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Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen zhang Yihui Zhai Ying Cai Xiang Gong Yunxuan Jiang Rong Rong Chao Zheng Binyu Zhu Helen He Zhu Hao Wang Yaping Li Pengcheng zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia Medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).Here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

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DYNAMIC ANALYSIS OF A TYPE OF FINANCIAL RISK CONTAGION MODEL INVOLVING IMMUNITY PERIOD AND SELF-RESCUE

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数学杂志 2024年第5期44卷 413-425页

作者： zhang Shuang-hui WANG Hai-xia XU hui-ling College of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China

In this paper,we study the dynamics of a Susceptible-Exposed-Infectious-Recovered(SEIR)nancial risk contagion model with time *** stability theory and Hopf bifurcation theory,equilibria stability and Hopf bifurcation are analyzed in *** on the epidemic model,we improve it by taking prior prevention and self-rescue into consideration,conclude pre-ventive intensity and self-rescue capabilities e ect the number of *** the same time,the analytical conditions for Hopf bifurcation are obtained,and the relevant results are veri ed by numerical simulations.

关键词： nancial risk contagion self-rescue time delay Hopf bifurcation

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Changes of growth-climate relationships of Smith fir forests along an altitudinal gradient

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Journal of Forestry Research 2024年第5期35卷 37-46页

作者： Jiacheng Zheng Jing Yang Hengfeng Jia Lixin Lyu Jiayang langzhen Qi-Bin zhang State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Linzhou Bureau of Meteorology LinzhouLhasa 851611TibetPeople’s Republic of China Institute of Plateau Ecology Tibet Agricultural and Animal Husbandry UniversityLinzhi 860000TibetPeople’s Republic of China

Temporal changes in the relationship between tree growth and climate have been observed in numerous forests across the *** patterns and the possible regu-lators(e.g.,forest community structure)of such changes are,however,not well understood.A vegetation survey and analyses of growth-climate relationships for Abies georgei ***(Smith fir)forests were carried along an altitudi-nal gradient from 3600 to 4200 m on Meili Snow Mountain,southeastern Tibetan *** results showed that the associations between growth and temperature have declined since the 1970s over the whole transect,while response to standardized precipitation-evapotranspiration indices(SPEI)strengthened in the mid-and *** between growth and vegetation data showed that tree growth was more sensitive to drought in stands with higher species richness and greater shrub *** stress on growth may be increased by heavy competition from shrub and herb *** results show the non-stationary nature of tree growth-climate associations and the linkage to for-est community *** components should be considered in future modeling and forecasting of forest dynamics in relation to climate changes.

关键词： Climate change Tree rings Altitudinal gradient Community structure Plant diversity

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Magnetism of NaYbS: From finite temperatures to ground state

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Weizhen Zhuo Zheng zhang Mingtai Xie Anmin zhang Jianting Ji Feng Jin Qingming zhang School of Physical Science and Technology Lanzhou University Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

Rare-earth chalcogenide compounds ARECh2（A = alkali or monovalent metal, RE = rare earth, Ch = O, S, Se, Te） are a large family of quantum spin liquid（QSL） candidate materials. NaYbS2is a representative member of the family. Several key issues on NaYbS2, particularly how to determine the highly anisotropic spin Hamiltonian and describe the magnetism at finite temperatures and the ground state, remain to be addressed. In this paper, we conducted an in-depth and comprehensive study on the magnetism of NaYbS2from finite temperatures to the ground state. Firstly, we successfully detected three crystalline electric field（CEF） excitation energy levels using low-temperature Raman scattering technique. Combining them with the CEF theory and magnetization data, we worked out the CEF parameters, CEF energy levels, and CEF wavefunctions. We further determined a characteristic temperature of ～40 K, above which the magnetism is dominated by CEF excitations while below which the spinexchange interactions play a main role. The characteristic temperature has been confirmed by the temperature-dependent electron spin resonance（ESR） linewidth. Low-temperature ESR experiments on the dilute magnetic doped crystal of NaYb0.1Lu0.9S2further helped us to determine the accurate g-factor. Next, we quantitatively obtained the spin-exchange interactions in the spin Hamiltonian by consistently simulating the magnetization and specific heat data. Finally, the above studies allow us to explore the ground state magnetism of NaYbS2by using the density matrix renormalization group. We combined numerical calculations and experimental results to demonstrate that the ground state of NaYbS2is a Dirac-like QSL.

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The dynamic surface evolution of halide perovskites induced by external energy stimulation

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National Science Review 2024年第4期11卷 185-194页

作者： Feiyu Cheng Pengdong Wang Chenzhe Xu Qingliang Liao Suicai zhang Haochun Sun Wenqiang Fan Guodong Liu Zhiyun Li Yaping Kong Li Wang Fangsen Li Zhuo Kang Yue zhang Academy for Advanced Interdisciplinary Science and Technology State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing Key Laboratory for Advanced Energy Materials and Technologies Key Laboratory of Advanced Materials and Devices for Post-Moore ChipsMinistry of EducationBeijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology Beijing Vacuum Interconnected Nanotech Workstation(Nano-X) Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

Tracking the dynamic surface evolution of metal halide perovskite is crucial for understanding the corresponding fundamental principles of photoelectric properties and intrinsic instability. However, due to the volatility elements and soft lattice nature of perovskites, several important dynamic behaviors remain unclear. Here, an ultra-high vacuum（UHV） interconnection system integrated by surface-sensitive probing techniques has been developed to investigate the freshly cleaved surface of CH3NH3PbBr3in situ under given energy stimulation. On this basis, the detailed three-step chemical decomposition pathway of perovskites has been clarified. Meanwhile, the evolution of crystal structure from cubic phase to tetragonal phase on the perovskite surface has been revealed under energy stimulation. Accompanied by chemical composition and crystal structure evolution, electronic structure changes including energy level position,hole effective mass, and Rashba splitting have also been accurately determined. These findings provide a clear perspective on the physical origin of optoelectronic properties and the decomposition mechanism of perovskites.

关键词： metal halide perovskite external energy stimulation surface dynamic evolution surface electronic structure ultra-high vacuum interconnection system

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Visible-light-induced organocatalyzed C（sp2）–H bond functionalization of 1,3-azoles with trifluoroacetylsilanes

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Science China Chemistry 2024年第11期 3662-3668页

作者： Zhengyu Li Zeguo zhang Zhihan zhang Gang Zhou Yizhi zhang Shanshan Liu Xiao Shen The Institute for Advanced Studies Engineering Research Center of Organosilicon Compounds & Materials Ministry of EducationWuhan University College of Chemistry Central China Normal University

Previous carbene insertion to C–H bonds of 1,3-azoles relied on metal carbene species. Herein, we report a metal-free C（sp2）–H bond functionalization of 1,3-azoles with trifluoroacetylsilanes. The reaction features mild conditions, broad substrate scope and wide functional group tolerance. The mechanistic study supports that the success of the reaction is probably attributed to the dual roles of trifluoroacetylsilanes under the photocatalyzed conditions: generating carbenes which undergo cyclopropanation and generating biradicals which promote ring-opening aromatization of the in situ generated fused cyclopropanes.

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氩气环境对激光诱导击穿光谱法检测钢中C、P、S元素的影响研究

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光谱学与光谱分析 2024年第10期44卷 2834-2839页

作者：张佳伟吴东升周洋李洋孙兰香沈阳理工大学辽宁沈阳110159 中国科学院沈阳自动化研究所机器人学国家重点实验室辽宁沈阳110016 中国科学院机器人与智能制造创新研究院辽宁沈阳110169 辽宁辽河实验室辽宁沈阳110169

激光诱导击穿光谱技术在实现钢水成分在线分析上展现了强大的应用潜力。然而,在测量钢中非常重要的C、P、S组成元素时,由于其有效的发射谱线无法在空气中远距离传输,这些元素的探测一直是个挑战。该论文工作研究了在1.5 m长探枪下,探枪... 详细信息

激光诱导击穿光谱技术在实现钢水成分在线分析上展现了强大的应用潜力。然而,在测量钢中非常重要的C、P、S组成元素时,由于其有效的发射谱线无法在空气中远距离传输,这些元素的探测一直是个挑战。该论文工作研究了在1.5 m长探枪下,探枪中氩气环境对检测钢中C、P、S元素的影响规律,发现氩气流量过大或过小都不利于光谱测量,在气流量设置为11 L·min^(-1)时,获得的光谱最稳定且谱线强度最大。使用14个标准钢样本,在最优气流量下对C、P、S三种元素实现了明显检出以及定量分析。通过内标标定后,三种元素获得的检出限(LOD)分别为0.009%、0.04%、0.015%,相对标准偏差(RSD)分别为2.34%、1.05%、1.01%,相关系数(R)分别为0.998、0.997、0.987,均方根误差(RMSE)分别为0.02%、0.02%、0.03%。该论文研究成果验证了该探枪设计的有效性,为实现钢水成分中C、P、S在线分析提供了重要的设计依据。

关键词：激光诱导击穿光谱真空紫外光谱长距离氩气流量元素检测碳磷硫

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Elucidating the cardioprotective mechanisms of sodium-glucose cotransporter-2 inhibitors beyond glycemic control

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World Journal of Diabetes 2024年第2期15卷 137-141页

作者： Ke-Xin zhang Cheng-Xia Kan Fang Han Jing-Wen zhang Xiao-Dong Sun Department of Endocrinology and Metabolism Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

Sodium-glucose cotransporter-2(SGLT2)inhibitors have emerged as a pivotal intervention in diabetes management,offering significant cardiovascular ***,in particular,has demonstrated cardioprotective effects beyond its glucose-lowering action,reducing heart failure hospitalizations and improving cardiac *** note,the cardioprotective mechanisms appear to be independent of glucose lowering,possibly mediated through several mechanisms involving shifts in cardiac metabolism and anti-fibrotic,anti-inflammatory,and anti-oxidative *** editorial summarizes the multifaceted cardiovascular advantages of SGLT2 inhibitors,highlighting the need for further research to elucidate their full therapeutic potential in cardiac care.

关键词： Diabetes Sodium-glucose cotransporter-2 Cardiovascular diseases Empagliflozin

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Securing multi-chain consensus against diverse miner behavior attacks in blockchain networks

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 540-554页

作者： Wenbo zhang Tao WANG Chaoyang zhang Jingyu FENG School of Cyberspace Security Xi’an University of Posts and TelecommunicationsXi’an 710121China Postal Savings Bank of China Xi’an 710000China

As cross-chain technologies enable interactions among different blockchains(hereinafter“chains”),multi-chain consensus is becoming increasingly important in blockchain ***,more attention has been paid to single-chain consensus ***-chain consensus schemes with trusted miner participation have not been considered,thus offering opportunities for malicious users to launch diverse miner behavior(DMB)attacks on different *** attackers can be friendly in the consensus process on some chains,called mask chains,to enhance their trust value,while on others,called kill chains,they engage in destructive behaviors on the *** this paper,we propose a multi-chain consensus scheme named Proof-of-DiscTrust(PoDT)to defend against DMB *** idea of distinctive trust(DiscTrust)is introduced to evaluate the trust value of each user across different *** trustworthiness of a user is split into local and global trust values.A dynamic behavior prediction scheme is designed to enforce DiscTrust to prevent an intensive DMB attacker from maintaining strong trust by alternately creating true or false blocks on the kill *** trusted miner selection algorithms for multi-chain environments can be implemented to select network miners,chain miners,and chain miner leaders,*** results show that PoDT is secure against DMB attacks and more effective than traditional consensus schemes in multi-chain environments.

关键词： Blockchain Cross-chain Trust mechanism Multi-chain consensus

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活性浴中惰性粒子形状对有效作用力的影响

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物理学报 2024年第15期73卷 235-242页

作者：宁鲁慧张雪杨明成郑宁刘鹏彭毅中国石油大学(北京) 油气光学探测技术北京市重点实验室北京102249 中国石油大学(北京)理学院能源交叉学科基础研究中心北京102249 北京理工大学物理学院北京100081 中国科学院物理研究所北京凝聚态物理国家研究中心软物质物理实验室北京100190 中国科学院大学物理科学学院北京100049 松山湖材料实验室东莞523808

活性物质是典型的非平衡态系统,其组成单元能够利用自身存储的能量或者周围环境的能量实现自驱动.在活性系统中,物体间的受力情况直接影响其结构和动力学行为,因此深入了解物体间的有效作用力是理解活性物质一切复杂现象的基础.本文通... 详细信息

活性物质是典型的非平衡态系统,其组成单元能够利用自身存储的能量或者周围环境的能量实现自驱动.在活性系统中,物体间的受力情况直接影响其结构和动力学行为,因此深入了解物体间的有效作用力是理解活性物质一切复杂现象的基础.本文通过光镊显微镜实验分别研究了活性大肠杆菌溶液中惰性球形聚苯乙烯胶体粒子间和板状粒子间的有效作用力,发现球形粒子间有效作用力的性质一直是短程排斥力,而板状粒子间的有效作用力则为长程吸引力,这说明惰性粒子间的有效作用力受粒子形状的影响.惰性粒子间的有效作用力主要来源于两部分的贡献,即细菌-惰性粒子间的直接碰撞,以及细菌运动产生的流场.在实验上通过对比粒子之间、粒子外侧细菌的浓度和取向有序性发现,球形粒子间的有效排斥力主要来源于细菌-粒子的直接碰撞,而板状粒子间的长程吸引力则主要源于细菌流场的贡献.本文通过光镊显微镜实验证明了惰性粒子间的有效作用力与惰性粒子的几何构型有关,为调控活性物质中的动态自组装提供了实验支撑.

关键词：活性物质光镊有效作用力粒子形状

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