OBr photocatalytic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

引用

Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li hui-min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于UPLC一测多评法测定西洋参及其保健食品中人参皂苷的含量

引用

食品与药品 2018年第3期20卷 173-179页

作者：鲁辉吴杨闵春艳苏州市药品检验检测研究中心江苏苏州215104

目的基于超高效液相色谱法(UPLC)建立西洋参药材及其保健食品中皂苷类成分的一测多评法(QAMS),对人参皂苷的含量进行快速、准确的测定,并比较一测多评法与外标法实测值的差异,进而判断一测多评法的适用性。方法采用UPLC,色谱柱为Acquity... 详细信息

目的基于超高效液相色谱法(UPLC)建立西洋参药材及其保健食品中皂苷类成分的一测多评法(QAMS),对人参皂苷的含量进行快速、准确的测定,并比较一测多评法与外标法实测值的差异,进而判断一测多评法的适用性。方法采用UPLC,色谱柱为Acquity UPLC BEH C18柱(50 mm×2.1 mm,1.7μm);流动相A为乙腈,流动性B为水,梯度洗脱:流速为0.3 ml/min;柱温30℃;检测波长203 nm;以人参皂苷Rb1为内参物,建立该成分与人参皂苷Re、Rg1、Rb2、Rb3、Rc、Rd的相对校正因子,进而测定样品中各人参皂苷的含量。结果以Rb1为内参物,人参皂苷Rg1、Re、Rc、Rb2、Rb3、Rd的相对校正因子分别为1.084,0.869,0.972,1.044,1.010,1.261。在测定范围内各成分呈良好的线性关系(r≥0.999),平均回收率位于87.6%~99.7%之间,RSD均小于3.0%,并在不同的耐用性条件下方法适用性良好。对21批西洋参药材、饮片及5批西洋参类保健食品同时采用QAMS和外标法测定皂苷成分的含量,结果表明两种方法无显著性差异。结论本文建立的基于UPLC的一测多评法具有较高的选择性,分析时间短,耐用性较强,适用于西洋参药材及其保健食品中7种人参皂苷成分的含量测定。

关键词：超高效液相色谱法(UPLC) 西洋参人参皂苷一测多评法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：