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Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope

Journal of Geriatric Cardiology 2024年第6期21卷 651-657页

作者： Bin TU Zi-Hao LAI Ai-Yue CHEN Zhi-Yuan WENG Si-Min CAI Zhu-Xin ZHANG li-Kun ZHOU li-hui zheng Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesNational Key LaboratoryChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiac Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiovascular Department The First Affiliated HospitalFujian Medical UniversityFujian Institute of HypertensionFujianChina Department of Cardiovascular The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiangChina

BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).However,data on different subtypes was *** This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(36.2%)]with the diagnosis of *** characteristics among different types of VVS and the outcomes after CNA were *** After a mean follow-up of 4.3±1.5 years,41 patients(29.1%)experienced syncope/pre-syncope events after ***/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest recurrence rate after the procedure(n=6,16.7%),followed by mixed(n=26,30.6%)and vasodepressive(n=9,45.0%).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02).Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(Pline deceleration capacity(DC)level than those without(7.4±1.0 ms vs.9.0±1.6 ms,P=0.01).Patients with DC<8.4 ms had an 8.1(HR=8.1,95%CI:2.2-30.0,P=0.02)times risk of syncope/pre-syncope recurrence after CNA compared to patients with DC≥8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95%CI:2.2-30.1,P=0.02).CONCLUSIONS Different subtypes exhibit different event-free *** vasodepressive type exhibited the lowest event-free rate,but those patients with DC≥8.4 ms might benefit from CNA.

关键词： syncope subtypes diagnosis

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Ultrasound-guided stellate ganglion blockade: an appealing tactic for cardiac electrical storm

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Journal of Geriatric Cardiology 2023年第5期20卷 376-382页

作者： Zi-Hao LAI li-hui zheng Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Ventricular arrhythmia(VA)is a life-threatening cardiac *** VA occurs three times or more within 24 h and interventions are required,it is defined as an electrical storm(ES)characterized by refractoriness and recurrence.[1]For patients with implantable cardioverter defibrillator(ICD),the notion is redefined as no fewer than three appropriate and separate(at least 5 min for each interval)ICD interventions given within 24 h.

关键词： cardiac storm electrical

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Conformation Disturbance of CopC by α-Naphthylamine

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Chemical Research in Chinese Universities 2009年第3期25卷 269-272页

作者： li hui-qing zheng Xiao-yan ZHAO Ya-qin YANG Bin-sheng Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University Taiyuan 030006 P. R. China

It is known that urea and guanidine hydrochloride（GuHC1） induce conformational change of proteins in a certain range of molar ratios. In our research, a-naphthylamine（NA） above 10^-4 mol/L at pH 7.0 was discovered to perturb the conformation of CopC, a copper resistant protein with a Greek fl-barrel motif; this was reflected by the greater fluorescence quenching and red-shifted emission peak of CopC. The conformation change of CopC was also verified in acrylamide collision experiment by comparing quenching levels of CopC in the presence or the abscence of NA. Comparison of emission change of CopC-Cu^2＋ with that of apo-CopC showed a consistent result with their denaturation in GuHCl. And decreasing fluorescence polarization of CopC with increasing NA concentration is consistent with a more extend conformation of CopC. Interaction mechanism was also explored.

关键词： α-Naphthylamine(NA) CopC Conformational change

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Situational continuity-based air combat autonomous maneuvering decision-making

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Defence Technology(防务技术) 2023年第11期29卷 66-79页

作者： Jian-dong Zhang Yi-fei Yu li-hui zheng Qi-ming Yang Guo-qing Shi Yong Wu School of Electronics and Information Northwestern Polytechnical UniversityXi'an710129China Military Representative Office of Haizhuang Wuhan Bureau in Luoyang Region 471000China

In order to improve the performance of UAV's autonomous maneuvering decision-making,this paper proposes a decision-making method based on situational *** algorithm in this paper designs a situation evaluation function with strong guidance,then trains the Long Short-Term Memory(LSTM)under the framework of Deep Q Network(DQN)for air combat maneuvering *** the continuity between adjacent situations,the method takes multiple consecutive situations as one input of the neural *** reflect the difference between adjacent situations,the method takes the difference of situation evaluation value as the reward of reinforcement *** different scenarios,the algorithm proposed in this paper is compared with the algorithm based on the Fully Neural Network(FNN)and the algorithm based on statistical principles *** results show that,compared with the FNN algorithm,the algorithm proposed in this paper is more accurate and *** with the algorithm based on the statistical principles,the decision-making of the algorithm proposed in this paper is more efficient and its real-time performance is better.

关键词： UAV Maneuvering decision-making Situational continuity Long short-term memory(LSTM) Deep Q network(DQN) Fully neural network(FNN)

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Experimental study on the degree and damage-control mechanisms of fuzzy-ball-induced damage in single and multi-layer commingled tight reservoirs

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Petroleum Science 2023年第6期20卷 3598-3609页

作者： Chinedu J.Okere James J.Sheng li-Kun Fan Xiao-Wei Huang li-hui zheng Pan-Feng Wei Bob L.Herd Department of Petroleum Engineering Texas Tech UniversityTXUSA College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China China Changqing Oilfield Company CNPCXi'an710018ShaanxiChina Beijing lihuiLab Energy Technology Co. Ltd.Beijing102200China

Fuzzy-ball working fluids(FBWFs)have been successfully applied in different development phases of tight *** reports revealed that FBWFs satisfactorily met all the operational and reservoir damage control requirements during their ***,the damage-control mechanisms and degree of formation damage caused by fuzzy-ball fluids have not been investigated in lab-scale studies so *** this study,the degree of fuzzy-ball-induced damage in single-and double-layer reservoirs was evaluated through core flooding experiments that were based on permeability and flow rate ***,its damage mechanisms were observed via scanning electron microscope and energy-dispersive spectroscopy *** results show that:(1)For single-layer reservoirs,the FBWF induced weak damage on coals and medium-to-weak damage on sandstones,and the difference of the damage in permeability or flow rate index on coals and sandstones is below 1%.Moreover,the minimum permeability recovery rate was above 66%.(2)For double-layer commingled reservoirs,the flow rate index revealed weak damage and the overall damage in double-layer was lower than the single-layer reservoirs.(3)There is no significant alteration in the microscopic structure of fuzzy-ball saturated cores with no evidence of fines *** dissolution of lead and sulfur occurred in coal samples,while tellurium in sandstone,aluminum,and magnesium in ***,the precipitation of aluminum,magnesium,and sodium occurred in sandstone but no precipitates found in coal and *** temporal plugging and dispersion characteristics of the FBWFs enable the generation of reservoir protection layers that will minimize formation damage due to solid and fluid invasion.

关键词： Drilling Fracture Fuzzy-ball fluids Formation damage analysis Muti-layer tight reservoirs Permeability damage index Flow rate damage index

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Relationship between red blood cell distribution width levels and atrial fibrillation in hypertensive patients

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Journal of Geriatric Cardiology 2020年第8期17卷 486-494页

作者： li-hui zheng Shang-Yu liU Feng HU Zhi-Cheng HU li-Shui SHEN ling-Min WU Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background Information on the relationship between red blood cell distribution width(RDW)and atrial fibrillation(AF)in patients with essential hypertension are *** study aimed to assess the relationship between AF and RDW in hypertensive *** We enrolled 432 hypertensive patients,including 350 AF patients and 82 patients as ***'demographic,clinical,laboratory and echocardiographic characteristics were *** AF patients were further divided into the persistent and paroxysmal AF *** were monitored to identify the cardiac rhythm during blood sampling,and based on the rhythm,the paroxysmal AF group was categorized into the presence(with AF rhythm during blood sampling)and absence(with sinus rhythm during blood sampling)*** The AF group had elevated RDW levels than the controls(12.7%±0.8%vs.12.4%±0.7%,P=0.002),and the persistent AF subgroup had higher RDW levels than the paroxysmal AF subgroup(12.9%±0.8%vs.12.6%±0.8%,P=0.007).Furthermore,in the paroxysmal AF group,the presence group had higher RDW levels than the absence group(13.0%±0.6%vs.12.5%±0.9%,P=0.001).There was no significant difference in RDW levels between the persistent AF subgroup and presence group of the paroxysmal AF subgroup(P=0.533)and between the absence group of the paroxysmal AF subgroup and control group(P=0.262).In multivariate regression analysis,in hypertensive patients,the presence of AF rhythm is an independent predictor for increased RDW concentration(P=0.001).Conclusions The RDW may be associated with the presence of AF rhythm,which implies the importance of maintaining the sinus rhythm in hypertensive patients.

关键词： Atrial fibrillation Hypertension Inflammation Red blood cell distribution width

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Local environment regulation of transition metal dichalcogenide-based single-atom catalysts

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Rare Metals 2024年第9期43卷 4019-4037页

作者： Ming-hui li Jing li Xiao-Yu zheng Yao Zhou Advanced Research Institute of Multidisciplinary Science andSchool of Chemistry and Chemical Engineering Beijing Institute of Technology Laser Micro/Nano Fabrication Laboratory School of Mechanical Engineering Beijing Institute of Technology

Single-atom catalysts have risen significant attention in the realm of green electrocatalytic energy conversion to address energy and environmental sustainability challenges. Transition metal dichalcogenide（TMD）-based single-atom catalysts are considered highly effective in electrocatalysis due to the TMDs' notable specific surface area, tunable elemental species and efficient utilization of single atoms. In order to enhance electrocatalytic performance, it is imperative to elaborately engineer the local environment surrounding the active sites of single atoms within TMDs. In this review, we initially explore the effects of synthesis methods on single-atom active sites and the influence of loading of single atoms on catalytic performance for TMDs. The modulation strategies of the local environment surrounding single-atom sites in TMDs are elaborated, including substitution engineering,surface adsorption, vacancies, spatial confinement and dual-atom site strategies. For each modulation strategy, the effects of diverse local environments on various electrocatalytic applications are presented, such as the oxygen evolution reaction, oxygen reduction reaction, nitrogen reduction reaction, CO2reduction reaction and CO oxidation. Ultimately, this study presents a comprehensive overview of the challenges encountered and the potential directions for the advancement of single-atom catalysts based on TMDs in the realm of electrocatalysis.

关键词： Electrocatalysis

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Electroencephalogram Brain Connectome:An Approach in Research to Identify the Effect of Acupuncture on Human Brain Wave

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World Journal of Traditional Chinese Medicine 2018年第3期4卷 127-133页

作者： Ida Ayu Anom Rastiti hui-li zheng Chang-Le Chen College of Acupuncture Moxibustion and Tuina Shanghai University of Traditional Chinese Medicine Department of Nursing Science Sekolah Tinggi Ilmu Kesehatan (STIKES) Bali Deputy Chief Physician of Shanghai Qigong Research Institute Shanghai University of Traditional Chinese Medicine Tai Chi Health Center Shanghai Institute of Chinese Medicine Qigong Comprehensive Research Laboratory

Acupuncture has been used for 1000 years, but how it gives therapeutic effect is not completely understood. Integration of brain wave as the central nervous system plays an important role in acupuncture efficacy. To explore the effect of acupuncture stimulation in the central nervous system, it is imperative to decide the adjustments in brain waves that produced because of acupuncture stimulation. Electroencephalogram(EEG) is often used in the acupuncture research area. EEG records spontaneous cerebral activity after some time by positioning electrodes on scalp surface. Using EEG, we can observe the brain connectivity regarding the acupuncture stimulation. An overview regarding the effect of manual acupuncture on human brain wave through EEG observation will be discussed in this review.

关键词： Acupuncture brain waves electroencephalography

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Ablation strategies for arrhythmogenic right ventricular cardiomyopathy: a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2020年第11期17卷 694-703页

作者： li-Shui SHEN li-Min liU li-hui zheng Feng HU Zhi-Cheng HU Shang-Yu liU Jin-Rui GUO Kush Kumar Bhagat Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Arrhythmia Center Yunnan Fuwai Cardiovascular HospitalKunmingChina Eternal hospital JaipurRajasthanIndia

Background Catheter ablation for ventricular tachycardia(VT) in patients with arrhythmogenic right ventricular cardiomyopathy(ARVC) has significantly evolved over the past decade. However, different ablation strategies showed inconsistency in acute and long-term outcomes. Methods We searched the databases of Medline, Embase and Cochrane library through October 17, 2019 for studies describing the clinical outcomes of VT ablation in ARVC. Data including VT recurrence, all-cause mortality, acute procedural efficacy and major procedural complications were extracted. A meta-analysis with trial sequential analysis was further performed in comparative studies of endo-epicardial versus endocardial-only ablation. Results A total of 24 studies with 717 participants were enrolled. The literatures of epicardial ablation were mainly published after 2010 with total ICD implantation of 73.7%, acute efficacy of 89.8%, major complication of 5.2%, follow-up of 28.9 months, VT freedom of 75.3%, all-cause mortality of 1.1% and heart transplantation of 0.6%. Meta-analysis of 10 comparative studies revealed that compared with endocardial-only approach, epicardial ablation significantly decreased VT recurrence(OR: 0.50;95% CI: 0.30–0.85;P = 0.010), but somehow increased major procedural complications(OR: 4.64;95% CI: 1.28–16.92;P = 0.02), with not evident improvement of acute efficacy(OR: 2.74;95% CI: 0.98–7.65;P = 0.051) or all-cause mortality(OR: 0.87;95% CI: 0.09–8.31;P = 0.90). Conclusion Catheter ablation for VT in ARVC is feasible and effective. Epicardial ablation is associated with better long-term VT freedom, but with more major complications and unremarkable survival or acute efficacy benefit.

关键词： Arrhythmogenic right ventricular cardiomyopathy Catheter ablation Ventricular tachycardia

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Numerical and experimental study on the falling film flow characteristics with the effect of co-current gas flow in hydrogen liquefaction process

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Petroleum Science 2024年第2期21卷 1369-1384页

作者： Chong-zheng Sun Yu-Xing li hui Han Xiao-Yi Geng Xiao Lu College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266590ShandongChina College of Pipeline and Civil Engineering/Shandong Provincial Key Laboratory of Oil&Gas Storage and Transportation Safety China University of PetroleumQingdao 266580ShandongChina

liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat exchanger structure and hydrogen liquefaction process(LH2). The methods of cryogenic visualization experiment, theoretical analysis and numerical simulation are conducted to study the falling film flow characteristics with the effect of co-current gas flow in LH2spiral wound heat *** results show that the flow rate of mixed refrigerant has a great influence on liquid film spreading process, falling film flow pattern and heat transfer performance. The liquid film of LH2mixed refrigerant with column flow pattern can not uniformly and completely cover the tube wall surface. As liquid flow rate increases, the falling film flow pattern evolves into sheet-column flow and sheet flow, and liquid film completely covers the surface of tube wall. With the increase of shear effect of gas-phase mixed refrigerant in the same direction, the liquid film gradually becomes unstable, and the flow pattern eventually evolves into a mist flow.

关键词： Hydrogen liquefaction Spiral wound heat exchanger Flow pattern transition Falling film flow

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