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Single-incision laparoscopic transabdominal preperitoneal repair in the treatment of adult female patients with inguinal hernia

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 49-58页

作者： Xiao-Jun Zhu Jing-Yi Jiao hui-min xue Peng Chen Chang-Fu Qin Peng Wang Department of General Surgery The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Hernia and Abdominal Wall Surgery Peking University People's HospitalBeijing 100044China

BACKGROUND Women have a 3%lifetime chance of developing an inguinal hernia,which is not as common in *** to its cosmetic benefits,single-incision laparoscopic transabdominal preperitoneal(SIL-TAPP)inguinal hernia repair is becoming in-creasingly popular in the management of inguinal hernia in ***,there are no studies comparing the safety and applicability of SIL-TAPP repair with conventional laparoscopic transabdominal preperitoneal(CL-TAPP)inguinal hernia repair for the treatment of inguinal hernia in *** To compare the outcomes of SIL-TAPP and CL-TAPP repair in adult female patients with inguinal hernia and to estimate the safety and applicability of SIL-TAPP repair in adult female inguinal hernia *** We retrospectively compared the clinical information and follow-up data of fe-male inguinal hernia patients who underwent SIL-TAPP inguinal hernia repair and those who underwent CL-TAPP inguinal hernia repair at the Affiliated Hos-pital of Nantong University from February 2018 to December 2020 and assessed the long-term and short-term outcomes of both *** This study included 123 patients,with 71 undergoing SIL-TAPP repair and 52 un-dergoing CL-TAPP *** two cohorts of patients and inguinal hernia charac-teristics were similar,with no statistically meaningful *** rate of intraoperative inferior epigastric vessel injury was lower in patients in the SIL-TAPP cohort(0,0%)than in patients in the CL-TAPP cohort(4,7.7%)and was significantly different(P<0.05).In addition,the median[interquartile range(IQR)]total hospitalization costs were significantly lower in patients in the SIL-TAPP cohort[$3287(3218-3325)]than in patients in the CL-TAPP cohort[$3511(3491-3599)].Postoperatively,the occurrence rate of trocar site hernia was lower in the SIL-TAPP cohort(0,0%)than in the CL-TAPP cohort(4,7.7%),and the median(IQR)cosmetic score was significantly higher in the SIL-TAPP cohort[10(10-10)]than in the CL-TAPP cohort[9(9

关键词： Single-incision Groin hernia Female Inguinal hernia Laparoscopic transabdominal preperitoneal inguinal hernia repair

Robot-assisted partial splenectomy for benign splenic tumors:Four case reports

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World Journal of Clinical Oncology 2024年第10期15卷 1366-1375页

作者： hui-min xue Peng Chen Xiao-Jun Zhu Jing-Yi Jiao Peng Wang Department of General Surgery The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Robotic-assisted partial splenectomy(RAPS)is a superior approach for treating splenic cysts and splenic hemangiomas,as it preserves the immune function of the spleen and reduces the risk of overwhelming post splenectomy ***-tly,there are no standardized guidelines for performing a partial *** SUMMARY Four patients with splenic cysts or splenic hemangiomas were treated by *** aspects with RAPS include carefully dissecting the splenic pedicle,accurately identifying and ligating the supplying vessels of the targeted segment,and ensuring precise hemostasis during splenic parenchymal *** successful RAPS cases are presented,where the tumors were removed by pret-reating the splenic artery,dissecting and ligating the corresponding segmental vessels of the splenic pedicle,transecting the ischemic segment of the spleen,and using electrocautery for optimal *** patients underwent successful surgeries with minimal bleeding during the procedure,and there were no signs of bleeding or recurrence *** Four cases confirm the feasibility and superiority of RAPS for the treatment of benign splenic tumors.

关键词： Partial splenectomy Robotic-assisted partial splenectomy Splenic cyst Splenic hemangiomas Case report

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汶川地震同震电离层扰动研究

地震 2017年第2期37卷 126-134页

作者：何建辉张学民林剑王敏申旭辉中国地震局地震预测研究所北京100036 中国地震局地震研究所武汉130071 中国地震局地壳应力研究所北京100085

利用中国大陆陆态观测网(CMONOC)的下关、昆明和庐州GPS台站,对汶川地震引起的同震电离层扰动(CID)进行研究。通过对GPS原始观测数据进行处理证实汶川地震存在5个明显的同震电离层扰动(CID)现象。根据GPS TEC时间序列和走时,得到在电离... 详细信息

利用中国大陆陆态观测网(CMONOC)的下关、昆明和庐州GPS台站,对汶川地震引起的同震电离层扰动(CID)进行研究。通过对GPS原始观测数据进行处理证实汶川地震存在5个明显的同震电离层扰动(CID)现象。根据GPS TEC时间序列和走时,得到在电离层高度CID的水平传播速度为1.1km/s,属于震中区地表抬升引起的声波在电离层中传播速度;同时,也得到次一级CID传播速度接近0.7km/s,认为可能是重力波。在此基础上,利用射线追踪模型寻找震中位置发现,当CID水平传播速度为1000m/s时,发震时刻对应的标准偏差能达到最小值19.55s,相应的CID起源位置是30.8°N,103.15°E,距离实际震中西南方向33.6km。

关键词： GPS TEC 电离层扰动传播速度声重波 2008年汶川地震

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针刺减肥对体成分影响的临床观察

针刺研究 2017年第2期42卷 173-177页

作者：张慧敏吴学良姜超史榕荇北京和睦家康复医院中医科北京100016 北京望京社区服务中心中医科北京100102 中日友好医院针灸科北京100029

目的:观察针刺对减肥患者人体成分中脂肪、骨质、肌肉、水分的影响。方法:将符合纳入标准的71例减肥需求患者按照个人意愿自行入组针灸营养组(简称针营组,40例)或单纯营养组(简称营养组,31例)。针营组每周3次针刺中脘、下脘、天枢、曲... 详细信息

目的:观察针刺对减肥患者人体成分中脂肪、骨质、肌肉、水分的影响。方法:将符合纳入标准的71例减肥需求患者按照个人意愿自行入组针灸营养组(简称针营组,40例)或单纯营养组(简称营养组,31例)。针营组每周3次针刺中脘、下脘、天枢、曲池、外关、足三里等穴和1次营养咨询,营养组每周进行1次营养咨询,两组均连续治疗4周。应用人体成分分析仪观察治疗前后两组患者的体质量、体质量指数、脂肪质量、体脂百分比、肌肉质量、蛋白质质量、水分质量、骨质质量。结果:治疗后,两组患者的体质量、体质量指数、脂肪质量和体脂百分比较治疗前均显著下降(P<0.01);针营组较营养组下降更显著(P<0.01)。结论:针刺对减少体质量、脂肪质量和体脂百分比的效果显著,对蛋白质、水分、骨质质量的影响不明显。

关键词：针刺肥胖减重体成分体质量

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li hui Ye xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

浙江省“2004·14”号台风暴潮综合分析

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水文 2006年第1期26卷 83-86页

作者：闵惠学邵学强陈立辉刘艳伟浙江省水文局浙江杭州310009

“2004·14”号台风是1956年以来登陆我国大陆最强的一次台风,影响范围广、强度强、降雨量大,给浙江省造成了严重灾害。本文对本次强台风特点、形成的暴雨洪水等做了较系统的分析,并与历史强台风进行了比较,对水利工程效益进行了分析。

关键词：台风暴潮综合分析减灾效益

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

“200608”号超强台风暴雨洪水及防洪效益综述

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水文 2009年第1期29卷 93-96页

作者：金新芽邵学强黄仕勇闵惠学浙江省水文局浙江杭州310009 浙江省人民政府防汛防旱指挥部办公室浙江杭州310009

"200608"号超强台风是建国以来登陆我国大陆强度最强的台风。登陆时中心气压达920hPa,气压之低、强度之强为近50年来所罕见,带来的区域性大风强度破建国以来的记录,给浙江省温州、丽水等地造成了严重的灾害。本文对该次超强台风作典型... 详细信息

"200608"号超强台风是建国以来登陆我国大陆强度最强的台风。登陆时中心气压达920hPa,气压之低、强度之强为近50年来所罕见,带来的区域性大风强度破建国以来的记录,给浙江省温州、丽水等地造成了严重的灾害。本文对该次超强台风作典型个例分析,供防汛抗台工作参考。

关键词：暴雨洪水防洪效益台风

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： hui Zhu Li Mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection